LeishMANIAdb
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Proteophosphoglycan ppg4

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Proteophosphoglycan ppg4
Gene product:
hypothetical protein, unknown function
Species:
Leishmania major
UniProt:
Q4Q6B8_LEIMA
TriTrypDb:
LmjF.31.1445 * , LMJLV39_000021100 * , LMJLV39_310022000 * , LMJSD75_310021400 *
Length:
530

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 17, no: 0
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0005929 cilium 4 18
GO:0016020 membrane 2 6
GO:0042995 cell projection 2 18
GO:0043226 organelle 2 18
GO:0043227 membrane-bounded organelle 3 18
GO:0110165 cellular anatomical entity 1 18
GO:0120025 plasma membrane bounded cell projection 3 18

Expansion

Sequence features

Q4Q6B8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6B8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 306 310 PF00656 0.467
CLV_C14_Caspase3-7 356 360 PF00656 0.476
CLV_C14_Caspase3-7 381 385 PF00656 0.473
CLV_NRD_NRD_1 225 227 PF00675 0.524
CLV_NRD_NRD_1 499 501 PF00675 0.591
CLV_NRD_NRD_1 6 8 PF00675 0.701
CLV_PCSK_KEX2_1 225 227 PF00082 0.524
CLV_PCSK_KEX2_1 499 501 PF00082 0.621
CLV_PCSK_KEX2_1 6 8 PF00082 0.701
CLV_PCSK_SKI1_1 177 181 PF00082 0.549
CLV_PCSK_SKI1_1 7 11 PF00082 0.674
DEG_APCC_DBOX_1 6 14 PF00400 0.511
DEG_SCF_FBW7_1 324 329 PF00400 0.485
DEG_SCF_FBW7_1 349 354 PF00400 0.475
DEG_SCF_FBW7_1 374 379 PF00400 0.471
DEG_SCF_FBW7_1 399 404 PF00400 0.473
DEG_SCF_FBW7_1 424 429 PF00400 0.472
DEG_SCF_FBW7_1 449 454 PF00400 0.475
DEG_SCF_FBW7_1 459 464 PF00400 0.452
DEG_SPOP_SBC_1 292 296 PF00917 0.558
DEG_SPOP_SBC_1 338 342 PF00917 0.481
DEG_SPOP_SBC_1 363 367 PF00917 0.476
DEG_SPOP_SBC_1 413 417 PF00917 0.483
DEG_SPOP_SBC_1 451 455 PF00917 0.549
DOC_ANK_TNKS_1 105 112 PF00023 0.321
DOC_CYCLIN_RxL_1 148 161 PF00134 0.277
DOC_MAPK_gen_1 148 157 PF00069 0.324
DOC_MAPK_gen_1 6 13 PF00069 0.425
DOC_MAPK_MEF2A_6 6 13 PF00069 0.390
DOC_PP1_RVXF_1 223 230 PF00149 0.300
DOC_PP2B_LxvP_1 23 26 PF13499 0.524
DOC_USP7_MATH_1 104 108 PF00917 0.363
DOC_USP7_MATH_1 193 197 PF00917 0.332
DOC_USP7_MATH_1 220 224 PF00917 0.312
DOC_USP7_MATH_1 299 303 PF00917 0.618
DOC_USP7_MATH_1 313 317 PF00917 0.537
DOC_USP7_MATH_1 324 328 PF00917 0.611
DOC_USP7_MATH_1 338 342 PF00917 0.473
DOC_USP7_MATH_1 349 353 PF00917 0.481
DOC_USP7_MATH_1 363 367 PF00917 0.464
DOC_USP7_MATH_1 374 378 PF00917 0.468
DOC_USP7_MATH_1 388 392 PF00917 0.480
DOC_USP7_MATH_1 399 403 PF00917 0.485
DOC_USP7_MATH_1 413 417 PF00917 0.471
DOC_USP7_MATH_1 424 428 PF00917 0.477
DOC_USP7_MATH_1 438 442 PF00917 0.469
DOC_USP7_MATH_1 449 453 PF00917 0.508
DOC_USP7_MATH_1 61 65 PF00917 0.365
DOC_USP7_MATH_1 76 80 PF00917 0.440
DOC_WW_Pin1_4 266 271 PF00397 0.361
DOC_WW_Pin1_4 293 298 PF00397 0.514
DOC_WW_Pin1_4 31 36 PF00397 0.467
DOC_WW_Pin1_4 322 327 PF00397 0.490
DOC_WW_Pin1_4 347 352 PF00397 0.480
DOC_WW_Pin1_4 372 377 PF00397 0.469
DOC_WW_Pin1_4 397 402 PF00397 0.474
DOC_WW_Pin1_4 422 427 PF00397 0.472
DOC_WW_Pin1_4 447 452 PF00397 0.523
DOC_WW_Pin1_4 455 460 PF00397 0.553
DOC_WW_Pin1_4 461 466 PF00397 0.471
DOC_WW_Pin1_4 51 56 PF00397 0.465
LIG_14-3-3_CanoR_1 177 182 PF00244 0.313
LIG_14-3-3_CanoR_1 481 485 PF00244 0.322
LIG_14-3-3_CanoR_1 63 68 PF00244 0.388
LIG_BIR_II_1 1 5 PF00653 0.698
LIG_BIR_III_4 309 313 PF00653 0.466
LIG_BIR_III_4 359 363 PF00653 0.469
LIG_BIR_III_4 384 388 PF00653 0.471
LIG_BRCT_BRCA1_1 174 178 PF00533 0.324
LIG_BRCT_BRCA1_1 482 486 PF00533 0.325
LIG_deltaCOP1_diTrp_1 264 273 PF00928 0.399
LIG_DLG_GKlike_1 244 251 PF00625 0.329
LIG_FHA_1 103 109 PF00498 0.398
LIG_FHA_1 137 143 PF00498 0.491
LIG_FHA_1 152 158 PF00498 0.467
LIG_FHA_1 209 215 PF00498 0.348
LIG_FHA_1 269 275 PF00498 0.370
LIG_FHA_1 510 516 PF00498 0.269
LIG_FHA_1 519 525 PF00498 0.276
LIG_FHA_1 64 70 PF00498 0.452
LIG_FHA_2 110 116 PF00498 0.467
LIG_FHA_2 211 217 PF00498 0.393
LIG_FHA_2 293 299 PF00498 0.501
LIG_FHA_2 318 324 PF00498 0.513
LIG_FHA_2 343 349 PF00498 0.498
LIG_FHA_2 368 374 PF00498 0.485
LIG_FHA_2 393 399 PF00498 0.489
LIG_FHA_2 418 424 PF00498 0.486
LIG_FHA_2 43 49 PF00498 0.414
LIG_FHA_2 443 449 PF00498 0.513
LIG_LIR_Gen_1 119 127 PF02991 0.423
LIG_LIR_Gen_1 169 178 PF02991 0.449
LIG_LIR_Gen_1 216 224 PF02991 0.375
LIG_LIR_Gen_1 241 248 PF02991 0.467
LIG_LIR_Gen_1 34 44 PF02991 0.446
LIG_LIR_Nem_3 119 125 PF02991 0.482
LIG_LIR_Nem_3 144 149 PF02991 0.392
LIG_LIR_Nem_3 175 181 PF02991 0.369
LIG_LIR_Nem_3 184 190 PF02991 0.406
LIG_LIR_Nem_3 271 276 PF02991 0.350
LIG_LIR_Nem_3 34 39 PF02991 0.436
LIG_LIR_Nem_3 483 489 PF02991 0.347
LIG_MYND_3 245 249 PF01753 0.343
LIG_PDZ_Class_2 525 530 PF00595 0.396
LIG_Pex14_2 238 242 PF04695 0.328
LIG_RPA_C_Fungi 1 13 PF08784 0.414
LIG_SH2_CRK 122 126 PF00017 0.481
LIG_SH2_CRK 159 163 PF00017 0.370
LIG_SH2_NCK_1 159 163 PF00017 0.370
LIG_SH2_NCK_1 49 53 PF00017 0.478
LIG_SH2_STAT5 159 162 PF00017 0.378
LIG_SH2_STAT5 489 492 PF00017 0.500
LIG_SH3_3 111 117 PF00018 0.507
LIG_SH3_3 29 35 PF00018 0.561
LIG_SH3_3 481 487 PF00018 0.387
LIG_Sin3_3 17 24 PF02671 0.425
LIG_SUMO_SIM_anti_2 521 526 PF11976 0.312
LIG_SUMO_SIM_par_1 17 22 PF11976 0.646
LIG_TYR_ITIM 120 125 PF00017 0.593
LIG_TYR_ITIM 157 162 PF00017 0.357
MOD_CDK_SPxK_1 461 467 PF00069 0.495
MOD_CK1_1 161 167 PF00069 0.572
MOD_CK1_1 169 175 PF00069 0.557
MOD_CK1_1 304 310 PF00069 0.720
MOD_CK1_1 311 317 PF00069 0.797
MOD_CK1_1 328 334 PF00069 0.775
MOD_CK1_1 336 342 PF00069 0.594
MOD_CK1_1 353 359 PF00069 0.571
MOD_CK1_1 361 367 PF00069 0.582
MOD_CK1_1 378 384 PF00069 0.571
MOD_CK1_1 386 392 PF00069 0.587
MOD_CK1_1 403 409 PF00069 0.589
MOD_CK1_1 411 417 PF00069 0.594
MOD_CK1_1 428 434 PF00069 0.592
MOD_CK1_1 436 442 PF00069 0.587
MOD_CK1_1 452 458 PF00069 0.600
MOD_CK2_1 109 115 PF00069 0.502
MOD_CK2_1 210 216 PF00069 0.373
MOD_CK2_1 292 298 PF00069 0.625
MOD_CK2_1 317 323 PF00069 0.606
MOD_CK2_1 342 348 PF00069 0.591
MOD_CK2_1 367 373 PF00069 0.588
MOD_CK2_1 392 398 PF00069 0.599
MOD_CK2_1 417 423 PF00069 0.592
MOD_CK2_1 42 48 PF00069 0.680
MOD_CK2_1 442 448 PF00069 0.633
MOD_CK2_1 56 62 PF00069 0.489
MOD_DYRK1A_RPxSP_1 31 35 PF00069 0.534
MOD_GlcNHglycan 216 221 PF01048 0.486
MOD_GlcNHglycan 303 306 PF01048 0.625
MOD_GlcNHglycan 309 313 PF01048 0.604
MOD_GlcNHglycan 328 331 PF01048 0.561
MOD_GlcNHglycan 335 338 PF01048 0.587
MOD_GlcNHglycan 353 356 PF01048 0.563
MOD_GlcNHglycan 359 363 PF01048 0.587
MOD_GlcNHglycan 378 381 PF01048 0.569
MOD_GlcNHglycan 384 388 PF01048 0.583
MOD_GlcNHglycan 403 406 PF01048 0.576
MOD_GlcNHglycan 410 413 PF01048 0.581
MOD_GlcNHglycan 428 431 PF01048 0.587
MOD_GlcNHglycan 435 438 PF01048 0.588
MOD_GlcNHglycan 82 85 PF01048 0.533
MOD_GSK3_1 138 145 PF00069 0.522
MOD_GSK3_1 157 164 PF00069 0.579
MOD_GSK3_1 168 175 PF00069 0.474
MOD_GSK3_1 177 184 PF00069 0.533
MOD_GSK3_1 216 223 PF00069 0.563
MOD_GSK3_1 234 241 PF00069 0.408
MOD_GSK3_1 262 269 PF00069 0.438
MOD_GSK3_1 299 306 PF00069 0.733
MOD_GSK3_1 311 318 PF00069 0.824
MOD_GSK3_1 322 329 PF00069 0.593
MOD_GSK3_1 333 340 PF00069 0.599
MOD_GSK3_1 343 350 PF00069 0.615
MOD_GSK3_1 354 361 PF00069 0.633
MOD_GSK3_1 363 370 PF00069 0.580
MOD_GSK3_1 372 379 PF00069 0.617
MOD_GSK3_1 386 393 PF00069 0.600
MOD_GSK3_1 397 404 PF00069 0.643
