LeishMANIAdb
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Surface membrane protein gp46-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Surface membrane protein gp46-like protein
Gene product:
surface membrane protein gp46-like protein
Species:
Leishmania major
UniProt:
Q4Q6B7_LEIMA
TriTrypDb:
LmjF.31.1450 , LMJLV39_310022200 * , LMJSD75_310021700
Length:
302

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 31, no: 8
NetGPI no yes: 0, no: 39
Cellular components
Term Name Level Count
GO:0005929 cilium 4 40
GO:0042995 cell projection 2 40
GO:0043226 organelle 2 40
GO:0043227 membrane-bounded organelle 3 40
GO:0110165 cellular anatomical entity 1 40
GO:0120025 plasma membrane bounded cell projection 3 40
GO:0016020 membrane 2 4

Expansion

Sequence features

Q4Q6B7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6B7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 237 241 PF00656 0.289
CLV_NRD_NRD_1 230 232 PF00675 0.341
CLV_NRD_NRD_1 50 52 PF00675 0.336
CLV_PCSK_SKI1_1 107 111 PF00082 0.486
CLV_PCSK_SKI1_1 15 19 PF00082 0.576
CLV_PCSK_SKI1_1 159 163 PF00082 0.489
CLV_PCSK_SKI1_1 183 187 PF00082 0.336
CLV_PCSK_SKI1_1 51 55 PF00082 0.501
DEG_APCC_DBOX_1 14 22 PF00400 0.632
DOC_CYCLIN_yClb5_NLxxxL_5 190 199 PF00134 0.454
DOC_CYCLIN_yClb5_NLxxxL_5 238 247 PF00134 0.383
DOC_MAPK_gen_1 13 21 PF00069 0.613
DOC_MAPK_gen_1 231 238 PF00069 0.309
DOC_MAPK_MEF2A_6 15 23 PF00069 0.542
DOC_PP2B_LxvP_1 28 31 PF13499 0.459
DOC_USP7_MATH_1 178 182 PF00917 0.460
DOC_USP7_MATH_1 274 278 PF00917 0.415
DOC_USP7_MATH_1 293 297 PF00917 0.487
DOC_USP7_MATH_1 98 102 PF00917 0.524
DOC_USP7_MATH_2 248 254 PF00917 0.338
DOC_USP7_UBL2_3 120 124 PF12436 0.345
DOC_USP7_UBL2_3 43 47 PF12436 0.262
DOC_WW_Pin1_4 34 39 PF00397 0.537
LIG_14-3-3_CanoR_1 183 188 PF00244 0.321
LIG_14-3-3_CanoR_1 231 238 PF00244 0.438
LIG_Actin_WH2_2 216 233 PF00022 0.543
LIG_APCC_ABBA_1 85 90 PF00400 0.298
LIG_BIR_III_2 59 63 PF00653 0.349
LIG_BRCT_BRCA1_1 276 280 PF00533 0.527
LIG_BRCT_BRCA1_1 68 72 PF00533 0.323
LIG_DCNL_PONY_1 1 4 PF03556 0.407
LIG_FHA_1 146 152 PF00498 0.404
LIG_FHA_1 170 176 PF00498 0.332
LIG_FHA_1 194 200 PF00498 0.418
LIG_FHA_1 218 224 PF00498 0.391
LIG_FHA_1 22 28 PF00498 0.568
LIG_FHA_1 242 248 PF00498 0.395
LIG_FHA_2 133 139 PF00498 0.383
LIG_FHA_2 172 178 PF00498 0.544
LIG_FHA_2 208 214 PF00498 0.469
LIG_FHA_2 235 241 PF00498 0.494
LIG_GBD_Chelix_1 19 27 PF00786 0.629
LIG_LIR_Gen_1 138 147 PF02991 0.361
LIG_LIR_Gen_1 154 161 PF02991 0.324
LIG_LIR_Gen_1 177 185 PF02991 0.356
LIG_LIR_Gen_1 186 195 PF02991 0.360
LIG_LIR_Nem_3 130 134 PF02991 0.358
LIG_LIR_Nem_3 138 142 PF02991 0.342
LIG_LIR_Nem_3 160 166 PF02991 0.396
LIG_LIR_Nem_3 177 182 PF02991 0.341
LIG_LIR_Nem_3 186 190 PF02991 0.414
LIG_LIR_Nem_3 226 230 PF02991 0.515
LIG_LIR_Nem_3 36 42 PF02991 0.542
LIG_NRBOX 24 30 PF00104 0.605
LIG_Pex14_1 163 167 PF04695 0.465
LIG_Pex14_2 53 57 PF04695 0.474
LIG_SH2_CRK 42 46 PF00017 0.389
LIG_SH2_GRB2like 143 146 PF00017 0.362
LIG_SH2_PTP2 108 111 PF00017 0.248
LIG_SH2_PTP2 139 142 PF00017 0.240
LIG_SH2_STAP1 143 147 PF00017 0.412
LIG_SH2_STAT5 108 111 PF00017 0.424
LIG_SH2_STAT5 139 142 PF00017 0.332
LIG_SH2_STAT5 88 91 PF00017 0.374
LIG_SH3_3 92 98 PF00018 0.395
LIG_TYR_ITIM 137 142 PF00017 0.432
LIG_TYR_ITSM 38 45 PF00017 0.318
MOD_CK1_1 101 107 PF00069 0.317
MOD_CK1_1 130 136 PF00069 0.374
MOD_CK1_1 141 147 PF00069 0.358
MOD_CK1_1 202 208 PF00069 0.474
MOD_CK1_1 234 240 PF00069 0.392
MOD_CK1_1 37 43 PF00069 0.541
MOD_CK1_1 78 84 PF00069 0.453
MOD_CK2_1 132 138 PF00069 0.425
MOD_CK2_1 171 177 PF00069 0.526
MOD_CK2_1 207 213 PF00069 0.472
MOD_GlcNHglycan 159 162 PF01048 0.410
MOD_GlcNHglycan 204 207 PF01048 0.441
MOD_GlcNHglycan 252 255 PF01048 0.484
MOD_GSK3_1 110 117 PF00069 0.354
MOD_GSK3_1 119 126 PF00069 0.412
MOD_GSK3_1 141 148 PF00069 0.394
MOD_GSK3_1 195 202 PF00069 0.439
MOD_GSK3_1 219 226 PF00069 0.444
MOD_GSK3_1 232 239 PF00069 0.323
MOD_GSK3_1 75 82 PF00069 0.412
MOD_N-GLC_1 114 119 PF02516 0.450
MOD_N-GLC_1 193 198 PF02516 0.366
MOD_N-GLC_1 241 246 PF02516 0.421
MOD_N-GLC_2 266 268 PF02516 0.481
MOD_N-GLC_2 299 301 PF02516 0.496
MOD_NEK2_1 110 115 PF00069 0.365
MOD_NEK2_1 123 128 PF00069 0.308
MOD_NEK2_1 147 152 PF00069 0.332
MOD_NEK2_1 171 176 PF00069 0.352
MOD_NEK2_1 195 200 PF00069 0.374
MOD_NEK2_1 219 224 PF00069 0.361
MOD_NEK2_2 119 124 PF00069 0.572
MOD_NEK2_2 178 183 PF00069 0.461
MOD_PIKK_1 37 43 PF00454 0.474
MOD_PK_1 232 238 PF00069 0.288
MOD_PK_1 66 72 PF00069 0.300
MOD_PKA_1 231 237 PF00069 0.302
MOD_PKA_2 217 223 PF00069 0.551
MOD_Plk_1 114 120 PF00069 0.398
MOD_Plk_1 286 292 PF00069 0.450
MOD_Plk_4 207 213 PF00069 0.486
MOD_Plk_4 276 282 PF00069 0.421
MOD_Plk_4 286 292 PF00069 0.361
MOD_ProDKin_1 34 40 PF00069 0.537
TRG_DiLeu_BaLyEn_6 59 64 PF01217 0.332
TRG_ENDOCYTIC_2 108 111 PF00928 0.485
TRG_ENDOCYTIC_2 139 142 PF00928 0.369
TRG_ENDOCYTIC_2 42 45 PF00928 0.378

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P227 Leptomonas seymouri 31% 96%
A0A0N0P276 Leptomonas seymouri 27% 98%
A0A0N0P2L4 Leptomonas seymouri 28% 100%
A0A0N0P4M2 Leptomonas seymouri 32% 100%
A0A0N1HY53 Leptomonas seymouri 33% 100%
A0A0S4IIK7 Bodo saltans 27% 73%
A0A0S4IQP4 Bodo saltans 35% 77%
A0A0S4IVN7 Bodo saltans 34% 79%
A0A0S4IZC7 Bodo saltans 27% 73%
A0A0S4J353 Bodo saltans 24% 100%
A0A0S4J3T7 Bodo saltans 31% 67%
A0A0S4JCG7 Bodo saltans 32% 80%
A0A0S4JEK1 Bodo saltans 28% 74%
A0A0S4JHM1 Bodo saltans 28% 93%
A0A0S4JMF9 Bodo saltans 31% 76%
A0A0S4JMG0 Bodo saltans 30% 87%
A0A0S4JP32 Bodo saltans 28% 100%
A0A0S4JS11 Bodo saltans 32% 94%
A0A0S4KFY6 Bodo saltans 33% 91%
A0A0S4KHE4 Bodo saltans 30% 82%
A0A0S4KMV2 Bodo saltans 29% 77%
A0A1X0NKN8 Trypanosomatidae 27% 100%
A0A3Q8I9A6 Leishmania donovani 34% 78%
A0A3Q8I9D0 Leishmania donovani 36% 100%
A0A3Q8IFC2 Leishmania donovani 32% 69%
A0A3Q8IIJ9 Leishmania donovani 91% 100%
A0A3S5H6D6 Leishmania donovani 27% 100%
A0A3S7WPB2 Leishmania donovani 26% 100%
A0A3S7X4J4 Leishmania donovani 90% 100%
A4H4D2 Leishmania braziliensis 24% 100%
A4H4G6 Leishmania braziliensis 29% 100%
A4H5P0 Leishmania braziliensis 29% 100%
A4HBX3 Leishmania braziliensis 36% 67%
A4HJC8 Leishmania braziliensis 69% 100%
A4HJX1 Leishmania braziliensis 34% 69%
A4HTX9 Leishmania infantum 27% 100%
A4HVB0 Leishmania infantum 34% 75%
A4I6S2 Leishmania infantum 32% 69%
A4I6S4 Leishmania infantum 91% 100%
E8NHG5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 68%
E8NHP8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9ACQ0 Leishmania major 26% 100%
E9AG65 Leishmania infantum 26% 100%
E9AGG5 Leishmania infantum 33% 72%
E9AGH0 Leishmania infantum 35% 80%
E9AKM8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AMQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AP02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 89%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 77%
E9AP07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 82%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 72%
E9B1U3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 66%
E9B1U4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 88%
E9B1U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 72%
E9B1U6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
P35334 Phaseolus vulgaris 24% 88%
Q00874 Arabidopsis thaliana 26% 81%
Q25331 Leishmania major 30% 100%
Q4PSE6 Arabidopsis thaliana 26% 70%
Q4Q6B6 Leishmania major 100% 100%
Q4QC79 Leishmania major 38% 66%
Q4QGJ4 Leishmania major 29% 78%
Q4QGJ7 Leishmania major 29% 81%
Q4QGK6 Leishmania major 29% 78%
Q4QGL4 Leishmania major 33% 76%
Q4QHW6 Leishmania major 28% 100%
Q6NQP4 Arabidopsis thaliana 29% 100%
Q8GT95 Oryza sativa subsp. japonica 26% 91%
Q8W3M4 Arabidopsis thaliana 26% 75%
Q9FPJ5 Arabidopsis thaliana 30% 100%
Q9LH52 Arabidopsis thaliana 24% 93%
Q9M5J8 Arabidopsis thaliana 29% 92%
Q9M5J9 Arabidopsis thaliana 27% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS