Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q6A2_LEIMA

TriTrypDb:

LmjF.31.1600 , LMJLV39_310023900 , LMJSD75_310023200

Length:

811

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	13
GO:0042995	cell projection	2	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0110165	cellular anatomical entity	1	13
GO:0120025	plasma membrane bounded cell projection	3	13
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q6A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6A2

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006457	protein folding	2	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0007021	tubulin complex assembly	6	2
GO:0007023	post-chaperonin tubulin folding pathway	3	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0043014	alpha-tubulin binding	5	2
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.383
CLV_C14_Caspase3-7	454	458	PF00656	0.470
CLV_NRD_NRD_1	286	288	PF00675	0.392
CLV_NRD_NRD_1	31	33	PF00675	0.674
CLV_NRD_NRD_1	60	62	PF00675	0.686
CLV_NRD_NRD_1	654	656	PF00675	0.462
CLV_NRD_NRD_1	765	767	PF00675	0.377
CLV_PCSK_FUR_1	29	33	PF00082	0.504
CLV_PCSK_FUR_1	58	62	PF00082	0.564
CLV_PCSK_KEX2_1	286	288	PF00082	0.362
CLV_PCSK_KEX2_1	31	33	PF00082	0.674
CLV_PCSK_KEX2_1	60	62	PF00082	0.686
CLV_PCSK_KEX2_1	654	656	PF00082	0.375
CLV_PCSK_KEX2_1	787	789	PF00082	0.445
CLV_PCSK_PC1ET2_1	787	789	PF00082	0.385
CLV_PCSK_SKI1_1	196	200	PF00082	0.454
CLV_PCSK_SKI1_1	420	424	PF00082	0.370
CLV_PCSK_SKI1_1	551	555	PF00082	0.438
CLV_PCSK_SKI1_1	766	770	PF00082	0.487
CLV_PCSK_SKI1_1	802	806	PF00082	0.456
DEG_SPOP_SBC_1	51	55	PF00917	0.498
DOC_CDC14_PxL_1	372	380	PF14671	0.365
DOC_CDC14_PxL_1	510	518	PF14671	0.368
DOC_CYCLIN_RxL_1	417	425	PF00134	0.564
DOC_CYCLIN_RxL_1	512	525	PF00134	0.399
DOC_MAPK_gen_1	466	475	PF00069	0.325
DOC_MAPK_gen_1	512	521	PF00069	0.491
DOC_MAPK_gen_1	766	775	PF00069	0.344
DOC_MAPK_MEF2A_6	512	520	PF00069	0.363
DOC_MAPK_MEF2A_6	741	750	PF00069	0.331
DOC_MAPK_MEF2A_6	766	775	PF00069	0.373
DOC_MAPK_NFAT4_5	766	774	PF00069	0.342
DOC_PP1_RVXF_1	433	440	PF00149	0.356
DOC_PP2B_LxvP_1	109	112	PF13499	0.585
DOC_USP7_MATH_1	22	26	PF00917	0.630
DOC_USP7_MATH_1	233	237	PF00917	0.389
DOC_USP7_MATH_1	30	34	PF00917	0.638
DOC_USP7_MATH_1	51	55	PF00917	0.540
DOC_USP7_MATH_1	659	663	PF00917	0.451
DOC_USP7_MATH_1	730	734	PF00917	0.391
DOC_USP7_MATH_1	90	94	PF00917	0.618
DOC_USP7_MATH_2	177	183	PF00917	0.462
DOC_USP7_UBL2_3	192	196	PF12436	0.415
DOC_USP7_UBL2_3	770	774	PF12436	0.509
DOC_WW_Pin1_4	171	176	PF00397	0.475
DOC_WW_Pin1_4	24	29	PF00397	0.623
DOC_WW_Pin1_4	620	625	PF00397	0.346
DOC_WW_Pin1_4	98	103	PF00397	0.548
LIG_14-3-3_CanoR_1	149	155	PF00244	0.496
LIG_14-3-3_CanoR_1	420	425	PF00244	0.498
LIG_14-3-3_CanoR_1	466	471	PF00244	0.434
LIG_14-3-3_CanoR_1	58	68	PF00244	0.498
LIG_14-3-3_CanoR_1	638	642	PF00244	0.430
LIG_14-3-3_CanoR_1	667	675	PF00244	0.512
LIG_Actin_WH2_2	202	219	PF00022	0.372
LIG_Actin_WH2_2	67	85	PF00022	0.436
LIG_Actin_WH2_2	686	702	PF00022	0.345
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BRCT_BRCA1_1	551	555	PF00533	0.408
LIG_BRCT_BRCA1_1	702	706	PF00533	0.319
LIG_BRCT_BRCA1_1	84	88	PF00533	0.598
LIG_Clathr_ClatBox_1	421	425	PF01394	0.336
LIG_Clathr_ClatBox_1	736	740	PF01394	0.349
LIG_FHA_1	104	110	PF00498	0.759
LIG_FHA_1	142	148	PF00498	0.544
LIG_FHA_1	188	194	PF00498	0.503
LIG_FHA_1	197	203	PF00498	0.392
LIG_FHA_1	211	217	PF00498	0.290
LIG_FHA_1	446	452	PF00498	0.475
LIG_FHA_1	92	98	PF00498	0.634
LIG_FHA_2	174	180	PF00498	0.442
LIG_FHA_2	377	383	PF00498	0.504
LIG_FHA_2	452	458	PF00498	0.434
LIG_FHA_2	467	473	PF00498	0.363
LIG_FHA_2	567	573	PF00498	0.363
LIG_FHA_2	681	687	PF00498	0.372
LIG_LIR_Gen_1	399	410	PF02991	0.442
LIG_LIR_Gen_1	44	52	PF02991	0.571
LIG_LIR_Gen_1	542	553	PF02991	0.524
LIG_LIR_Gen_1	703	712	PF02991	0.378
LIG_LIR_Gen_1	751	759	PF02991	0.352
LIG_LIR_Gen_1	777	786	PF02991	0.378
LIG_LIR_Nem_3	271	276	PF02991	0.392
LIG_LIR_Nem_3	399	405	PF02991	0.433
LIG_LIR_Nem_3	44	48	PF02991	0.594
LIG_LIR_Nem_3	542	548	PF02991	0.525
LIG_LIR_Nem_3	552	557	PF02991	0.409
LIG_LIR_Nem_3	687	693	PF02991	0.392
LIG_LIR_Nem_3	703	709	PF02991	0.266
LIG_LIR_Nem_3	751	755	PF02991	0.558
LIG_LIR_Nem_3	777	783	PF02991	0.387
LIG_LRP6_Inhibitor_1	429	435	PF00058	0.331
LIG_MLH1_MIPbox_1	551	555	PF16413	0.408
LIG_NRBOX	153	159	PF00104	0.378
LIG_NRBOX	417	423	PF00104	0.351
LIG_PCNA_yPIPBox_3	149	158	PF02747	0.402
LIG_SH2_CRK	752	756	PF00017	0.378
LIG_SH2_GRB2like	402	405	PF00017	0.337
LIG_SH2_NCK_1	780	784	PF00017	0.383
LIG_SH2_SRC	780	783	PF00017	0.381
LIG_SH2_STAP1	210	214	PF00017	0.390
LIG_SH2_STAP1	780	784	PF00017	0.383
LIG_SH2_STAT5	377	380	PF00017	0.372
LIG_SH2_STAT5	402	405	PF00017	0.337
LIG_SH2_STAT5	42	45	PF00017	0.465
LIG_SH2_STAT5	752	755	PF00017	0.370
LIG_SH2_STAT5	785	788	PF00017	0.442
LIG_SH3_3	172	178	PF00018	0.433
LIG_SH3_3	264	270	PF00018	0.521
LIG_SUMO_SIM_anti_2	528	533	PF11976	0.536
LIG_SUMO_SIM_anti_2	7	14	PF11976	0.514
LIG_SUMO_SIM_anti_2	806	811	PF11976	0.477
LIG_SUMO_SIM_par_1	419	425	PF11976	0.563
LIG_SUMO_SIM_par_1	447	454	PF11976	0.517
LIG_SUMO_SIM_par_1	517	522	PF11976	0.335
LIG_SUMO_SIM_par_1	7	14	PF11976	0.559
LIG_TRAF2_1	608	611	PF00917	0.364
LIG_TYR_ITIM	400	405	PF00017	0.341
LIG_TYR_ITIM	750	755	PF00017	0.355
LIG_TYR_ITIM	778	783	PF00017	0.345
LIG_UBA3_1	400	407	PF00899	0.350
LIG_UBA3_1	768	774	PF00899	0.359
LIG_WRC_WIRS_1	205	210	PF05994	0.371
LIG_WRC_WIRS_1	42	47	PF05994	0.439
MOD_CDK_SPK_2	24	29	PF00069	0.505
MOD_CDK_SPxxK_3	24	31	PF00069	0.616
MOD_CK1_1	171	177	PF00069	0.464
MOD_CK1_1	194	200	PF00069	0.466
MOD_CK1_1	2	8	PF00069	0.633
MOD_CK1_1	212	218	PF00069	0.451
MOD_CK1_1	445	451	PF00069	0.475
MOD_CK1_1	53	59	PF00069	0.727
MOD_CK1_1	561	567	PF00069	0.383
MOD_CK1_1	593	599	PF00069	0.461
MOD_CK1_1	640	646	PF00069	0.394
MOD_CK1_1	662	668	PF00069	0.510
MOD_CK2_1	150	156	PF00069	0.415
MOD_CK2_1	173	179	PF00069	0.498
MOD_CK2_1	233	239	PF00069	0.374
MOD_CK2_1	605	611	PF00069	0.486
MOD_CK2_1	716	722	PF00069	0.381
MOD_Cter_Amidation	58	61	PF01082	0.564
MOD_GlcNHglycan	103	106	PF01048	0.468
MOD_GlcNHglycan	133	136	PF01048	0.680
MOD_GlcNHglycan	170	173	PF01048	0.433
MOD_GlcNHglycan	196	199	PF01048	0.557
MOD_GlcNHglycan	313	316	PF01048	0.310
MOD_GlcNHglycan	457	460	PF01048	0.507
MOD_GlcNHglycan	550	554	PF01048	0.446
MOD_GlcNHglycan	560	563	PF01048	0.422
MOD_GlcNHglycan	669	672	PF01048	0.430
MOD_GlcNHglycan	756	759	PF01048	0.346
MOD_GlcNHglycan	84	87	PF01048	0.657
MOD_GSK3_1	187	194	PF00069	0.445
MOD_GSK3_1	204	211	PF00069	0.429
MOD_GSK3_1	274	281	PF00069	0.373
MOD_GSK3_1	30	37	PF00069	0.777
MOD_GSK3_1	307	314	PF00069	0.357
MOD_GSK3_1	382	389	PF00069	0.436
MOD_GSK3_1	405	412	PF00069	0.390
MOD_GSK3_1	416	423	PF00069	0.379
MOD_GSK3_1	447	454	PF00069	0.389
MOD_GSK3_1	471	478	PF00069	0.354
MOD_GSK3_1	521	528	PF00069	0.359
MOD_GSK3_1	589	596	PF00069	0.456
MOD_GSK3_1	620	627	PF00069	0.389
MOD_GSK3_1	636	643	PF00069	0.406
MOD_GSK3_1	658	665	PF00069	0.404
MOD_GSK3_1	700	707	PF00069	0.321
MOD_GSK3_1	725	732	PF00069	0.450
MOD_GSK3_1	750	757	PF00069	0.386
MOD_N-GLC_1	138	143	PF02516	0.509
MOD_N-GLC_1	150	155	PF02516	0.339
MOD_N-GLC_1	168	173	PF02516	0.321
MOD_N-GLC_1	481	486	PF02516	0.360
MOD_N-GLC_1	678	683	PF02516	0.345
MOD_N-GLC_1	748	753	PF02516	0.429
MOD_NEK2_1	150	155	PF00069	0.502
MOD_NEK2_1	208	213	PF00069	0.568
MOD_NEK2_1	288	293	PF00069	0.416
MOD_NEK2_1	307	312	PF00069	0.398
MOD_NEK2_1	335	340	PF00069	0.351
MOD_NEK2_1	381	386	PF00069	0.450
MOD_NEK2_1	394	399	PF00069	0.433
MOD_NEK2_1	405	410	PF00069	0.313
MOD_NEK2_1	41	46	PF00069	0.649
MOD_NEK2_1	440	445	PF00069	0.442
MOD_NEK2_1	451	456	PF00069	0.356
MOD_NEK2_1	475	480	PF00069	0.469
MOD_NEK2_1	497	502	PF00069	0.472
MOD_NEK2_1	519	524	PF00069	0.466
MOD_NEK2_1	555	560	PF00069	0.503
MOD_NEK2_1	614	619	PF00069	0.486
MOD_NEK2_1	626	631	PF00069	0.458
MOD_NEK2_1	636	641	PF00069	0.399
MOD_NEK2_1	678	683	PF00069	0.325
MOD_NEK2_1	704	709	PF00069	0.427
MOD_NEK2_1	748	753	PF00069	0.316
MOD_NEK2_1	82	87	PF00069	0.646
MOD_NEK2_2	637	642	PF00069	0.526
MOD_PIKK_1	113	119	PF00454	0.539
MOD_PIKK_1	35	41	PF00454	0.468
MOD_PIKK_1	394	400	PF00454	0.370
MOD_PIKK_1	53	59	PF00454	0.576
MOD_PIKK_1	707	713	PF00454	0.324
MOD_PKA_2	187	193	PF00069	0.347
MOD_PKA_2	30	36	PF00069	0.560
MOD_PKA_2	340	346	PF00069	0.403
MOD_PKA_2	478	484	PF00069	0.416
MOD_PKA_2	59	65	PF00069	0.502
MOD_PKA_2	637	643	PF00069	0.530
MOD_PKA_2	760	766	PF00069	0.494
MOD_PKA_2	82	88	PF00069	0.512
MOD_PKB_1	32	40	PF00069	0.528
MOD_Plk_1	150	156	PF00069	0.598
MOD_Plk_1	435	441	PF00069	0.348
MOD_Plk_1	471	477	PF00069	0.472
MOD_Plk_1	549	555	PF00069	0.515
MOD_Plk_1	564	570	PF00069	0.286
MOD_Plk_1	659	665	PF00069	0.513
MOD_Plk_1	748	754	PF00069	0.453
MOD_Plk_1	805	811	PF00069	0.490
MOD_Plk_2-3	525	531	PF00069	0.344
MOD_Plk_2-3	605	611	PF00069	0.378
MOD_Plk_4	204	210	PF00069	0.403
MOD_Plk_4	249	255	PF00069	0.482
MOD_Plk_4	383	389	PF00069	0.517
MOD_Plk_4	396	402	PF00069	0.392
MOD_Plk_4	435	441	PF00069	0.370
MOD_Plk_4	451	457	PF00069	0.362
MOD_Plk_4	497	503	PF00069	0.457
MOD_Plk_4	805	811	PF00069	0.502
MOD_ProDKin_1	171	177	PF00069	0.478
MOD_ProDKin_1	24	30	PF00069	0.620
MOD_ProDKin_1	620	626	PF00069	0.343
MOD_ProDKin_1	98	104	PF00069	0.549
MOD_SUMO_for_1	533	536	PF00179	0.331
MOD_SUMO_rev_2	536	546	PF00179	0.368
TRG_DiLeu_BaEn_2	203	209	PF01217	0.384
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.350
TRG_DiLeu_BaLyEn_6	583	588	PF01217	0.370
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.358
TRG_ENDOCYTIC_2	402	405	PF00928	0.337
TRG_ENDOCYTIC_2	42	45	PF00928	0.436
TRG_ENDOCYTIC_2	752	755	PF00928	0.370
TRG_ENDOCYTIC_2	780	783	PF00928	0.445
TRG_ER_diArg_1	108	111	PF00400	0.571
TRG_ER_diArg_1	28	31	PF00400	0.751
TRG_ER_diArg_1	285	287	PF00400	0.365
TRG_ER_diArg_1	339	342	PF00400	0.381
TRG_ER_diArg_1	58	61	PF00400	0.707
TRG_ER_diArg_1	653	655	PF00400	0.462
TRG_LysEnd_GGAAcLL_1	806	811	PF00790	0.477
TRG_NES_CRM1_1	413	425	PF08389	0.337
TRG_NES_CRM1_1	511	525	PF08389	0.341
TRG_Pf-PMV_PEXEL_1	420	425	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	468	472	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	607	611	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P1M5	Trypanosomatidae	27%	92%
A0A3Q8IGD6	Leishmania donovani	94%	100%
A0A3S5ISR4	Trypanosoma rangeli	26%	97%
A4H3H4	Leishmania braziliensis	22%	83%
A4H3R1	Leishmania braziliensis	23%	100%
A4I6T8	Leishmania infantum	95%	100%
D0A4F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	96%
E9AIU4	Leishmania braziliensis	76%	100%
E9B1W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QJ80	Leishmania major	25%	100%
V5BKI3	Trypanosoma cruzi	26%	97%