LeishMANIAdb
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DUF222 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF222 domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania major
UniProt:
Q4Q677_LEIMA
TriTrypDb:
LmjF.31.1850 , LMJLV39_310026500 , LMJSD75_310026300
Length:
101

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q677
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q677

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 5 9 PF00082 0.649
CLV_PCSK_SKI1_1 69 73 PF00082 0.551
CLV_PCSK_SKI1_1 76 80 PF00082 0.519
DEG_APCC_DBOX_1 75 83 PF00400 0.548
DOC_MAPK_MEF2A_6 41 50 PF00069 0.644
DOC_USP7_MATH_1 20 24 PF00917 0.647
LIG_14-3-3_CanoR_1 49 59 PF00244 0.634
LIG_14-3-3_CanoR_1 87 97 PF00244 0.539
LIG_14-3-3_CterR_2 98 101 PF00244 0.676
LIG_FHA_1 24 30 PF00498 0.740
LIG_FHA_1 54 60 PF00498 0.628
LIG_NRP_CendR_1 98 101 PF00754 0.676
MOD_CK1_1 11 17 PF00069 0.639
MOD_CK1_1 23 29 PF00069 0.665
MOD_GlcNHglycan 65 68 PF01048 0.635
MOD_GlcNHglycan 72 75 PF01048 0.595
MOD_GSK3_1 7 14 PF00069 0.683
MOD_N-GLC_1 63 68 PF02516 0.523
MOD_NEK2_1 7 12 PF00069 0.641
MOD_NEK2_1 72 77 PF00069 0.554
MOD_PKA_2 89 95 PF00069 0.537
MOD_Plk_1 23 29 PF00069 0.691
MOD_Plk_1 8 14 PF00069 0.638
MOD_Plk_4 55 61 PF00069 0.625
MOD_Plk_4 8 14 PF00069 0.638
TRG_DiLeu_BaEn_1 55 60 PF01217 0.583
TRG_Pf-PMV_PEXEL_1 5 9 PF00026 0.649

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X4K5 Leishmania donovani 88% 100%
A4I6V9 Leishmania infantum 85% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS