MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MYND finger, putative

Species:

Leishmania major

UniProt:

Q4Q697_LEIMA

TriTrypDb:

LmjF.31.1650 , LMJLV39_310024400 , LMJSD75_310023900

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q697

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q697

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.371
CLV_C14_Caspase3-7	39	43	PF00656	0.513
CLV_C14_Caspase3-7	4	8	PF00656	0.620
CLV_NRD_NRD_1	163	165	PF00675	0.482
CLV_NRD_NRD_1	174	176	PF00675	0.482
CLV_NRD_NRD_1	453	455	PF00675	0.456
CLV_NRD_NRD_1	475	477	PF00675	0.552
CLV_PCSK_KEX2_1	174	176	PF00082	0.482
CLV_PCSK_KEX2_1	453	455	PF00082	0.535
CLV_PCSK_KEX2_1	475	477	PF00082	0.671

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJJ2	Leptomonas seymouri	80%	100%
A0A0S4JQ55	Bodo saltans	30%	71%
A0A1X0NPU0	Trypanosomatidae	35%	99%
A0A3R7M2S8	Trypanosoma rangeli	35%	98%
A0A3S7X4J0	Leishmania donovani	99%	100%
A4HJE7	Leishmania braziliensis	93%	100%
A4I6U2	Leishmania infantum	98%	100%
C9ZMB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	93%
E9B1W5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5B432	Trypanosoma cruzi	36%	98%

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