LeishMANIAdb
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Mannosyltransferase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mannosyltransferase-like protein
Gene product:
mannosyltransferase-like protein
Species:
Leishmania major
UniProt:
Q4Q675_LEIMA
TriTrypDb:
LmjF.31.1870 , LMJLV39_310027300 , LMJSD75_310027000
Length:
978

Annotations

LeishMANIAdb annotations

A complex and fast-evolving family of glycosyltransferases. Their structural innovations and expansion is in accordance with a role in interactions with the environment. Despite the short hydrophobic segment, the N-terminal signal-like stretch is likely to be a signal-anchor as wil all Golgi-resident glycosyltransferases, not a secretory signal. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 13
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

Q4Q675
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q675

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 15
GO:0016740 transferase activity 2 15
GO:0016757 glycosyltransferase activity 3 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 399 403 PF00656 0.476
CLV_NRD_NRD_1 383 385 PF00675 0.666
CLV_NRD_NRD_1 413 415 PF00675 0.695
CLV_NRD_NRD_1 516 518 PF00675 0.677
CLV_NRD_NRD_1 52 54 PF00675 0.453
CLV_NRD_NRD_1 585 587 PF00675 0.601
CLV_NRD_NRD_1 625 627 PF00675 0.594
CLV_NRD_NRD_1 692 694 PF00675 0.629
CLV_NRD_NRD_1 758 760 PF00675 0.557
CLV_NRD_NRD_1 941 943 PF00675 0.513
CLV_NRD_NRD_1 945 947 PF00675 0.494
CLV_PCSK_FUR_1 622 626 PF00082 0.535
CLV_PCSK_KEX2_1 383 385 PF00082 0.689
CLV_PCSK_KEX2_1 413 415 PF00082 0.704
CLV_PCSK_KEX2_1 51 53 PF00082 0.459
CLV_PCSK_KEX2_1 515 517 PF00082 0.672
CLV_PCSK_KEX2_1 585 587 PF00082 0.601
CLV_PCSK_KEX2_1 624 626 PF00082 0.611
CLV_PCSK_KEX2_1 692 694 PF00082 0.599
CLV_PCSK_KEX2_1 941 943 PF00082 0.494
CLV_PCSK_KEX2_1 945 947 PF00082 0.473
CLV_PCSK_PC7_1 620 626 PF00082 0.537
CLV_PCSK_PC7_1 941 947 PF00082 0.524
CLV_PCSK_SKI1_1 190 194 PF00082 0.683
CLV_PCSK_SKI1_1 230 234 PF00082 0.714
CLV_PCSK_SKI1_1 317 321 PF00082 0.682
CLV_PCSK_SKI1_1 493 497 PF00082 0.707
CLV_PCSK_SKI1_1 625 629 PF00082 0.664
CLV_PCSK_SKI1_1 747 751 PF00082 0.564
CLV_Separin_Metazoa 928 932 PF03568 0.318
DEG_Nend_UBRbox_3 1 3 PF02207 0.645
DEG_SCF_FBW7_1 213 218 PF00400 0.520
DEG_SPOP_SBC_1 109 113 PF00917 0.372
DOC_ANK_TNKS_1 894 901 PF00023 0.381
DOC_CYCLIN_RxL_1 59 71 PF00134 0.419
DOC_CYCLIN_yClb5_NLxxxL_5 138 147 PF00134 0.422
DOC_CYCLIN_yCln2_LP_2 119 125 PF00134 0.410
DOC_CYCLIN_yCln2_LP_2 250 256 PF00134 0.441
DOC_MAPK_gen_1 622 631 PF00069 0.431
