Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q667_LEIMA

TriTrypDb:

LmjF.31.1950 , LMJLV39_310027800 , LMJSD75_310027800

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q667

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q667

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.482
CLV_NRD_NRD_1	195	197	PF00675	0.519
CLV_NRD_NRD_1	282	284	PF00675	0.564
CLV_NRD_NRD_1	315	317	PF00675	0.559
CLV_NRD_NRD_1	36	38	PF00675	0.533
CLV_NRD_NRD_1	500	502	PF00675	0.595
CLV_PCSK_FUR_1	129	133	PF00082	0.525
CLV_PCSK_FUR_1	313	317	PF00082	0.561
CLV_PCSK_KEX2_1	131	133	PF00082	0.482
CLV_PCSK_KEX2_1	195	197	PF00082	0.519
CLV_PCSK_KEX2_1	281	283	PF00082	0.639
CLV_PCSK_KEX2_1	315	317	PF00082	0.559
CLV_PCSK_KEX2_1	36	38	PF00082	0.559
CLV_PCSK_PC7_1	127	133	PF00082	0.529
CLV_PCSK_PC7_1	32	38	PF00082	0.473
CLV_PCSK_SKI1_1	226	230	PF00082	0.559
DEG_SPOP_SBC_1	467	471	PF00917	0.695
DOC_CKS1_1	259	264	PF01111	0.671
DOC_CYCLIN_yCln2_LP_2	545	551	PF00134	0.806
DOC_MAPK_RevD_3	489	502	PF00069	0.679
DOC_PP2B_LxvP_1	31	34	PF13499	0.674
DOC_PP4_FxxP_1	534	537	PF00568	0.724
DOC_PP4_FxxP_1	549	552	PF00568	0.828
DOC_USP7_MATH_1	16	20	PF00917	0.464
DOC_USP7_MATH_1	222	226	PF00917	0.712
DOC_USP7_MATH_1	233	237	PF00917	0.785
DOC_USP7_MATH_1	248	252	PF00917	0.718
DOC_USP7_MATH_1	292	296	PF00917	0.792
DOC_USP7_MATH_1	71	75	PF00917	0.792
DOC_WW_Pin1_4	110	115	PF00397	0.735
DOC_WW_Pin1_4	180	185	PF00397	0.712
DOC_WW_Pin1_4	199	204	PF00397	0.744
DOC_WW_Pin1_4	244	249	PF00397	0.766
DOC_WW_Pin1_4	258	263	PF00397	0.768
DOC_WW_Pin1_4	283	288	PF00397	0.838
DOC_WW_Pin1_4	294	299	PF00397	0.714
DOC_WW_Pin1_4	356	361	PF00397	0.830
DOC_WW_Pin1_4	376	381	PF00397	0.576
DOC_WW_Pin1_4	394	399	PF00397	0.666
DOC_WW_Pin1_4	450	455	PF00397	0.736
DOC_WW_Pin1_4	468	473	PF00397	0.718
DOC_WW_Pin1_4	496	501	PF00397	0.806
DOC_WW_Pin1_4	532	537	PF00397	0.762
DOC_WW_Pin1_4	544	549	PF00397	0.771
LIG_14-3-3_CanoR_1	195	203	PF00244	0.721
LIG_14-3-3_CanoR_1	206	212	PF00244	0.692
LIG_14-3-3_CanoR_1	385	393	PF00244	0.761
LIG_14-3-3_CanoR_1	447	452	PF00244	0.730
LIG_14-3-3_CanoR_1	540	548	PF00244	0.832
LIG_BIR_II_1	1	5	PF00653	0.465
LIG_BIR_III_4	291	295	PF00653	0.774
LIG_BRCT_BRCA1_1	182	186	PF00533	0.701
LIG_BRCT_BRCA1_1	239	243	PF00533	0.766
LIG_BRCT_BRCA1_1	275	279	PF00533	0.650
LIG_BRCT_BRCA1_1	322	326	PF00533	0.756
LIG_BRCT_BRCA1_1	378	382	PF00533	0.757
LIG_FHA_1	359	365	PF00498	0.781
LIG_FHA_1	376	382	PF00498	0.732
LIG_FHA_2	165	171	PF00498	0.689
LIG_FHA_2	286	292	PF00498	0.791
LIG_FHA_2	320	326	PF00498	0.758
LIG_FHA_2	44	50	PF00498	0.708
LIG_Integrin_RGD_1	65	67	PF01839	0.584
LIG_LIR_Apic_2	532	537	PF02991	0.740
LIG_LIR_Apic_2	547	552	PF02991	0.825
LIG_LIR_Gen_1	25	34	PF02991	0.684
LIG_LIR_Gen_1	323	331	PF02991	0.750
LIG_LIR_Nem_3	151	155	PF02991	0.691
LIG_LIR_Nem_3	25	31	PF02991	0.668
LIG_LIR_Nem_3	323	329	PF02991	0.752
LIG_LIR_Nem_3	439	443	PF02991	0.761
LIG_LIR_Nem_3	462	467	PF02991	0.769
LIG_LYPXL_yS_3	464	467	PF13949	0.768
LIG_REV1ctd_RIR_1	277	286	PF16727	0.773
LIG_SH2_CRK	28	32	PF00017	0.643
LIG_SH2_NCK_1	219	223	PF00017	0.676
LIG_SH2_NCK_1	39	43	PF00017	0.724
LIG_SH2_SRC	39	42	PF00017	0.756
LIG_SH2_STAP1	415	419	PF00017	0.773
LIG_SH3_3	108	114	PF00018	0.737
LIG_SH3_3	242	248	PF00018	0.752
LIG_SH3_3	418	424	PF00018	0.685
LIG_SH3_3	448	454	PF00018	0.780
LIG_SH3_3	488	494	PF00018	0.772
LIG_SH3_3	554	560	PF00018	0.721
LIG_SUMO_SIM_anti_2	2	9	PF11976	0.366
LIG_SUMO_SIM_par_1	13	19	PF11976	0.316
LIG_SUMO_SIM_par_1	164	170	PF11976	0.766
LIG_SUMO_SIM_par_1	2	9	PF11976	0.390
LIG_TRAF2_1	167	170	PF00917	0.687
LIG_TRAF2_1	46	49	PF00917	0.764
LIG_TYR_ITSM	460	467	PF00017	0.661
LIG_WRC_WIRS_1	531	536	PF05994	0.827
MOD_CDC14_SPxK_1	286	289	PF00782	0.842
MOD_CDC14_SPxK_1	499	502	PF00782	0.796
MOD_CDK_SPK_2	496	501	PF00069	0.796
MOD_CDK_SPxK_1	283	289	PF00069	0.841
MOD_CDK_SPxK_1	496	502	PF00069	0.797
MOD_CDK_SPxxK_3	199	206	PF00069	0.763
MOD_CDK_SPxxK_3	356	363	PF00069	0.747
MOD_CK1_1	220	226	PF00069	0.736
MOD_CK1_1	237	243	PF00069	0.727
MOD_CK1_1	268	274	PF00069	0.747
MOD_CK1_1	307	313	PF00069	0.810
MOD_CK1_1	356	362	PF00069	0.830
MOD_CK1_1	392	398	PF00069	0.824
MOD_CK1_1	439	445	PF00069	0.747
MOD_CK1_1	450	456	PF00069	0.739
MOD_CK1_1	471	477	PF00069	0.781
MOD_CK1_1	535	541	PF00069	0.765
MOD_CK1_1	547	553	PF00069	0.753
MOD_CK1_1	562	568	PF00069	0.837
MOD_CK2_1	164	170	PF00069	0.693
MOD_CK2_1	43	49	PF00069	0.747
MOD_CK2_1	475	481	PF00069	0.702
MOD_Cter_Amidation	193	196	PF01082	0.511
MOD_DYRK1A_RPxSP_1	110	114	PF00069	0.718
MOD_DYRK1A_RPxSP_1	244	248	PF00069	0.750
MOD_GlcNHglycan	222	225	PF01048	0.510
MOD_GlcNHglycan	250	253	PF01048	0.565
MOD_GlcNHglycan	270	273	PF01048	0.590
MOD_GlcNHglycan	28	31	PF01048	0.466
MOD_GlcNHglycan	309	312	PF01048	0.587
MOD_GlcNHglycan	447	450	PF01048	0.517
MOD_GlcNHglycan	473	476	PF01048	0.560
MOD_GlcNHglycan	477	480	PF01048	0.560
MOD_GlcNHglycan	49	53	PF01048	0.575
MOD_GlcNHglycan	513	516	PF01048	0.630
MOD_GlcNHglycan	542	545	PF01048	0.609
MOD_GlcNHglycan	561	564	PF01048	0.579
MOD_GlcNHglycan	57	60	PF01048	0.534
MOD_GlcNHglycan	73	76	PF01048	0.595
MOD_GSK3_1	195	202	PF00069	0.736
MOD_GSK3_1	22	29	PF00069	0.582
MOD_GSK3_1	233	240	PF00069	0.801
MOD_GSK3_1	244	251	PF00069	0.687
MOD_GSK3_1	292	299	PF00069	0.791
MOD_GSK3_1	371	378	PF00069	0.794
MOD_GSK3_1	385	392	PF00069	0.679
MOD_GSK3_1	411	418	PF00069	0.702
MOD_GSK3_1	467	474	PF00069	0.782
MOD_GSK3_1	535	542	PF00069	0.744
MOD_GSK3_1	547	554	PF00069	0.753
MOD_GSK3_1	555	562	PF00069	0.790
MOD_N-GLC_1	436	441	PF02516	0.565
MOD_NEK2_1	105	110	PF00069	0.654
MOD_NEK2_1	15	20	PF00069	0.352
MOD_NEK2_1	205	210	PF00069	0.721
MOD_NEK2_1	217	222	PF00069	0.693
MOD_NEK2_1	375	380	PF00069	0.809
MOD_NEK2_1	436	441	PF00069	0.750
MOD_NEK2_1	473	478	PF00069	0.855
MOD_NEK2_1	6	11	PF00069	0.457
MOD_NEK2_2	239	244	PF00069	0.840
MOD_PIKK_1	296	302	PF00454	0.782
MOD_PIKK_1	353	359	PF00454	0.656
MOD_PIKK_1	76	82	PF00454	0.822
MOD_PK_1	447	453	PF00069	0.730
MOD_PKA_1	195	201	PF00069	0.719
MOD_PKA_2	194	200	PF00069	0.718
MOD_PKA_2	205	211	PF00069	0.695
MOD_PKA_2	389	395	PF00069	0.777
MOD_PKA_2	519	525	PF00069	0.675
MOD_PKA_2	539	545	PF00069	0.834
MOD_PKA_2	76	82	PF00069	0.781
MOD_Plk_1	234	240	PF00069	0.830
MOD_Plk_1	327	333	PF00069	0.748
MOD_Plk_1	415	421	PF00069	0.821
MOD_Plk_1	436	442	PF00069	0.820
MOD_Plk_1	48	54	PF00069	0.764
MOD_Plk_2-3	320	326	PF00069	0.758
MOD_Plk_2-3	43	49	PF00069	0.730
MOD_Plk_4	16	22	PF00069	0.421
MOD_Plk_4	207	213	PF00069	0.694
MOD_ProDKin_1	110	116	PF00069	0.733
MOD_ProDKin_1	180	186	PF00069	0.713
MOD_ProDKin_1	199	205	PF00069	0.745
MOD_ProDKin_1	244	250	PF00069	0.765
MOD_ProDKin_1	258	264	PF00069	0.765
MOD_ProDKin_1	283	289	PF00069	0.841
MOD_ProDKin_1	294	300	PF00069	0.713
MOD_ProDKin_1	356	362	PF00069	0.829
MOD_ProDKin_1	376	382	PF00069	0.577
MOD_ProDKin_1	394	400	PF00069	0.665
MOD_ProDKin_1	450	456	PF00069	0.738
MOD_ProDKin_1	468	474	PF00069	0.721
MOD_ProDKin_1	496	502	PF00069	0.807
MOD_ProDKin_1	532	538	PF00069	0.761
MOD_ProDKin_1	544	550	PF00069	0.771
MOD_SUMO_for_1	348	351	PF00179	0.779
TRG_DiLeu_BaEn_4	169	175	PF01217	0.756
TRG_ENDOCYTIC_2	102	105	PF00928	0.750
TRG_ENDOCYTIC_2	28	31	PF00928	0.637
TRG_ENDOCYTIC_2	464	467	PF00928	0.778
TRG_ER_diArg_1	127	130	PF00400	0.696
TRG_ER_diArg_1	135	138	PF00400	0.656
TRG_ER_diArg_1	280	283	PF00400	0.762
TRG_ER_diArg_1	312	315	PF00400	0.841
TRG_ER_diArg_1	36	38	PF00400	0.756
TRG_NLS_MonoExtC_3	282	287	PF00514	0.780
TRG_NLS_MonoExtN_4	281	287	PF00514	0.780

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYM8	Leptomonas seymouri	42%	77%
A0A3S7X4M7	Leishmania donovani	90%	100%
A4HJH7	Leishmania braziliensis	63%	100%
A4I6X0	Leishmania infantum	90%	100%
E9B1Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%