Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q6C4_LEIMA

TriTrypDb:

LmjF.31.1390 , LMJLV39_310021000 , LMJSD75_310020500

Length:

762

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q6C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6C4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.575
CLV_C14_Caspase3-7	554	558	PF00656	0.581
CLV_NRD_NRD_1	163	165	PF00675	0.784
CLV_NRD_NRD_1	221	223	PF00675	0.847
CLV_NRD_NRD_1	484	486	PF00675	0.810
CLV_NRD_NRD_1	494	496	PF00675	0.704
CLV_NRD_NRD_1	628	630	PF00675	0.804
CLV_PCSK_KEX2_1	184	186	PF00082	0.707
CLV_PCSK_KEX2_1	221	223	PF00082	0.847
CLV_PCSK_KEX2_1	483	485	PF00082	0.819
CLV_PCSK_KEX2_1	494	496	PF00082	0.701
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.707
CLV_PCSK_SKI1_1	19	23	PF00082	0.806
CLV_PCSK_SKI1_1	221	225	PF00082	0.796
CLV_PCSK_SKI1_1	658	662	PF00082	0.800
DEG_APCC_DBOX_1	657	665	PF00400	0.598
DEG_APCC_DBOX_1	683	691	PF00400	0.529
DEG_APCC_DBOX_1	750	758	PF00400	0.482
DEG_COP1_1	303	313	PF00400	0.568
DEG_Nend_UBRbox_1	1	4	PF02207	0.585
DEG_SPOP_SBC_1	204	208	PF00917	0.618
DOC_CYCLIN_RxL_1	16	24	PF00134	0.605
DOC_CYCLIN_yCln2_LP_2	414	420	PF00134	0.485
DOC_MAPK_MEF2A_6	316	323	PF00069	0.600
DOC_MAPK_MEF2A_6	437	446	PF00069	0.484
DOC_MAPK_MEF2A_6	583	591	PF00069	0.580
DOC_PP1_RVXF_1	175	181	PF00149	0.496
DOC_PP2B_LxvP_1	444	447	PF13499	0.653
DOC_PP2B_LxvP_1	469	472	PF13499	0.533
DOC_USP7_MATH_1	203	207	PF00917	0.638
DOC_USP7_MATH_1	243	247	PF00917	0.580
DOC_USP7_MATH_1	257	261	PF00917	0.538
DOC_USP7_MATH_1	296	300	PF00917	0.622
DOC_USP7_MATH_1	319	323	PF00917	0.557
DOC_USP7_MATH_1	327	331	PF00917	0.462
DOC_USP7_MATH_1	427	431	PF00917	0.523
DOC_USP7_MATH_1	487	491	PF00917	0.518
DOC_USP7_MATH_1	496	500	PF00917	0.510
DOC_USP7_MATH_1	542	546	PF00917	0.505
DOC_USP7_MATH_1	558	562	PF00917	0.473
DOC_USP7_MATH_1	574	578	PF00917	0.595
DOC_USP7_MATH_1	616	620	PF00917	0.592
DOC_USP7_MATH_1	636	640	PF00917	0.430
DOC_USP7_MATH_1	646	650	PF00917	0.481
DOC_USP7_MATH_1	665	669	PF00917	0.438
DOC_USP7_MATH_1	677	681	PF00917	0.331
DOC_WW_Pin1_4	135	140	PF00397	0.484
DOC_WW_Pin1_4	221	226	PF00397	0.638
DOC_WW_Pin1_4	239	244	PF00397	0.429
DOC_WW_Pin1_4	247	252	PF00397	0.534
DOC_WW_Pin1_4	271	276	PF00397	0.610
DOC_WW_Pin1_4	309	314	PF00397	0.507
DOC_WW_Pin1_4	351	356	PF00397	0.591
DOC_WW_Pin1_4	378	383	PF00397	0.514
DOC_WW_Pin1_4	413	418	PF00397	0.557
DOC_WW_Pin1_4	513	518	PF00397	0.623
DOC_WW_Pin1_4	527	532	PF00397	0.498
DOC_WW_Pin1_4	617	622	PF00397	0.510
DOC_WW_Pin1_4	663	668	PF00397	0.436
DOC_WW_Pin1_4	74	79	PF00397	0.663
LIG_14-3-3_CanoR_1	228	234	PF00244	0.634
LIG_14-3-3_CanoR_1	494	503	PF00244	0.585
LIG_14-3-3_CanoR_1	604	612	PF00244	0.493
LIG_14-3-3_CanoR_1	622	626	PF00244	0.451
LIG_14-3-3_CanoR_1	684	688	PF00244	0.378
LIG_14-3-3_CanoR_1	695	705	PF00244	0.607
LIG_BIR_III_2	306	310	PF00653	0.599
LIG_BIR_III_2	578	582	PF00653	0.639
LIG_BIR_III_4	61	65	PF00653	0.624
LIG_BRCT_BRCA1_1	296	300	PF00533	0.577
LIG_Clathr_ClatBox_1	719	723	PF01394	0.529
LIG_deltaCOP1_diTrp_1	723	729	PF00928	0.425
LIG_eIF4E_1	656	662	PF01652	0.600
LIG_eIF4E_1	692	698	PF01652	0.699
LIG_FHA_1	278	284	PF00498	0.608
LIG_FHA_1	358	364	PF00498	0.500
LIG_FHA_1	584	590	PF00498	0.578
LIG_FHA_1	684	690	PF00498	0.375
LIG_FHA_1	697	703	PF00498	0.586
LIG_FHA_1	714	720	PF00498	0.328
LIG_FHA_1	734	740	PF00498	0.486
LIG_FHA_2	276	282	PF00498	0.577
LIG_FHA_2	40	46	PF00498	0.631
LIG_FHA_2	406	412	PF00498	0.574
LIG_FHA_2	522	528	PF00498	0.532
LIG_FHA_2	549	555	PF00498	0.611
LIG_GBD_Chelix_1	697	705	PF00786	0.487
LIG_Integrin_isoDGR_2	627	629	PF01839	0.774
LIG_IRF3_LxIS_1	585	592	PF10401	0.617
LIG_LIR_Apic_2	654	659	PF02991	0.598
LIG_LIR_Gen_1	340	347	PF02991	0.592
LIG_LIR_Nem_3	340	344	PF02991	0.591
LIG_LIR_Nem_3	727	732	PF02991	0.402
LIG_PCNA_yPIPBox_3	728	740	PF02747	0.391
LIG_SH2_CRK	656	660	PF00017	0.601
LIG_SH2_NCK_1	599	603	PF00017	0.471
LIG_SH2_SRC	106	109	PF00017	0.663
LIG_SH2_SRC	235	238	PF00017	0.607
LIG_SH2_SRC	317	320	PF00017	0.570
LIG_SH2_STAP1	101	105	PF00017	0.645
LIG_SH2_STAP1	201	205	PF00017	0.484
LIG_SH2_STAP1	235	239	PF00017	0.593
LIG_SH2_STAP1	341	345	PF00017	0.566
LIG_SH2_STAP1	735	739	PF00017	0.549
LIG_SH2_STAT5	12	15	PF00017	0.656
LIG_SH2_STAT5	317	320	PF00017	0.570
LIG_SH2_STAT5	656	659	PF00017	0.599
LIG_SH2_STAT5	735	738	PF00017	0.429
LIG_SH3_1	185	191	PF00018	0.496
LIG_SH3_2	382	387	PF14604	0.676
LIG_SH3_3	185	191	PF00018	0.584
LIG_SH3_3	307	313	PF00018	0.515
LIG_SH3_3	379	385	PF00018	0.632
LIG_SH3_3	439	445	PF00018	0.619
LIG_SH3_3	469	475	PF00018	0.519
LIG_SH3_3	500	506	PF00018	0.539
LIG_SH3_3	511	517	PF00018	0.580
LIG_SH3_3	579	585	PF00018	0.606
LIG_SH3_3	659	665	PF00018	0.510
LIG_SH3_3	73	79	PF00018	0.665
LIG_SUMO_SIM_anti_2	416	423	PF11976	0.488
LIG_SUMO_SIM_anti_2	686	691	PF11976	0.467
LIG_SUMO_SIM_par_1	416	423	PF11976	0.606
LIG_SUMO_SIM_par_1	730	736	PF11976	0.496
LIG_TRAF2_1	551	554	PF00917	0.612
LIG_WW_3	78	82	PF00397	0.655
MOD_CDC14_SPxK_1	250	253	PF00782	0.604
MOD_CDC14_SPxK_1	384	387	PF00782	0.676
MOD_CDK_SPK_2	271	276	PF00069	0.601
MOD_CDK_SPK_2	617	622	PF00069	0.479
MOD_CDK_SPxK_1	247	253	PF00069	0.610
MOD_CDK_SPxK_1	381	387	PF00069	0.675
MOD_CDK_SPxxK_3	221	228	PF00069	0.638
MOD_CDK_SPxxK_3	309	316	PF00069	0.477
MOD_CDK_SPxxK_3	74	81	PF00069	0.663
MOD_CK1_1	10	16	PF00069	0.641
MOD_CK1_1	207	213	PF00069	0.602
MOD_CK1_1	351	357	PF00069	0.510
MOD_CK1_1	376	382	PF00069	0.668
MOD_CK1_1	562	568	PF00069	0.592
MOD_CK1_1	733	739	PF00069	0.522
MOD_CK2_1	205	211	PF00069	0.482
MOD_CK2_1	359	365	PF00069	0.659
MOD_CK2_1	39	45	PF00069	0.633
MOD_CK2_1	427	433	PF00069	0.584
MOD_CK2_1	521	527	PF00069	0.519
MOD_CK2_1	548	554	PF00069	0.615
MOD_CK2_1	597	603	PF00069	0.592
MOD_CK2_1	746	752	PF00069	0.550
MOD_CMANNOS	726	729	PF00535	0.744
MOD_Cter_Amidation	481	484	PF01082	0.792
MOD_Cter_Amidation	627	630	PF01082	0.803
MOD_GlcNHglycan	207	210	PF01048	0.841
MOD_GlcNHglycan	259	262	PF01048	0.823
MOD_GlcNHglycan	325	328	PF01048	0.724
MOD_GlcNHglycan	341	344	PF01048	0.685
MOD_GlcNHglycan	345	348	PF01048	0.643
MOD_GlcNHglycan	405	408	PF01048	0.814
MOD_GlcNHglycan	429	432	PF01048	0.698
MOD_GlcNHglycan	466	469	PF01048	0.856
MOD_GlcNHglycan	480	483	PF01048	0.694
MOD_GlcNHglycan	485	488	PF01048	0.630
MOD_GlcNHglycan	496	499	PF01048	0.656
MOD_GlcNHglycan	561	564	PF01048	0.820
MOD_GlcNHglycan	646	649	PF01048	0.764
MOD_GlcNHglycan	679	682	PF01048	0.488
MOD_GlcNHglycan	707	710	PF01048	0.343
MOD_GSK3_1	203	210	PF00069	0.598
MOD_GSK3_1	239	246	PF00069	0.595
MOD_GSK3_1	257	264	PF00069	0.462
MOD_GSK3_1	27	34	PF00069	0.649
MOD_GSK3_1	271	278	PF00069	0.499
MOD_GSK3_1	290	297	PF00069	0.474
MOD_GSK3_1	319	326	PF00069	0.628
MOD_GSK3_1	339	346	PF00069	0.413
MOD_GSK3_1	35	42	PF00069	0.588
MOD_GSK3_1	359	366	PF00069	0.456
MOD_GSK3_1	373	380	PF00069	0.522
MOD_GSK3_1	386	393	PF00069	0.520
MOD_GSK3_1	399	406	PF00069	0.516
MOD_GSK3_1	483	490	PF00069	0.512
MOD_GSK3_1	513	520	PF00069	0.545
MOD_GSK3_1	521	528	PF00069	0.503
MOD_GSK3_1	558	565	PF00069	0.564
MOD_GSK3_1	570	577	PF00069	0.614
MOD_GSK3_1	583	590	PF00069	0.472
MOD_GSK3_1	616	623	PF00069	0.573
MOD_GSK3_1	632	639	PF00069	0.454
MOD_GSK3_1	640	647	PF00069	0.462
MOD_GSK3_1	665	672	PF00069	0.532
MOD_LATS_1	357	363	PF00433	0.499
MOD_LATS_1	513	519	PF00433	0.531
MOD_N-GLC_1	559	564	PF02516	0.702
MOD_N-GLC_1	597	602	PF02516	0.775
MOD_N-GLC_1	7	12	PF02516	0.784
MOD_NEK2_1	205	210	PF00069	0.569
MOD_NEK2_1	21	26	PF00069	0.650
MOD_NEK2_1	300	305	PF00069	0.579
MOD_NEK2_1	363	368	PF00069	0.500
MOD_NEK2_1	410	415	PF00069	0.600
MOD_NEK2_1	587	592	PF00069	0.609
MOD_NEK2_1	651	656	PF00069	0.447
MOD_NEK2_1	669	674	PF00069	0.444
MOD_NEK2_1	697	702	PF00069	0.672
MOD_NEK2_1	705	710	PF00069	0.492
MOD_NEK2_1	713	718	PF00069	0.247
MOD_NEK2_1	746	751	PF00069	0.550
MOD_NEK2_2	216	221	PF00069	0.582
MOD_NEK2_2	243	248	PF00069	0.610
MOD_NEK2_2	521	526	PF00069	0.503
MOD_NEK2_2	542	547	PF00069	0.506
MOD_NEK2_2	730	735	PF00069	0.458
MOD_PIKK_1	148	154	PF00454	0.528
MOD_PIKK_1	2	8	PF00454	0.623
MOD_PIKK_1	294	300	PF00454	0.628
MOD_PIKK_1	31	37	PF00454	0.665
MOD_PIKK_1	345	351	PF00454	0.571
MOD_PIKK_1	724	730	PF00454	0.408
MOD_PKA_1	483	489	PF00069	0.596
MOD_PKA_1	494	500	PF00069	0.515
MOD_PKA_2	386	392	PF00069	0.614
MOD_PKA_2	399	405	PF00069	0.506
MOD_PKA_2	477	483	PF00069	0.631
MOD_PKA_2	494	500	PF00069	0.486
MOD_PKA_2	525	531	PF00069	0.588
MOD_PKA_2	569	575	PF00069	0.616
MOD_PKA_2	610	616	PF00069	0.548
MOD_PKA_2	621	627	PF00069	0.592
MOD_PKA_2	683	689	PF00069	0.467
MOD_Plk_1	410	416	PF00069	0.571
MOD_Plk_1	7	13	PF00069	0.585
MOD_Plk_2-3	115	121	PF00069	0.568
MOD_Plk_4	410	416	PF00069	0.556
MOD_Plk_4	621	627	PF00069	0.508
MOD_Plk_4	651	657	PF00069	0.597
MOD_Plk_4	669	675	PF00069	0.223
MOD_Plk_4	697	703	PF00069	0.688
MOD_Plk_4	730	736	PF00069	0.458
MOD_ProDKin_1	135	141	PF00069	0.485
MOD_ProDKin_1	221	227	PF00069	0.638
MOD_ProDKin_1	239	245	PF00069	0.432
MOD_ProDKin_1	247	253	PF00069	0.533
MOD_ProDKin_1	271	277	PF00069	0.610
MOD_ProDKin_1	309	315	PF00069	0.507
MOD_ProDKin_1	351	357	PF00069	0.593
MOD_ProDKin_1	378	384	PF00069	0.514
MOD_ProDKin_1	413	419	PF00069	0.558
MOD_ProDKin_1	513	519	PF00069	0.624
MOD_ProDKin_1	527	533	PF00069	0.498
MOD_ProDKin_1	617	623	PF00069	0.510
MOD_ProDKin_1	663	669	PF00069	0.436
MOD_ProDKin_1	74	80	PF00069	0.663
MOD_SUMO_rev_2	303	310	PF00179	0.483
TRG_DiLeu_BaLyEn_6	656	661	PF01217	0.600
TRG_ENDOCYTIC_2	341	344	PF00928	0.565
TRG_ER_diArg_1	220	222	PF00400	0.655
TRG_ER_diArg_1	483	485	PF00400	0.503
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.841
TRG_Pf-PMV_PEXEL_1	658	663	PF00026	0.801

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IG54	Leishmania donovani	82%	99%
A4HJC2	Leishmania braziliensis	49%	99%
A4I6R5	Leishmania infantum	82%	99%
E9B1T7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%