LeishMANIAdb
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Mannosyltransferase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mannosyltransferase-like protein
Gene product:
mannosyltransferase-like protein
Species:
Leishmania major
UniProt:
Q4Q674_LEIMA
TriTrypDb:
LmjF.31.1870 * , LMJLV39_310027300 * , LMJSD75_310027000 *
Length:
858

Annotations

LeishMANIAdb annotations

A complex and fast-evolving family of glycosyltransferases. Their structural innovations and expansion is in accordance with a role in interactions with the environment. Despite the short hydrophobic segment, the N-terminal signal-like stretch is likely to be a signal-anchor as wil all Golgi-resident glycosyltransferases, not a secretory signal. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 13
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

Q4Q674
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q674

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 15
GO:0016740 transferase activity 2 15
GO:0016757 glycosyltransferase activity 3 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 279 283 PF00656 0.513
CLV_NRD_NRD_1 263 265 PF00675 0.511
CLV_NRD_NRD_1 293 295 PF00675 0.568
CLV_NRD_NRD_1 396 398 PF00675 0.437
CLV_NRD_NRD_1 465 467 PF00675 0.400
CLV_NRD_NRD_1 505 507 PF00675 0.392
CLV_NRD_NRD_1 572 574 PF00675 0.456
CLV_NRD_NRD_1 638 640 PF00675 0.394
CLV_NRD_NRD_1 821 823 PF00675 0.335
CLV_NRD_NRD_1 825 827 PF00675 0.308
CLV_PCSK_FUR_1 502 506 PF00082 0.330
CLV_PCSK_KEX2_1 263 265 PF00082 0.546
CLV_PCSK_KEX2_1 293 295 PF00082 0.582
CLV_PCSK_KEX2_1 395 397 PF00082 0.443
CLV_PCSK_KEX2_1 465 467 PF00082 0.400
CLV_PCSK_KEX2_1 504 506 PF00082 0.415
CLV_PCSK_KEX2_1 572 574 PF00082 0.421
CLV_PCSK_KEX2_1 821 823 PF00082 0.308
CLV_PCSK_KEX2_1 825 827 PF00082 0.281
CLV_PCSK_PC7_1 500 506 PF00082 0.341
CLV_PCSK_PC7_1 821 827 PF00082 0.350
CLV_PCSK_SKI1_1 110 114 PF00082 0.638
CLV_PCSK_SKI1_1 197 201 PF00082 0.575
CLV_PCSK_SKI1_1 373 377 PF00082 0.594
CLV_PCSK_SKI1_1 505 509 PF00082 0.519
CLV_PCSK_SKI1_1 627 631 PF00082 0.407
CLV_PCSK_SKI1_1 70 74 PF00082 0.595
CLV_Separin_Metazoa 808 812 PF03568 0.342
DEG_SCF_FBW7_1 93 98 PF00400 0.569
DOC_ANK_TNKS_1 774 781 PF00023 0.360
DOC_CYCLIN_yClb5_NLxxxL_5 18 27 PF00134 0.440
DOC_CYCLIN_yCln2_LP_2 130 136 PF00134 0.484
DOC_MAPK_gen_1 502 511 PF00069 0.467
DOC_MAPK_gen_1 639 646 PF00069 0.400
DOC_MAPK_gen_1 662 669 PF00069 0.456
DOC_MAPK_MEF2A_6 328 337 PF00069 0.529
DOC_MAPK_MEF2A_6 526 535 PF00069 0.504
DOC_PP1_RVXF_1 625 632 PF00149 0.423
DOC_PP2B_LxvP_1 130 133 PF13499 0.550
DOC_PP2B_PxIxI_1 708 714 PF00149 0.411
DOC_PP4_FxxP_1 433 436 PF00568 0.446
DOC_PP4_FxxP_1 520 523 PF00568 0.432
DOC_PP4_FxxP_1 733 736 PF00568 0.295
DOC_PP4_FxxP_1 774 777 PF00568 0.356
DOC_USP7_MATH_1 367 371 PF00917 0.616
DOC_USP7_MATH_1 39 43 PF00917 0.555
DOC_USP7_MATH_1 494 498 PF00917 0.611
DOC_USP7_MATH_1 59 63 PF00917 0.679
DOC_USP7_MATH_1 602 606 PF00917 0.457
DOC_USP7_MATH_1 799 803 PF00917 0.302
DOC_USP7_MATH_1 95 99 PF00917 0.630
DOC_WW_Pin1_4 489 494 PF00397 0.627
DOC_WW_Pin1_4 574 579 PF00397 0.499
DOC_WW_Pin1_4 675 680 PF00397 0.478
DOC_WW_Pin1_4 782 787 PF00397 0.355
DOC_WW_Pin1_4 91 96 PF00397 0.727
LIG_14-3-3_CanoR_1 127 131 PF00244 0.483
LIG_14-3-3_CanoR_1 172 178 PF00244 0.748
LIG_14-3-3_CanoR_1 230 236 PF00244 0.615
LIG_14-3-3_CanoR_1 274 278 PF00244 0.593
LIG_14-3-3_CanoR_1 373 379 PF00244 0.556
LIG_14-3-3_CanoR_1 384 390 PF00244 0.395
LIG_14-3-3_CanoR_1 428 436 PF00244 0.566
LIG_14-3-3_CanoR_1 454 460 PF00244 0.464
LIG_14-3-3_CanoR_1 465 469 PF00244 0.553
LIG_14-3-3_CanoR_1 616 625 PF00244 0.508
LIG_14-3-3_CanoR_1 664 668 PF00244 0.547
LIG_BIR_III_4 297 301 PF00653 0.616
LIG_CtBP_PxDLS_1 658 662 PF00389 0.419
LIG_deltaCOP1_diTrp_1 558 567 PF00928 0.339
LIG_deltaCOP1_diTrp_1 760 767 PF00928 0.339
LIG_FHA_1 13 19 PF00498 0.566
LIG_FHA_1 139 145 PF00498 0.614
LIG_FHA_1 187 193 PF00498 0.581
LIG_FHA_1 260 266 PF00498 0.598
LIG_FHA_1 350 356 PF00498 0.557
LIG_FHA_1 414 420 PF00498 0.625
LIG_FHA_1 663 669 PF00498 0.539
LIG_FHA_1 713 719 PF00498 0.339
LIG_FHA_1 804 810 PF00498 0.358
LIG_FHA_2 138 144 PF00498 0.693
LIG_FHA_2 182 188 PF00498 0.664
LIG_FHA_2 230 236 PF00498 0.615
LIG_FHA_2 553 559 PF00498 0.505
LIG_FHA_2 560 566 PF00498 0.479
LIG_FHA_2 618 624 PF00498 0.478
LIG_FHA_2 735 741 PF00498 0.296
LIG_LIR_Apic_2 221 227 PF02991 0.656
LIG_LIR_Apic_2 431 436 PF02991 0.549
LIG_LIR_Apic_2 731 736 PF02991 0.296
LIG_LIR_Apic_2 740 745 PF02991 0.297
LIG_LIR_Apic_2 759 764 PF02991 0.342
LIG_LIR_Apic_2 771 777 PF02991 0.272
LIG_LIR_Gen_1 14 24 PF02991 0.642
LIG_LIR_Gen_1 159 168 PF02991 0.468
LIG_LIR_Gen_1 276 284 PF02991 0.592
LIG_LIR_Gen_1 485 494 PF02991 0.602
LIG_LIR_Gen_1 565 571 PF02991 0.446
LIG_LIR_Nem_3 14 20 PF02991 0.578
LIG_LIR_Nem_3 159 164 PF02991 0.481
LIG_LIR_Nem_3 276 280 PF02991 0.598
LIG_LIR_Nem_3 485 490 PF02991 0.592
LIG_LIR_Nem_3 565 570 PF02991 0.371
LIG_LYPXL_yS_3 708 711 PF13949 0.339
LIG_NRBOX 19 25 PF00104 0.471
LIG_PCNA_yPIPBox_3 365 379 PF02747 0.593
LIG_Pex14_2 630 634 PF04695 0.421
LIG_Pex14_2 689 693 PF04695 0.539
LIG_PTAP_UEV_1 654 659 PF05743 0.434
LIG_REV1ctd_RIR_1 496 506 PF16727 0.512
LIG_RPA_C_Fungi 345 357 PF08784 0.396
LIG_SH2_CRK 296 300 PF00017 0.612
LIG_SH2_CRK 387 391 PF00017 0.597
LIG_SH2_CRK 480 484 PF00017 0.560
LIG_SH2_GRB2like 727 730 PF00017 0.375
LIG_SH2_NCK_1 175 179 PF00017 0.645
LIG_SH2_NCK_1 268 272 PF00017 0.571
LIG_SH2_NCK_1 296 300 PF00017 0.612
LIG_SH2_NCK_1 387 391 PF00017 0.467
LIG_SH2_NCK_1 593 597 PF00017 0.490
LIG_SH2_NCK_1 727 731 PF00017 0.375
LIG_SH2_PTP2 17 20 PF00017 0.428
LIG_SH2_PTP2 447 450 PF00017 0.446
LIG_SH2_SRC 593 596 PF00017 0.486
LIG_SH2_SRC 727 730 PF00017 0.375
LIG_SH2_SRC 792 795 PF00017 0.422
LIG_SH2_STAT3 598 601 PF00017 0.500
LIG_SH2_STAT5 17 20 PF00017 0.428
LIG_SH2_STAT5 175 178 PF00017 0.702
LIG_SH2_STAT5 260 263 PF00017 0.511
LIG_SH2_STAT5 447 450 PF00017 0.395
LIG_SH2_STAT5 534 537 PF00017 0.381
LIG_SH2_STAT5 628 631 PF00017 0.400
LIG_SH2_STAT5 812 815 PF00017 0.290
LIG_SH3_3 130 136 PF00018 0.484
LIG_SH3_3 253 259 PF00018 0.692
LIG_SH3_3 395 401 PF00018 0.552
LIG_SH3_3 487 493 PF00018 0.556
LIG_SH3_3 652 658 PF00018 0.349
LIG_SH3_3 783 789 PF00018 0.331
LIG_SH3_3 811 817 PF00018 0.333
LIG_SUMO_SIM_anti_2 126 132 PF11976 0.558
LIG_SUMO_SIM_anti_2 139 147 PF11976 0.621
LIG_SUMO_SIM_par_1 665 671 PF11976 0.424
LIG_SUMO_SIM_par_1 710 715 PF11976 0.374
LIG_SUMO_SIM_par_1 754 760 PF11976 0.339
LIG_TRAF2_1 276 279 PF00917 0.600
LIG_TRAF2_1 620 623 PF00917 0.488
LIG_TYR_ITIM 478 483 PF00017 0.540
LIG_WRC_WIRS_1 164 169 PF05994 0.552
LIG_WRC_WIRS_1 631 636 PF05994 0.371
LIG_WW_3 227 231 PF00397 0.552
MOD_CDC14_SPxK_1 577 580 PF00782 0.516
MOD_CDK_SPxK_1 574 580 PF00069 0.499
MOD_CK1_1 11 17 PF00069 0.547
MOD_CK1_1 266 272 PF00069 0.569
MOD_CK1_1 349 355 PF00069 0.454
MOD_CK1_1 388 394 PF00069 0.623
MOD_CK1_1 409 415 PF00069 0.556
MOD_CK1_1 489 495 PF00069 0.525
MOD_CK1_1 540 546 PF00069 0.388
MOD_CK1_1 682 688 PF00069 0.460
MOD_CK1_1 785 791 PF00069 0.390
MOD_CK2_1 137 143 PF00069 0.633
MOD_CK2_1 181 187 PF00069 0.771
MOD_CK2_1 229 235 PF00069 0.626
MOD_CK2_1 266 272 PF00069 0.629
MOD_CK2_1 273 279 PF00069 0.642
MOD_CK2_1 313 319 PF00069 0.691
MOD_CK2_1 535 541 PF00069 0.390
MOD_CK2_1 615 621 PF00069 0.483
MOD_CK2_1 716 722 PF00069 0.502
MOD_CK2_1 734 740 PF00069 0.296
MOD_CMANNOS 344 347 PF00535 0.478
MOD_CMANNOS 99 102 PF00535 0.415
MOD_Cter_Amidation 463 466 PF01082 0.435
MOD_Cter_Amidation 823 826 PF01082 0.294
MOD_GlcNHglycan 10 13 PF01048 0.569
MOD_GlcNHglycan 220 223 PF01048 0.659
MOD_GlcNHglycan 265 268 PF01048 0.553
MOD_GlcNHglycan 315 318 PF01048 0.675
MOD_GlcNHglycan 37 40 PF01048 0.709
MOD_GlcNHglycan 411 414 PF01048 0.626
MOD_GlcNHglycan 432 436 PF01048 0.553
MOD_GlcNHglycan 470 473 PF01048 0.582
MOD_GlcNHglycan 55 58 PF01048 0.644
MOD_GlcNHglycan 655 658 PF01048 0.558
MOD_GlcNHglycan 717 721 PF01048 0.366
MOD_GlcNHglycan 79 82 PF01048 0.572
MOD_GSK3_1 259 266 PF00069 0.545
MOD_GSK3_1 35 42 PF00069 0.526
MOD_GSK3_1 409 416 PF00069 0.695
MOD_GSK3_1 464 471 PF00069 0.561
MOD_GSK3_1 485 492 PF00069 0.711
MOD_GSK3_1 671 678 PF00069 0.510
MOD_GSK3_1 712 719 PF00069 0.460
MOD_GSK3_1 799 806 PF00069 0.329
MOD_GSK3_1 8 15 PF00069 0.608
MOD_GSK3_1 91 98 PF00069 0.600
MOD_N-GLC_1 12 17 PF02516 0.480
MOD_N-GLC_1 39 44 PF02516 0.544
MOD_N-GLC_1 608 613 PF02516 0.489
MOD_NEK2_1 168 173 PF00069 0.682
MOD_NEK2_1 195 200 PF00069 0.604
MOD_NEK2_1 486 491 PF00069 0.557
MOD_NEK2_1 566 571 PF00069 0.402
MOD_NEK2_1 630 635 PF00069 0.370
MOD_NEK2_1 689 694 PF00069 0.497
MOD_NEK2_1 848 853 PF00069 0.528
MOD_NEK2_2 331 336 PF00069 0.445
MOD_NEK2_2 494 499 PF00069 0.498
MOD_PIKK_1 197 203 PF00454 0.557
MOD_PIKK_1 40 46 PF00454 0.663
MOD_PKA_1 263 269 PF00069 0.550
MOD_PKA_2 126 132 PF00069 0.618
MOD_PKA_2 229 235 PF00069 0.626
MOD_PKA_2 263 269 PF00069 0.612
MOD_PKA_2 273 279 PF00069 0.544
MOD_PKA_2 349 355 PF00069 0.594
MOD_PKA_2 464 470 PF00069 0.589
MOD_PKA_2 615 621 PF00069 0.543
MOD_PKA_2 663 669 PF00069 0.449
MOD_PKA_2 671 677 PF00069 0.394
MOD_PKA_2 682 688 PF00069 0.258
MOD_PKA_2 769 775 PF00069 0.375
MOD_Plk_1 12 18 PF00069 0.435
MOD_Plk_1 138 144 PF00069 0.619
MOD_Plk_1 413 419 PF00069 0.558
MOD_Plk_1 608 614 PF00069 0.597
MOD_Plk_1 662 668 PF00069 0.466
MOD_Plk_4 126 132 PF00069 0.608
MOD_Plk_4 163 169 PF00069 0.613
MOD_Plk_4 210 216 PF00069 0.502
MOD_Plk_4 385 391 PF00069 0.574
MOD_Plk_4 494 500 PF00069 0.625
MOD_Plk_4 546 552 PF00069 0.351
MOD_Plk_4 566 572 PF00069 0.474
MOD_Plk_4 60 66 PF00069 0.649
MOD_Plk_4 663 669 PF00069 0.395
MOD_Plk_4 682 688 PF00069 0.282
MOD_Plk_4 848 854 PF00069 0.415
MOD_ProDKin_1 489 495 PF00069 0.619
MOD_ProDKin_1 574 580 PF00069 0.499
MOD_ProDKin_1 675 681 PF00069 0.469
MOD_ProDKin_1 782 788 PF00069 0.355
MOD_ProDKin_1 91 97 PF00069 0.726
MOD_SUMO_for_1 634 637 PF00179 0.334
TRG_DiLeu_BaEn_1 187 192 PF01217 0.575
TRG_DiLeu_BaEn_1 663 668 PF01217 0.455
TRG_ENDOCYTIC_2 17 20 PF00928 0.568
TRG_ENDOCYTIC_2 296 299 PF00928 0.628
TRG_ENDOCYTIC_2 387 390 PF00928 0.604
TRG_ENDOCYTIC_2 480 483 PF00928 0.546
TRG_ENDOCYTIC_2 628 631 PF00928 0.400
TRG_ENDOCYTIC_2 708 711 PF00928 0.339
TRG_ER_diArg_1 150 153 PF00400 0.616
TRG_ER_diArg_1 263 265 PF00400 0.491
TRG_ER_diArg_1 293 295 PF00400 0.639
TRG_ER_diArg_1 362 365 PF00400 0.437
TRG_ER_diArg_1 395 397 PF00400 0.450
TRG_ER_diArg_1 402 405 PF00400 0.489
TRG_ER_diArg_1 502 505 PF00400 0.562
TRG_ER_diArg_1 523 526 PF00400 0.568
TRG_ER_diArg_1 553 556 PF00400 0.512
TRG_ER_diArg_1 571 573 PF00400 0.447
TRG_ER_diArg_1 821 823 PF00400 0.304
TRG_ER_diArg_1 825 828 PF00400 0.278
TRG_Pf-PMV_PEXEL_1 122 126 PF00026 0.624
TRG_Pf-PMV_PEXEL_1 449 453 PF00026 0.434
TRG_Pf-PMV_PEXEL_1 833 837 PF00026 0.477

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NJI2 Trypanosomatidae 36% 96%
A0A1X0NR25 Trypanosomatidae 31% 83%
A0A3R7NS98 Trypanosoma rangeli 32% 85%
A0A3R7RH60 Trypanosoma rangeli 39% 100%
A0A3S7X4M2 Leishmania donovani 94% 89%
A0A3S7X4P3 Leishmania donovani 94% 89%
A4HJG8 Leishmania braziliensis 76% 89%
A4I6X8 Leishmania infantum 94% 100%
E9B1Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 89%
E9B1Y6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 97%
E9B1Y7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q675 Leishmania major 100% 88%
V5BEQ4 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS