Nucleosome assembly protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleosome assembly protein-like protein

Species:

Leishmania major

UniProt:

Q4Q687_LEIMA

TriTrypDb:

LmjF.31.1750 , LMJLV39_310025500 , LMJSD75_310025000

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	2
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q687

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q687

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	12
GO:0006334	nucleosome assembly	7	12
GO:0006338	chromatin remodeling	5	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0034728	nucleosome organization	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0065004	protein-DNA complex assembly	6	12
GO:0071824	protein-DNA complex subunit organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0042393	histone binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.745
CLV_C14_Caspase3-7	350	354	PF00656	0.775
CLV_NRD_NRD_1	40	42	PF00675	0.280
CLV_NRD_NRD_1	80	82	PF00675	0.336
CLV_PCSK_KEX2_1	39	41	PF00082	0.333
CLV_PCSK_SKI1_1	119	123	PF00082	0.318
CLV_PCSK_SKI1_1	169	173	PF00082	0.283
CLV_PCSK_SKI1_1	192	196	PF00082	0.398
CLV_PCSK_SKI1_1	240	244	PF00082	0.277
CLV_PCSK_SKI1_1	315	319	PF00082	0.322
CLV_PCSK_SKI1_1	89	93	PF00082	0.297
DEG_APCC_DBOX_1	168	176	PF00400	0.492
DOC_ANK_TNKS_1	179	186	PF00023	0.530
DOC_MAPK_gen_1	236	246	PF00069	0.511
DOC_MAPK_gen_1	252	261	PF00069	0.404
DOC_MAPK_gen_1	58	66	PF00069	0.480
DOC_MAPK_MEF2A_6	239	246	PF00069	0.543
DOC_PP1_RVXF_1	117	124	PF00149	0.530
DOC_PP1_RVXF_1	190	196	PF00149	0.522
DOC_PP4_FxxP_1	123	126	PF00568	0.530
DOC_PP4_FxxP_1	274	277	PF00568	0.483
DOC_USP7_MATH_1	140	144	PF00917	0.542
DOC_USP7_MATH_1	159	163	PF00917	0.567
DOC_USP7_MATH_1	20	24	PF00917	0.730
DOC_USP7_MATH_1	267	271	PF00917	0.567
DOC_USP7_UBL2_3	118	122	PF12436	0.538
DOC_USP7_UBL2_3	236	240	PF12436	0.497
DOC_USP7_UBL2_3	250	254	PF12436	0.445
DOC_WW_Pin1_4	138	143	PF00397	0.551
DOC_WW_Pin1_4	195	200	PF00397	0.542
DOC_WW_Pin1_4	273	278	PF00397	0.567
DOC_WW_Pin1_4	382	387	PF00397	0.726
LIG_14-3-3_CanoR_1	173	182	PF00244	0.434
LIG_14-3-3_CanoR_1	98	108	PF00244	0.558
LIG_BIR_III_2	113	117	PF00653	0.586
LIG_CaM_IQ_9	42	58	PF13499	0.567
LIG_eIF4E_1	43	49	PF01652	0.492
LIG_FHA_1	224	230	PF00498	0.577
LIG_FHA_1	241	247	PF00498	0.480
LIG_FHA_1	307	313	PF00498	0.560
LIG_FHA_2	104	110	PF00498	0.481
LIG_FHA_2	11	17	PF00498	0.688
LIG_FHA_2	163	169	PF00498	0.482
LIG_FHA_2	174	180	PF00498	0.483
LIG_FHA_2	212	218	PF00498	0.527
LIG_FHA_2	326	332	PF00498	0.610
LIG_FHA_2	33	39	PF00498	0.501
LIG_FHA_2	90	96	PF00498	0.490
LIG_LIR_Gen_1	269	280	PF02991	0.483
LIG_LIR_Nem_3	269	275	PF02991	0.483
LIG_LIR_Nem_3	51	55	PF02991	0.506
LIG_NRBOX	44	50	PF00104	0.492
LIG_PCNA_PIPBox_1	46	55	PF02747	0.586
LIG_PCNA_yPIPBox_3	39	53	PF02747	0.480
LIG_Pex14_2	271	275	PF04695	0.481
LIG_SH2_STAT3	43	46	PF00017	0.567
LIG_SH2_STAT5	202	205	PF00017	0.549
LIG_SH2_STAT5	320	323	PF00017	0.492
LIG_SH3_2	105	110	PF14604	0.586
LIG_SH3_3	102	108	PF00018	0.586
LIG_SH3_3	274	280	PF00018	0.568
LIG_SUMO_SIM_anti_2	26	33	PF11976	0.581
LIG_SUMO_SIM_par_1	26	33	PF11976	0.552
LIG_TRAF2_1	354	357	PF00917	0.712
LIG_TRAF2_1	401	404	PF00917	0.785
LIG_TRAF2_1	92	95	PF00917	0.506
MOD_CDK_SPxxK_3	382	389	PF00069	0.732
MOD_CK1_1	15	21	PF00069	0.734
MOD_CK1_1	162	168	PF00069	0.475
MOD_CK2_1	152	158	PF00069	0.560
MOD_CK2_1	173	179	PF00069	0.530
MOD_CK2_1	18	24	PF00069	0.686
MOD_CK2_1	195	201	PF00069	0.550
MOD_CK2_1	32	38	PF00069	0.387
MOD_CK2_1	325	331	PF00069	0.574
MOD_CK2_1	351	357	PF00069	0.724
MOD_CK2_1	89	95	PF00069	0.502
MOD_GlcNHglycan	132	135	PF01048	0.351
MOD_GlcNHglycan	142	145	PF01048	0.320
MOD_GlcNHglycan	255	258	PF01048	0.273
MOD_GSK3_1	15	22	PF00069	0.724
MOD_GSK3_1	99	106	PF00069	0.481
MOD_N-GLC_1	204	209	PF02516	0.339
MOD_N-GLC_1	240	245	PF02516	0.292
MOD_N-GLC_2	68	70	PF02516	0.386
MOD_NEK2_1	10	15	PF00069	0.565
MOD_NEK2_1	149	154	PF00069	0.481
MOD_NEK2_1	242	247	PF00069	0.573
MOD_NEK2_2	267	272	PF00069	0.567
MOD_PIKK_1	306	312	PF00454	0.586
MOD_PIKK_1	394	400	PF00454	0.780
MOD_PKA_2	223	229	PF00069	0.579
MOD_Plk_1	204	210	PF00069	0.539
MOD_Plk_1	240	246	PF00069	0.485
MOD_Plk_1	32	38	PF00069	0.474
MOD_Plk_2-3	349	355	PF00069	0.740
MOD_Plk_4	159	165	PF00069	0.484
MOD_Plk_4	267	273	PF00069	0.478
MOD_ProDKin_1	138	144	PF00069	0.551
MOD_ProDKin_1	195	201	PF00069	0.542
MOD_ProDKin_1	273	279	PF00069	0.567
MOD_ProDKin_1	382	388	PF00069	0.728
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.475
TRG_ENDOCYTIC_2	52	55	PF00928	0.485
TRG_ER_diArg_1	377	380	PF00400	0.751
TRG_ER_diArg_1	39	41	PF00400	0.412
TRG_ER_diArg_1	55	58	PF00400	0.471
TRG_NES_CRM1_1	26	38	PF08389	0.482
TRG_NLS_Bipartite_1	239	253	PF00514	0.567
TRG_NLS_MonoExtN_4	247	253	PF00514	0.481
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.219
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.294

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J2	Leptomonas seymouri	31%	100%
A0A0N1IJI7	Leptomonas seymouri	68%	100%
A0A0S4J1L1	Bodo saltans	41%	99%
A0A1X0NTY9	Trypanosomatidae	42%	94%
A0A1X0P6J1	Trypanosomatidae	30%	97%
A0A3Q8IA70	Leishmania donovani	32%	100%
A0A3R7KHX6	Trypanosoma rangeli	42%	94%
A0A3R7KRI5	Trypanosoma rangeli	30%	100%
A0A3S7X4M4	Leishmania donovani	93%	100%
A4HA02	Leishmania braziliensis	33%	100%
A4HJF7	Leishmania braziliensis	83%	100%
A4HY66	Leishmania infantum	31%	100%
A4I6V2	Leishmania infantum	93%	100%
A6H767	Bos taurus	34%	100%
B8B2R4	Oryza sativa subsp. indica	34%	100%
C9ZXT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	97%
D0A0I6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ARZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B1X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O59797	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
P25293	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	98%
P28656	Mus musculus	34%	100%
P55209	Homo sapiens	34%	100%
P78920	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q28EB4	Xenopus tropicalis	33%	100%
Q2TA40	Bos taurus	33%	100%
Q4QDH7	Leishmania major	31%	100%
Q4U0Y4	Xenopus laevis	32%	100%
Q55ED1	Dictyostelium discoideum	28%	100%
Q5AAI8	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	94%
Q5R4D4	Pongo abelii	34%	100%
Q5U2Z3	Rattus norvegicus	34%	100%
Q70Z17	Nicotiana tabacum	33%	100%
Q70Z18	Nicotiana tabacum	34%	100%
Q70Z19	Nicotiana tabacum	32%	100%
Q78ZA7	Mus musculus	34%	100%
Q7ZY81	Xenopus laevis	33%	100%
Q94K07	Arabidopsis thaliana	34%	100%
Q99733	Homo sapiens	33%	100%
Q9SZI2	Arabidopsis thaliana	34%	100%
Q9Z2G8	Rattus norvegicus	34%	100%
Q9ZUP3	Arabidopsis thaliana	33%	100%
V5BUC1	Trypanosoma cruzi	42%	90%
V5BX23	Trypanosoma cruzi	25%	100%