DOC_MAPK_gen_1 759 766 PF00069 0.357
DOC_MAPK_gen_1 782 789 PF00069 0.457
DOC_MAPK_MEF2A_6 448 457 PF00069 0.534
DOC_MAPK_MEF2A_6 63 72 PF00069 0.501
DOC_MAPK_MEF2A_6 646 655 PF00069 0.495
DOC_PP1_RVXF_1 61 68 PF00149 0.416
DOC_PP1_RVXF_1 745 752 PF00149 0.433
DOC_PP2B_LxvP_1 119 122 PF13499 0.432
DOC_PP2B_LxvP_1 250 253 PF13499 0.456
DOC_PP2B_PxIxI_1 828 834 PF00149 0.361
DOC_PP4_FxxP_1 553 556 PF00568 0.438
DOC_PP4_FxxP_1 640 643 PF00568 0.443
DOC_PP4_FxxP_1 853 856 PF00568 0.285
DOC_PP4_FxxP_1 894 897 PF00568 0.327
DOC_USP7_MATH_1 109 113 PF00917 0.386
DOC_USP7_MATH_1 159 163 PF00917 0.460
DOC_USP7_MATH_1 179 183 PF00917 0.504
DOC_USP7_MATH_1 215 219 PF00917 0.510
DOC_USP7_MATH_1 27 31 PF00917 0.668
DOC_USP7_MATH_1 487 491 PF00917 0.534
DOC_USP7_MATH_1 614 618 PF00917 0.524
DOC_USP7_MATH_1 7 11 PF00917 0.629
DOC_USP7_MATH_1 722 726 PF00917 0.463
DOC_USP7_MATH_1 919 923 PF00917 0.290
DOC_USP7_MATH_1 92 96 PF00917 0.426
DOC_WW_Pin1_4 102 107 PF00397 0.435
DOC_WW_Pin1_4 211 216 PF00397 0.570
DOC_WW_Pin1_4 609 614 PF00397 0.532
DOC_WW_Pin1_4 694 699 PF00397 0.427
DOC_WW_Pin1_4 795 800 PF00397 0.468
DOC_WW_Pin1_4 902 907 PF00397 0.375
LIG_14-3-3_CanoR_1 247 251 PF00244 0.477
LIG_14-3-3_CanoR_1 292 298 PF00244 0.582
LIG_14-3-3_CanoR_1 350 356 PF00244 0.578
LIG_14-3-3_CanoR_1 394 398 PF00244 0.517
LIG_14-3-3_CanoR_1 493 499 PF00244 0.545
LIG_14-3-3_CanoR_1 504 510 PF00244 0.412
LIG_14-3-3_CanoR_1 548 556 PF00244 0.477
LIG_14-3-3_CanoR_1 574 580 PF00244 0.432
LIG_14-3-3_CanoR_1 585 589 PF00244 0.503
LIG_14-3-3_CanoR_1 736 745 PF00244 0.436
LIG_14-3-3_CanoR_1 784 788 PF00244 0.447
LIG_BIR_III_4 417 421 PF00653 0.523
LIG_BRCT_BRCA1_1 32 36 PF00533 0.627
LIG_CtBP_PxDLS_1 778 782 PF00389 0.404
LIG_deltaCOP1_diTrp_1 678 687 PF00928 0.322
LIG_deltaCOP1_diTrp_1 880 887 PF00928 0.357
LIG_FHA_1 133 139 PF00498 0.469
LIG_FHA_1 259 265 PF00498 0.478
LIG_FHA_1 307 313 PF00498 0.529
LIG_FHA_1 36 42 PF00498 0.702
LIG_FHA_1 380 386 PF00498 0.519
LIG_FHA_1 470 476 PF00498 0.510
LIG_FHA_1 534 540 PF00498 0.549
LIG_FHA_1 76 82 PF00498 0.336
LIG_FHA_1 783 789 PF00498 0.415
LIG_FHA_1 833 839 PF00498 0.357
LIG_FHA_1 924 930 PF00498 0.312
LIG_FHA_2 258 264 PF00498 0.539
LIG_FHA_2 302 308 PF00498 0.556
LIG_FHA_2 350 356 PF00498 0.578
LIG_FHA_2 673 679 PF00498 0.439
LIG_FHA_2 680 686 PF00498 0.405
LIG_FHA_2 738 744 PF00498 0.474
LIG_FHA_2 855 861 PF00498 0.285
LIG_LIR_Apic_2 341 347 PF02991 0.598
LIG_LIR_Apic_2 551 556 PF02991 0.471
LIG_LIR_Apic_2 851 856 PF02991 0.285
LIG_LIR_Apic_2 860 865 PF02991 0.286
LIG_LIR_Apic_2 879 884 PF02991 0.285
LIG_LIR_Apic_2 891 897 PF02991 0.266
LIG_LIR_Gen_1 134 144 PF02991 0.502
LIG_LIR_Gen_1 279 288 PF02991 0.408
LIG_LIR_Gen_1 396 404 PF02991 0.507
LIG_LIR_Gen_1 605 614 PF02991 0.507
LIG_LIR_Gen_1 685 691 PF02991 0.382
LIG_LIR_Gen_1 90 101 PF02991 0.417
LIG_LIR_Nem_3 134 140 PF02991 0.465
LIG_LIR_Nem_3 279 284 PF02991 0.403
LIG_LIR_Nem_3 396 400 PF02991 0.507
LIG_LIR_Nem_3 605 610 PF02991 0.492
LIG_LIR_Nem_3 61 65 PF02991 0.570
LIG_LIR_Nem_3 685 690 PF02991 0.329
LIG_LIR_Nem_3 90 96 PF02991 0.523
LIG_LYPXL_yS_3 828 831 PF13949 0.357
LIG_NRBOX 139 145 PF00104 0.459
LIG_PCNA_yPIPBox_3 485 499 PF02747 0.514
LIG_Pex14_2 750 754 PF04695 0.354
LIG_Pex14_2 809 813 PF04695 0.441
LIG_PTAP_UEV_1 774 779 PF05743 0.428
LIG_REV1ctd_RIR_1 616 626 PF16727 0.523
LIG_RPA_C_Fungi 465 477 PF08784 0.485
LIG_SH2_CRK 416 420 PF00017 0.671
LIG_SH2_CRK 507 511 PF00017 0.680
LIG_SH2_CRK 600 604 PF00017 0.695
LIG_SH2_GRB2like 847 850 PF00017 0.491
LIG_SH2_NCK_1 295 299 PF00017 0.759
LIG_SH2_NCK_1 388 392 PF00017 0.707
LIG_SH2_NCK_1 416 420 PF00017 0.671
LIG_SH2_NCK_1 507 511 PF00017 0.632
LIG_SH2_NCK_1 713 717 PF00017 0.620
LIG_SH2_NCK_1 847 851 PF00017 0.491
LIG_SH2_PTP2 137 140 PF00017 0.490
LIG_SH2_PTP2 567 570 PF00017 0.595
LIG_SH2_SRC 713 716 PF00017 0.610
LIG_SH2_SRC 847 850 PF00017 0.491
LIG_SH2_SRC 912 915 PF00017 0.448
LIG_SH2_STAT3 718 721 PF00017 0.618
LIG_SH2_STAT5 137 140 PF00017 0.490
LIG_SH2_STAT5 295 298 PF00017 0.737
LIG_SH2_STAT5 380 383 PF00017 0.588
LIG_SH2_STAT5 567 570 PF00017 0.473
LIG_SH2_STAT5 654 657 PF00017 0.439
LIG_SH2_STAT5 748 751 PF00017 0.519
LIG_SH2_STAT5 932 935 PF00017 0.327
LIG_SH3_3 250 256 PF00018 0.551
LIG_SH3_3 3 9 PF00018 0.528
LIG_SH3_3 373 379 PF00018 0.765
LIG_SH3_3 515 521 PF00018 0.712
LIG_SH3_3 607 613 PF00018 0.601
LIG_SH3_3 772 778 PF00018 0.387
LIG_SH3_3 903 909 PF00018 0.423
LIG_SH3_3 931 937 PF00018 0.371
LIG_SH3_3 97 103 PF00018 0.611
LIG_SUMO_SIM_anti_2 246 252 PF11976 0.591
LIG_SUMO_SIM_anti_2 259 267 PF11976 0.629
LIG_SUMO_SIM_par_1 105 114 PF11976 0.589
LIG_SUMO_SIM_par_1 785 791 PF11976 0.543
LIG_SUMO_SIM_par_1 830 835 PF11976 0.409
LIG_SUMO_SIM_par_1 874 880 PF11976 0.377
LIG_TRAF2_1 396 399 PF00917 0.740
LIG_TRAF2_1 740 743 PF00917 0.526
LIG_TRAF2_2 17 22 PF00917 0.545
LIG_TYR_ITIM 598 603 PF00017 0.681
LIG_WRC_WIRS_1 284 289 PF05994 0.652
LIG_WRC_WIRS_1 751 756 PF05994 0.469
LIG_WRC_WIRS_1 77 82 PF05994 0.320
LIG_WW_3 347 351 PF00397 0.646
MOD_CDC14_SPxK_1 697 700 PF00782 0.548
MOD_CDK_SPxK_1 694 700 PF00069 0.531
MOD_CK1_1 131 137 PF00069 0.578
MOD_CK1_1 30 36 PF00069 0.706
MOD_CK1_1 386 392 PF00069 0.707
MOD_CK1_1 469 475 PF00069 0.546
MOD_CK1_1 508 514 PF00069 0.701
MOD_CK1_1 529 535 PF00069 0.680
MOD_CK1_1 609 615 PF00069 0.651
MOD_CK1_1 660 666 PF00069 0.429
MOD_CK1_1 802 808 PF00069 0.502
MOD_CK1_1 905 911 PF00069 0.422
MOD_CK2_1 257 263 PF00069 0.643
MOD_CK2_1 301 307 PF00069 0.795
MOD_CK2_1 349 355 PF00069 0.754
MOD_CK2_1 386 392 PF00069 0.675
MOD_CK2_1 393 399 PF00069 0.692
MOD_CK2_1 433 439 PF00069 0.724
MOD_CK2_1 655 661 PF00069 0.442
MOD_CK2_1 735 741 PF00069 0.524
MOD_CK2_1 836 842 PF00069 0.480
MOD_CK2_1 854 860 PF00069 0.194
MOD_CMANNOS 219 222 PF00535 0.444
MOD_CMANNOS 464 467 PF00535 0.587
MOD_Cter_Amidation 583 586 PF01082 0.506
MOD_Cter_Amidation 943 946 PF01082 0.331
MOD_GlcNHglycan 130 133 PF01048 0.595
MOD_GlcNHglycan 157 160 PF01048 0.703
MOD_GlcNHglycan 175 178 PF01048 0.638
MOD_GlcNHglycan 199 202 PF01048 0.586
MOD_GlcNHglycan 340 343 PF01048 0.685
MOD_GlcNHglycan 385 388 PF01048 0.695
MOD_GlcNHglycan 435 438 PF01048 0.713
MOD_GlcNHglycan 531 534 PF01048 0.683
MOD_GlcNHglycan 552 556 PF01048 0.598
MOD_GlcNHglycan 590 593 PF01048 0.634
MOD_GlcNHglycan 775 778 PF01048 0.578
MOD_GlcNHglycan 837 841 PF01048 0.399
MOD_GSK3_1 128 135 PF00069 0.607
MOD_GSK3_1 155 162 PF00069 0.552
MOD_GSK3_1 211 218 PF00069 0.625
MOD_GSK3_1 26 33 PF00069 0.686
MOD_GSK3_1 36 43 PF00069 0.629
MOD_GSK3_1 379 386 PF00069 0.705
MOD_GSK3_1 529 536 PF00069 0.737
MOD_GSK3_1 584 591 PF00069 0.638
MOD_GSK3_1 605 612 PF00069 0.714
MOD_GSK3_1 791 798 PF00069 0.522
MOD_GSK3_1 832 839 PF00069 0.477
MOD_GSK3_1 919 926 PF00069 0.367
MOD_N-GLC_1 132 137 PF02516 0.555
MOD_N-GLC_1 159 164 PF02516 0.565
MOD_N-GLC_1 728 733 PF02516 0.541
MOD_NEK2_1 115 120 PF00069 0.448
MOD_NEK2_1 288 293 PF00069 0.672
MOD_NEK2_1 315 320 PF00069 0.628
MOD_NEK2_1 36 41 PF00069 0.772
MOD_NEK2_1 606 611 PF00069 0.592
MOD_NEK2_1 686 691 PF00069 0.428
MOD_NEK2_1 75 80 PF00069 0.309
MOD_NEK2_1 750 755 PF00069 0.468
MOD_NEK2_1 809 814 PF00069 0.519
MOD_NEK2_1 968 973 PF00069 0.586
MOD_NEK2_2 451 456 PF00069 0.511
MOD_NEK2_2 614 619 PF00069 0.638
MOD_PIKK_1 160 166 PF00454 0.666
MOD_PIKK_1 317 323 PF00454 0.657
MOD_PKA_1 383 389 PF00069 0.699
MOD_PKA_2 246 252 PF00069 0.635
MOD_PKA_2 30 36 PF00069 0.752
MOD_PKA_2 349 355 PF00069 0.754
MOD_PKA_2 383 389 PF00069 0.667
MOD_PKA_2 393 399 PF00069 0.604
MOD_PKA_2 469 475 PF00069 0.676
MOD_PKA_2 584 590 PF00069 0.666
MOD_PKA_2 735 741 PF00069 0.572
MOD_PKA_2 783 789 PF00069 0.567
MOD_PKA_2 791 797 PF00069 0.465
MOD_PKA_2 802 808 PF00069 0.271
MOD_PKA_2 889 895 PF00069 0.491
MOD_Plk_1 132 138 PF00069 0.484
MOD_Plk_1 258 264 PF00069 0.633
MOD_Plk_1 533 539 PF00069 0.646
MOD_Plk_1 728 734 PF00069 0.603
MOD_Plk_1 782 788 PF00069 0.502
MOD_Plk_4 115 121 PF00069 0.439
MOD_Plk_4 180 186 PF00069 0.617
MOD_Plk_4 246 252 PF00069 0.628
MOD_Plk_4 283 289 PF00069 0.630
MOD_Plk_4 330 336 PF00069 0.594
MOD_Plk_4 505 511 PF00069 0.660
MOD_Plk_4 614 620 PF00069 0.680
MOD_Plk_4 666 672 PF00069 0.394
MOD_Plk_4 68 74 PF00069 0.361
MOD_Plk_4 686 692 PF00069 0.488
MOD_Plk_4 76 82 PF00069 0.305
MOD_Plk_4 783 789 PF00069 0.435
MOD_Plk_4 802 808 PF00069 0.306
MOD_Plk_4 92 98 PF00069 0.505
MOD_Plk_4 968 974 PF00069 0.540
MOD_ProDKin_1 102 108 PF00069 0.544
MOD_ProDKin_1 211 217 PF00069 0.728
MOD_ProDKin_1 609 615 PF00069 0.675
MOD_ProDKin_1 694 700 PF00069 0.531
MOD_ProDKin_1 795 801 PF00069 0.581
MOD_ProDKin_1 902 908 PF00069 0.460
MOD_SUMO_for_1 754 757 PF00179 0.375
TRG_DiLeu_BaEn_1 307 312 PF01217 0.680
TRG_DiLeu_BaEn_1 783 788 PF01217 0.573
TRG_DiLeu_BaLyEn_6 119 124 PF01217 0.497
TRG_DiLeu_BaLyEn_6 43 48 PF01217 0.500
TRG_ENDOCYTIC_2 137 140 PF00928 0.581
TRG_ENDOCYTIC_2 416 419 PF00928 0.668
TRG_ENDOCYTIC_2 507 510 PF00928 0.689
TRG_ENDOCYTIC_2 600 603 PF00928 0.692
TRG_ENDOCYTIC_2 748 751 PF00928 0.519
TRG_ENDOCYTIC_2 828 831 PF00928 0.435
TRG_ER_diArg_1 270 273 PF00400 0.628
TRG_ER_diArg_1 383 385 PF00400 0.567
TRG_ER_diArg_1 413 415 PF00400 0.686
TRG_ER_diArg_1 482 485 PF00400 0.506
TRG_ER_diArg_1 50 53 PF00400 0.613
TRG_ER_diArg_1 515 517 PF00400 0.603
TRG_ER_diArg_1 522 525 PF00400 0.623
TRG_ER_diArg_1 622 625 PF00400 0.626
TRG_ER_diArg_1 643 646 PF00400 0.608
TRG_ER_diArg_1 673 676 PF00400 0.559
TRG_ER_diArg_1 691 693 PF00400 0.426
TRG_ER_diArg_1 941 943 PF00400 0.342
TRG_ER_diArg_1 945 948 PF00400 0.313
TRG_Pf-PMV_PEXEL_1 242 246 PF00026 0.636
TRG_Pf-PMV_PEXEL_1 569 573 PF00026 0.521
TRG_Pf-PMV_PEXEL_1 953 957 PF00026 0.521

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NJI2 Trypanosomatidae 36% 100%
A0A1X0NR25 Trypanosomatidae 31% 94%
A0A3R7NS98 Trypanosoma rangeli 32% 97%
A0A3R7RH60 Trypanosoma rangeli 39% 100%
A0A3S7X4M2 Leishmania donovani 94% 100%
A0A3S7X4P3 Leishmania donovani 94% 100%
A4HJG8 Leishmania braziliensis 70% 100%
A4I6X8 Leishmania infantum 94% 100%
E9B1Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E9B1Y6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9B1Y7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q674 Leishmania major 100% 100%
V5BEQ4 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS