Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q671_LEIMA

TriTrypDb:

LmjF.31.1910 , LMJLV39_310027400 , LMJSD75_310027400

Length:

848

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q671

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q671

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	237	239	PF00675	0.597
CLV_NRD_NRD_1	312	314	PF00675	0.818
CLV_NRD_NRD_1	349	351	PF00675	0.610
CLV_NRD_NRD_1	477	479	PF00675	0.738
CLV_NRD_NRD_1	54	56	PF00675	0.728
CLV_NRD_NRD_1	651	653	PF00675	0.679
CLV_NRD_NRD_1	68	70	PF00675	0.564
CLV_NRD_NRD_1	749	751	PF00675	0.675
CLV_NRD_NRD_1	758	760	PF00675	0.573
CLV_NRD_NRD_1	797	799	PF00675	0.734
CLV_PCSK_KEX2_1	102	104	PF00082	0.736
CLV_PCSK_KEX2_1	237	239	PF00082	0.597
CLV_PCSK_KEX2_1	312	314	PF00082	0.818
CLV_PCSK_KEX2_1	349	351	PF00082	0.610
CLV_PCSK_KEX2_1	477	479	PF00082	0.742
CLV_PCSK_KEX2_1	54	56	PF00082	0.728
CLV_PCSK_KEX2_1	651	653	PF00082	0.813
CLV_PCSK_KEX2_1	68	70	PF00082	0.564
CLV_PCSK_KEX2_1	751	753	PF00082	0.706
CLV_PCSK_KEX2_1	758	760	PF00082	0.579
CLV_PCSK_KEX2_1	796	798	PF00082	0.612
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.736
CLV_PCSK_PC1ET2_1	751	753	PF00082	0.706
CLV_PCSK_PC1ET2_1	758	760	PF00082	0.579
CLV_PCSK_PC1ET2_1	796	798	PF00082	0.612
CLV_PCSK_PC7_1	754	760	PF00082	0.460
CLV_PCSK_SKI1_1	103	107	PF00082	0.611
CLV_PCSK_SKI1_1	277	281	PF00082	0.703
CLV_PCSK_SKI1_1	407	411	PF00082	0.799
CLV_PCSK_SKI1_1	41	45	PF00082	0.697
CLV_PCSK_SKI1_1	478	482	PF00082	0.759
CLV_PCSK_SKI1_1	626	630	PF00082	0.690
CLV_PCSK_SKI1_1	68	72	PF00082	0.595
CLV_PCSK_SKI1_1	91	95	PF00082	0.719
DEG_APCC_DBOX_1	477	485	PF00400	0.710
DEG_APCC_DBOX_1	672	680	PF00400	0.708
DEG_Nend_Nbox_1	1	3	PF02207	0.729
DEG_SPOP_SBC_1	371	375	PF00917	0.836
DOC_CYCLIN_yCln2_LP_2	631	637	PF00134	0.732
DOC_MAPK_gen_1	494	501	PF00069	0.695
DOC_MAPK_gen_1	52	61	PF00069	0.724
DOC_MAPK_gen_1	758	767	PF00069	0.489
DOC_PP1_RVXF_1	624	630	PF00149	0.694
DOC_PP2B_LxvP_1	364	367	PF13499	0.590
DOC_USP7_MATH_1	121	125	PF00917	0.602
DOC_USP7_MATH_1	17	21	PF00917	0.749
DOC_USP7_MATH_1	256	260	PF00917	0.652
DOC_USP7_MATH_1	265	269	PF00917	0.555
DOC_USP7_MATH_1	272	276	PF00917	0.569
DOC_USP7_MATH_1	385	389	PF00917	0.741
DOC_USP7_MATH_1	441	445	PF00917	0.614
DOC_USP7_MATH_1	461	465	PF00917	0.601
DOC_USP7_MATH_1	472	476	PF00917	0.723
DOC_USP7_MATH_1	600	604	PF00917	0.810
DOC_USP7_MATH_1	658	662	PF00917	0.624
DOC_USP7_MATH_1	703	707	PF00917	0.766
DOC_USP7_MATH_2	335	341	PF00917	0.693
DOC_USP7_UBL2_3	257	261	PF12436	0.795
DOC_WW_Pin1_4	201	206	PF00397	0.648
DOC_WW_Pin1_4	353	358	PF00397	0.833
DOC_WW_Pin1_4	372	377	PF00397	0.527
DOC_WW_Pin1_4	468	473	PF00397	0.805
DOC_WW_Pin1_4	482	487	PF00397	0.575
DOC_WW_Pin1_4	510	515	PF00397	0.821
DOC_WW_Pin1_4	681	686	PF00397	0.759
LIG_14-3-3_CanoR_1	237	245	PF00244	0.771
LIG_14-3-3_CanoR_1	27	37	PF00244	0.719
LIG_14-3-3_CanoR_1	312	322	PF00244	0.797
LIG_14-3-3_CanoR_1	349	358	PF00244	0.688
LIG_14-3-3_CanoR_1	386	396	PF00244	0.737
LIG_14-3-3_CanoR_1	54	60	PF00244	0.763
LIG_14-3-3_CanoR_1	645	653	PF00244	0.645
LIG_Actin_WH2_2	763	781	PF00022	0.458
LIG_BIR_III_2	508	512	PF00653	0.605
LIG_BRCT_BRCA1_1	392	396	PF00533	0.699
LIG_BRCT_BRCA1_1	589	593	PF00533	0.712
LIG_BRCT_BRCA1_1	653	657	PF00533	0.629
LIG_CSL_BTD_1	323	326	PF09270	0.541
LIG_FHA_1	136	142	PF00498	0.697
LIG_FHA_1	16	22	PF00498	0.747
LIG_FHA_1	483	489	PF00498	0.705
LIG_FHA_1	56	62	PF00498	0.687
LIG_FHA_1	562	568	PF00498	0.836
LIG_FHA_2	149	155	PF00498	0.756
LIG_FHA_2	182	188	PF00498	0.759
LIG_FHA_2	485	491	PF00498	0.761
LIG_FHA_2	710	716	PF00498	0.628
LIG_FHA_2	824	830	PF00498	0.579
LIG_FHA_2	92	98	PF00498	0.665
LIG_IBAR_NPY_1	583	585	PF08397	0.592
LIG_Integrin_isoDGR_2	800	802	PF01839	0.656
LIG_Integrin_RGD_1	708	710	PF01839	0.653
LIG_LIR_Apic_2	321	327	PF02991	0.766
LIG_LIR_Apic_2	331	335	PF02991	0.617
LIG_LIR_Gen_1	393	401	PF02991	0.616
LIG_LIR_Gen_1	536	544	PF02991	0.721
LIG_LIR_Gen_1	742	749	PF02991	0.593
LIG_LIR_Gen_1	818	825	PF02991	0.564
LIG_LIR_Nem_3	536	540	PF02991	0.722
LIG_LIR_Nem_3	742	748	PF02991	0.602
LIG_LIR_Nem_3	76	82	PF02991	0.825
LIG_LIR_Nem_3	818	824	PF02991	0.577
LIG_LYPXL_yS_3	728	731	PF13949	0.816
LIG_MAD2	626	634	PF02301	0.700
LIG_MYND_3	225	229	PF01753	0.697
LIG_PCNA_yPIPBox_3	758	771	PF02747	0.483
LIG_PDZ_Class_1	843	848	PF00595	0.761
LIG_SH2_CRK	537	541	PF00017	0.567
LIG_SH2_CRK	67	71	PF00017	0.749
LIG_SH2_CRK	745	749	PF00017	0.629
LIG_SH2_CRK	79	83	PF00017	0.697
LIG_SH2_CRK	821	825	PF00017	0.696
LIG_SH2_NCK_1	565	569	PF00017	0.752
LIG_SH2_NCK_1	745	749	PF00017	0.629
LIG_SH2_SRC	549	552	PF00017	0.595
LIG_SH2_STAP1	297	301	PF00017	0.705
LIG_SH2_STAP1	565	569	PF00017	0.752
LIG_SH2_STAP1	745	749	PF00017	0.629
LIG_SH2_STAP1	821	825	PF00017	0.696
LIG_SH2_STAT5	518	521	PF00017	0.723
LIG_SH3_2	619	624	PF14604	0.727
LIG_SH3_2	634	639	PF14604	0.767
LIG_SH3_3	175	181	PF00018	0.738
LIG_SH3_3	320	326	PF00018	0.545
LIG_SH3_3	508	514	PF00018	0.745
LIG_SH3_3	616	622	PF00018	0.738
LIG_SH3_3	631	637	PF00018	0.678
LIG_SH3_3	647	653	PF00018	0.602
LIG_SH3_3	67	73	PF00018	0.738
LIG_SH3_3	682	688	PF00018	0.649
LIG_SH3_3	728	734	PF00018	0.812
LIG_SH3_3	767	773	PF00018	0.441
LIG_SH3_4	257	264	PF00018	0.798
LIG_SUMO_SIM_par_1	167	175	PF11976	0.600
LIG_TRAF2_1	403	406	PF00917	0.674
LIG_TRAF2_1	669	672	PF00917	0.581
LIG_TYR_ITIM	65	70	PF00017	0.698
LIG_TYR_ITIM	819	824	PF00017	0.580
LIG_TYR_ITSM	741	748	PF00017	0.619
LIG_WW_3	732	736	PF00397	0.809
MOD_CDK_SPxK_1	372	378	PF00069	0.792
MOD_CDK_SPxxK_3	372	379	PF00069	0.845
MOD_CK1_1	107	113	PF00069	0.786
MOD_CK1_1	126	132	PF00069	0.728
MOD_CK1_1	139	145	PF00069	0.541
MOD_CK1_1	206	212	PF00069	0.650
MOD_CK1_1	240	246	PF00069	0.785
MOD_CK1_1	248	254	PF00069	0.670
MOD_CK1_1	259	265	PF00069	0.492
MOD_CK1_1	275	281	PF00069	0.583
MOD_CK1_1	345	351	PF00069	0.693
MOD_CK1_1	353	359	PF00069	0.717
MOD_CK1_1	372	378	PF00069	0.600
MOD_CK1_1	387	393	PF00069	0.596
MOD_CK1_1	473	479	PF00069	0.780
MOD_CK1_1	482	488	PF00069	0.640
MOD_CK1_1	573	579	PF00069	0.606
MOD_CK1_1	665	671	PF00069	0.596
MOD_CK1_1	85	91	PF00069	0.755
MOD_CK2_1	385	391	PF00069	0.816
MOD_CK2_1	400	406	PF00069	0.551
MOD_CK2_1	473	479	PF00069	0.807
MOD_CK2_1	484	490	PF00069	0.632
MOD_CK2_1	573	579	PF00069	0.606
MOD_CK2_1	666	672	PF00069	0.614
MOD_CK2_1	714	720	PF00069	0.673
MOD_GlcNHglycan	118	121	PF01048	0.802
MOD_GlcNHglycan	158	162	PF01048	0.728
MOD_GlcNHglycan	173	177	PF01048	0.615
MOD_GlcNHglycan	263	266	PF01048	0.733
MOD_GlcNHglycan	267	270	PF01048	0.678
MOD_GlcNHglycan	292	295	PF01048	0.582
MOD_GlcNHglycan	352	355	PF01048	0.742
MOD_GlcNHglycan	393	396	PF01048	0.760
MOD_GlcNHglycan	4	7	PF01048	0.608
MOD_GlcNHglycan	414	417	PF01048	0.572
MOD_GlcNHglycan	465	468	PF01048	0.762
MOD_GlcNHglycan	472	475	PF01048	0.729
MOD_GlcNHglycan	481	484	PF01048	0.649
MOD_GlcNHglycan	514	517	PF01048	0.787
MOD_GlcNHglycan	537	540	PF01048	0.626
MOD_GlcNHglycan	576	579	PF01048	0.697
MOD_GlcNHglycan	589	592	PF01048	0.726
MOD_GlcNHglycan	660	663	PF01048	0.632
MOD_GSK3_1	103	110	PF00069	0.770
MOD_GSK3_1	122	129	PF00069	0.786
MOD_GSK3_1	135	142	PF00069	0.550
MOD_GSK3_1	201	208	PF00069	0.648
MOD_GSK3_1	209	216	PF00069	0.685
MOD_GSK3_1	232	239	PF00069	0.819
MOD_GSK3_1	240	247	PF00069	0.672
MOD_GSK3_1	248	255	PF00069	0.517
MOD_GSK3_1	261	268	PF00069	0.576
MOD_GSK3_1	273	280	PF00069	0.718
MOD_GSK3_1	286	293	PF00069	0.613
MOD_GSK3_1	314	321	PF00069	0.715
MOD_GSK3_1	345	352	PF00069	0.805
MOD_GSK3_1	380	387	PF00069	0.819
MOD_GSK3_1	461	468	PF00069	0.768
MOD_GSK3_1	512	519	PF00069	0.743
MOD_GSK3_1	570	577	PF00069	0.780
MOD_GSK3_1	640	647	PF00069	0.714
MOD_GSK3_1	658	665	PF00069	0.530
MOD_GSK3_1	740	747	PF00069	0.679
MOD_GSK3_1	82	89	PF00069	0.749
MOD_LATS_1	377	383	PF00433	0.860
MOD_LATS_1	398	404	PF00433	0.592
MOD_LATS_1	53	59	PF00433	0.687
MOD_LATS_1	805	811	PF00433	0.721
MOD_N-GLC_1	108	113	PF02516	0.807
MOD_N-GLC_1	135	140	PF02516	0.805
MOD_N-GLC_1	318	323	PF02516	0.550
MOD_N-GLC_1	343	348	PF02516	0.602
MOD_N-GLC_1	74	79	PF02516	0.747
MOD_NEK2_1	104	109	PF00069	0.778
MOD_NEK2_1	171	176	PF00069	0.796
MOD_NEK2_1	2	7	PF00069	0.607
MOD_NEK2_1	227	232	PF00069	0.743
MOD_NEK2_1	245	250	PF00069	0.484
MOD_NEK2_1	279	284	PF00069	0.705
MOD_NEK2_1	314	319	PF00069	0.640
MOD_NEK2_1	37	42	PF00069	0.565
MOD_NEK2_1	414	419	PF00069	0.763
MOD_NEK2_1	535	540	PF00069	0.780
MOD_NEK2_1	666	671	PF00069	0.691
MOD_NEK2_2	740	745	PF00069	0.642
MOD_NEK2_2	774	779	PF00069	0.666
MOD_OFUCOSY	412	418	PF10250	0.685
MOD_PIKK_1	126	132	PF00454	0.712
MOD_PIKK_1	343	349	PF00454	0.602
MOD_PIKK_1	465	471	PF00454	0.727
MOD_PIKK_1	570	576	PF00454	0.599
MOD_PIKK_1	644	650	PF00454	0.705
MOD_PIKK_1	651	657	PF00454	0.710
MOD_PIKK_1	666	672	PF00454	0.655
MOD_PK_1	74	80	PF00069	0.708
MOD_PKA_1	237	243	PF00069	0.584
MOD_PKA_1	312	318	PF00069	0.804
MOD_PKA_1	349	355	PF00069	0.610
MOD_PKA_1	651	657	PF00069	0.603
MOD_PKA_1	68	74	PF00069	0.582
MOD_PKA_2	154	160	PF00069	0.762
MOD_PKA_2	171	177	PF00069	0.608
MOD_PKA_2	236	242	PF00069	0.749
MOD_PKA_2	312	318	PF00069	0.804
MOD_PKA_2	349	355	PF00069	0.614
MOD_PKA_2	385	391	PF00069	0.789
MOD_PKA_2	461	467	PF00069	0.626
MOD_PKA_2	640	646	PF00069	0.768
MOD_PKA_2	651	657	PF00069	0.642
MOD_PKA_2	68	74	PF00069	0.606
MOD_PKA_2	806	812	PF00069	0.712
MOD_PKA_2	86	92	PF00069	0.694
MOD_PKB_1	72	80	PF00069	0.743
MOD_Plk_1	135	141	PF00069	0.771
MOD_Plk_1	172	178	PF00069	0.805
MOD_Plk_1	209	215	PF00069	0.656
MOD_Plk_1	318	324	PF00069	0.595
MOD_Plk_1	709	715	PF00069	0.755
MOD_Plk_1	74	80	PF00069	0.747
MOD_Plk_1	740	746	PF00069	0.634
MOD_Plk_4	136	142	PF00069	0.782
MOD_Plk_4	241	247	PF00069	0.636
MOD_Plk_4	318	324	PF00069	0.776
MOD_Plk_4	74	80	PF00069	0.751
MOD_Plk_4	740	746	PF00069	0.684
MOD_ProDKin_1	201	207	PF00069	0.649
MOD_ProDKin_1	353	359	PF00069	0.831
MOD_ProDKin_1	372	378	PF00069	0.530
MOD_ProDKin_1	468	474	PF00069	0.804
MOD_ProDKin_1	482	488	PF00069	0.573
MOD_ProDKin_1	510	516	PF00069	0.817
MOD_ProDKin_1	681	687	PF00069	0.758
MOD_SUMO_rev_2	187	195	PF00179	0.611
TRG_DiLeu_BaEn_1	306	311	PF01217	0.588
TRG_DiLeu_BaEn_4	405	411	PF01217	0.681
TRG_ENDOCYTIC_2	537	540	PF00928	0.604
TRG_ENDOCYTIC_2	67	70	PF00928	0.796
TRG_ENDOCYTIC_2	728	731	PF00928	0.816
TRG_ENDOCYTIC_2	745	748	PF00928	0.429
TRG_ENDOCYTIC_2	79	82	PF00928	0.654
TRG_ENDOCYTIC_2	821	824	PF00928	0.733
TRG_ER_diArg_1	311	313	PF00400	0.773
TRG_ER_diArg_1	54	56	PF00400	0.728
TRG_ER_diArg_1	639	642	PF00400	0.649
TRG_ER_diArg_1	650	652	PF00400	0.630
TRG_ER_diArg_1	67	69	PF00400	0.581
TRG_NLS_MonoCore_2	749	754	PF00514	0.629
TRG_NLS_MonoCore_2	795	800	PF00514	0.611
TRG_NLS_MonoExtC_3	749	754	PF00514	0.512
TRG_NLS_MonoExtN_4	794	800	PF00514	0.611
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.566
TRG_PTS1	845	848	PF00515	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFN0	Leishmania donovani	82%	100%
A4HJH3	Leishmania braziliensis	47%	100%
A4I6W6	Leishmania infantum	82%	100%
E9B1Z0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%