Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q691_LEIMA

TriTrypDb:

LmjF.31.1710 , LMJLV39_310025000 , LMJSD75_310024500

Length:

668

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q691

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q691

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.645
CLV_C14_Caspase3-7	567	571	PF00656	0.615
CLV_NRD_NRD_1	19	21	PF00675	0.573
CLV_NRD_NRD_1	448	450	PF00675	0.493
CLV_NRD_NRD_1	517	519	PF00675	0.584
CLV_NRD_NRD_1	82	84	PF00675	0.704
CLV_PCSK_KEX2_1	19	21	PF00082	0.573
CLV_PCSK_KEX2_1	352	354	PF00082	0.500
CLV_PCSK_KEX2_1	448	450	PF00082	0.493
CLV_PCSK_KEX2_1	509	511	PF00082	0.498
CLV_PCSK_KEX2_1	516	518	PF00082	0.583
CLV_PCSK_KEX2_1	565	567	PF00082	0.544
CLV_PCSK_KEX2_1	82	84	PF00082	0.688
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.480
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.410
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.544
CLV_PCSK_PC7_1	348	354	PF00082	0.480
CLV_PCSK_SKI1_1	19	23	PF00082	0.558
CLV_PCSK_SKI1_1	442	446	PF00082	0.493
CLV_PCSK_SKI1_1	510	514	PF00082	0.594
CLV_PCSK_SKI1_1	620	624	PF00082	0.363
DEG_APCC_KENBOX_2	214	218	PF00400	0.583
DEG_MDM2_SWIB_1	380	387	PF02201	0.450
DEG_SPOP_SBC_1	25	29	PF00917	0.702
DOC_ANK_TNKS_1	285	292	PF00023	0.614
DOC_ANK_TNKS_1	544	551	PF00023	0.520
DOC_CDC14_PxL_1	432	440	PF14671	0.486
DOC_CKS1_1	115	120	PF01111	0.551
DOC_CKS1_1	278	283	PF01111	0.758
DOC_MAPK_MEF2A_6	408	416	PF00069	0.568
DOC_MAPK_MEF2A_6	424	432	PF00069	0.571
DOC_PP2B_LxvP_1	574	577	PF13499	0.604
DOC_PP4_FxxP_1	461	464	PF00568	0.469
DOC_USP7_MATH_1	103	107	PF00917	0.570
DOC_USP7_MATH_1	154	158	PF00917	0.660
DOC_USP7_MATH_1	245	249	PF00917	0.688
DOC_USP7_MATH_1	273	277	PF00917	0.813
DOC_USP7_MATH_1	34	38	PF00917	0.684
DOC_USP7_MATH_1	483	487	PF00917	0.585
DOC_USP7_MATH_1	493	497	PF00917	0.506
DOC_USP7_MATH_1	597	601	PF00917	0.534
DOC_USP7_MATH_1	66	70	PF00917	0.697
DOC_USP7_MATH_1	86	90	PF00917	0.558
DOC_USP7_UBL2_3	214	218	PF12436	0.655
DOC_WW_Pin1_4	111	116	PF00397	0.641
DOC_WW_Pin1_4	126	131	PF00397	0.593
DOC_WW_Pin1_4	132	137	PF00397	0.546
DOC_WW_Pin1_4	241	246	PF00397	0.672
DOC_WW_Pin1_4	269	274	PF00397	0.794
DOC_WW_Pin1_4	277	282	PF00397	0.697
DOC_WW_Pin1_4	334	339	PF00397	0.566
DOC_WW_Pin1_4	402	407	PF00397	0.658
DOC_WW_Pin1_4	408	413	PF00397	0.617
DOC_WW_Pin1_4	42	47	PF00397	0.712
DOC_WW_Pin1_4	442	447	PF00397	0.497
DOC_WW_Pin1_4	576	581	PF00397	0.658
DOC_WW_Pin1_4	600	605	PF00397	0.605
