Putative dihydrouridine synthase (Dus)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrouridine synthase (Dus), putative

Species:

Leishmania major

UniProt:

Q4Q669_LEIMA

TriTrypDb:

LmjF.31.1930 , LMJLV39_310027600 , LMJSD75_310027600

Length:

661

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q669

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q669

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0016491	oxidoreductase activity	2	10
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	10
GO:0017150	tRNA dihydrouridine synthase activity	5	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0050660	flavin adenine dinucleotide binding	4	10
GO:0097159	organic cyclic compound binding	2	10
GO:0106413	dihydrouridine synthase activity	4	10
GO:0140098	catalytic activity, acting on RNA	3	10
GO:0140101	catalytic activity, acting on a tRNA	4	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.491
CLV_C14_Caspase3-7	358	362	PF00656	0.665
CLV_C14_Caspase3-7	76	80	PF00656	0.625
CLV_NRD_NRD_1	296	298	PF00675	0.260
CLV_NRD_NRD_1	32	34	PF00675	0.713
CLV_NRD_NRD_1	421	423	PF00675	0.290
CLV_NRD_NRD_1	58	60	PF00675	0.545
CLV_NRD_NRD_1	624	626	PF00675	0.498
CLV_NRD_NRD_1	88	90	PF00675	0.806
CLV_PCSK_KEX2_1	296	298	PF00082	0.260
CLV_PCSK_KEX2_1	32	34	PF00082	0.713
CLV_PCSK_KEX2_1	421	423	PF00082	0.305
CLV_PCSK_KEX2_1	624	626	PF00082	0.505
CLV_PCSK_KEX2_1	88	90	PF00082	0.806
CLV_PCSK_PC7_1	84	90	PF00082	0.637
CLV_PCSK_SKI1_1	113	117	PF00082	0.292
CLV_PCSK_SKI1_1	22	26	PF00082	0.489
CLV_PCSK_SKI1_1	33	37	PF00082	0.574
CLV_PCSK_SKI1_1	375	379	PF00082	0.494
CLV_PCSK_SKI1_1	405	409	PF00082	0.303
CLV_PCSK_SKI1_1	424	428	PF00082	0.337
DEG_APCC_DBOX_1	532	540	PF00400	0.541
DOC_ANK_TNKS_1	624	631	PF00023	0.534
DOC_CYCLIN_yCln2_LP_2	322	328	PF00134	0.478
DOC_MAPK_gen_1	642	650	PF00069	0.604
DOC_MAPK_MEF2A_6	505	513	PF00069	0.462
DOC_PP2B_LxvP_1	322	325	PF13499	0.478
DOC_PP4_FxxP_1	333	336	PF00568	0.541
DOC_PP4_FxxP_1	470	473	PF00568	0.478
DOC_SPAK_OSR1_1	232	236	PF12202	0.436
DOC_USP7_MATH_1	178	182	PF00917	0.583
DOC_USP7_MATH_1	20	24	PF00917	0.426
DOC_USP7_MATH_1	367	371	PF00917	0.667
DOC_USP7_MATH_1	569	573	PF00917	0.742
DOC_USP7_MATH_1	596	600	PF00917	0.621
DOC_USP7_UBL2_3	547	551	PF12436	0.446
DOC_USP7_UBL2_3	640	644	PF12436	0.657
DOC_WW_Pin1_4	139	144	PF00397	0.460
DOC_WW_Pin1_4	176	181	PF00397	0.717
DOC_WW_Pin1_4	63	68	PF00397	0.531
LIG_14-3-3_CanoR_1	22	27	PF00244	0.450
LIG_14-3-3_CanoR_1	250	259	PF00244	0.552
LIG_14-3-3_CanoR_1	490	498	PF00244	0.541
LIG_14-3-3_CanoR_1	624	629	PF00244	0.567
LIG_Actin_WH2_2	554	570	PF00022	0.524
LIG_BIR_II_1	1	5	PF00653	0.466
LIG_BIR_III_4	425	429	PF00653	0.503
LIG_FHA_1	140	146	PF00498	0.541
LIG_FHA_1	206	212	PF00498	0.545
LIG_FHA_1	315	321	PF00498	0.541
LIG_FHA_1	325	331	PF00498	0.541
LIG_FHA_1	428	434	PF00498	0.537
LIG_FHA_1	494	500	PF00498	0.568
LIG_FHA_1	544	550	PF00498	0.432
LIG_FHA_1	636	642	PF00498	0.485
LIG_FHA_2	367	373	PF00498	0.618
LIG_FHA_2	439	445	PF00498	0.460
LIG_FHA_2	450	456	PF00498	0.460
LIG_FHA_2	74	80	PF00498	0.612
LIG_GBD_Chelix_1	314	322	PF00786	0.351
LIG_Integrin_isoDGR_2	30	32	PF01839	0.553
LIG_LIR_Gen_1	158	166	PF02991	0.537
LIG_LIR_Gen_1	306	315	PF02991	0.460
LIG_LIR_Gen_1	351	362	PF02991	0.496
LIG_LIR_Gen_1	383	393	PF02991	0.336
LIG_LIR_Gen_1	441	449	PF02991	0.460
LIG_LIR_Nem_3	125	131	PF02991	0.460
LIG_LIR_Nem_3	158	163	PF02991	0.537
LIG_LIR_Nem_3	306	311	PF02991	0.465
LIG_LIR_Nem_3	351	357	PF02991	0.567
LIG_LIR_Nem_3	441	445	PF02991	0.460
LIG_LIR_Nem_3	9	14	PF02991	0.408
LIG_PDZ_Class_2	656	661	PF00595	0.667
LIG_Pex14_1	503	507	PF04695	0.541
LIG_Pex14_2	519	523	PF04695	0.503
LIG_SH2_CRK	11	15	PF00017	0.417
LIG_SH2_CRK	61	65	PF00017	0.498
LIG_SH2_NCK_1	61	65	PF00017	0.492
LIG_SH2_SRC	442	445	PF00017	0.541
LIG_SH2_STAP1	386	390	PF00017	0.460
LIG_SH2_STAP1	442	446	PF00017	0.541
LIG_SH2_STAT5	141	144	PF00017	0.478
LIG_SH2_STAT5	28	31	PF00017	0.449
LIG_SH3_2	476	481	PF14604	0.541
LIG_SH3_3	160	166	PF00018	0.629
LIG_SH3_3	208	214	PF00018	0.503
LIG_SH3_3	253	259	PF00018	0.636
LIG_SH3_3	470	476	PF00018	0.478
LIG_SH3_3	61	67	PF00018	0.495
LIG_SUMO_SIM_anti_2	379	386	PF11976	0.439
LIG_SUMO_SIM_par_1	615	621	PF11976	0.419
LIG_TRAF2_1	165	168	PF00917	0.496
LIG_TRAF2_1	356	359	PF00917	0.582
LIG_TRAF2_1	643	646	PF00917	0.643
LIG_WRC_WIRS_1	300	305	PF05994	0.478
MOD_CDK_SPxxK_3	63	70	PF00069	0.500
MOD_CK1_1	471	477	PF00069	0.482
MOD_CK1_1	635	641	PF00069	0.484
MOD_CK2_1	265	271	PF00069	0.694
MOD_CK2_1	366	372	PF00069	0.627
MOD_CK2_1	449	455	PF00069	0.503
MOD_CK2_1	528	534	PF00069	0.503
MOD_CMANNOS	50	53	PF00535	0.387
MOD_Cter_Amidation	30	33	PF01082	0.565
MOD_GlcNHglycan	109	112	PF01048	0.505
MOD_GlcNHglycan	252	255	PF01048	0.764
MOD_GlcNHglycan	47	50	PF01048	0.608
MOD_GlcNHglycan	491	494	PF01048	0.321
MOD_GlcNHglycan	541	544	PF01048	0.381
MOD_GlcNHglycan	571	574	PF01048	0.687
MOD_GlcNHglycan	575	578	PF01048	0.695
MOD_GlcNHglycan	584	590	PF01048	0.610
MOD_GlcNHglycan	600	603	PF01048	0.474
MOD_GlcNHglycan	634	637	PF01048	0.730
MOD_GlcNHglycan	79	83	PF01048	0.710
MOD_GSK3_1	135	142	PF00069	0.473
MOD_GSK3_1	155	162	PF00069	0.497
MOD_GSK3_1	246	253	PF00069	0.627
MOD_GSK3_1	310	317	PF00069	0.545
MOD_GSK3_1	41	48	PF00069	0.643
MOD_GSK3_1	489	496	PF00069	0.515
MOD_GSK3_1	539	546	PF00069	0.485
MOD_GSK3_1	569	576	PF00069	0.691
MOD_GSK3_1	596	603	PF00069	0.542
MOD_GSK3_1	73	80	PF00069	0.644
MOD_NEK2_1	106	111	PF00069	0.558
MOD_NEK2_1	310	315	PF00069	0.531
MOD_NEK2_1	427	432	PF00069	0.477
MOD_NEK2_1	449	454	PF00069	0.460
MOD_NEK2_1	528	533	PF00069	0.546
MOD_NEK2_1	539	544	PF00069	0.533
MOD_NEK2_1	73	78	PF00069	0.561
MOD_NEK2_2	189	194	PF00069	0.654
MOD_PIKK_1	471	477	PF00454	0.537
MOD_PK_1	624	630	PF00069	0.495
MOD_PKA_1	624	630	PF00069	0.495
MOD_PKA_2	489	495	PF00069	0.508
MOD_PKA_2	624	630	PF00069	0.575
MOD_Plk_1	33	39	PF00069	0.602
MOD_Plk_1	350	356	PF00069	0.684
MOD_Plk_1	73	79	PF00069	0.565
MOD_Plk_4	223	229	PF00069	0.337
MOD_Plk_4	299	305	PF00069	0.469
MOD_Plk_4	310	316	PF00069	0.444
MOD_Plk_4	380	386	PF00069	0.459
MOD_ProDKin_1	139	145	PF00069	0.460
MOD_ProDKin_1	176	182	PF00069	0.720
MOD_ProDKin_1	63	69	PF00069	0.526
MOD_SUMO_for_1	643	646	PF00179	0.643
MOD_SUMO_rev_2	162	172	PF00179	0.564
MOD_SUMO_rev_2	461	470	PF00179	0.541
TRG_DiLeu_BaEn_1	306	311	PF01217	0.465
TRG_DiLeu_BaEn_4	534	540	PF01217	0.537
TRG_DiLeu_BaLyEn_6	459	464	PF01217	0.478
TRG_ENDOCYTIC_2	11	14	PF00928	0.391
TRG_ENDOCYTIC_2	141	144	PF00928	0.460
TRG_ENDOCYTIC_2	300	303	PF00928	0.495
TRG_ENDOCYTIC_2	386	389	PF00928	0.460
TRG_ENDOCYTIC_2	442	445	PF00928	0.541
TRG_ENDOCYTIC_2	61	64	PF00928	0.503
TRG_ER_diArg_1	420	422	PF00400	0.490
TRG_ER_diArg_1	87	89	PF00400	0.645
TRG_NES_CRM1_1	309	323	PF08389	0.470
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	129	134	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS31	Leptomonas seymouri	61%	100%
A0A0S4JUA9	Bodo saltans	36%	100%
A0A3Q8ICM1	Leishmania donovani	92%	100%
A4HJH5	Leishmania braziliensis	77%	99%
A4I6W8	Leishmania infantum	92%	100%
C9ZWQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B1Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5D2B4	Trypanosoma cruzi	39%	100%