Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q694_LEIMA

TriTrypDb:

LmjF.31.1680 , LMJLV39_310024700 , LMJSD75_310024200

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0005930	axoneme	2	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q694

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q694

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	90	94	PF00656	0.509
CLV_NRD_NRD_1	134	136	PF00675	0.548
CLV_NRD_NRD_1	149	151	PF00675	0.387
CLV_NRD_NRD_1	264	266	PF00675	0.578
CLV_PCSK_KEX2_1	142	144	PF00082	0.523
CLV_PCSK_KEX2_1	171	173	PF00082	0.582
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.609
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.514
CLV_PCSK_PC7_1	138	144	PF00082	0.534
CLV_PCSK_SKI1_1	104	108	PF00082	0.554
CLV_PCSK_SKI1_1	151	155	PF00082	0.469
CLV_PCSK_SKI1_1	172	176	PF00082	0.611
DOC_ANK_TNKS_1	164	171	PF00023	0.584
DOC_PP1_RVXF_1	72	78	PF00149	0.707
DOC_USP7_MATH_1	196	200	PF00917	0.546
DOC_USP7_MATH_1	235	239	PF00917	0.482
DOC_USP7_MATH_1	270	274	PF00917	0.676
DOC_USP7_MATH_1	67	71	PF00917	0.647
DOC_USP7_MATH_1	99	103	PF00917	0.692
LIG_14-3-3_CanoR_1	120	126	PF00244	0.677
LIG_14-3-3_CanoR_1	263	271	PF00244	0.560
LIG_BIR_III_4	167	171	PF00653	0.586
LIG_FHA_2	205	211	PF00498	0.616
LIG_FHA_2	214	220	PF00498	0.456
LIG_Integrin_isoDGR_2	95	97	PF01839	0.564
LIG_LIR_Gen_1	238	248	PF02991	0.611
LIG_LIR_Nem_3	219	224	PF02991	0.475
LIG_LIR_Nem_3	238	243	PF02991	0.610
LIG_PTAP_UEV_1	1	6	PF05743	0.505
LIG_SH2_CRK	240	244	PF00017	0.616
LIG_SH2_STAT5	230	233	PF00017	0.611
LIG_SH2_STAT5	247	250	PF00017	0.460
LIG_SH2_STAT5	61	64	PF00017	0.566
LIG_SUMO_SIM_par_1	212	219	PF11976	0.539
LIG_UBA3_1	162	171	PF00899	0.531
MOD_CK1_1	102	108	PF00069	0.568
MOD_CK1_1	3	9	PF00069	0.686
MOD_CK2_1	213	219	PF00069	0.503
MOD_Cter_Amidation	169	172	PF01082	0.582
MOD_GlcNHglycan	131	134	PF01048	0.610
MOD_GlcNHglycan	2	5	PF01048	0.667
MOD_GlcNHglycan	68	72	PF01048	0.559
MOD_GlcNHglycan	87	90	PF01048	0.478
MOD_GSK3_1	120	127	PF00069	0.615
MOD_GSK3_1	29	36	PF00069	0.658
MOD_GSK3_1	98	105	PF00069	0.738
MOD_NEK2_1	131	136	PF00069	0.631
MOD_NEK2_1	181	186	PF00069	0.529
MOD_NEK2_1	204	209	PF00069	0.643
MOD_NEK2_2	196	201	PF00069	0.554
MOD_NEK2_2	73	78	PF00069	0.766
MOD_NEK2_2	99	104	PF00069	0.569
MOD_OFUCOSY	47	53	PF10250	0.698
MOD_PIKK_1	19	25	PF00454	0.533
MOD_PKA_2	264	270	PF00069	0.459
MOD_Plk_1	67	73	PF00069	0.695
MOD_Plk_4	210	216	PF00069	0.552
MOD_SUMO_for_1	141	144	PF00179	0.607
MOD_SUMO_rev_2	144	153	PF00179	0.453
MOD_SUMO_rev_2	167	173	PF00179	0.598
TRG_DiLeu_BaEn_4	250	256	PF01217	0.470
TRG_ENDOCYTIC_2	221	224	PF00928	0.476
TRG_ENDOCYTIC_2	240	243	PF00928	0.521
TRG_ER_diArg_1	257	260	PF00400	0.587
TRG_NLS_MonoExtC_3	134	140	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I0	Leptomonas seymouri	60%	100%
A0A1X0NRC6	Trypanosomatidae	46%	99%
A0A3Q8IFD5	Leishmania donovani	95%	100%
A0A422MYM9	Trypanosoma rangeli	45%	99%
A4HJF0	Leishmania braziliensis	85%	100%
A4I6U5	Leishmania infantum	95%	100%
C9ZMB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B1W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5AZM2	Trypanosoma cruzi	44%	100%