Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q692_LEIMA

TriTrypDb:

LmjF.31.1700 , LMJLV39_310024900 , LMJSD75_310024400

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q692

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q692

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	409	413	PF00656	0.655
CLV_C14_Caspase3-7	653	657	PF00656	0.507
CLV_NRD_NRD_1	137	139	PF00675	0.705
CLV_NRD_NRD_1	167	169	PF00675	0.676
CLV_NRD_NRD_1	195	197	PF00675	0.593
CLV_NRD_NRD_1	226	228	PF00675	0.496
CLV_NRD_NRD_1	303	305	PF00675	0.561
CLV_NRD_NRD_1	667	669	PF00675	0.494
CLV_PCSK_KEX2_1	137	139	PF00082	0.735
CLV_PCSK_KEX2_1	158	160	PF00082	0.595
CLV_PCSK_KEX2_1	169	171	PF00082	0.582
CLV_PCSK_KEX2_1	195	197	PF00082	0.641
CLV_PCSK_KEX2_1	225	227	PF00082	0.512
CLV_PCSK_KEX2_1	303	305	PF00082	0.649
CLV_PCSK_KEX2_1	667	669	PF00082	0.499
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.607
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.582
CLV_PCSK_PC7_1	154	160	PF00082	0.530
CLV_PCSK_SKI1_1	196	200	PF00082	0.606
CLV_PCSK_SKI1_1	494	498	PF00082	0.343
CLV_PCSK_SKI1_1	546	550	PF00082	0.501
CLV_PCSK_SKI1_1	584	588	PF00082	0.526
CLV_PCSK_SKI1_1	633	637	PF00082	0.460
DEG_COP1_1	585	593	PF00400	0.400
DEG_SCF_TRCP1_1	378	384	PF00400	0.381
DEG_SPOP_SBC_1	125	129	PF00917	0.590
DEG_SPOP_SBC_1	355	359	PF00917	0.541
DOC_ANK_TNKS_1	556	563	PF00023	0.616
DOC_CKS1_1	350	355	PF01111	0.585
DOC_CYCLIN_RxL_1	275	289	PF00134	0.477
DOC_CYCLIN_RxL_1	543	553	PF00134	0.524
DOC_MAPK_gen_1	225	231	PF00069	0.502
DOC_MAPK_gen_1	424	433	PF00069	0.555
DOC_MAPK_gen_1	66	75	PF00069	0.751
DOC_MAPK_MEF2A_6	211	220	PF00069	0.509
DOC_PP1_RVXF_1	234	241	PF00149	0.445
DOC_PP1_RVXF_1	544	551	PF00149	0.467
DOC_PP4_FxxP_1	549	552	PF00568	0.551
DOC_USP7_MATH_1	126	130	PF00917	0.742
DOC_USP7_MATH_1	145	149	PF00917	0.643
DOC_USP7_MATH_1	162	166	PF00917	0.637
DOC_USP7_MATH_1	188	192	PF00917	0.715
DOC_USP7_MATH_1	355	359	PF00917	0.473
DOC_USP7_MATH_1	398	402	PF00917	0.554
DOC_USP7_MATH_1	404	408	PF00917	0.601
DOC_USP7_MATH_1	411	415	PF00917	0.649
DOC_USP7_MATH_1	425	429	PF00917	0.645
DOC_USP7_MATH_1	532	536	PF00917	0.393
DOC_USP7_MATH_1	650	654	PF00917	0.577
DOC_USP7_MATH_1	92	96	PF00917	0.691
DOC_USP7_UBL2_3	241	245	PF12436	0.464
DOC_WW_Pin1_4	158	163	PF00397	0.599
DOC_WW_Pin1_4	16	21	PF00397	0.607
DOC_WW_Pin1_4	260	265	PF00397	0.460
DOC_WW_Pin1_4	349	354	PF00397	0.588
DOC_WW_Pin1_4	359	364	PF00397	0.532
DOC_WW_Pin1_4	381	386	PF00397	0.516
DOC_WW_Pin1_4	413	418	PF00397	0.729
DOC_WW_Pin1_4	447	452	PF00397	0.434
DOC_WW_Pin1_4	48	53	PF00397	0.800
DOC_WW_Pin1_4	485	490	PF00397	0.495
DOC_WW_Pin1_4	88	93	PF00397	0.735
LIG_14-3-3_CanoR_1	10	17	PF00244	0.682
LIG_14-3-3_CanoR_1	124	131	PF00244	0.689
LIG_14-3-3_CanoR_1	137	146	PF00244	0.612
LIG_14-3-3_CanoR_1	35	40	PF00244	0.720
LIG_14-3-3_CanoR_1	643	651	PF00244	0.528
LIG_Actin_WH2_2	541	559	PF00022	0.505
LIG_APCC_ABBA_1	218	223	PF00400	0.568
LIG_APCC_ABBA_1	660	665	PF00400	0.461
LIG_BIR_III_4	412	416	PF00653	0.592
LIG_BRCT_BRCA1_1	546	550	PF00533	0.527
LIG_Clathr_ClatBox_1	430	434	PF01394	0.494
LIG_FHA_1	100	106	PF00498	0.612
LIG_FHA_1	131	137	PF00498	0.784
LIG_FHA_1	204	210	PF00498	0.596
LIG_FHA_1	382	388	PF00498	0.459
LIG_FHA_1	389	395	PF00498	0.431
LIG_FHA_1	495	501	PF00498	0.472
LIG_FHA_1	519	525	PF00498	0.375
LIG_FHA_1	585	591	PF00498	0.459
LIG_FHA_1	593	599	PF00498	0.326
LIG_FHA_1	611	617	PF00498	0.365
LIG_FHA_2	287	293	PF00498	0.382
LIG_FHA_2	407	413	PF00498	0.612
LIG_FHA_2	448	454	PF00498	0.413
LIG_FHA_2	479	485	PF00498	0.443
LIG_LIR_Apic_2	547	552	PF02991	0.526
LIG_LIR_Gen_1	288	298	PF02991	0.359
LIG_LIR_Gen_1	34	44	PF02991	0.463
LIG_LIR_Gen_1	458	465	PF02991	0.425
LIG_LIR_Gen_1	595	604	PF02991	0.377
LIG_LIR_Gen_1	606	617	PF02991	0.336
LIG_LIR_LC3C_4	215	220	PF02991	0.593
LIG_LIR_Nem_3	288	293	PF02991	0.379
LIG_LIR_Nem_3	34	39	PF02991	0.571
LIG_LIR_Nem_3	367	373	PF02991	0.360
LIG_LIR_Nem_3	4	8	PF02991	0.470
LIG_LIR_Nem_3	458	462	PF02991	0.375
LIG_LIR_Nem_3	540	545	PF02991	0.353
LIG_LIR_Nem_3	606	612	PF02991	0.451
LIG_LIR_Nem_3	618	624	PF02991	0.455
LIG_MLH1_MIPbox_1	546	550	PF16413	0.464
LIG_MYND_3	672	676	PF01753	0.654
LIG_NRBOX	630	636	PF00104	0.390
LIG_SH2_CRK	373	377	PF00017	0.448
LIG_SH2_CRK	492	496	PF00017	0.362
LIG_SH2_CRK	545	549	PF00017	0.358
LIG_SH2_NCK_1	290	294	PF00017	0.374
LIG_SH2_PTP2	459	462	PF00017	0.321
LIG_SH2_SRC	214	217	PF00017	0.583
LIG_SH2_SRC	290	293	PF00017	0.369
LIG_SH2_STAP1	290	294	PF00017	0.345
LIG_SH2_STAP1	492	496	PF00017	0.362
LIG_SH2_STAP1	505	509	PF00017	0.391
LIG_SH2_STAT5	163	166	PF00017	0.578
LIG_SH2_STAT5	33	36	PF00017	0.680
LIG_SH2_STAT5	375	378	PF00017	0.533
LIG_SH2_STAT5	390	393	PF00017	0.316
LIG_SH2_STAT5	454	457	PF00017	0.337
LIG_SH2_STAT5	459	462	PF00017	0.321
LIG_SH2_STAT5	5	8	PF00017	0.588
LIG_SH2_STAT5	505	508	PF00017	0.505
LIG_SH2_STAT5	523	526	PF00017	0.449
LIG_SH2_STAT5	609	612	PF00017	0.511