LIG_14-3-3_CanoR_1	146	154	PF00244	0.633
LIG_14-3-3_CanoR_1	20	26	PF00244	0.587
LIG_14-3-3_CanoR_1	246	250	PF00244	0.647
LIG_14-3-3_CanoR_1	274	278	PF00244	0.647
LIG_14-3-3_CanoR_1	342	347	PF00244	0.528
LIG_14-3-3_CanoR_1	361	369	PF00244	0.556
LIG_14-3-3_CanoR_1	413	419	PF00244	0.692
LIG_14-3-3_CanoR_1	472	477	PF00244	0.692
LIG_14-3-3_CanoR_1	49	55	PF00244	0.635
LIG_14-3-3_CanoR_1	523	532	PF00244	0.534
LIG_14-3-3_CanoR_1	57	62	PF00244	0.630
LIG_14-3-3_CanoR_1	572	577	PF00244	0.625
LIG_14-3-3_CanoR_1	664	668	PF00244	0.623
LIG_Actin_WH2_2	604	622	PF00022	0.409
LIG_APCC_ABBA_1	198	203	PF00400	0.578
LIG_BRCT_BRCA1_1	500	504	PF00533	0.399
LIG_deltaCOP1_diTrp_1	179	187	PF00928	0.561
LIG_deltaCOP1_diTrp_1	382	388	PF00928	0.507
LIG_DLG_GKlike_1	472	479	PF00625	0.564
LIG_eIF4E_1	618	624	PF01652	0.494
LIG_FHA_1	148	154	PF00498	0.631
LIG_FHA_1	388	394	PF00498	0.540
LIG_FHA_1	524	530	PF00498	0.521
LIG_FHA_1	571	577	PF00498	0.598
LIG_FHA_2	189	195	PF00498	0.566
LIG_GBD_Chelix_1	611	619	PF00786	0.379
LIG_HP1_1	245	249	PF01393	0.640
LIG_LIR_Apic_2	431	436	PF02991	0.469
LIG_LIR_Gen_1	382	391	PF02991	0.665
LIG_LIR_Gen_1	616	625	PF02991	0.422
LIG_LIR_Gen_1	644	655	PF02991	0.556
LIG_LIR_Nem_3	199	204	PF02991	0.583
LIG_LIR_Nem_3	307	313	PF02991	0.538
LIG_LIR_Nem_3	371	377	PF02991	0.436
LIG_LIR_Nem_3	382	387	PF02991	0.601
LIG_LIR_Nem_3	431	435	PF02991	0.494
LIG_LIR_Nem_3	501	507	PF02991	0.399
LIG_LIR_Nem_3	559	564	PF02991	0.400
LIG_LIR_Nem_3	616	621	PF02991	0.482
LIG_LIR_Nem_3	644	650	PF02991	0.690
LIG_Pex14_1	384	388	PF04695	0.522
LIG_Pex14_1	631	635	PF04695	0.465
LIG_Pex14_2	380	384	PF04695	0.426
LIG_SH2_PTP2	433	436	PF00017	0.472
LIG_SH2_STAP1	656	660	PF00017	0.485
LIG_SH2_STAT3	313	316	PF00017	0.590
LIG_SH2_STAT3	629	632	PF00017	0.480
LIG_SH2_STAT5	188	191	PF00017	0.631
LIG_SH2_STAT5	374	377	PF00017	0.413
LIG_SH2_STAT5	433	436	PF00017	0.472
LIG_SH2_STAT5	538	541	PF00017	0.359
LIG_SH2_STAT5	563	566	PF00017	0.439
LIG_SH2_STAT5	610	613	PF00017	0.405
LIG_SH2_STAT5	618	621	PF00017	0.402
LIG_SH3_2	278	283	PF14604	0.661
LIG_SH3_3	112	118	PF00018	0.728
LIG_SH3_3	275	281	PF00018	0.700
LIG_SH3_3	295	301	PF00018	0.474
LIG_SH3_3	401	407	PF00018	0.684
LIG_SH3_3	409	415	PF00018	0.570
LIG_SH3_3	454	460	PF00018	0.525
LIG_SH3_3	574	580	PF00018	0.670
LIG_SUMO_SIM_par_1	570	579	PF11976	0.548
LIG_WW_3	280	284	PF00397	0.562
LIG_WW_3	405	409	PF00397	0.523
MOD_CDC14_SPxK_1	405	408	PF00782	0.520
MOD_CDK_SPK_2	111	116	PF00069	0.558
MOD_CDK_SPK_2	126	131	PF00069	0.592
