Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6A6_LEIMA

TriTrypDb:

LmjF.31.1560 , LMJLV39_310023500 , LMJSD75_310022800

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6A6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.460
CLV_NRD_NRD_1	226	228	PF00675	0.501
CLV_NRD_NRD_1	319	321	PF00675	0.564
CLV_PCSK_KEX2_1	226	228	PF00082	0.446
CLV_PCSK_SKI1_1	260	264	PF00082	0.358
CLV_PCSK_SKI1_1	77	81	PF00082	0.500
DEG_Nend_Nbox_1	1	3	PF02207	0.388
DOC_CKS1_1	58	63	PF01111	0.450
DOC_MAPK_gen_1	41	48	PF00069	0.515
DOC_MAPK_MEF2A_6	41	48	PF00069	0.482
DOC_PP2B_LxvP_1	44	47	PF13499	0.529
DOC_PP4_FxxP_1	67	70	PF00568	0.489
DOC_USP7_MATH_1	106	110	PF00917	0.570
DOC_USP7_MATH_1	245	249	PF00917	0.468
DOC_USP7_MATH_1	291	295	PF00917	0.470
DOC_USP7_MATH_1	71	75	PF00917	0.745
DOC_WW_Pin1_4	57	62	PF00397	0.545
DOC_WW_Pin1_4	66	71	PF00397	0.695
LIG_14-3-3_CanoR_1	148	155	PF00244	0.368
LIG_14-3-3_CanoR_1	214	224	PF00244	0.498
LIG_14-3-3_CanoR_1	268	274	PF00244	0.462
LIG_14-3-3_CanoR_1	309	315	PF00244	0.439
LIG_14-3-3_CanoR_1	41	47	PF00244	0.506
LIG_14-3-3_CanoR_1	5	11	PF00244	0.484
LIG_14-3-3_CanoR_1	93	101	PF00244	0.645
LIG_Actin_WH2_2	307	322	PF00022	0.523
LIG_BRCT_BRCA1_1	108	112	PF00533	0.602
LIG_CSL_BTD_1	11	14	PF09270	0.319
LIG_eIF4E_1	82	88	PF01652	0.457
LIG_FHA_1	182	188	PF00498	0.302
LIG_FHA_1	280	286	PF00498	0.566
LIG_FHA_1	29	35	PF00498	0.365
LIG_LIR_Apic_2	66	70	PF02991	0.490
LIG_LIR_Gen_1	109	119	PF02991	0.404
LIG_LIR_Nem_3	109	115	PF02991	0.447
LIG_LIR_Nem_3	183	188	PF02991	0.357
LIG_PCNA_yPIPBox_3	226	237	PF02747	0.443
LIG_SH2_CRK	212	216	PF00017	0.376
LIG_SH2_SRC	118	121	PF00017	0.362
LIG_SH2_STAT5	118	121	PF00017	0.476
LIG_SH2_STAT5	212	215	PF00017	0.478
LIG_SH3_3	88	94	PF00018	0.451
LIG_SUMO_SIM_anti_2	19	24	PF11976	0.319
LIG_SUMO_SIM_par_1	135	141	PF11976	0.367
LIG_SUMO_SIM_par_1	153	159	PF11976	0.464
LIG_SUMO_SIM_par_1	234	242	PF11976	0.471
LIG_SUMO_SIM_par_1	30	36	PF11976	0.400
LIG_TRAF2_1	276	279	PF00917	0.588
MOD_CK1_1	122	128	PF00069	0.468
MOD_CK1_1	138	144	PF00069	0.499
MOD_CK1_1	294	300	PF00069	0.553
MOD_CK2_1	111	117	PF00069	0.511
MOD_CK2_1	166	172	PF00069	0.593
MOD_CK2_1	273	279	PF00069	0.574
MOD_GlcNHglycan	108	111	PF01048	0.517
MOD_GlcNHglycan	129	132	PF01048	0.478
MOD_GlcNHglycan	202	205	PF01048	0.485
MOD_GlcNHglycan	241	244	PF01048	0.528
MOD_GlcNHglycan	285	288	PF01048	0.497
MOD_GlcNHglycan	296	299	PF01048	0.403
MOD_GlcNHglycan	95	98	PF01048	0.592
MOD_GSK3_1	119	126	PF00069	0.494
MOD_GSK3_1	12	19	PF00069	0.423
MOD_GSK3_1	143	150	PF00069	0.494
MOD_GSK3_1	269	276	PF00069	0.556
MOD_GSK3_1	279	286	PF00069	0.554
MOD_GSK3_1	33	40	PF00069	0.396
MOD_GSK3_1	71	78	PF00069	0.637
MOD_N-GLC_1	273	278	PF02516	0.523
MOD_NEK2_1	119	124	PF00069	0.516
MOD_NEK2_1	135	140	PF00069	0.289
MOD_NEK2_1	147	152	PF00069	0.359
MOD_NEK2_1	161	166	PF00069	0.441
MOD_NEK2_1	187	192	PF00069	0.379
MOD_NEK2_1	200	205	PF00069	0.422
MOD_NEK2_1	215	220	PF00069	0.333
MOD_NEK2_1	33	38	PF00069	0.516
MOD_PIKK_1	104	110	PF00454	0.531
MOD_PIKK_1	245	251	PF00454	0.688
MOD_PKA_2	147	153	PF00069	0.368
MOD_PKA_2	279	285	PF00069	0.524
MOD_PKA_2	294	300	PF00069	0.398
MOD_PKA_2	42	48	PF00069	0.497
MOD_Plk_1	119	125	PF00069	0.474
MOD_Plk_1	161	167	PF00069	0.410
MOD_Plk_1	273	279	PF00069	0.506
MOD_Plk_1	75	81	PF00069	0.636
MOD_Plk_4	111	117	PF00069	0.449
MOD_Plk_4	16	22	PF00069	0.274
MOD_Plk_4	28	34	PF00069	0.361
MOD_Plk_4	6	12	PF00069	0.344
MOD_ProDKin_1	57	63	PF00069	0.556
MOD_ProDKin_1	66	72	PF00069	0.693
MOD_SUMO_rev_2	171	181	PF00179	0.488
TRG_DiLeu_BaEn_1	76	81	PF01217	0.509
TRG_DiLeu_BaEn_4	196	202	PF01217	0.469
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.544
TRG_ENDOCYTIC_2	212	215	PF00928	0.373
TRG_ER_diArg_1	226	228	PF00400	0.501
TRG_ER_diArg_1	41	44	PF00400	0.545
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A2	Leptomonas seymouri	62%	99%
A0A1X0NQ31	Trypanosomatidae	41%	97%
A0A3R7KN88	Trypanosoma rangeli	43%	100%
A0A3S7X4K4	Leishmania donovani	95%	100%
A4HJD7	Leishmania braziliensis	87%	100%
A4I6T4	Leishmania infantum	95%	100%
C9ZMA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B1V6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BFH9	Trypanosoma cruzi	41%	100%