Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q686_LEIMA

TriTrypDb:

LmjF.31.1760 , LMJLV39_310025600 , LMJSD75_310025100

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q686

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q686

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.645
CLV_C14_Caspase3-7	144	148	PF00656	0.703
CLV_NRD_NRD_1	123	125	PF00675	0.587
CLV_NRD_NRD_1	128	130	PF00675	0.590
CLV_NRD_NRD_1	153	155	PF00675	0.613
CLV_NRD_NRD_1	188	190	PF00675	0.560
CLV_NRD_NRD_1	353	355	PF00675	0.589
CLV_NRD_NRD_1	360	362	PF00675	0.626
CLV_PCSK_KEX2_1	123	125	PF00082	0.587
CLV_PCSK_KEX2_1	128	130	PF00082	0.590
CLV_PCSK_KEX2_1	269	271	PF00082	0.626
CLV_PCSK_KEX2_1	353	355	PF00082	0.589
CLV_PCSK_KEX2_1	360	362	PF00082	0.626
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.720
CLV_PCSK_PC7_1	124	130	PF00082	0.691
CLV_PCSK_SKI1_1	100	104	PF00082	0.597
CLV_PCSK_SKI1_1	257	261	PF00082	0.655
CLV_PCSK_SKI1_1	313	317	PF00082	0.798
CLV_PCSK_SKI1_1	354	358	PF00082	0.598
DEG_SPOP_SBC_1	31	35	PF00917	0.670
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.792
DOC_MAPK_gen_1	100	108	PF00069	0.727
DOC_MAPK_MEF2A_6	89	96	PF00069	0.634
DOC_PP2B_LxvP_1	108	111	PF13499	0.664
DOC_PP4_FxxP_1	326	329	PF00568	0.715
DOC_USP7_MATH_1	122	126	PF00917	0.540
DOC_USP7_MATH_1	134	138	PF00917	0.726
DOC_USP7_MATH_1	146	150	PF00917	0.705
DOC_USP7_MATH_1	4	8	PF00917	0.749
DOC_USP7_MATH_1	55	59	PF00917	0.693
DOC_USP7_UBL2_3	155	159	PF12436	0.598
DOC_USP7_UBL2_3	309	313	PF12436	0.775
DOC_WW_Pin1_4	19	24	PF00397	0.777
DOC_WW_Pin1_4	191	196	PF00397	0.639
DOC_WW_Pin1_4	220	225	PF00397	0.747
DOC_WW_Pin1_4	314	319	PF00397	0.804
DOC_WW_Pin1_4	38	43	PF00397	0.815
DOC_WW_Pin1_4	59	64	PF00397	0.677
DOC_WW_Pin1_4	72	77	PF00397	0.583
LIG_14-3-3_CanoR_1	123	127	PF00244	0.655
LIG_14-3-3_CanoR_1	154	163	PF00244	0.587
LIG_14-3-3_CanoR_1	263	267	PF00244	0.619
LIG_14-3-3_CanoR_1	360	368	PF00244	0.631
LIG_14-3-3_CanoR_1	69	74	PF00244	0.784
LIG_BIR_II_1	1	5	PF00653	0.799
LIG_BIR_III_3	1	5	PF00653	0.799
LIG_BRCT_BRCA1_1	74	78	PF00533	0.560
LIG_FHA_1	172	178	PF00498	0.600
LIG_FHA_1	19	25	PF00498	0.715
LIG_FHA_1	245	251	PF00498	0.583
LIG_FHA_1	274	280	PF00498	0.673
LIG_FHA_1	285	291	PF00498	0.703
LIG_FHA_1	59	65	PF00498	0.692
LIG_FHA_1	66	72	PF00498	0.694
LIG_FHA_2	142	148	PF00498	0.604
LIG_FHA_2	156	162	PF00498	0.608
LIG_FHA_2	171	177	PF00498	0.732
LIG_FHA_2	287	293	PF00498	0.773
LIG_FHA_2	332	338	PF00498	0.707
LIG_FHA_2	360	366	PF00498	0.626
LIG_Integrin_RGD_1	164	166	PF01839	0.777
LIG_LIR_Apic_2	323	329	PF02991	0.717
LIG_LIR_Apic_2	365	371	PF02991	0.628
LIG_LIR_Gen_1	213	224	PF02991	0.729
LIG_LIR_Gen_1	334	343	PF02991	0.616
LIG_LIR_Nem_3	334	338	PF02991	0.611
LIG_MAD2	314	322	PF02301	0.596
LIG_PCNA_PIPBox_1	80	89	PF02747	0.672
LIG_Pex14_2	168	172	PF04695	0.758
LIG_SH2_CRK	368	372	PF00017	0.631
LIG_SH2_STAT5	187	190	PF00017	0.639
LIG_SH2_STAT5	255	258	PF00017	0.708
LIG_SH3_1	192	198	PF00018	0.736
LIG_SH3_3	103	109	PF00018	0.632
LIG_SH3_3	11	17	PF00018	0.674
LIG_SH3_3	157	163	PF00018	0.682
LIG_SH3_3	192	198	PF00018	0.638
LIG_SH3_3	226	232	PF00018	0.718
LIG_SH3_3	275	281	PF00018	0.663
LIG_SH3_3	312	318	PF00018	0.721
LIG_SH3_3	321	327	PF00018	0.673
LIG_SH3_3	41	47	PF00018	0.749
LIG_SH3_3	68	74	PF00018	0.669
LIG_SUMO_SIM_anti_2	104	109	PF11976	0.719
LIG_SUMO_SIM_par_1	341	346	PF11976	0.704
LIG_WW_3	161	165	PF00397	0.569
MOD_CDC14_SPxK_1	22	25	PF00782	0.788
MOD_CDK_SPxK_1	19	25	PF00069	0.791
MOD_CK1_1	18	24	PF00069	0.679
MOD_CK1_1	298	304	PF00069	0.752
MOD_CK1_1	317	323	PF00069	0.531
MOD_CK1_1	35	41	PF00069	0.703
MOD_CK1_1	58	64	PF00069	0.737
MOD_CK1_1	72	78	PF00069	0.610
MOD_CK2_1	134	140	PF00069	0.748
MOD_CK2_1	170	176	PF00069	0.681
MOD_CK2_1	211	217	PF00069	0.609
MOD_CK2_1	286	292	PF00069	0.770
MOD_CK2_1	359	365	PF00069	0.623
MOD_GlcNHglycan	150	153	PF01048	0.711
MOD_GlcNHglycan	297	300	PF01048	0.718
MOD_GlcNHglycan	35	38	PF01048	0.710
MOD_GlcNHglycan	57	60	PF01048	0.754
MOD_GlcNHglycan	80	83	PF01048	0.695
MOD_GSK3_1	12	19	PF00069	0.661
MOD_GSK3_1	29	36	PF00069	0.646
MOD_GSK3_1	291	298	PF00069	0.629
MOD_GSK3_1	316	323	PF00069	0.709
MOD_GSK3_1	4	11	PF00069	0.734
MOD_GSK3_1	50	57	PF00069	0.686
MOD_GSK3_1	58	65	PF00069	0.681
MOD_GSK3_1	72	79	PF00069	0.684
MOD_LATS_1	359	365	PF00433	0.623
MOD_N-GLC_1	168	173	PF02516	0.551
MOD_N-GLC_1	211	216	PF02516	0.514
MOD_NEK2_1	132	137	PF00069	0.731
MOD_NEK2_1	141	146	PF00069	0.604
MOD_NEK2_1	168	173	PF00069	0.662
MOD_NEK2_1	293	298	PF00069	0.650
MOD_NEK2_1	54	59	PF00069	0.594
MOD_NEK2_1	78	83	PF00069	0.638
MOD_NEK2_1	87	92	PF00069	0.664
MOD_NEK2_2	255	260	PF00069	0.704
MOD_PIKK_1	69	75	PF00454	0.703
MOD_PKA_1	154	160	PF00069	0.596
MOD_PKA_2	122	128	PF00069	0.657
MOD_PKA_2	262	268	PF00069	0.623
MOD_PKA_2	359	365	PF00069	0.654
MOD_PKA_2	88	94	PF00069	0.629
MOD_Plk_1	168	174	PF00069	0.669
MOD_Plk_4	262	268	PF00069	0.681
MOD_Plk_4	279	285	PF00069	0.526
MOD_Plk_4	88	94	PF00069	0.639
MOD_ProDKin_1	19	25	PF00069	0.778
MOD_ProDKin_1	191	197	PF00069	0.633
MOD_ProDKin_1	220	226	PF00069	0.748
MOD_ProDKin_1	314	320	PF00069	0.803
MOD_ProDKin_1	38	44	PF00069	0.807
MOD_ProDKin_1	59	65	PF00069	0.680
MOD_ProDKin_1	72	78	PF00069	0.582
MOD_SUMO_rev_2	147	157	PF00179	0.603
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.720
TRG_ENDOCYTIC_2	335	338	PF00928	0.710
TRG_ER_diArg_1	127	129	PF00400	0.653
TRG_NES_CRM1_1	254	268	PF08389	0.703
TRG_NLS_MonoExtN_4	303	310	PF00514	0.652
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V3	Leptomonas seymouri	39%	92%
A0A3Q8ISN5	Leishmania donovani	88%	100%
A4I6V3	Leishmania infantum	87%	100%
E9B1X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%