Acetylornithine deacetylase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acetylornithine deacetylase-like protein

Species:

Leishmania major

UniProt:

Q4Q681_LEIMA

TriTrypDb:

LmjF.31.1810 , LMJLV39_000015800 , LMJSD75_310025700

Length:

126

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q681

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q681

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006520	amino acid metabolic process	3	2
GO:0006525	arginine metabolic process	6	2
GO:0006526	arginine biosynthetic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008652	amino acid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009064	glutamine family amino acid metabolic process	5	2
GO:0009084	glutamine family amino acid biosynthetic process	6	2
GO:0009987	cellular process	1	2
GO:0016053	organic acid biosynthetic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901605	alpha-amino acid metabolic process	4	2
GO:1901607	alpha-amino acid biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008777	acetylornithine deacetylase activity	4	2
GO:0016787	hydrolase activity	2	3
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	2
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	2
GO:0019213	deacetylase activity	3	2
GO:0004180	carboxypeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008238	exopeptidase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.423
CLV_PCSK_KEX2_1	120	122	PF00082	0.423
CLV_PCSK_SKI1_1	27	31	PF00082	0.478
DOC_USP7_MATH_1	52	56	PF00917	0.362
LIG_14-3-3_CanoR_1	27	35	PF00244	0.320
LIG_14-3-3_CanoR_1	86	95	PF00244	0.434
LIG_BIR_II_1	1	5	PF00653	0.387
LIG_FHA_1	95	101	PF00498	0.361
LIG_FHA_2	72	78	PF00498	0.285
LIG_FHA_2	80	86	PF00498	0.290
LIG_SH2_STAP1	63	67	PF00017	0.346
LIG_SH2_STAP1	88	92	PF00017	0.265
LIG_SH2_STAT3	63	66	PF00017	0.320
LIG_SH2_STAT5	3	6	PF00017	0.523
LIG_SH3_3	116	122	PF00018	0.320
LIG_TRAF2_1	82	85	PF00917	0.320
LIG_UBA3_1	4	11	PF00899	0.377
MOD_CK2_1	79	85	PF00069	0.320
MOD_GlcNHglycan	103	106	PF01048	0.232
MOD_GlcNHglycan	48	51	PF01048	0.232
MOD_GSK3_1	101	108	PF00069	0.316
MOD_N-GLC_1	86	91	PF02516	0.320
MOD_NEK2_1	53	58	PF00069	0.480
MOD_NEK2_1	71	76	PF00069	0.280
MOD_PIKK_1	3	9	PF00454	0.355
TRG_ER_diArg_1	119	121	PF00400	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0R6YB63	Leishmania donovani	85%	100%
A0A1X0NDP9	Trypanosomatidae	39%	87%
A0A3R7MJC5	Trypanosoma rangeli	27%	68%
A4I6W2	Leishmania infantum	85%	100%