Triplex capsid protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6B0_LEIMA

TriTrypDb:

LmjF.31.1520 , LMJLV39_310023100 , LMJSD75_310022400

Length:

951

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6B0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	409	413	PF00656	0.697
CLV_C14_Caspase3-7	431	435	PF00656	0.746
CLV_C14_Caspase3-7	544	548	PF00656	0.671
CLV_NRD_NRD_1	174	176	PF00675	0.539
CLV_NRD_NRD_1	614	616	PF00675	0.441
CLV_NRD_NRD_1	636	638	PF00675	0.733
CLV_NRD_NRD_1	702	704	PF00675	0.654
CLV_PCSK_KEX2_1	174	176	PF00082	0.546
CLV_PCSK_KEX2_1	253	255	PF00082	0.420
CLV_PCSK_KEX2_1	614	616	PF00082	0.501
CLV_PCSK_KEX2_1	702	704	PF00082	0.578
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.420
CLV_PCSK_SKI1_1	115	119	PF00082	0.399
CLV_PCSK_SKI1_1	196	200	PF00082	0.400
CLV_PCSK_SKI1_1	295	299	PF00082	0.492
CLV_PCSK_SKI1_1	376	380	PF00082	0.499
CLV_PCSK_SKI1_1	584	588	PF00082	0.503
CLV_PCSK_SKI1_1	719	723	PF00082	0.589
CLV_PCSK_SKI1_1	85	89	PF00082	0.441
DEG_APCC_DBOX_1	114	122	PF00400	0.381
DEG_COP1_1	3	13	PF00400	0.401
DEG_SPOP_SBC_1	433	437	PF00917	0.518
DOC_CDC14_PxL_1	215	223	PF14671	0.413
DOC_CKS1_1	35	40	PF01111	0.434
DOC_CKS1_1	687	692	PF01111	0.542
DOC_CYCLIN_RxL_1	80	91	PF00134	0.432
DOC_CYCLIN_yCln2_LP_2	723	729	PF00134	0.579
DOC_MAPK_DCC_7	229	237	PF00069	0.381
DOC_MAPK_gen_1	174	181	PF00069	0.423
DOC_MAPK_MEF2A_6	164	173	PF00069	0.555
DOC_MAPK_MEF2A_6	229	237	PF00069	0.437
DOC_MAPK_RevD_3	161	175	PF00069	0.348
DOC_PP2B_LxvP_1	249	252	PF13499	0.504
DOC_PP4_FxxP_1	15	18	PF00568	0.466
DOC_PP4_FxxP_1	35	38	PF00568	0.357
DOC_PP4_FxxP_1	454	457	PF00568	0.497
DOC_PP4_FxxP_1	628	631	PF00568	0.524
DOC_USP7_MATH_1	132	136	PF00917	0.495
DOC_USP7_MATH_1	139	143	PF00917	0.590
DOC_USP7_MATH_1	252	256	PF00917	0.548
DOC_USP7_MATH_1	355	359	PF00917	0.629
DOC_USP7_MATH_1	377	381	PF00917	0.458
DOC_USP7_MATH_1	432	436	PF00917	0.522
DOC_USP7_MATH_1	465	469	PF00917	0.647
DOC_USP7_MATH_1	537	541	PF00917	0.695
DOC_USP7_MATH_1	598	602	PF00917	0.443
DOC_USP7_MATH_1	660	664	PF00917	0.707
DOC_USP7_MATH_1	711	715	PF00917	0.671
DOC_USP7_MATH_1	744	748	PF00917	0.552
DOC_USP7_MATH_1	861	865	PF00917	0.638
DOC_USP7_UBL2_3	715	719	PF12436	0.660
DOC_WW_Pin1_4	137	142	PF00397	0.553
DOC_WW_Pin1_4	34	39	PF00397	0.358
DOC_WW_Pin1_4	359	364	PF00397	0.527
DOC_WW_Pin1_4	414	419	PF00397	0.605
DOC_WW_Pin1_4	463	468	PF00397	0.613
DOC_WW_Pin1_4	535	540	PF00397	0.670
DOC_WW_Pin1_4	680	685	PF00397	0.699
DOC_WW_Pin1_4	686	691	PF00397	0.590
DOC_WW_Pin1_4	728	733	PF00397	0.700
DOC_WW_Pin1_4	812	817	PF00397	0.690
DOC_WW_Pin1_4	838	843	PF00397	0.712
DOC_WW_Pin1_4	895	900	PF00397	0.677
DOC_WW_Pin1_4	932	937	PF00397	0.697
LIG_14-3-3_CanoR_1	143	153	PF00244	0.448
LIG_14-3-3_CanoR_1	376	384	PF00244	0.542
LIG_14-3-3_CanoR_1	405	409	PF00244	0.588
LIG_14-3-3_CanoR_1	725	734	PF00244	0.619
LIG_14-3-3_CanoR_1	89	97	PF00244	0.549
LIG_Actin_WH2_2	766	781	PF00022	0.531
LIG_BIR_III_2	692	696	PF00653	0.588
LIG_BRCT_BRCA1_1	221	225	PF00533	0.314
LIG_BRCT_BRCA1_1	515	519	PF00533	0.567
LIG_EVH1_1	686	690	PF00568	0.539
LIG_EVH1_1	748	752	PF00568	0.673
LIG_FHA_1	126	132	PF00498	0.452
LIG_FHA_1	157	163	PF00498	0.443
LIG_FHA_1	365	371	PF00498	0.500
LIG_FHA_1	373	379	PF00498	0.488
LIG_FHA_1	397	403	PF00498	0.448
LIG_FHA_1	415	421	PF00498	0.628
LIG_FHA_1	435	441	PF00498	0.654
LIG_FHA_1	485	491	PF00498	0.696
LIG_FHA_1	498	504	PF00498	0.644
LIG_FHA_1	680	686	PF00498	0.578
LIG_FHA_1	867	873	PF00498	0.574
LIG_FHA_1	896	902	PF00498	0.630
LIG_FHA_2	399	405	PF00498	0.481
LIG_FHA_2	471	477	PF00498	0.522
LIG_FHA_2	531	537	PF00498	0.667
LIG_FHA_2	542	548	PF00498	0.756
LIG_FHA_2	585	591	PF00498	0.513
LIG_FHA_2	687	693	PF00498	0.551
LIG_Integrin_RGD_1	448	450	PF01839	0.373
LIG_LIR_Apic_2	12	18	PF02991	0.486
LIG_LIR_Apic_2	32	38	PF02991	0.372
LIG_LIR_Apic_2	453	458	PF02991	0.617
LIG_LIR_Apic_2	48	53	PF02991	0.447
LIG_LIR_Gen_1	147	156	PF02991	0.449
LIG_LIR_Gen_1	222	233	PF02991	0.413
LIG_LIR_Gen_1	333	343	PF02991	0.517
LIG_LIR_Gen_1	911	919	PF02991	0.579
LIG_LIR_Nem_3	110	114	PF02991	0.422
LIG_LIR_Nem_3	147	152	PF02991	0.461
LIG_LIR_Nem_3	222	228	PF02991	0.436
LIG_LIR_Nem_3	333	338	PF02991	0.546
LIG_LIR_Nem_3	619	625	PF02991	0.466
LIG_LIR_Nem_3	781	786	PF02991	0.667
LIG_LIR_Nem_3	803	807	PF02991	0.625
LIG_LIR_Nem_3	908	912	PF02991	0.586
LIG_MYND_1	684	688	PF01753	0.647
LIG_MYND_1	836	840	PF01753	0.622
LIG_PCNA_PIPBox_1	277	286	PF02747	0.374
LIG_PCNA_yPIPBox_3	99	113	PF02747	0.448
LIG_PTB_Apo_2	777	784	PF02174	0.523
LIG_PTB_Phospho_1	777	783	PF10480	0.523
LIG_SH2_CRK	58	62	PF00017	0.500
LIG_SH2_CRK	622	626	PF00017	0.389
LIG_SH2_NCK_1	335	339	PF00017	0.589
LIG_SH2_NCK_1	50	54	PF00017	0.414
LIG_SH2_NCK_1	595	599	PF00017	0.497
LIG_SH2_PTP2	455	458	PF00017	0.492
LIG_SH2_PTP2	912	915	PF00017	0.559
LIG_SH2_SRC	455	458	PF00017	0.530
LIG_SH2_SRC	595	598	PF00017	0.497
LIG_SH2_STAP1	335	339	PF00017	0.563
LIG_SH2_STAP1	831	835	PF00017	0.557
LIG_SH2_STAT3	205	208	PF00017	0.418
LIG_SH2_STAT5	130	133	PF00017	0.452
LIG_SH2_STAT5	203	206	PF00017	0.360
LIG_SH2_STAT5	258	261	PF00017	0.416
LIG_SH2_STAT5	262	265	PF00017	0.394
LIG_SH2_STAT5	272	275	PF00017	0.427
LIG_SH2_STAT5	284	287	PF00017	0.409
LIG_SH2_STAT5	335	338	PF00017	0.584
LIG_SH2_STAT5	34	37	PF00017	0.526
LIG_SH2_STAT5	368	371	PF00017	0.457
LIG_SH2_STAT5	373	376	PF00017	0.428
LIG_SH2_STAT5	392	395	PF00017	0.236
LIG_SH2_STAT5	455	458	PF00017	0.589
LIG_SH2_STAT5	50	53	PF00017	0.287
LIG_SH2_STAT5	609	612	PF00017	0.416
LIG_SH2_STAT5	738	741	PF00017	0.577
LIG_SH2_STAT5	802	805	PF00017	0.649
LIG_SH2_STAT5	897	900	PF00017	0.650
LIG_SH2_STAT5	912	915	PF00017	0.403
LIG_SH3_2	11	16	PF14604	0.408
LIG_SH3_2	169	174	PF14604	0.430
LIG_SH3_3	133	139	PF00018	0.560
LIG_SH3_3	160	166	PF00018	0.480
LIG_SH3_3	213	219	PF00018	0.356
LIG_SH3_3	35	41	PF00018	0.440
LIG_SH3_3	681	687	PF00018	0.631
LIG_SH3_3	693	699	PF00018	0.625
LIG_SH3_3	743	749	PF00018	0.686
LIG_SH3_3	8	14	PF00018	0.453
LIG_SH3_3	833	839	PF00018	0.647
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.396
LIG_SUMO_SIM_anti_2	397	404	PF11976	0.431
LIG_SUMO_SIM_par_1	397	404	PF11976	0.418
LIG_SxIP_EBH_1	225	239	PF03271	0.347
LIG_WRC_WIRS_1	284	289	PF05994	0.415
LIG_WRC_WIRS_1	451	456	PF05994	0.496
LIG_WRC_WIRS_1	801	806	PF05994	0.653
LIG_WW_1	751	754	PF00397	0.683
LIG_WW_2	836	839	PF00397	0.611
MOD_CDC14_SPxK_1	140	143	PF00782	0.548
MOD_CDK_SPxK_1	137	143	PF00069	0.519
MOD_CDK_SPxK_1	359	365	PF00069	0.460
MOD_CK1_1	144	150	PF00069	0.387
MOD_CK1_1	305	311	PF00069	0.623
MOD_CK1_1	333	339	PF00069	0.591
MOD_CK1_1	358	364	PF00069	0.568
MOD_CK1_1	382	388	PF00069	0.427
MOD_CK1_1	398	404	PF00069	0.407
MOD_CK1_1	435	441	PF00069	0.484
MOD_CK1_1	459	465	PF00069	0.654
MOD_CK1_1	470	476	PF00069	0.592
MOD_CK1_1	497	503	PF00069	0.659
MOD_CK1_1	504	510	PF00069	0.733
MOD_CK1_1	541	547	PF00069	0.692
MOD_CK1_1	728	734	PF00069	0.748
MOD_CK1_1	757	763	PF00069	0.803
MOD_CK1_1	812	818	PF00069	0.766
MOD_CK1_1	866	872	PF00069	0.640
MOD_CK1_1	908	914	PF00069	0.627
MOD_CK2_1	475	481	PF00069	0.686
MOD_CK2_1	485	491	PF00069	0.544
MOD_CK2_1	503	509	PF00069	0.652
MOD_CK2_1	530	536	PF00069	0.581
MOD_GlcNHglycan	143	146	PF01048	0.565
MOD_GlcNHglycan	187	190	PF01048	0.447
MOD_GlcNHglycan	19	22	PF01048	0.527
MOD_GlcNHglycan	221	224	PF01048	0.425
MOD_GlcNHglycan	357	360	PF01048	0.594
MOD_GlcNHglycan	437	440	PF01048	0.573
MOD_GlcNHglycan	5	8	PF01048	0.463
MOD_GlcNHglycan	515	518	PF01048	0.622
MOD_GlcNHglycan	533	536	PF01048	0.521
MOD_GlcNHglycan	540	543	PF01048	0.570
MOD_GlcNHglycan	643	646	PF01048	0.698
MOD_GlcNHglycan	66	69	PF01048	0.562
MOD_GlcNHglycan	667	670	PF01048	0.770
MOD_GlcNHglycan	727	730	PF01048	0.630
MOD_GlcNHglycan	759	762	PF01048	0.819
MOD_GlcNHglycan	886	889	PF01048	0.670
MOD_GSK3_1	137	144	PF00069	0.476
MOD_GSK3_1	219	226	PF00069	0.450
MOD_GSK3_1	298	305	PF00069	0.654
MOD_GSK3_1	326	333	PF00069	0.600
MOD_GSK3_1	355	362	PF00069	0.577
MOD_GSK3_1	372	379	PF00069	0.412
MOD_GSK3_1	412	419	PF00069	0.586
MOD_GSK3_1	456	463	PF00069	0.626
MOD_GSK3_1	465	472	PF00069	0.701
MOD_GSK3_1	494	501	PF00069	0.691
MOD_GSK3_1	505	512	PF00069	0.580
MOD_GSK3_1	525	532	PF00069	0.557
MOD_GSK3_1	537	544	PF00069	0.690
MOD_GSK3_1	567	574	PF00069	0.391
MOD_GSK3_1	64	71	PF00069	0.559
MOD_GSK3_1	665	672	PF00069	0.573
MOD_GSK3_1	721	728	PF00069	0.803
MOD_GSK3_1	778	785	PF00069	0.632
MOD_GSK3_1	857	864	PF00069	0.730
MOD_GSK3_1	893	900	PF00069	0.652
MOD_GSK3_1	921	928	PF00069	0.617
MOD_GSK3_1	932	939	PF00069	0.629
MOD_N-GLC_1	192	197	PF02516	0.423
MOD_N-GLC_1	382	387	PF02516	0.485
MOD_N-GLC_1	497	502	PF02516	0.657
MOD_N-GLC_1	598	603	PF02516	0.354
MOD_NEK2_1	221	226	PF00069	0.343
MOD_NEK2_1	469	474	PF00069	0.780
MOD_NEK2_1	484	489	PF00069	0.623
MOD_NEK2_1	502	507	PF00069	0.697
MOD_NEK2_1	567	572	PF00069	0.395
MOD_NEK2_1	769	774	PF00069	0.678
MOD_NEK2_1	778	783	PF00069	0.608
MOD_NEK2_1	88	93	PF00069	0.469
MOD_NEK2_1	884	889	PF00069	0.600
MOD_NEK2_1	922	927	PF00069	0.730
MOD_NEK2_2	223	228	PF00069	0.500
MOD_NMyristoyl	1	7	PF02799	0.449
MOD_PIKK_1	705	711	PF00454	0.682
MOD_PIKK_1	755	761	PF00454	0.626
MOD_PIKK_1	861	867	PF00454	0.622
MOD_PKA_1	556	562	PF00069	0.491
MOD_PKA_2	404	410	PF00069	0.588
MOD_PKA_2	632	638	PF00069	0.633
MOD_PKA_2	88	94	PF00069	0.477
MOD_Plk_1	192	198	PF00069	0.420
MOD_Plk_1	396	402	PF00069	0.448
MOD_Plk_1	497	503	PF00069	0.543
MOD_Plk_1	598	604	PF00069	0.536
MOD_Plk_1	68	74	PF00069	0.475
MOD_Plk_2-3	404	410	PF00069	0.571
MOD_Plk_2-3	549	555	PF00069	0.496
MOD_Plk_4	126	132	PF00069	0.413
MOD_Plk_4	302	308	PF00069	0.577
MOD_Plk_4	330	336	PF00069	0.585
MOD_Plk_4	398	404	PF00069	0.417
MOD_Plk_4	450	456	PF00069	0.528
MOD_Plk_4	498	504	PF00069	0.573
MOD_Plk_4	567	573	PF00069	0.439
MOD_Plk_4	604	610	PF00069	0.455
MOD_Plk_4	778	784	PF00069	0.621
MOD_Plk_4	800	806	PF00069	0.652
MOD_Plk_4	908	914	PF00069	0.624
MOD_ProDKin_1	137	143	PF00069	0.565
MOD_ProDKin_1	34	40	PF00069	0.355
MOD_ProDKin_1	359	365	PF00069	0.517
MOD_ProDKin_1	414	420	PF00069	0.612
MOD_ProDKin_1	463	469	PF00069	0.617
MOD_ProDKin_1	535	541	PF00069	0.668
MOD_ProDKin_1	680	686	PF00069	0.700
MOD_ProDKin_1	728	734	PF00069	0.693
MOD_ProDKin_1	812	818	PF00069	0.688
MOD_ProDKin_1	838	844	PF00069	0.715
MOD_ProDKin_1	895	901	PF00069	0.674
MOD_ProDKin_1	932	938	PF00069	0.697
MOD_SUMO_for_1	290	293	PF00179	0.446
MOD_SUMO_rev_2	574	583	PF00179	0.397
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.458
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.433
TRG_ENDOCYTIC_2	284	287	PF00928	0.481
TRG_ENDOCYTIC_2	335	338	PF00928	0.545
TRG_ENDOCYTIC_2	622	625	PF00928	0.411
TRG_ENDOCYTIC_2	802	805	PF00928	0.662
TRG_ENDOCYTIC_2	912	915	PF00928	0.541
TRG_ER_diArg_1	112	115	PF00400	0.457
TRG_ER_diArg_1	173	175	PF00400	0.528
TRG_ER_diArg_1	613	615	PF00400	0.462
TRG_ER_diArg_1	701	703	PF00400	0.574
TRG_NLS_MonoExtN_4	252	257	PF00514	0.382
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBS8	Leptomonas seymouri	41%	100%
A0A3S7X4H0	Leishmania donovani	91%	100%
A4HJD3	Leishmania braziliensis	71%	99%
A4I6T0	Leishmania infantum	90%	100%
E9B1V2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5DGF9	Trypanosoma cruzi	31%	100%