Peptidase m20/m25/m40 family-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidase m20/m25/m40 family-like protein

Species:

Leishmania major

UniProt:

Q4Q673_LEIMA

TriTrypDb:

LmjF.31.1890 , LMJLV39_000007300 , LMJSD75_310027200

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	yes	yes: 3
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q673

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q673

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0019538	protein metabolic process	3	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044238	primary metabolic process	2	4
GO:0071704	organic substance metabolic process	2	4
GO:1901564	organonitrogen compound metabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	23
GO:0008233	peptidase activity	3	4
GO:0016787	hydrolase activity	2	23
GO:0140096	catalytic activity, acting on a protein	2	4
GO:0005488	binding	1	1
GO:0005506	iron ion binding	6	1
GO:0016491	oxidoreductase activity	2	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.573
CLV_NRD_NRD_1	77	79	PF00675	0.597
CLV_PCSK_KEX2_1	459	461	PF00082	0.464
CLV_PCSK_KEX2_1	77	79	PF00082	0.597
CLV_PCSK_PC1ET2_1	459	461	PF00082	0.464
CLV_PCSK_SKI1_1	347	351	PF00082	0.385
CLV_PCSK_SKI1_1	459	463	PF00082	0.369
CLV_PCSK_SKI1_1	471	475	PF00082	0.372
CLV_PCSK_SKI1_1	557	561	PF00082	0.398
DEG_APCC_DBOX_1	346	354	PF00400	0.384
DEG_Nend_UBRbox_1	1	4	PF02207	0.556
DEG_SPOP_SBC_1	70	74	PF00917	0.566
DOC_ANK_TNKS_1	211	218	PF00023	0.475
DOC_ANK_TNKS_1	313	320	PF00023	0.386
DOC_CYCLIN_RxL_1	344	354	PF00134	0.372
DOC_CYCLIN_RxL_1	75	83	PF00134	0.547
DOC_MAPK_FxFP_2	55	58	PF00069	0.572
DOC_MAPK_gen_1	285	293	PF00069	0.448
DOC_MAPK_gen_1	77	84	PF00069	0.555
DOC_MAPK_MEF2A_6	181	189	PF00069	0.469
DOC_MAPK_MEF2A_6	287	295	PF00069	0.400
DOC_MAPK_MEF2A_6	434	443	PF00069	0.390
DOC_MAPK_MEF2A_6	77	84	PF00069	0.555
DOC_MAPK_NFAT4_5	77	85	PF00069	0.550
DOC_PP1_RVXF_1	469	475	PF00149	0.413
DOC_PP2B_LxvP_1	30	33	PF13499	0.562
DOC_PP2B_LxvP_1	551	554	PF13499	0.370
DOC_PP4_FxxP_1	411	414	PF00568	0.448
DOC_PP4_FxxP_1	55	58	PF00568	0.572
DOC_USP7_MATH_1	104	108	PF00917	0.412
DOC_USP7_MATH_1	16	20	PF00917	0.556
DOC_USP7_MATH_1	248	252	PF00917	0.506
DOC_USP7_MATH_1	58	62	PF00917	0.556
DOC_USP7_MATH_1	69	73	PF00917	0.548
DOC_USP7_MATH_1	7	11	PF00917	0.573
DOC_USP7_UBL2_3	471	475	PF12436	0.518
DOC_WW_Pin1_4	136	141	PF00397	0.478
DOC_WW_Pin1_4	14	19	PF00397	0.572
DOC_WW_Pin1_4	179	184	PF00397	0.458
DOC_WW_Pin1_4	23	28	PF00397	0.563
DOC_WW_Pin1_4	271	276	PF00397	0.474
DOC_WW_Pin1_4	41	46	PF00397	0.564
DOC_WW_Pin1_4	571	576	PF00397	0.505
DOC_WW_Pin1_4	59	64	PF00397	0.526
DOC_WW_Pin1_4	71	76	PF00397	0.563
DOC_WW_Pin1_4	95	100	PF00397	0.508
LIG_14-3-3_CanoR_1	114	118	PF00244	0.484
LIG_14-3-3_CanoR_1	434	440	PF00244	0.400
LIG_14-3-3_CanoR_1	77	81	PF00244	0.547
LIG_14-3-3_CanoR_1	87	97	PF00244	0.512
LIG_APCC_ABBA_1	524	529	PF00400	0.386
LIG_BRCT_BRCA1_1	138	142	PF00533	0.572
LIG_EH1_1	531	539	PF00400	0.399
LIG_FHA_1	146	152	PF00498	0.552
LIG_FHA_1	180	186	PF00498	0.448
LIG_FHA_1	308	314	PF00498	0.388
LIG_FHA_1	340	346	PF00498	0.436
LIG_FHA_1	356	362	PF00498	0.322
LIG_FHA_1	436	442	PF00498	0.415
LIG_FHA_1	533	539	PF00498	0.388
LIG_FHA_1	558	564	PF00498	0.392
LIG_FHA_2	323	329	PF00498	0.400
LIG_FHA_2	35	41	PF00498	0.580
LIG_FHA_2	360	366	PF00498	0.517
LIG_FHA_2	89	95	PF00498	0.549
LIG_LIR_Apic_2	52	58	PF02991	0.569
LIG_LIR_Gen_1	130	140	PF02991	0.451
LIG_LIR_Gen_1	172	178	PF02991	0.505
LIG_LIR_Gen_1	182	190	PF02991	0.403
LIG_LIR_Gen_1	237	248	PF02991	0.429
LIG_LIR_Gen_1	301	309	PF02991	0.386
LIG_LIR_Gen_1	549	556	PF02991	0.400
LIG_LIR_Gen_1	98	108	PF02991	0.597
LIG_LIR_Nem_3	107	113	PF02991	0.477
LIG_LIR_Nem_3	130	135	PF02991	0.450
LIG_LIR_Nem_3	153	159	PF02991	0.514
LIG_LIR_Nem_3	172	176	PF02991	0.441
LIG_LIR_Nem_3	182	187	PF02991	0.399
LIG_LIR_Nem_3	237	243	PF02991	0.398
LIG_LIR_Nem_3	301	307	PF02991	0.386
LIG_LIR_Nem_3	549	553	PF02991	0.400
LIG_LIR_Nem_3	98	103	PF02991	0.621
LIG_LRP6_Inhibitor_1	428	434	PF00058	0.471
LIG_MYND_1	209	213	PF01753	0.388
LIG_MYND_1	486	490	PF01753	0.400
LIG_Pex14_2	142	146	PF04695	0.601
LIG_Pex14_2	386	390	PF04695	0.413
LIG_SH2_CRK	173	177	PF00017	0.482
LIG_SH2_PTP2	132	135	PF00017	0.467
LIG_SH2_SRC	132	135	PF00017	0.480
LIG_SH2_SRC	173	176	PF00017	0.402
LIG_SH2_STAP1	240	244	PF00017	0.442
LIG_SH2_STAP1	304	308	PF00017	0.400
LIG_SH2_STAT3	508	511	PF00017	0.512
LIG_SH2_STAT5	132	135	PF00017	0.467
LIG_SH2_STAT5	175	178	PF00017	0.406
LIG_SH2_STAT5	41	44	PF00017	0.595
LIG_SH3_1	207	213	PF00018	0.388
LIG_SH3_3	19	25	PF00018	0.574
LIG_SH3_3	207	213	PF00018	0.397
LIG_SH3_3	358	364	PF00018	0.437
LIG_SH3_3	42	48	PF00018	0.573
LIG_SH3_3	83	89	PF00018	0.559
LIG_SH3_3	93	99	PF00018	0.498
LIG_SH3_4	489	496	PF00018	0.299
LIG_SH3_5	275	279	PF00018	0.442
LIG_SUMO_SIM_par_1	262	267	PF11976	0.390
LIG_TRAF2_1	268	271	PF00917	0.384
LIG_TYR_ITIM	171	176	PF00017	0.510
LIG_UBA3_1	349	357	PF00899	0.464
LIG_WRC_WIRS_1	100	105	PF05994	0.467
MOD_CDC14_SPxK_1	17	20	PF00782	0.568
MOD_CDC14_SPxK_1	21	24	PF00782	0.568
MOD_CDC14_SPxK_1	74	77	PF00782	0.557
MOD_CDK_SPK_2	571	576	PF00069	0.505
MOD_CDK_SPxK_1	14	20	PF00069	0.574
MOD_CDK_SPxK_1	71	77	PF00069	0.564
MOD_CDK_SPxxK_3	71	78	PF00069	0.559
MOD_CK1_1	10	16	PF00069	0.583
MOD_CK1_1	329	335	PF00069	0.428
MOD_CK2_1	322	328	PF00069	0.400
MOD_CK2_1	348	354	PF00069	0.524
MOD_CK2_1	359	365	PF00069	0.454
MOD_DYRK1A_RPxSP_1	95	99	PF00069	0.507
MOD_GlcNHglycan	106	109	PF01048	0.572
MOD_GlcNHglycan	129	132	PF01048	0.514
MOD_GlcNHglycan	270	274	PF01048	0.402
MOD_GlcNHglycan	298	301	PF01048	0.382
MOD_GlcNHglycan	331	334	PF01048	0.392
MOD_GlcNHglycan	34	37	PF01048	0.563
MOD_GSK3_1	10	17	PF00069	0.580
MOD_GSK3_1	244	251	PF00069	0.544
MOD_GSK3_1	298	305	PF00069	0.463
MOD_GSK3_1	322	329	PF00069	0.529
MOD_GSK3_1	339	346	PF00069	0.444
MOD_GSK3_1	355	362	PF00069	0.428
MOD_GSK3_1	412	419	PF00069	0.541
MOD_GSK3_1	435	442	PF00069	0.409
MOD_GSK3_1	76	83	PF00069	0.590
MOD_GSK3_1	95	102	PF00069	0.690
MOD_N-GLC_1	136	141	PF02516	0.491
MOD_N-GLC_1	195	200	PF02516	0.395
MOD_N-GLC_1	302	307	PF02516	0.505
MOD_N-GLC_2	481	483	PF02516	0.469
MOD_NEK2_1	302	307	PF00069	0.428
MOD_NEK2_1	309	314	PF00069	0.369
MOD_NEK2_1	326	331	PF00069	0.412
MOD_NEK2_1	416	421	PF00069	0.471
MOD_NEK2_1	504	509	PF00069	0.424
MOD_NEK2_1	532	537	PF00069	0.422
MOD_NEK2_1	559	564	PF00069	0.485
MOD_PIKK_1	302	308	PF00454	0.480
MOD_PIKK_1	47	53	PF00454	0.560
MOD_PKA_2	113	119	PF00069	0.477
MOD_PKA_2	343	349	PF00069	0.520
MOD_PKA_2	76	82	PF00069	0.587
MOD_Plk_1	121	127	PF00069	0.475
MOD_Plk_1	195	201	PF00069	0.443
MOD_Plk_1	302	308	PF00069	0.505
MOD_Plk_1	319	325	PF00069	0.460
MOD_Plk_1	359	365	PF00069	0.386
MOD_Plk_4	121	127	PF00069	0.468
MOD_Plk_4	195	201	PF00069	0.481
MOD_ProDKin_1	136	142	PF00069	0.482
MOD_ProDKin_1	14	20	PF00069	0.574
MOD_ProDKin_1	179	185	PF00069	0.455
MOD_ProDKin_1	23	29	PF00069	0.563
MOD_ProDKin_1	271	277	PF00069	0.474
MOD_ProDKin_1	41	47	PF00069	0.559
MOD_ProDKin_1	59	65	PF00069	0.526
MOD_ProDKin_1	71	77	PF00069	0.564
MOD_ProDKin_1	95	101	PF00069	0.506
MOD_SUMO_for_1	449	452	PF00179	0.386
MOD_SUMO_rev_2	351	358	PF00179	0.448
TRG_ENDOCYTIC_2	132	135	PF00928	0.467
TRG_ENDOCYTIC_2	173	176	PF00928	0.478
TRG_ENDOCYTIC_2	202	205	PF00928	0.388
TRG_ENDOCYTIC_2	240	243	PF00928	0.465
TRG_ENDOCYTIC_2	304	307	PF00928	0.400
TRG_NES_CRM1_1	286	298	PF08389	0.532
TRG_Pf-PMV_PEXEL_1	460	465	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q9	Leptomonas seymouri	75%	100%
A0A0N1PBD8	Leptomonas seymouri	78%	100%
A0A0S4JJE7	Bodo saltans	60%	100%
A0A1X0P1Q0	Trypanosomatidae	64%	100%
A0A381MQ29	Leishmania infantum	98%	100%
A0A3Q8IFP2	Leishmania donovani	95%	100%
A0A3R7KSZ4	Trypanosoma rangeli	63%	100%
A0A3S7X4P6	Leishmania donovani	97%	100%
A0A3S7X6U2	Leishmania donovani	75%	100%
A4HJG9	Leishmania braziliensis	92%	100%
A4HJH1	Leishmania braziliensis	92%	100%
A4HJI4	Leishmania braziliensis	92%	100%
A4HLM2	Leishmania braziliensis	72%	100%
A4I933	Leishmania infantum	75%	100%
C9ZQ48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
D0A536	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9B201	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B3Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q426	Leishmania major	74%	100%
Q4Q660	Leishmania major	100%	100%
Q6Q0N1	Rattus norvegicus	27%	100%
Q9D1A2	Mus musculus	27%	100%
V5BHA2	Trypanosoma cruzi	62%	100%