Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q6A8_LEIMA

TriTrypDb:

LmjF.31.1540 , LMJLV39_310023300 , LMJSD75_310022600

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6A8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.641
CLV_NRD_NRD_1	79	81	PF00675	0.797
CLV_PCSK_KEX2_1	79	81	PF00082	0.797
CLV_PCSK_SKI1_1	237	241	PF00082	0.709
DEG_SCF_FBW7_1	162	169	PF00400	0.800
DEG_SCF_FBW7_1	364	371	PF00400	0.591
DEG_SPOP_SBC_1	172	176	PF00917	0.729
DEG_SPOP_SBC_1	226	230	PF00917	0.625
DOC_CKS1_1	238	243	PF01111	0.753
DOC_CKS1_1	365	370	PF01111	0.787
DOC_CYCLIN_yCln2_LP_2	239	245	PF00134	0.716
DOC_MAPK_gen_1	416	425	PF00069	0.622
DOC_MAPK_MEF2A_6	416	425	PF00069	0.700
DOC_MAPK_MEF2A_6	68	76	PF00069	0.771
DOC_PP2B_LxvP_1	239	242	PF13499	0.762
DOC_PP4_FxxP_1	264	267	PF00568	0.704
DOC_USP7_MATH_1	139	143	PF00917	0.629
DOC_USP7_MATH_1	172	176	PF00917	0.799
DOC_USP7_MATH_1	219	223	PF00917	0.739
DOC_USP7_MATH_1	226	230	PF00917	0.778
DOC_USP7_MATH_1	267	271	PF00917	0.780
DOC_USP7_MATH_1	313	317	PF00917	0.640
DOC_USP7_MATH_1	355	359	PF00917	0.778
DOC_USP7_MATH_1	387	391	PF00917	0.756
DOC_USP7_MATH_1	392	396	PF00917	0.644
DOC_USP7_MATH_1	401	405	PF00917	0.636
DOC_WW_Pin1_4	101	106	PF00397	0.649
DOC_WW_Pin1_4	113	118	PF00397	0.733
DOC_WW_Pin1_4	158	163	PF00397	0.752
DOC_WW_Pin1_4	183	188	PF00397	0.688
DOC_WW_Pin1_4	194	199	PF00397	0.711
DOC_WW_Pin1_4	237	242	PF00397	0.742
DOC_WW_Pin1_4	247	252	PF00397	0.800
DOC_WW_Pin1_4	294	299	PF00397	0.809
DOC_WW_Pin1_4	364	369	PF00397	0.737
DOC_WW_Pin1_4	46	51	PF00397	0.705
DOC_WW_Pin1_4	84	89	PF00397	0.799
LIG_14-3-3_CanoR_1	113	117	PF00244	0.755
LIG_14-3-3_CanoR_1	180	185	PF00244	0.678
LIG_14-3-3_CanoR_1	419	424	PF00244	0.574
LIG_14-3-3_CanoR_1	79	85	PF00244	0.816
LIG_Actin_WH2_2	314	332	PF00022	0.647
LIG_APCC_ABBAyCdc20_2	411	417	PF00400	0.605
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_FHA_1	261	267	PF00498	0.691
LIG_FHA_1	275	281	PF00498	0.677
LIG_FHA_2	309	315	PF00498	0.696
LIG_FHA_2	39	45	PF00498	0.771
LIG_LIR_Apic_2	116	122	PF02991	0.829
LIG_LIR_Apic_2	262	267	PF02991	0.670
LIG_LIR_Gen_1	165	173	PF02991	0.804
LIG_LIR_Gen_1	417	425	PF02991	0.698
LIG_LIR_Nem_3	165	171	PF02991	0.803
LIG_LIR_Nem_3	2	7	PF02991	0.558
LIG_LIR_Nem_3	417	423	PF02991	0.588
LIG_PDZ_Class_2	420	425	PF00595	0.590
LIG_Pex14_1	25	29	PF04695	0.542
LIG_SH2_CRK	119	123	PF00017	0.826
LIG_SH2_CRK	235	239	PF00017	0.799
LIG_SH2_CRK	245	249	PF00017	0.646
LIG_SH2_NCK_1	119	123	PF00017	0.826
LIG_SH2_NCK_1	245	249	PF00017	0.733
LIG_SH2_STAT5	273	276	PF00017	0.661
LIG_SH2_STAT5	366	369	PF00017	0.716
LIG_SH3_1	235	241	PF00018	0.715
LIG_SH3_1	245	251	PF00018	0.605
LIG_SH3_2	372	377	PF14604	0.745
LIG_SH3_3	181	187	PF00018	0.681
LIG_SH3_3	235	241	PF00018	0.662
LIG_SH3_3	245	251	PF00018	0.564
LIG_SH3_3	277	283	PF00018	0.694
LIG_SH3_3	369	375	PF00018	0.738
LIG_SUMO_SIM_anti_2	277	282	PF11976	0.706
LIG_UBA3_1	57	61	PF00899	0.728
MOD_CDC14_SPxK_1	161	164	PF00782	0.708
MOD_CDK_SPxK_1	158	164	PF00069	0.694
