LeishMANIAdb
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NTPase_I-T domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
NTPase_I-T domain-containing protein
Gene product:
Protein of unknown function DUF84, putative
Species:
Leishmania major
UniProt:
Q4Q6A0_LEIMA
TriTrypDb:
LmjF.31.1620 , LMJLV39_310024100 , LMJSD75_310023400
Length:
179

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6A0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6A0

Function

Biological processes
Term Name Level Count
GO:0006066 alcohol metabolic process 3 2
GO:0006725 cellular aromatic compound metabolic process 3 2
GO:0006766 vitamin metabolic process 3 2
GO:0006767 water-soluble vitamin metabolic process 4 2
GO:0006772 thiamine metabolic process 5 2
GO:0006790 sulfur compound metabolic process 3 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 2
GO:0009987 cellular process 1 2
GO:0034308 primary alcohol metabolic process 4 2
GO:0034641 cellular nitrogen compound metabolic process 3 2
GO:0042723 thiamine-containing compound metabolic process 4 2
GO:0044237 cellular metabolic process 2 2
GO:0044281 small molecule metabolic process 2 2
GO:0046483 heterocycle metabolic process 3 2
GO:0071704 organic substance metabolic process 2 2
GO:0072527 pyrimidine-containing compound metabolic process 4 2
GO:1901360 organic cyclic compound metabolic process 3 2
GO:1901564 organonitrogen compound metabolic process 3 2
GO:1901615 organic hydroxy compound metabolic process 3 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0016462 pyrophosphatase activity 5 2
GO:0016787 hydrolase activity 2 2
GO:0016817 hydrolase activity, acting on acid anhydrides 3 2
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 2
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 129 133 PF00656 0.452
CLV_NRD_NRD_1 96 98 PF00675 0.420
CLV_PCSK_SKI1_1 118 122 PF00082 0.452
CLV_PCSK_SKI1_1 53 57 PF00082 0.371
CLV_PCSK_SKI1_1 60 64 PF00082 0.326
DEG_APCC_DBOX_1 140 148 PF00400 0.420
DEG_MDM2_SWIB_1 87 95 PF02201 0.308
DOC_CDC14_PxL_1 167 175 PF14671 0.293
DOC_MAPK_gen_1 11 20 PF00069 0.381
DOC_MAPK_gen_1 58 65 PF00069 0.425
LIG_14-3-3_CanoR_1 33 38 PF00244 0.401
LIG_BRCT_BRCA1_1 106 110 PF00533 0.308
LIG_FHA_1 27 33 PF00498 0.390
LIG_FHA_2 133 139 PF00498 0.349
LIG_LIR_Gen_1 88 95 PF02991 0.308
LIG_LIR_Nem_3 88 94 PF02991 0.292
LIG_Pex14_2 87 91 PF04695 0.308
LIG_PTB_Apo_2 19 26 PF02174 0.381
LIG_SH2_SRC 161 164 PF00017 0.420
LIG_SUMO_SIM_anti_2 15 22 PF11976 0.413
LIG_SUMO_SIM_par_1 91 96 PF11976 0.432
LIG_TRAF2_1 135 138 PF00917 0.349
LIG_TRAF2_1 47 50 PF00917 0.328
LIG_TRFH_1 167 171 PF08558 0.328
LIG_UBA3_1 116 125 PF00899 0.308
MOD_CK1_1 16 22 PF00069 0.452
MOD_CK1_1 36 42 PF00069 0.378
MOD_CK2_1 132 138 PF00069 0.407
MOD_CK2_1 44 50 PF00069 0.308
MOD_GlcNHglycan 106 109 PF01048 0.325
MOD_GlcNHglycan 141 144 PF01048 0.318
MOD_GlcNHglycan 38 41 PF01048 0.305
MOD_GlcNHglycan 46 49 PF01048 0.275
MOD_GSK3_1 35 42 PF00069 0.391
MOD_GSK3_1 44 51 PF00069 0.312
MOD_N-GLC_1 132 137 PF02516 0.452
MOD_N-GLC_1 26 31 PF02516 0.417
MOD_N-GLC_2 22 24 PF02516 0.351
MOD_NEK2_1 112 117 PF00069 0.316
MOD_NEK2_1 173 178 PF00069 0.465
MOD_PIKK_1 48 54 PF00454 0.316
MOD_PK_1 13 19 PF00069 0.381
MOD_PK_1 33 39 PF00069 0.401
MOD_PKA_2 96 102 PF00069 0.308
MOD_Plk_2-3 64 70 PF00069 0.287
MOD_Plk_4 112 118 PF00069 0.420
MOD_Plk_4 13 19 PF00069 0.436
MOD_SUMO_for_1 12 15 PF00179 0.420
TRG_Pf-PMV_PEXEL_1 125 129 PF00026 0.397

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL97 Leptomonas seymouri 78% 100%
A0A0S4J605 Bodo saltans 62% 97%
A0A1X0NPT0 Trypanosomatidae 66% 99%
A0A3S7X4I2 Leishmania donovani 98% 100%
A0A422NZA6 Trypanosoma rangeli 65% 99%
A0L0M2 Shewanella sp. (strain ANA-3) 28% 100%
A1JJB7 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) 32% 100%
A1RUC0 Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) 31% 100%
A3MVS2 Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1) 28% 100%
A4HJE2 Leishmania braziliensis 90% 100%
A4I6U0 Leishmania infantum 98% 100%
A4TQH6 Yersinia pestis (strain Pestoides F) 32% 99%
A4W6B2 Enterobacter sp. (strain 638) 34% 100%
A4WJ90 Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6) 30% 100%
A6TI08 Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) 32% 100%
A6WS92 Shewanella baltica (strain OS185) 27% 96%
A7FMF9 Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) 33% 99%
A7MIJ1 Cronobacter sakazakii (strain ATCC BAA-894) 31% 100%
A8ALW2 Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) 32% 100%
A8G9J3 Serratia proteamaculans (strain 568) 35% 100%
A8MA42 Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167) 30% 99%
A9L1P1 Shewanella baltica (strain OS195) 27% 96%
A9MR95 Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) 30% 100%
A9N7F4 Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) 32% 100%
A9R033 Yersinia pestis bv. Antiqua (strain Angola) 32% 99%
B1IS25 Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks) 32% 100%
B1JL21 Yersinia pseudotuberculosis serotype O:3 (strain YPIII) 33% 99%
B1L5W9 Korarchaeum cryptofilum (strain OPF8) 36% 100%
B1XFK4 Escherichia coli (strain K12 / DH10B) 32% 100%
B2K3K4 Yersinia pseudotuberculosis serotype IB (strain PB1/+) 33% 99%
B2VH10 Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99) 33% 98%
B4EY51 Proteus mirabilis (strain HI4320) 33% 100%
B4T4I8 Salmonella newport (strain SL254) 32% 100%
B4TH17 Salmonella heidelberg (strain SL476) 32% 100%
B4TU54 Salmonella schwarzengrund (strain CVM19633) 32% 100%
B5BAL0 Salmonella paratyphi A (strain AKU_12601) 32% 100%
B5F542 Salmonella agona (strain SL483) 32% 100%
B5FAQ4 Aliivibrio fischeri (strain MJ11) 36% 100%
B5FTD8 Salmonella dublin (strain CT_02021853) 32% 100%
B5R3B6 Salmonella enteritidis PT4 (strain P125109) 32% 100%
B5R9W2 Salmonella gallinarum (strain 287/91 / NCTC 13346) 32% 100%
B5Y265 Klebsiella pneumoniae (strain 342) 35% 100%
B6I6P2 Escherichia coli (strain SE11) 32% 100%
B7LEP0 Escherichia coli (strain 55989 / EAEC) 32% 100%
B7MNK3 Escherichia coli O45:K1 (strain S88 / ExPEC) 32% 100%
B7UR24 Escherichia coli O127:H6 (strain E2348/69 / EPEC) 32% 100%
C0Q8F4 Salmonella paratyphi C (strain RKS4594) 32% 100%
C3LSV6 Vibrio cholerae serotype O1 (strain M66-2) 36% 98%
C3MJC4 Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) 34% 100%
C3MTQ6 Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) 33% 100%
C3N0B6 Sulfolobus islandicus (strain M.16.27) 34% 100%
C3N7X4 Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) 34% 100%
C3NJ80 Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) 34% 100%
C4KJG4 Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) 34% 100%
C4ZT76 Escherichia coli (strain K12 / MC4100 / BW2952) 32% 100%
C6DF26 Pectobacterium carotovorum subsp. carotovorum (strain PC1) 36% 100%
C9ZMB1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 99%
E9B1W2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O27919 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 33% 98%
O29361 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 28% 100%
P39411 Escherichia coli (strain K12) 32% 100%
P39432 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 32% 100%
Q0HM78 Shewanella sp. (strain MR-4) 28% 100%
Q0HRK8 Shewanella sp. (strain MR-7) 28% 100%
Q0W5C7 Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50) 34% 100%
Q1C0L6 Yersinia pestis bv. Antiqua (strain Antiqua) 32% 99%
Q1CMX3 Yersinia pestis bv. Antiqua (strain Nepal516) 32% 99%
Q57709 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 29% 100%
Q57G27 Salmonella choleraesuis (strain SC-B67) 32% 100%
Q5E7E1 Aliivibrio fischeri (strain ATCC 700601 / ES114) 36% 100%
Q5JJ32 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 36% 100%
Q5PK30 Salmonella paratyphi A (strain ATCC 9150 / SARB42) 32% 100%
Q66EU4 Yersinia pseudotuberculosis serotype I (strain IP32953) 33% 99%
Q6D0A1 Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 35% 100%
Q6LUG1 Photobacterium profundum (strain SS9) 35% 100%
Q7MNK7 Vibrio vulnificus (strain YJ016) 35% 98%
Q7N901 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) 34% 100%
Q87S70 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) 38% 98%
Q8DEU6 Vibrio vulnificus (strain CMCP6) 33% 98%
Q8EIC6 Shewanella oneidensis (strain MR-1) 28% 100%
Q8EP79 Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831) 30% 100%
Q8FA41 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 32% 100%
Q8TV89 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 31% 100%
Q8XB14 Escherichia coli O157:H7 33% 100%
Q8ZIP1 Yersinia pestis 32% 99%
Q8ZUF6 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 27% 100%
Q96YP8 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 35% 100%
Q97WI6 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 33% 100%
Q9K7V3 Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) 38% 100%
Q9KU27 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 36% 98%
Q9YDY1 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 32% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS