CULLIN_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cullin protein neddylation domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q690_LEIMA

TriTrypDb:

LmjF.31.1720 , LMJLV39_310025100 , LMJSD75_310024600

Length:

1198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Show entries

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0031461	cullin-RING ubiquitin ligase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Previous1Next

Expansion

Sequence features

Q4Q690

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q690

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2

Previous1 2Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0031625	ubiquitin protein ligase binding	5	2
GO:0044389	ubiquitin-like protein ligase binding	4	2

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1187	1191	PF00656	0.563
CLV_C14_Caspase3-7	241	245	PF00656	0.703
CLV_C14_Caspase3-7	313	317	PF00656	0.673
CLV_NRD_NRD_1	1050	1052	PF00675	0.530
CLV_NRD_NRD_1	1113	1115	PF00675	0.624
CLV_NRD_NRD_1	1129	1131	PF00675	0.346
CLV_NRD_NRD_1	246	248	PF00675	0.684
CLV_NRD_NRD_1	360	362	PF00675	0.748
CLV_NRD_NRD_1	623	625	PF00675	0.697
CLV_PCSK_KEX2_1	1043	1045	PF00082	0.530

Previous1 2 3 4 5…41Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V8	Leptomonas seymouri	48%	100%
A0A3S7X4J1	Leishmania donovani	94%	100%
A4HJF4	Leishmania braziliensis	80%	100%
A4I6U9	Leishmania infantum	94%	100%
E9B1X2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%

Previous1Next