LIG_SH3_2	552	557	PF14604	0.652
LIG_SH3_3	357	363	PF00018	0.508
LIG_SH3_3	549	555	PF00018	0.596
LIG_SH3_3	86	92	PF00018	0.701
LIG_Sin3_3	508	515	PF02671	0.482
LIG_SUMO_SIM_anti_2	428	434	PF11976	0.514
LIG_SUMO_SIM_par_1	428	434	PF11976	0.514
LIG_TRAF2_1	481	484	PF00917	0.561
LIG_TRFH_1	447	451	PF08558	0.391
LIG_UBA3_1	152	158	PF00899	0.498
LIG_UBA3_1	430	436	PF00899	0.291
LIG_UBA3_1	630	636	PF00899	0.430
LIG_WRC_WIRS_1	593	598	PF05994	0.481
MOD_CDK_SPK_2	381	386	PF00069	0.512
MOD_CDK_SPxxK_3	260	267	PF00069	0.457
MOD_CK1_1	100	106	PF00069	0.656
MOD_CK1_1	127	133	PF00069	0.784
MOD_CK1_1	148	154	PF00069	0.601
MOD_CK1_1	260	266	PF00069	0.481
MOD_CK1_1	315	321	PF00069	0.699
MOD_CK1_1	354	360	PF00069	0.509
MOD_CK1_1	407	413	PF00069	0.671
MOD_CK1_1	592	598	PF00069	0.389
MOD_CK1_1	65	71	PF00069	0.756
MOD_CK2_1	110	116	PF00069	0.606
MOD_CK2_1	260	266	PF00069	0.429
MOD_CK2_1	447	453	PF00069	0.435
MOD_CK2_1	478	484	PF00069	0.436
MOD_CMANNOS	329	332	PF00535	0.537
MOD_GlcNHglycan	11	14	PF01048	0.643
MOD_GlcNHglycan	118	121	PF01048	0.586
MOD_GlcNHglycan	148	151	PF01048	0.633
MOD_GlcNHglycan	186	189	PF01048	0.650
MOD_GlcNHglycan	318	321	PF01048	0.656
MOD_GlcNHglycan	323	326	PF01048	0.690
MOD_GlcNHglycan	341	344	PF01048	0.678
MOD_GlcNHglycan	353	356	PF01048	0.588
MOD_GlcNHglycan	378	381	PF01048	0.404
MOD_GlcNHglycan	412	416	PF01048	0.713
MOD_GlcNHglycan	427	430	PF01048	0.609
MOD_GlcNHglycan	558	561	PF01048	0.641
MOD_GlcNHglycan	584	587	PF01048	0.568
MOD_GlcNHglycan	652	655	PF01048	0.566
MOD_GlcNHglycan	69	72	PF01048	0.623
MOD_GSK3_1	110	117	PF00069	0.680
MOD_GSK3_1	120	127	PF00069	0.712
MOD_GSK3_1	148	155	PF00069	0.579
MOD_GSK3_1	158	165	PF00069	0.629
MOD_GSK3_1	184	191	PF00069	0.640
MOD_GSK3_1	31	38	PF00069	0.739
MOD_GSK3_1	312	319	PF00069	0.694
MOD_GSK3_1	335	342	PF00069	0.635
MOD_GSK3_1	351	358	PF00069	0.497
MOD_GSK3_1	407	414	PF00069	0.679
MOD_GSK3_1	474	481	PF00069	0.397
MOD_GSK3_1	580	587	PF00069	0.612
MOD_GSK3_1	603	610	PF00069	0.540
MOD_GSK3_1	88	95	PF00069	0.702
MOD_LATS_1	135	141	PF00433	0.626
MOD_N-GLC_1	579	584	PF02516	0.435
MOD_N-GLC_2	331	333	PF02516	0.588
MOD_NEK2_1	1	6	PF00069	0.688
MOD_NEK2_1	316	321	PF00069	0.650
MOD_NEK2_1	339	344	PF00069	0.623
MOD_NEK2_1	376	381	PF00069	0.490
MOD_NEK2_1	388	393	PF00069	0.379
MOD_NEK2_1	544	549	PF00069	0.401
MOD_NEK2_1	67	72	PF00069	0.649
MOD_NEK2_2	163	168	PF00069	0.571
MOD_PIKK_1	137	143	PF00454	0.579
MOD_PIKK_1	603	609	PF00454	0.447
MOD_PKA_1	137	143	PF00069	0.705