MOD_CDK_SPK_2	241	246	PF00069	0.643
MOD_CDK_SPK_2	269	274	PF00069	0.645
MOD_CDK_SPK_2	408	413	PF00069	0.610
MOD_CDK_SPxK_1	277	283	PF00069	0.660
MOD_CDK_SPxK_1	402	408	PF00069	0.525
MOD_CDK_SPxK_1	442	448	PF00069	0.498
MOD_CDK_SPxxK_3	42	49	PF00069	0.674
MOD_CDK_SPxxK_3	442	449	PF00069	0.496
MOD_CK1_1	111	117	PF00069	0.662
MOD_CK1_1	123	129	PF00069	0.554
MOD_CK1_1	152	158	PF00069	0.644
MOD_CK1_1	24	30	PF00069	0.748
MOD_CK1_1	268	274	PF00069	0.656
MOD_CK1_1	332	338	PF00069	0.588
MOD_CK1_1	351	357	PF00069	0.332
MOD_CK1_1	365	371	PF00069	0.426
MOD_CK1_1	402	408	PF00069	0.668
MOD_CK1_1	498	504	PF00069	0.438
MOD_CK1_1	50	56	PF00069	0.800
MOD_CK1_1	511	517	PF00069	0.668
MOD_CK1_1	575	581	PF00069	0.673
MOD_CK1_1	600	606	PF00069	0.572
MOD_CK1_1	76	82	PF00069	0.601
MOD_CK2_1	188	194	PF00069	0.572
MOD_CK2_1	334	340	PF00069	0.518
MOD_CK2_1	478	484	PF00069	0.637
MOD_CK2_1	525	531	PF00069	0.589
MOD_CK2_1	610	616	PF00069	0.478
MOD_CK2_1	651	657	PF00069	0.546
MOD_GlcNHglycan	105	108	PF01048	0.558
MOD_GlcNHglycan	15	18	PF01048	0.566
MOD_GlcNHglycan	156	159	PF01048	0.550
MOD_GlcNHglycan	239	242	PF01048	0.833
MOD_GlcNHglycan	255	259	PF01048	0.553
MOD_GlcNHglycan	32	35	PF01048	0.622
MOD_GlcNHglycan	353	356	PF01048	0.395
MOD_GlcNHglycan	36	39	PF01048	0.613
MOD_GlcNHglycan	418	421	PF01048	0.656
MOD_GlcNHglycan	491	494	PF01048	0.552
MOD_GlcNHglycan	581	584	PF01048	0.631
MOD_GlcNHglycan	599	602	PF01048	0.504
MOD_GlcNHglycan	604	607	PF01048	0.455
MOD_GlcNHglycan	636	639	PF01048	0.658
MOD_GlcNHglycan	653	656	PF01048	0.405
MOD_GlcNHglycan	68	71	PF01048	0.644
MOD_GSK3_1	116	123	PF00069	0.652
MOD_GSK3_1	148	155	PF00069	0.651
MOD_GSK3_1	205	212	PF00069	0.742
MOD_GSK3_1	21	28	PF00069	0.643
MOD_GSK3_1	226	233	PF00069	0.675
MOD_GSK3_1	237	244	PF00069	0.679
MOD_GSK3_1	265	272	PF00069	0.797
MOD_GSK3_1	273	280	PF00069	0.678
MOD_GSK3_1	30	37	PF00069	0.572
MOD_GSK3_1	38	45	PF00069	0.703
MOD_GSK3_1	383	390	PF00069	0.518
MOD_GSK3_1	416	423	PF00069	0.563
MOD_GSK3_1	424	431	PF00069	0.539
MOD_GSK3_1	489	496	PF00069	0.545
MOD_GSK3_1	49	56	PF00069	0.595
MOD_GSK3_1	540	547	PF00069	0.382
MOD_GSK3_1	568	575	PF00069	0.650
MOD_GSK3_1	591	598	PF00069	0.687
MOD_GSK3_1	68	75	PF00069	0.830
MOD_GSK3_1	99	106	PF00069	0.642
MOD_N-GLC_1	147	152	PF02516	0.758
MOD_N-GLC_1	265	270	PF02516	0.673
MOD_N-GLC_1	523	528	PF02516	0.715
MOD_N-GLC_1	651	656	PF02516	0.485
MOD_N-GLC_1	66	71	PF02516	0.816
MOD_NEK2_1	109	114	PF00069	0.650
MOD_NEK2_1	181	186	PF00069	0.555
MOD_NEK2_1	21	26	PF00069	0.660
MOD_NEK2_1	259	264	PF00069	0.608
MOD_NEK2_1	303	308	PF00069	0.574
MOD_NEK2_1	324	329	PF00069	0.611
MOD_NEK2_1	362	367	PF00069	0.401
MOD_NEK2_1	387	392	PF00069	0.535
MOD_NEK2_1	416	421	PF00069	0.515
MOD_NEK2_1	453	458	PF00069	0.450
MOD_NEK2_1	633	638	PF00069	0.488
MOD_NEK2_1	660	665	PF00069	0.568
MOD_NEK2_1	73	78	PF00069	0.653
MOD_NEK2_2	383	388	PF00069	0.514
MOD_NEK2_2	500	505	PF00069	0.369
MOD_PIKK_1	324	330	PF00454	0.648
MOD_PIKK_1	368	374	PF00454	0.491
MOD_PIKK_1	68	74	PF00454	0.628
MOD_PK_1	424	430	PF00069	0.574
MOD_PK_1	517	523	PF00069	0.553
MOD_PKA_1	516	522	PF00069	0.577
MOD_PKA_2	140	146	PF00069	0.664
MOD_PKA_2	245	251	PF00069	0.688
MOD_PKA_2	273	279	PF00069	0.791
MOD_PKA_2	453	459	PF00069	0.523
MOD_PKA_2	50	56	PF00069	0.623
MOD_PKA_2	516	522	PF00069	0.573
MOD_PKA_2	544	550	PF00069	0.468
MOD_Plk_1	254	260	PF00069	0.598
MOD_Plk_1	265	271	PF00069	0.622
MOD_Plk_1	651	657	PF00069	0.461
MOD_Plk_1	92	98	PF00069	0.642
MOD_Plk_4	21	27	PF00069	0.602
MOD_Plk_4	383	389	PF00069	0.516
MOD_Plk_4	392	398	PF00069	0.560
MOD_Plk_4	428	434	PF00069	0.502
MOD_Plk_4	453	459	PF00069	0.523
MOD_Plk_4	500	506	PF00069	0.411
MOD_Plk_4	517	523	PF00069	0.573
MOD_Plk_4	556	562	PF00069	0.477
MOD_Plk_4	57	63	PF00069	0.668
MOD_Plk_4	641	647	PF00069	0.583
MOD_ProDKin_1	111	117	PF00069	0.641
MOD_ProDKin_1	126	132	PF00069	0.593
MOD_ProDKin_1	241	247	PF00069	0.672
MOD_ProDKin_1	269	275	PF00069	0.797
MOD_ProDKin_1	277	283	PF00069	0.694
MOD_ProDKin_1	334	340	PF00069	0.562
MOD_ProDKin_1	402	408	PF00069	0.660
MOD_ProDKin_1	42	48	PF00069	0.712
MOD_ProDKin_1	442	448	PF00069	0.498
MOD_ProDKin_1	576	582	PF00069	0.658
MOD_ProDKin_1	600	606	PF00069	0.587
MOD_SUMO_for_1	564	567	PF00179	0.537
MOD_SUMO_rev_2	190	198	PF00179	0.614
MOD_SUMO_rev_2	199	208	PF00179	0.542
MOD_SUMO_rev_2	212	220	PF00179	0.589
MOD_SUMO_rev_2	235	241	PF00179	0.602
TRG_DiLeu_BaEn_1	293	298	PF01217	0.505
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.447
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.360
TRG_ENDOCYTIC_2	377	380	PF00928	0.438
TRG_ENDOCYTIC_2	618	621	PF00928	0.402
TRG_ER_diArg_1	19	21	PF00400	0.571
TRG_ER_diArg_1	447	449	PF00400	0.506
TRG_ER_diArg_1	516	518	PF00400	0.587
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P597	Leptomonas seymouri	45%	98%
A0A3S7X4L3	Leishmania donovani	88%	94%
A4HJF3	Leishmania braziliensis	62%	95%
A4I6U8	Leishmania infantum	88%	100%
E9B1X1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	95%