MOD_CK1_1	111	117	PF00069	0.836
MOD_CK1_1	120	126	PF00069	0.780
MOD_CK1_1	143	149	PF00069	0.710
MOD_CK1_1	158	164	PF00069	0.504
MOD_CK1_1	175	181	PF00069	0.582
MOD_CK1_1	183	189	PF00069	0.600
MOD_CK1_1	250	256	PF00069	0.744
MOD_CK1_1	262	268	PF00069	0.626
MOD_CK1_1	296	302	PF00069	0.705
MOD_CK1_1	341	347	PF00069	0.771
MOD_CK1_1	38	44	PF00069	0.723
MOD_CK1_1	404	410	PF00069	0.710
MOD_CK1_1	63	69	PF00069	0.648
MOD_CK2_1	95	101	PF00069	0.722
MOD_DYRK1A_RPxSP_1	113	117	PF00069	0.755
MOD_GlcNHglycan	110	113	PF01048	0.744
MOD_GlcNHglycan	129	132	PF01048	0.483
MOD_GlcNHglycan	137	140	PF01048	0.590
MOD_GlcNHglycan	175	178	PF01048	0.818
MOD_GlcNHglycan	190	193	PF01048	0.487
MOD_GlcNHglycan	209	212	PF01048	0.661
MOD_GlcNHglycan	253	256	PF01048	0.738
MOD_GlcNHglycan	270	273	PF01048	0.489
MOD_GlcNHglycan	286	289	PF01048	0.727
MOD_GlcNHglycan	306	309	PF01048	0.722
MOD_GlcNHglycan	336	339	PF01048	0.677
MOD_GlcNHglycan	340	343	PF01048	0.667
MOD_GlcNHglycan	37	40	PF01048	0.574
MOD_GlcNHglycan	389	392	PF01048	0.723
MOD_GlcNHglycan	394	397	PF01048	0.670
MOD_GlcNHglycan	405	409	PF01048	0.573
MOD_GlcNHglycan	65	68	PF01048	0.797
MOD_GSK3_1	108	115	PF00069	0.823
MOD_GSK3_1	117	124	PF00069	0.772
MOD_GSK3_1	127	134	PF00069	0.523
MOD_GSK3_1	135	142	PF00069	0.647
MOD_GSK3_1	158	165	PF00069	0.761
MOD_GSK3_1	171	178	PF00069	0.607
MOD_GSK3_1	221	228	PF00069	0.729
MOD_GSK3_1	247	254	PF00069	0.716
MOD_GSK3_1	304	311	PF00069	0.700
MOD_GSK3_1	334	341	PF00069	0.569
MOD_GSK3_1	353	360	PF00069	0.620
MOD_GSK3_1	364	371	PF00069	0.557
MOD_GSK3_1	400	407	PF00069	0.646
MOD_GSK3_1	63	70	PF00069	0.675
MOD_GSK3_1	80	87	PF00069	0.709
MOD_N-GLC_1	140	145	PF02516	0.707
MOD_N-GLC_1	207	212	PF02516	0.708
MOD_N-GLC_1	304	309	PF02516	0.741
MOD_N-GLC_1	46	51	PF02516	0.794
MOD_N-GLC_1	63	68	PF02516	0.609
MOD_NEK2_1	188	193	PF00069	0.699
MOD_NEK2_1	268	273	PF00069	0.768
MOD_NEK2_1	60	65	PF00069	0.720
MOD_PIKK_1	221	227	PF00454	0.720
MOD_PK_1	180	186	PF00069	0.717
MOD_PKA_1	79	85	PF00069	0.606
MOD_PKA_2	112	118	PF00069	0.842
MOD_PKA_2	155	161	PF00069	0.751
MOD_PKA_2	78	84	PF00069	0.812
MOD_Plk_1	143	149	PF00069	0.680
MOD_Plk_1	166	172	PF00069	0.709
MOD_Plk_1	313	319	PF00069	0.657
MOD_Plk_4	200	206	PF00069	0.681
MOD_Plk_4	276	282	PF00069	0.770
MOD_Plk_4	296	302	PF00069	0.708
MOD_Plk_4	313	319	PF00069	0.651
MOD_ProDKin_1	101	107	PF00069	0.650
MOD_ProDKin_1	113	119	PF00069	0.734
MOD_ProDKin_1	158	164	PF00069	0.756
MOD_ProDKin_1	183	189	PF00069	0.692
MOD_ProDKin_1	194	200	PF00069	0.709
MOD_ProDKin_1	237	243	PF00069	0.744
MOD_ProDKin_1	247	253	PF00069	0.618
MOD_ProDKin_1	294	300	PF00069	0.810
MOD_ProDKin_1	364	370	PF00069	0.737
MOD_ProDKin_1	46	52	PF00069	0.705
MOD_ProDKin_1	84	90	PF00069	0.798
TRG_ENDOCYTIC_2	20	23	PF00928	0.748

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC35	Leptomonas seymouri	27%	99%
A0A3S7X4K9	Leishmania donovani	88%	96%
A4HJD5	Leishmania braziliensis	64%	100%
A4I6T2	Leishmania infantum	87%	96%
E9B1V4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%