Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q676_LEIMA

TriTrypDb:

LmjF.31.1860 , LMJLV39_310027000 , LMJSD75_310026800

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q676

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q676

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.585
CLV_NRD_NRD_1	83	85	PF00675	0.483
CLV_NRD_NRD_1	91	93	PF00675	0.495
CLV_PCSK_KEX2_1	137	139	PF00082	0.585
CLV_PCSK_KEX2_1	217	219	PF00082	0.497
CLV_PCSK_KEX2_1	85	87	PF00082	0.497
CLV_PCSK_KEX2_1	91	93	PF00082	0.502
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.497
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.497
CLV_PCSK_SKI1_1	91	95	PF00082	0.618
DEG_Nend_Nbox_1	1	3	PF02207	0.504
DOC_CYCLIN_yClb5_NLxxxL_5	168	177	PF00134	0.656
DOC_MAPK_DCC_7	101	111	PF00069	0.668
DOC_MAPK_RevD_3	72	86	PF00069	0.558
DOC_PP2B_PxIxI_1	106	112	PF00149	0.780
DOC_PP4_FxxP_1	183	186	PF00568	0.792
DOC_USP7_MATH_1	140	144	PF00917	0.710
DOC_USP7_MATH_1	148	152	PF00917	0.735
DOC_USP7_MATH_1	186	190	PF00917	0.833
DOC_USP7_MATH_1	26	30	PF00917	0.510
DOC_USP7_MATH_1	47	51	PF00917	0.603
DOC_WW_Pin1_4	226	231	PF00397	0.768
DOC_WW_Pin1_4	43	48	PF00397	0.508
LIG_14-3-3_CanoR_1	19	23	PF00244	0.538
LIG_14-3-3_CanoR_1	25	33	PF00244	0.543
LIG_14-3-3_CanoR_1	84	94	PF00244	0.726
LIG_BRCT_BRCA1_1	179	183	PF00533	0.666
LIG_EH_1	180	184	PF12763	0.768
LIG_FHA_1	128	134	PF00498	0.689
LIG_FHA_1	165	171	PF00498	0.752
LIG_FHA_1	34	40	PF00498	0.531
LIG_FHA_1	47	53	PF00498	0.458
LIG_FHA_2	13	19	PF00498	0.479
LIG_FHA_2	85	91	PF00498	0.690
LIG_IRF3_LxIS_1	173	180	PF10401	0.654
LIG_LIR_Apic_2	180	186	PF02991	0.711
LIG_LIR_Nem_3	213	219	PF02991	0.800
LIG_Pex14_2	4	8	PF04695	0.524
LIG_SH2_CRK	227	231	PF00017	0.731
LIG_SH2_NCK_1	119	123	PF00017	0.723
LIG_SH2_PTP2	6	9	PF00017	0.549
LIG_SH2_SRC	252	255	PF00017	0.682
LIG_SH2_STAT3	11	14	PF00017	0.436
LIG_SH2_STAT5	6	9	PF00017	0.460
LIG_SH2_STAT5	78	81	PF00017	0.712
LIG_SH3_1	6	12	PF00018	0.418
LIG_SH3_3	6	12	PF00018	0.418
LIG_SUMO_SIM_par_1	150	157	PF11976	0.648
LIG_TRAF2_1	129	132	PF00917	0.804
LIG_TRAF2_1	87	90	PF00917	0.689
MOD_CK1_1	120	126	PF00069	0.758
MOD_CK1_1	151	157	PF00069	0.758
MOD_CK1_1	184	190	PF00069	0.825
MOD_CK1_1	234	240	PF00069	0.697
MOD_CK1_1	42	48	PF00069	0.554
MOD_CK1_1	58	64	PF00069	0.358
MOD_CK2_1	12	18	PF00069	0.505
MOD_CK2_1	126	132	PF00069	0.769
MOD_CK2_1	185	191	PF00069	0.756
MOD_CK2_1	84	90	PF00069	0.683
MOD_GlcNHglycan	119	122	PF01048	0.556
MOD_GlcNHglycan	222	225	PF01048	0.627
MOD_GlcNHglycan	39	42	PF01048	0.708
MOD_GSK3_1	14	21	PF00069	0.541
MOD_GSK3_1	147	154	PF00069	0.784
MOD_GSK3_1	177	184	PF00069	0.747
MOD_GSK3_1	24	31	PF00069	0.459
MOD_GSK3_1	33	40	PF00069	0.467
MOD_GSK3_1	42	49	PF00069	0.486
MOD_N-GLC_1	237	242	PF02516	0.496
MOD_N-GLC_1	27	32	PF02516	0.687
MOD_N-GLC_1	37	42	PF02516	0.737
MOD_NEK2_1	117	122	PF00069	0.779
MOD_NEK2_1	177	182	PF00069	0.695
MOD_NEK2_1	225	230	PF00069	0.847
MOD_NEK2_1	39	44	PF00069	0.500
MOD_NEK2_1	68	73	PF00069	0.412
MOD_PKA_1	84	90	PF00069	0.709
MOD_PKA_2	177	183	PF00069	0.658
MOD_PKA_2	18	24	PF00069	0.516
MOD_PKA_2	85	91	PF00069	0.718
MOD_Plk_1	164	170	PF00069	0.746
MOD_Plk_1	212	218	PF00069	0.749
MOD_Plk_2-3	18	24	PF00069	0.549
MOD_Plk_4	148	154	PF00069	0.650
MOD_Plk_4	55	61	PF00069	0.433
MOD_Plk_4	68	74	PF00069	0.264
MOD_ProDKin_1	226	232	PF00069	0.769
MOD_ProDKin_1	43	49	PF00069	0.507
TRG_DiLeu_BaEn_4	131	137	PF01217	0.754
TRG_DiLeu_BaEn_4	89	95	PF01217	0.726
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.744
TRG_ENDOCYTIC_2	77	80	PF00928	0.652
TRG_ER_diArg_1	136	138	PF00400	0.761
TRG_ER_diArg_1	159	162	PF00400	0.730
TRG_ER_diArg_1	83	86	PF00400	0.688
TRG_ER_diArg_1	91	93	PF00400	0.695
TRG_NLS_MonoExtC_3	83	89	PF00514	0.676
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	208	213	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFE3	Leishmania donovani	79%	98%
A4I6W0	Leishmania infantum	79%	98%
E9AIU6	Leishmania braziliensis	50%	98%
E9B1Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	98%