MOD_GSK3_1 408 415 PF00069 0.621
MOD_GSK3_1 418 425 PF00069 0.592
MOD_GSK3_1 429 436 PF00069 0.613
MOD_GSK3_1 438 445 PF00069 0.679
MOD_GSK3_1 447 454 PF00069 0.746
MOD_GSK3_1 457 464 PF00069 0.591
MOD_GSK3_1 76 83 PF00069 0.439
MOD_GSK3_1 98 105 PF00069 0.456
MOD_N-GLC_1 98 103 PF02516 0.454
MOD_N-GLC_2 257 259 PF02516 0.382
MOD_NEK2_1 1 6 PF00069 0.579
MOD_NEK2_1 102 107 PF00069 0.459
MOD_NEK2_1 157 162 PF00069 0.603
MOD_NEK2_1 179 184 PF00069 0.373
MOD_NEK2_1 186 191 PF00069 0.340
MOD_NEK2_1 19 24 PF00069 0.506
MOD_NEK2_1 234 239 PF00069 0.477
MOD_NEK2_1 480 485 PF00069 0.379
MOD_NEK2_1 80 85 PF00069 0.470
MOD_NEK2_2 220 225 PF00069 0.317
MOD_PIKK_1 205 211 PF00454 0.443
MOD_PKA_2 480 486 PF00069 0.373
MOD_Plk_1 120 126 PF00069 0.455
MOD_Plk_1 216 222 PF00069 0.439
MOD_Plk_1 98 104 PF00069 0.455
MOD_Plk_2-3 42 48 PF00069 0.533
MOD_Plk_4 120 126 PF00069 0.404
MOD_Plk_4 262 268 PF00069 0.435
MOD_Plk_4 518 524 PF00069 0.279
MOD_Plk_4 98 104 PF00069 0.511
MOD_ProDKin_1 266 272 PF00069 0.408
MOD_ProDKin_1 293 299 PF00069 0.632
MOD_ProDKin_1 31 37 PF00069 0.566
MOD_ProDKin_1 322 328 PF00069 0.596
MOD_ProDKin_1 347 353 PF00069 0.582
MOD_ProDKin_1 372 378 PF00069 0.568
MOD_ProDKin_1 397 403 PF00069 0.575
MOD_ProDKin_1 422 428 PF00069 0.571
MOD_ProDKin_1 447 453 PF00069 0.638
MOD_ProDKin_1 455 461 PF00069 0.663
MOD_ProDKin_1 51 57 PF00069 0.557
TRG_ENDOCYTIC_2 122 125 PF00928 0.598
TRG_ENDOCYTIC_2 159 162 PF00928 0.367
TRG_ENDOCYTIC_2 235 238 PF00928 0.402
TRG_ER_diArg_1 224 226 PF00400 0.366
TRG_ER_diArg_1 29 32 PF00400 0.580
TRG_ER_diArg_1 498 500 PF00400 0.426
TRG_ER_diArg_1 6 8 PF00400 0.602

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1II82 Leptomonas seymouri 27% 77%
A0A3Q8I9A6 Leishmania donovani 35% 100%
A0A3Q8IK15 Leishmania donovani 85% 100%
A4HJX1 Leishmania braziliensis 38% 100%
A4HVB0 Leishmania infantum 35% 100%
A4I6S2 Leishmania infantum 82% 100%
E8NHQ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 81%
E9AGG5 Leishmania infantum 35% 100%
E9AGH0 Leishmania infantum 38% 100%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9AP07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9B1U3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
E9B1U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
Q4QGJ6 Leishmania major 29% 100%
Q4QGL4 Leishmania major 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS