LeishMANIAdb
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zf-LSD1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
zf-LSD1 domain-containing protein
Gene product:
zinc finger domain, LSD1 subclass, putative
Species:
Leishmania major
UniProt:
Q4Q6C3_LEIMA
TriTrypDb:
LmjF.31.1395 , LMJLV39_310021200 , LMJSD75_310020600
Length:
126

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 13
GO:0043226 organelle 2 13
GO:0043227 membrane-bounded organelle 3 13
GO:0043229 intracellular organelle 3 13
GO:0043231 intracellular membrane-bounded organelle 4 13
GO:0110165 cellular anatomical entity 1 13

Expansion

Sequence features

Q4Q6C3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6C3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 51 55 PF00082 0.381
DOC_CYCLIN_yCln2_LP_2 20 26 PF00134 0.289
DOC_MAPK_gen_1 67 74 PF00069 0.397
DOC_PP2B_LxvP_1 54 57 PF13499 0.361
DOC_WW_Pin1_4 1 6 PF00397 0.605
DOC_WW_Pin1_4 35 40 PF00397 0.376
LIG_14-3-3_CanoR_1 67 72 PF00244 0.451
LIG_APCC_ABBAyCdc20_2 90 96 PF00400 0.510
LIG_FHA_1 6 12 PF00498 0.410
LIG_FHA_2 113 119 PF00498 0.551
LIG_SH2_STAT5 94 97 PF00017 0.513
LIG_SH3_2 85 90 PF14604 0.662
LIG_SH3_3 26 32 PF00018 0.289
LIG_SH3_3 82 88 PF00018 0.661
MOD_CK1_1 4 10 PF00069 0.521
MOD_CK2_1 74 80 PF00069 0.513
MOD_GlcNHglycan 103 106 PF01048 0.562
MOD_GSK3_1 1 8 PF00069 0.633
MOD_GSK3_1 70 77 PF00069 0.552
MOD_GSK3_1 97 104 PF00069 0.581
MOD_N-GLC_1 101 106 PF02516 0.508
MOD_N-GLC_1 58 63 PF02516 0.357
MOD_NEK2_1 43 48 PF00069 0.420
MOD_Plk_1 58 64 PF00069 0.364
MOD_ProDKin_1 1 7 PF00069 0.593
MOD_ProDKin_1 35 41 PF00069 0.382
TRG_ER_diArg_1 66 69 PF00400 0.419

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7F7 Leptomonas seymouri 92% 100%
A0A0S4ILH2 Bodo saltans 63% 100%
A0A1X0NRG5 Trypanosomatidae 81% 98%
A0A3R7KN79 Trypanosoma rangeli 82% 97%
A0A3R7L3Y9 Trypanosoma rangeli 34% 78%
A0A3S5H7P9 Leishmania donovani 99% 100%
A4HJB5 Leishmania braziliensis 95% 100%
A4I6R6 Leishmania infantum 99% 100%
C9ZM96 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 65% 100%
C9ZWT2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 69% 100%
E9B1T8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS