Tyrosine kinase-like (TKL) protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6C0_LEIMA

TriTrypDb:

LmjF.31.1420 , LMJLV39_310021700 , LMJSD75_310021100

Length:

1157

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6C0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6C0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1137	1141	PF00656	0.786
CLV_C14_Caspase3-7	465	469	PF00656	0.723
CLV_C14_Caspase3-7	53	57	PF00656	0.764
CLV_C14_Caspase3-7	700	704	PF00656	0.828
CLV_C14_Caspase3-7	912	916	PF00656	0.592
CLV_NRD_NRD_1	118	120	PF00675	0.748
CLV_NRD_NRD_1	187	189	PF00675	0.788
CLV_NRD_NRD_1	19	21	PF00675	0.772
CLV_NRD_NRD_1	260	262	PF00675	0.716
CLV_NRD_NRD_1	30	32	PF00675	0.633
CLV_NRD_NRD_1	328	330	PF00675	0.741
CLV_NRD_NRD_1	370	372	PF00675	0.744
CLV_NRD_NRD_1	377	379	PF00675	0.552
CLV_NRD_NRD_1	748	750	PF00675	0.656
CLV_NRD_NRD_1	82	84	PF00675	0.734
CLV_NRD_NRD_1	847	849	PF00675	0.790
CLV_NRD_NRD_1	986	988	PF00675	0.849
CLV_PCSK_FUR_1	845	849	PF00082	0.832
CLV_PCSK_KEX2_1	187	189	PF00082	0.788
CLV_PCSK_KEX2_1	260	262	PF00082	0.716
CLV_PCSK_KEX2_1	29	31	PF00082	0.815
CLV_PCSK_KEX2_1	328	330	PF00082	0.741
CLV_PCSK_KEX2_1	370	372	PF00082	0.744
CLV_PCSK_KEX2_1	377	379	PF00082	0.552
CLV_PCSK_KEX2_1	748	750	PF00082	0.657
CLV_PCSK_KEX2_1	82	84	PF00082	0.734
CLV_PCSK_KEX2_1	847	849	PF00082	0.790
CLV_PCSK_KEX2_1	964	966	PF00082	0.847
CLV_PCSK_KEX2_1	986	988	PF00082	0.849
CLV_PCSK_PC1ET2_1	964	966	PF00082	0.847
CLV_PCSK_PC7_1	26	32	PF00082	0.733
CLV_PCSK_PC7_1	744	750	PF00082	0.615
CLV_PCSK_SKI1_1	1091	1095	PF00082	0.858
CLV_PCSK_SKI1_1	314	318	PF00082	0.699
CLV_PCSK_SKI1_1	847	851	PF00082	0.831
DEG_APCC_DBOX_1	846	854	PF00400	0.753
DEG_SCF_TRCP1_1	1102	1108	PF00400	0.651
DOC_AGCK_PIF_2	722	727	PF00069	0.780
DOC_CDC14_PxL_1	347	355	PF14671	0.705
DOC_CKS1_1	967	972	PF01111	0.754
DOC_CYCLIN_RxL_1	845	855	PF00134	0.730
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.602
DOC_MAPK_FxFP_2	207	210	PF00069	0.815
DOC_MAPK_gen_1	26	36	PF00069	0.795
DOC_MAPK_gen_1	370	381	PF00069	0.727
DOC_MAPK_gen_1	845	853	PF00069	0.800
DOC_MAPK_MEF2A_6	845	853	PF00069	0.832
DOC_PP1_RVXF_1	1144	1150	PF00149	0.799
DOC_PP1_RVXF_1	406	412	PF00149	0.742
DOC_PP2B_LxvP_1	1072	1075	PF13499	0.786
DOC_PP2B_LxvP_1	272	275	PF13499	0.838
DOC_PP4_FxxP_1	207	210	PF00568	0.815
DOC_PP4_FxxP_1	271	274	PF00568	0.833
DOC_PP4_FxxP_1	46	49	PF00568	0.721
DOC_PP4_FxxP_1	564	567	PF00568	0.743
DOC_USP7_MATH_1	1020	1024	PF00917	0.650
DOC_USP7_MATH_1	144	148	PF00917	0.683
DOC_USP7_MATH_1	175	179	PF00917	0.776
DOC_USP7_MATH_1	189	193	PF00917	0.633
DOC_USP7_MATH_1	210	214	PF00917	0.733
DOC_USP7_MATH_1	236	240	PF00917	0.802
DOC_USP7_MATH_1	244	248	PF00917	0.642
DOC_USP7_MATH_1	337	341	PF00917	0.741
DOC_USP7_MATH_1	437	441	PF00917	0.760
DOC_USP7_MATH_1	450	454	PF00917	0.611
DOC_USP7_MATH_1	480	484	PF00917	0.800
DOC_USP7_MATH_1	489	493	PF00917	0.716
DOC_USP7_MATH_1	591	595	PF00917	0.808
DOC_USP7_MATH_1	60	64	PF00917	0.751
DOC_USP7_MATH_1	611	615	PF00917	0.628
DOC_USP7_MATH_1	645	649	PF00917	0.867
DOC_USP7_MATH_1	659	663	PF00917	0.643
DOC_USP7_MATH_1	690	694	PF00917	0.764
DOC_USP7_MATH_1	709	713	PF00917	0.546
DOC_USP7_MATH_1	776	780	PF00917	0.839
DOC_USP7_MATH_1	78	82	PF00917	0.544
DOC_USP7_MATH_1	825	829	PF00917	0.720
DOC_USP7_MATH_1	864	868	PF00917	0.843
DOC_USP7_MATH_1	892	896	PF00917	0.661
DOC_USP7_MATH_1	922	926	PF00917	0.762
DOC_USP7_MATH_1	937	941	PF00917	0.568
DOC_USP7_MATH_1	943	947	PF00917	0.734
DOC_USP7_MATH_1	997	1001	PF00917	0.589
DOC_WW_Pin1_4	1	6	PF00397	0.748
DOC_WW_Pin1_4	190	195	PF00397	0.764
DOC_WW_Pin1_4	198	203	PF00397	0.775
DOC_WW_Pin1_4	411	416	PF00397	0.771
DOC_WW_Pin1_4	56	61	PF00397	0.729
DOC_WW_Pin1_4	632	637	PF00397	0.655
DOC_WW_Pin1_4	646	651	PF00397	0.856
DOC_WW_Pin1_4	672	677	PF00397	0.783
DOC_WW_Pin1_4	686	691	PF00397	0.583
DOC_WW_Pin1_4	74	79	PF00397	0.539
DOC_WW_Pin1_4	866	871	PF00397	0.602
DOC_WW_Pin1_4	966	971	PF00397	0.786
LIG_14-3-3_CanoR_1	188	194	PF00244	0.785
LIG_14-3-3_CanoR_1	342	350	PF00244	0.739
LIG_14-3-3_CanoR_1	588	596	PF00244	0.705
LIG_14-3-3_CanoR_1	646	650	PF00244	0.641
LIG_14-3-3_CanoR_1	671	676	PF00244	0.849
LIG_14-3-3_CanoR_1	848	854	PF00244	0.750
LIG_Actin_WH2_2	343	359	PF00022	0.710
LIG_BIR_III_2	93	97	PF00653	0.745
LIG_BIR_III_4	1140	1144	PF00653	0.790
LIG_BRCT_BRCA1_1	238	242	PF00533	0.763
LIG_BRCT_BRCA1_1	339	343	PF00533	0.738
LIG_BRCT_BRCA1_1	351	355	PF00533	0.489
LIG_BRCT_BRCA1_1	64	68	PF00533	0.624
LIG_BRCT_BRCA1_1	907	911	PF00533	0.824
LIG_BRCT_BRCA1_1	940	944	PF00533	0.768
LIG_BRCT_BRCA1_1	97	101	PF00533	0.742
LIG_CaM_IQ_9	363	379	PF13499	0.727
LIG_FHA_1	1069	1075	PF00498	0.689
LIG_FHA_1	209	215	PF00498	0.758
LIG_FHA_1	367	373	PF00498	0.592
LIG_FHA_1	414	420	PF00498	0.697
LIG_FHA_1	505	511	PF00498	0.702
LIG_FHA_1	514	520	PF00498	0.565
LIG_FHA_1	672	678	PF00498	0.746
LIG_FHA_1	733	739	PF00498	0.715
LIG_FHA_1	784	790	PF00498	0.798
LIG_FHA_1	867	873	PF00498	0.607
LIG_FHA_2	1008	1014	PF00498	0.713
LIG_FHA_2	154	160	PF00498	0.741
LIG_FHA_2	288	294	PF00498	0.795
LIG_FHA_2	51	57	PF00498	0.757
LIG_FHA_2	528	534	PF00498	0.789
LIG_FHA_2	967	973	PF00498	0.833
LIG_GBD_Chelix_1	394	402	PF00786	0.679
LIG_LIR_Apic_2	269	274	PF02991	0.828
LIG_LIR_Apic_2	562	567	PF02991	0.742
LIG_LIR_Gen_1	247	256	PF02991	0.750
LIG_LIR_Gen_1	296	303	PF02991	0.735
LIG_LIR_Gen_1	340	351	PF02991	0.649
LIG_LIR_Gen_1	40	49	PF02991	0.713
LIG_LIR_Gen_1	404	413	PF02991	0.655
LIG_LIR_Nem_3	1041	1045	PF02991	0.812
LIG_LIR_Nem_3	1150	1154	PF02991	0.729
LIG_LIR_Nem_3	121	126	PF02991	0.739
LIG_LIR_Nem_3	132	138	PF02991	0.560
LIG_LIR_Nem_3	247	251	PF02991	0.679
LIG_LIR_Nem_3	296	300	PF02991	0.740
LIG_LIR_Nem_3	340	346	PF02991	0.663
LIG_LIR_Nem_3	40	46	PF02991	0.708
LIG_LIR_Nem_3	404	409	PF02991	0.559
LIG_LYPXL_yS_3	135	138	PF13949	0.720
LIG_Pex14_1	618	622	PF04695	0.809
LIG_Pex14_2	1054	1058	PF04695	0.586
LIG_Pex14_2	317	321	PF04695	0.706
LIG_PTAP_UEV_1	710	715	PF05743	0.620
LIG_PTB_Apo_2	965	972	PF02174	0.837
LIG_PTB_Phospho_1	965	971	PF10480	0.838
LIG_Rb_LxCxE_1	358	369	PF01857	0.640
LIG_SH2_GRB2like	859	862	PF00017	0.832
LIG_SH2_GRB2like	966	969	PF00017	0.842
LIG_SH2_NCK_1	297	301	PF00017	0.729
LIG_SH2_SRC	859	862	PF00017	0.754
LIG_SH2_SRC	971	974	PF00017	0.830
LIG_SH2_STAP1	142	146	PF00017	0.680
LIG_SH2_STAP1	149	153	PF00017	0.600
LIG_SH2_STAP1	297	301	PF00017	0.729
LIG_SH2_STAP1	575	579	PF00017	0.805
LIG_SH2_STAP1	859	863	PF00017	0.681
LIG_SH2_STAT3	164	167	PF00017	0.747
LIG_SH2_STAT3	323	326	PF00017	0.678
LIG_SH2_STAT5	1042	1045	PF00017	0.688
LIG_SH2_STAT5	117	120	PF00017	0.745
LIG_SH2_STAT5	13	16	PF00017	0.775
LIG_SH2_STAT5	323	326	PF00017	0.678
LIG_SH2_STAT5	605	608	PF00017	0.782
LIG_SH2_STAT5	627	630	PF00017	0.813
LIG_SH2_STAT5	723	726	PF00017	0.785
LIG_SH2_STAT5	734	737	PF00017	0.584
LIG_SH2_STAT5	85	88	PF00017	0.783
LIG_SH2_STAT5	966	969	PF00017	0.764
LIG_SH3_2	658	663	PF14604	0.865
LIG_SH3_3	1090	1096	PF00018	0.743
LIG_SH3_3	1118	1124	PF00018	0.835
LIG_SH3_3	238	244	PF00018	0.791
LIG_SH3_3	330	336	PF00018	0.755
LIG_SH3_3	412	418	PF00018	0.698
LIG_SH3_3	521	527	PF00018	0.782
LIG_SH3_3	649	655	PF00018	0.801
LIG_SH3_3	708	714	PF00018	0.629
LIG_SH3_3	951	957	PF00018	0.823
LIG_SH3_3	964	970	PF00018	0.624
LIG_SUMO_SIM_anti_2	33	38	PF11976	0.794
LIG_SUMO_SIM_par_1	849	855	PF11976	0.832
LIG_TRAF2_1	555	558	PF00917	0.709
LIG_TYR_ITIM	133	138	PF00017	0.729
LIG_UBA3_1	36	42	PF00899	0.786
LIG_WRC_WIRS_1	138	143	PF05994	0.706
LIG_WW_2	336	339	PF00397	0.733
LIG_WW_3	216	220	PF00397	0.757
MOD_CDC14_SPxK_1	4	7	PF00782	0.720
MOD_CDK_SPK_2	74	79	PF00069	0.614
MOD_CDK_SPxK_1	1	7	PF00069	0.744
MOD_CK1_1	1023	1029	PF00069	0.636
MOD_CK1_1	122	128	PF00069	0.739
MOD_CK1_1	267	273	PF00069	0.822
MOD_CK1_1	440	446	PF00069	0.622
MOD_CK1_1	453	459	PF00069	0.628
MOD_CK1_1	51	57	PF00069	0.800
MOD_CK1_1	648	654	PF00069	0.811
MOD_CK1_1	675	681	PF00069	0.732
MOD_CK1_1	686	692	PF00069	0.821
MOD_CK1_1	74	80	PF00069	0.692
MOD_CK1_1	799	805	PF00069	0.857
MOD_CK1_1	812	818	PF00069	0.640
MOD_CK1_1	827	833	PF00069	0.578
MOD_CK1_1	852	858	PF00069	0.827
MOD_CK1_1	866	872	PF00069	0.607
MOD_CK2_1	1150	1156	PF00069	0.695
MOD_CK2_1	144	150	PF00069	0.694
MOD_CK2_1	287	293	PF00069	0.812
MOD_CK2_1	303	309	PF00069	0.500
MOD_CK2_1	527	533	PF00069	0.789
MOD_CK2_1	552	558	PF00069	0.697
MOD_CK2_1	763	769	PF00069	0.815
MOD_CK2_1	933	939	PF00069	0.790
MOD_CK2_1	966	972	PF00069	0.784
MOD_GlcNHglycan	1102	1105	PF01048	0.667
MOD_GlcNHglycan	225	228	PF01048	0.832
MOD_GlcNHglycan	266	269	PF01048	0.815
MOD_GlcNHglycan	305	308	PF01048	0.740
MOD_GlcNHglycan	430	433	PF01048	0.742
MOD_GlcNHglycan	442	445	PF01048	0.739
MOD_GlcNHglycan	453	456	PF01048	0.753
MOD_GlcNHglycan	478	481	PF01048	0.708
MOD_GlcNHglycan	482	485	PF01048	0.716
MOD_GlcNHglycan	499	502	PF01048	0.560
MOD_GlcNHglycan	50	53	PF01048	0.751
MOD_GlcNHglycan	553	557	PF01048	0.707
MOD_GlcNHglycan	62	65	PF01048	0.726
MOD_GlcNHglycan	710	714	PF01048	0.838
MOD_GlcNHglycan	778	781	PF01048	0.790
MOD_GlcNHglycan	786	789	PF01048	0.752
MOD_GlcNHglycan	798	801	PF01048	0.578
MOD_GlcNHglycan	817	820	PF01048	0.539
MOD_GlcNHglycan	838	841	PF01048	0.756
MOD_GlcNHglycan	866	869	PF01048	0.797
MOD_GlcNHglycan	872	875	PF01048	0.755
MOD_GlcNHglycan	924	927	PF01048	0.809
MOD_GlcNHglycan	935	938	PF01048	0.649
MOD_GlcNHglycan	939	943	PF01048	0.569
MOD_GSK3_1	1019	1026	PF00069	0.724
MOD_GSK3_1	337	344	PF00069	0.743
MOD_GSK3_1	462	469	PF00069	0.695
MOD_GSK3_1	476	483	PF00069	0.612
MOD_GSK3_1	490	497	PF00069	0.635
MOD_GSK3_1	50	57	PF00069	0.833
MOD_GSK3_1	513	520	PF00069	0.600
MOD_GSK3_1	58	65	PF00069	0.718
MOD_GSK3_1	587	594	PF00069	0.714
MOD_GSK3_1	596	603	PF00069	0.581
MOD_GSK3_1	661	668	PF00069	0.769
MOD_GSK3_1	67	74	PF00069	0.579
MOD_GSK3_1	671	678	PF00069	0.757
MOD_GSK3_1	686	693	PF00069	0.576
MOD_GSK3_1	792	799	PF00069	0.837
MOD_GSK3_1	805	812	PF00069	0.650
MOD_GSK3_1	821	828	PF00069	0.579
MOD_GSK3_1	836	843	PF00069	0.566
MOD_GSK3_1	859	866	PF00069	0.664
MOD_GSK3_1	933	940	PF00069	0.779
MOD_GSK3_1	986	993	PF00069	0.842
MOD_N-GLC_1	437	442	PF02516	0.561
MOD_N-GLC_1	927	932	PF02516	0.652
MOD_N-GLC_2	231	233	PF02516	0.785
MOD_NEK2_1	1100	1105	PF00069	0.724
MOD_NEK2_1	1112	1117	PF00069	0.774
MOD_NEK2_1	366	371	PF00069	0.747
MOD_NEK2_1	462	467	PF00069	0.694
MOD_NEK2_1	598	603	PF00069	0.654
MOD_NEK2_1	677	682	PF00069	0.847
MOD_NEK2_1	849	854	PF00069	0.831
MOD_NEK2_2	144	149	PF00069	0.687
MOD_NEK2_2	175	180	PF00069	0.547
MOD_NEK2_2	504	509	PF00069	0.793
MOD_NEK2_2	600	605	PF00069	0.532
MOD_NEK2_2	892	897	PF00069	0.663
MOD_NMyristoyl	1	7	PF02799	0.822
MOD_PIKK_1	1105	1111	PF00454	0.773
MOD_PIKK_1	111	117	PF00454	0.756
MOD_PIKK_1	661	667	PF00454	0.869
MOD_PIKK_1	799	805	PF00454	0.857
MOD_PK_1	573	579	PF00069	0.803
MOD_PKA_1	119	125	PF00069	0.745
MOD_PKA_1	986	992	PF00069	0.845
MOD_PKA_2	341	347	PF00069	0.748
MOD_PKA_2	587	593	PF00069	0.700
MOD_PKA_2	645	651	PF00069	0.795
MOD_PKA_2	78	84	PF00069	0.671
MOD_PKA_2	813	819	PF00069	0.853
MOD_PKA_2	840	846	PF00069	0.754
MOD_PKA_2	986	992	PF00069	0.845
MOD_Plk_1	32	38	PF00069	0.798
MOD_Plk_1	437	443	PF00069	0.562
MOD_Plk_1	573	579	PF00069	0.803
MOD_Plk_1	859	865	PF00069	0.605
MOD_Plk_2-3	1150	1156	PF00069	0.695
MOD_Plk_2-3	790	796	PF00069	0.763
MOD_Plk_4	137	143	PF00069	0.708
MOD_Plk_4	236	242	PF00069	0.799
MOD_Plk_4	244	250	PF00069	0.632
MOD_Plk_4	267	273	PF00069	0.822
MOD_Plk_4	32	38	PF00069	0.798
MOD_Plk_4	527	533	PF00069	0.789
MOD_Plk_4	600	606	PF00069	0.535
MOD_Plk_4	884	890	PF00069	0.591
MOD_Plk_4	997	1003	PF00069	0.593
MOD_ProDKin_1	1	7	PF00069	0.744
MOD_ProDKin_1	190	196	PF00069	0.761
MOD_ProDKin_1	198	204	PF00069	0.774
MOD_ProDKin_1	411	417	PF00069	0.772
MOD_ProDKin_1	56	62	PF00069	0.731
MOD_ProDKin_1	632	638	PF00069	0.658
MOD_ProDKin_1	646	652	PF00069	0.853
MOD_ProDKin_1	672	678	PF00069	0.781
MOD_ProDKin_1	686	692	PF00069	0.584
MOD_ProDKin_1	74	80	PF00069	0.535
MOD_ProDKin_1	866	872	PF00069	0.605
MOD_ProDKin_1	966	972	PF00069	0.784
MOD_SUMO_rev_2	1137	1145	PF00179	0.712
TRG_DiLeu_BaEn_1	458	463	PF01217	0.784
TRG_DiLeu_BaEn_2	297	303	PF01217	0.730
TRG_DiLeu_BaEn_2	396	402	PF01217	0.679
TRG_ENDOCYTIC_2	135	138	PF00928	0.720
TRG_ENDOCYTIC_2	297	300	PF00928	0.734
TRG_ER_diArg_1	187	189	PF00400	0.671
TRG_ER_diArg_1	259	261	PF00400	0.698
TRG_ER_diArg_1	29	31	PF00400	0.815
TRG_ER_diArg_1	359	362	PF00400	0.702
TRG_ER_diArg_1	370	372	PF00400	0.562
TRG_ER_diArg_1	376	378	PF00400	0.554
TRG_ER_diArg_1	845	848	PF00400	0.820
TRG_ER_diArg_1	986	988	PF00400	0.849
TRG_NLS_MonoCore_2	19	24	PF00514	0.662
TRG_NLS_MonoExtN_4	20	25	PF00514	0.735
TRG_Pf-PMV_PEXEL_1	1098	1102	PF00026	0.729
TRG_Pf-PMV_PEXEL_1	1152	1156	PF00026	0.702
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.699
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.705
TRG_Pf-PMV_PEXEL_1	986	990	PF00026	0.769

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4F1	Leishmania donovani	92%	100%
A4HJC4	Leishmania braziliensis	72%	100%
A4I6R9	Leishmania infantum	92%	100%
E9B1U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%