MOD_PKA_2	137	143	PF00069	0.672
MOD_PKA_2	173	179	PF00069	0.729
MOD_PKA_2	34	40	PF00069	0.741
MOD_PKA_2	425	431	PF00069	0.568
MOD_PKA_2	474	480	PF00069	0.388
MOD_PKA_2	532	538	PF00069	0.406
MOD_PKA_2	556	562	PF00069	0.689
MOD_PKA_2	9	15	PF00069	0.622
MOD_PKB_1	284	292	PF00069	0.394
MOD_Plk_1	452	458	PF00069	0.349
MOD_Plk_1	610	616	PF00069	0.564
MOD_Plk_1	97	103	PF00069	0.620
MOD_Plk_2-3	205	211	PF00069	0.549
MOD_Plk_4	100	106	PF00069	0.739
MOD_Plk_4	148	154	PF00069	0.621
MOD_Plk_4	18	24	PF00069	0.633
MOD_Plk_4	267	273	PF00069	0.515
MOD_Plk_4	293	299	PF00069	0.489
MOD_Plk_4	35	41	PF00069	0.664
MOD_Plk_4	356	362	PF00069	0.490
MOD_Plk_4	436	442	PF00069	0.347
MOD_Plk_4	455	461	PF00069	0.326
MOD_Plk_4	519	525	PF00069	0.483
MOD_Plk_4	537	543	PF00069	0.285
MOD_Plk_4	589	595	PF00069	0.471
MOD_Plk_4	610	616	PF00069	0.520
MOD_ProDKin_1	158	164	PF00069	0.595
MOD_ProDKin_1	16	22	PF00069	0.610
MOD_ProDKin_1	260	266	PF00069	0.461
MOD_ProDKin_1	349	355	PF00069	0.580
MOD_ProDKin_1	359	365	PF00069	0.524
MOD_ProDKin_1	381	387	PF00069	0.512
MOD_ProDKin_1	413	419	PF00069	0.728
MOD_ProDKin_1	447	453	PF00069	0.435
MOD_ProDKin_1	48	54	PF00069	0.802
MOD_ProDKin_1	485	491	PF00069	0.487
MOD_ProDKin_1	88	94	PF00069	0.737
MOD_SUMO_rev_2	428	437	PF00179	0.495
MOD_SUMO_rev_2	653	660	PF00179	0.541
TRG_DiLeu_BaLyEn_6	491	496	PF01217	0.345
TRG_ENDOCYTIC_2	247	250	PF00928	0.379
TRG_ENDOCYTIC_2	290	293	PF00928	0.349
TRG_ENDOCYTIC_2	33	36	PF00928	0.487
TRG_ENDOCYTIC_2	373	376	PF00928	0.380
TRG_ENDOCYTIC_2	459	462	PF00928	0.321
TRG_ENDOCYTIC_2	492	495	PF00928	0.374
TRG_ENDOCYTIC_2	5	8	PF00928	0.474
TRG_ENDOCYTIC_2	545	548	PF00928	0.364
TRG_ENDOCYTIC_2	609	612	PF00928	0.385
TRG_ENDOCYTIC_2	621	624	PF00928	0.406
TRG_ER_diArg_1	131	134	PF00400	0.638
TRG_ER_diArg_1	136	138	PF00400	0.650
TRG_ER_diArg_1	167	170	PF00400	0.606
TRG_ER_diArg_1	225	227	PF00400	0.536
TRG_ER_diArg_1	283	286	PF00400	0.427
TRG_ER_diArg_1	302	304	PF00400	0.607
TRG_ER_diArg_1	423	426	PF00400	0.534
TRG_NLS_Bipartite_1	158	172	PF00514	0.553
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ1	Leptomonas seymouri	64%	100%
A0A1X0NQ51	Trypanosomatidae	43%	100%
A0A3R7LJ81	Trypanosoma rangeli	44%	100%
A0A3S7X4H9	Leishmania donovani	94%	100%
A4HJF2	Leishmania braziliensis	79%	100%
A4I6U7	Leishmania infantum	94%	100%
C9ZMB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B1X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B8N6	Trypanosoma cruzi	41%	100%