Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q688_LEIMA

TriTrypDb:

LmjF.31.1740 , LMJLV39_310025300 , LMJSD75_310024800

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q688

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q688

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.515
CLV_NRD_NRD_1	214	216	PF00675	0.446
CLV_NRD_NRD_1	355	357	PF00675	0.565
CLV_NRD_NRD_1	510	512	PF00675	0.646
CLV_PCSK_FUR_1	505	509	PF00082	0.625
CLV_PCSK_KEX2_1	103	105	PF00082	0.520
CLV_PCSK_KEX2_1	355	357	PF00082	0.565
CLV_PCSK_KEX2_1	507	509	PF00082	0.614
CLV_PCSK_KEX2_1	510	512	PF00082	0.602
CLV_PCSK_PC7_1	505	511	PF00082	0.564
CLV_PCSK_SKI1_1	13	17	PF00082	0.446
CLV_PCSK_SKI1_1	215	219	PF00082	0.403
CLV_PCSK_SKI1_1	236	240	PF00082	0.386
CLV_PCSK_SKI1_1	316	320	PF00082	0.369
CLV_PCSK_SKI1_1	480	484	PF00082	0.482
CLV_PCSK_SKI1_1	89	93	PF00082	0.491
DEG_APCC_DBOX_1	12	20	PF00400	0.450
DEG_MDM2_SWIB_1	401	408	PF02201	0.385
DEG_SPOP_SBC_1	303	307	PF00917	0.429
DOC_CKS1_1	207	212	PF01111	0.495
DOC_CKS1_1	391	396	PF01111	0.561
DOC_CYCLIN_RxL_1	86	94	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	176	179	PF00134	0.585
DOC_MAPK_gen_1	215	225	PF00069	0.378
DOC_MAPK_gen_1	311	321	PF00069	0.371
DOC_MAPK_MEF2A_6	216	225	PF00069	0.374
DOC_MAPK_NFAT4_5	218	226	PF00069	0.380
DOC_PP2B_LxvP_1	176	179	PF13499	0.585
DOC_PP2B_LxvP_1	227	230	PF13499	0.364
DOC_PP2B_LxvP_1	9	12	PF13499	0.441
DOC_PP4_FxxP_1	76	79	PF00568	0.447
DOC_USP7_MATH_1	115	119	PF00917	0.617
DOC_USP7_MATH_1	303	307	PF00917	0.471
DOC_USP7_MATH_1	334	338	PF00917	0.644
DOC_USP7_MATH_1	339	343	PF00917	0.502
DOC_USP7_MATH_1	384	388	PF00917	0.473
DOC_USP7_MATH_1	397	401	PF00917	0.577
DOC_USP7_MATH_1	450	454	PF00917	0.586
DOC_USP7_MATH_1	464	468	PF00917	0.454
DOC_USP7_MATH_1	497	501	PF00917	0.640
DOC_WW_Pin1_4	187	192	PF00397	0.549
DOC_WW_Pin1_4	206	211	PF00397	0.537
DOC_WW_Pin1_4	304	309	PF00397	0.441
DOC_WW_Pin1_4	33	38	PF00397	0.517
DOC_WW_Pin1_4	344	349	PF00397	0.665
DOC_WW_Pin1_4	360	365	PF00397	0.319
DOC_WW_Pin1_4	390	395	PF00397	0.597
DOC_WW_Pin1_4	454	459	PF00397	0.632
LIG_14-3-3_CanoR_1	109	114	PF00244	0.648
LIG_14-3-3_CanoR_1	121	125	PF00244	0.569
LIG_14-3-3_CanoR_1	167	177	PF00244	0.607
LIG_14-3-3_CanoR_1	215	225	PF00244	0.378
LIG_14-3-3_CanoR_1	380	388	PF00244	0.592
LIG_Actin_RPEL_3	208	227	PF02755	0.469
LIG_BRCT_BRCA1_1	356	360	PF00533	0.517
LIG_BRCT_BRCA1_1	52	56	PF00533	0.364
LIG_BRCT_BRCA1_1	72	76	PF00533	0.419
LIG_CaM_NSCaTE_8	235	242	PF13499	0.381
LIG_deltaCOP1_diTrp_1	403	410	PF00928	0.372
LIG_FHA_1	108	114	PF00498	0.682
LIG_FHA_1	129	135	PF00498	0.598
LIG_FHA_1	286	292	PF00498	0.550
LIG_FHA_1	393	399	PF00498	0.588
LIG_FHA_1	47	53	PF00498	0.433
LIG_FHA_1	499	505	PF00498	0.689
LIG_FHA_1	514	520	PF00498	0.542
LIG_FHA_2	190	196	PF00498	0.590
LIG_FHA_2	207	213	PF00498	0.489
LIG_LIR_Apic_2	73	79	PF02991	0.444
LIG_LIR_Gen_1	219	230	PF02991	0.467
LIG_LIR_Gen_1	400	409	PF02991	0.397
LIG_LIR_Gen_1	41	52	PF02991	0.374
LIG_LIR_Gen_1	53	64	PF02991	0.373
LIG_LIR_Nem_3	140	146	PF02991	0.655
LIG_LIR_Nem_3	219	225	PF02991	0.363
LIG_LIR_Nem_3	400	404	PF02991	0.412
LIG_LIR_Nem_3	41	47	PF02991	0.391
LIG_LIR_Nem_3	53	59	PF02991	0.351
LIG_LYPXL_yS_3	143	146	PF13949	0.595
LIG_MLH1_MIPbox_1	72	76	PF16413	0.445
LIG_MYND_1	125	129	PF01753	0.583
LIG_MYND_1	33	37	PF01753	0.490
LIG_NRBOX	369	375	PF00104	0.375
LIG_Pex14_2	401	405	PF04695	0.393
LIG_PTAP_UEV_1	138	143	PF05743	0.572
LIG_PTAP_UEV_1	178	183	PF05743	0.486
LIG_SH2_CRK	17	21	PF00017	0.460
LIG_SH2_CRK	329	333	PF00017	0.485
LIG_SH2_CRK	416	420	PF00017	0.408
LIG_SH2_CRK	463	467	PF00017	0.535
LIG_SH2_NCK_1	265	269	PF00017	0.383
LIG_SH2_NCK_1	329	333	PF00017	0.485
LIG_SH2_NCK_1	463	467	PF00017	0.535
LIG_SH2_SRC	329	332	PF00017	0.477
LIG_SH2_STAP1	81	85	PF00017	0.457
LIG_SH2_STAT3	204	207	PF00017	0.556
LIG_SH2_STAT5	475	478	PF00017	0.464
LIG_SH2_STAT5	81	84	PF00017	0.454
LIG_SH3_3	136	142	PF00018	0.574
LIG_SH3_3	176	182	PF00018	0.668
LIG_SH3_3	185	191	PF00018	0.644
LIG_SH3_3	325	331	PF00018	0.441
LIG_SH3_3	34	40	PF00018	0.514
LIG_SH3_3	342	348	PF00018	0.707
LIG_SH3_3	356	362	PF00018	0.442
LIG_SH3_3	388	394	PF00018	0.569
LIG_SH3_3	63	69	PF00018	0.454
LIG_SUMO_SIM_anti_2	425	433	PF11976	0.443
LIG_SUMO_SIM_anti_2	43	49	PF11976	0.370
LIG_SUMO_SIM_par_1	68	73	PF11976	0.442
LIG_TRAF2_1	348	351	PF00917	0.774
LIG_TYR_ITIM	15	20	PF00017	0.455
LIG_TYR_ITIM	461	466	PF00017	0.619
LIG_UBA3_1	370	376	PF00899	0.393
LIG_WRC_WIRS_1	398	403	PF05994	0.495
LIG_WRC_WIRS_1	59	64	PF05994	0.408
MOD_CDK_SPxxK_3	304	311	PF00069	0.437
MOD_CK1_1	152	158	PF00069	0.726
MOD_CK1_1	206	212	PF00069	0.399
MOD_CK1_1	25	31	PF00069	0.565
MOD_CK1_1	282	288	PF00069	0.476
MOD_CK1_1	306	312	PF00069	0.443
MOD_CK1_1	354	360	PF00069	0.715
MOD_CK1_1	383	389	PF00069	0.704
MOD_CK1_1	453	459	PF00069	0.604
MOD_CK1_1	495	501	PF00069	0.629
MOD_CK2_1	344	350	PF00069	0.636
MOD_GlcNHglycan	118	121	PF01048	0.663
MOD_GlcNHglycan	139	142	PF01048	0.673
MOD_GlcNHglycan	253	256	PF01048	0.453
MOD_GlcNHglycan	332	335	PF01048	0.724
MOD_GlcNHglycan	382	385	PF01048	0.461
MOD_GlcNHglycan	453	456	PF01048	0.619
MOD_GlcNHglycan	494	497	PF01048	0.599
MOD_GlcNHglycan	52	55	PF01048	0.361
MOD_GlcNHglycan	85	88	PF01048	0.464
MOD_GSK3_1	116	123	PF00069	0.685
MOD_GSK3_1	183	190	PF00069	0.518
MOD_GSK3_1	278	285	PF00069	0.476
MOD_GSK3_1	298	305	PF00069	0.493
MOD_GSK3_1	330	337	PF00069	0.486
MOD_GSK3_1	340	347	PF00069	0.717
MOD_GSK3_1	350	357	PF00069	0.655
MOD_GSK3_1	380	387	PF00069	0.504
MOD_GSK3_1	450	457	PF00069	0.572
MOD_GSK3_1	46	53	PF00069	0.477
MOD_GSK3_1	491	498	PF00069	0.578
MOD_GSK3_1	79	86	PF00069	0.552
MOD_GSK3_1	91	98	PF00069	0.551
MOD_N-GLC_1	83	88	PF02516	0.461
MOD_NEK2_1	107	112	PF00069	0.593
MOD_NEK2_1	225	230	PF00069	0.357
MOD_NEK2_1	50	55	PF00069	0.346
MOD_NEK2_1	70	75	PF00069	0.420
MOD_NEK2_1	91	96	PF00069	0.551
MOD_NEK2_2	130	135	PF00069	0.613
MOD_NEK2_2	161	166	PF00069	0.487
MOD_NEK2_2	397	402	PF00069	0.488
MOD_PIKK_1	152	158	PF00454	0.623
MOD_PIKK_1	203	209	PF00454	0.446
MOD_PIKK_1	392	398	PF00454	0.615
MOD_PIKK_1	433	439	PF00454	0.695
MOD_PIKK_1	464	470	PF00454	0.669
MOD_PIKK_1	91	97	PF00454	0.497
MOD_PK_1	150	156	PF00069	0.529
MOD_PKA_2	108	114	PF00069	0.661
MOD_PKA_2	115	121	PF00069	0.610
MOD_PKA_2	137	143	PF00069	0.752
MOD_PKA_2	149	155	PF00069	0.574
MOD_PKA_2	354	360	PF00069	0.601
MOD_PKB_1	114	122	PF00069	0.618
MOD_Plk_1	334	340	PF00069	0.560
MOD_Plk_4	130	136	PF00069	0.696
MOD_ProDKin_1	187	193	PF00069	0.546
MOD_ProDKin_1	206	212	PF00069	0.527
MOD_ProDKin_1	304	310	PF00069	0.440
MOD_ProDKin_1	33	39	PF00069	0.510
MOD_ProDKin_1	344	350	PF00069	0.665
MOD_ProDKin_1	360	366	PF00069	0.308
MOD_ProDKin_1	390	396	PF00069	0.593
MOD_ProDKin_1	454	460	PF00069	0.632
MOD_SUMO_rev_2	194	201	PF00179	0.633
MOD_SUMO_rev_2	211	217	PF00179	0.431
MOD_SUMO_rev_2	232	238	PF00179	0.473
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.568
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.438
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.478
TRG_ENDOCYTIC_2	143	146	PF00928	0.595
TRG_ENDOCYTIC_2	17	20	PF00928	0.461
TRG_ENDOCYTIC_2	416	419	PF00928	0.408
TRG_ENDOCYTIC_2	463	466	PF00928	0.542
TRG_ER_diArg_1	103	105	PF00400	0.578
TRG_ER_diArg_1	113	116	PF00400	0.620
TRG_ER_diArg_1	507	510	PF00400	0.653
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3T2	Leptomonas seymouri	47%	100%
A0A3S7X4N0	Leishmania donovani	93%	100%
A4HJF6	Leishmania braziliensis	72%	100%
A4I6V1	Leishmania infantum	92%	100%
E9B1X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%