L51_S25_CI-B8 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q6A7_LEIMA

TriTrypDb:

LmjF.31.1550 , LMJLV39_310023400 , LMJSD75_310022700

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000315	organellar large ribosomal subunit	5	2
GO:0005739	mitochondrion	5	9
GO:0005762	mitochondrial large ribosomal subunit	3	2
GO:0005840	ribosome	5	9
GO:0015934	large ribosomal subunit	4	2
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9

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Expansion

Sequence features

Q4Q6A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6A7

PDB structure(s): 7aih_Ab , 7am2_Ab , 7ane_Ab

Function

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Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0032543	mitochondrial translation	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11

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Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.458
CLV_NRD_NRD_1	134	136	PF00675	0.477
CLV_NRD_NRD_1	165	167	PF00675	0.596
CLV_NRD_NRD_1	241	243	PF00675	0.473
CLV_NRD_NRD_1	253	255	PF00675	0.473
CLV_PCSK_FUR_1	163	167	PF00082	0.619
CLV_PCSK_KEX2_1	106	108	PF00082	0.473
CLV_PCSK_KEX2_1	165	167	PF00082	0.595
CLV_PCSK_KEX2_1	240	242	PF00082	0.477
CLV_PCSK_SKI1_1	135	139	PF00082	0.517

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZE9	Leptomonas seymouri	88%	100%
A0A0S4IRQ7	Bodo saltans	52%	94%
A0A1X0NRH7	Trypanosomatidae	63%	100%
A0A3Q8ISM3	Leishmania donovani	98%	100%
A0A3R7MT16	Trypanosoma rangeli	65%	100%
A4HJD6	Leishmania braziliensis	92%	100%
A4I6T3	Leishmania infantum	97%	100%
C9ZMA5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9B1V5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5BPL4	Trypanosoma cruzi	64%	100%

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