LeishMANIAdb
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Tryparedoxin-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Tryparedoxin-like protein
Gene product:
tryparedoxin 3, putative
Species:
Leishmania major
UniProt:
Q4Q666_LEIMA
TriTrypDb:
LmjF.31.1960 , LMJLV39_310027900 , LMJSD75_310027900
Length:
186

Annotations

LeishMANIAdb annotations

A large family of kinetoplastid-specific oxidoreductases. Only expanded in the Leptomonas genus. Localization: ER (by feature) / Mitochondial outer membrane (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 27
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 22
NetGPI no yes: 0, no: 22
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 3
GO:0032473 cytoplasmic side of mitochondrial outer membrane 4 2
GO:0043226 organelle 2 4
GO:0043227 membrane-bounded organelle 3 4
GO:0043229 intracellular organelle 3 4
GO:0043231 intracellular membrane-bounded organelle 4 4
GO:0098552 side of membrane 2 2
GO:0098562 cytoplasmic side of membrane 3 2
GO:0110165 cellular anatomical entity 1 9
GO:0016020 membrane 2 5
GO:0005739 mitochondrion 5 1
GO:0005829 cytosol 2 1

Expansion

Sequence features

Q4Q666
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q666

PDB structure(s): 3s9f_A

Function

Biological processes
Term Name Level Count
GO:0009892 negative regulation of metabolic process 4 3
GO:0009966 regulation of signal transduction 4 3
GO:0009968 negative regulation of signal transduction 5 3
GO:0010605 negative regulation of macromolecule metabolic process 5 3
GO:0010646 regulation of cell communication 4 3
GO:0010648 negative regulation of cell communication 5 3
GO:0019222 regulation of metabolic process 3 3
GO:0023051 regulation of signaling 3 3
GO:0023057 negative regulation of signaling 4 3
GO:0030111 regulation of Wnt signaling pathway 5 3
GO:0030178 negative regulation of Wnt signaling pathway 6 3
GO:0031396 regulation of protein ubiquitination 8 3
GO:0031397 negative regulation of protein ubiquitination 9 3
GO:0031399 regulation of protein modification process 6 3
GO:0031400 negative regulation of protein modification process 7 3
GO:0048519 negative regulation of biological process 3 3
GO:0048523 negative regulation of cellular process 4 3
GO:0048583 regulation of response to stimulus 3 3
GO:0048585 negative regulation of response to stimulus 4 3
GO:0050789 regulation of biological process 2 3
GO:0050794 regulation of cellular process 3 3
GO:0051171 regulation of nitrogen compound metabolic process 4 3
GO:0051172 negative regulation of nitrogen compound metabolic process 5 3
GO:0051246 regulation of protein metabolic process 5 3
GO:0051248 negative regulation of protein metabolic process 6 3
GO:0060255 regulation of macromolecule metabolic process 4 3
GO:0065007 biological regulation 1 3
GO:0080090 regulation of primary metabolic process 4 3
GO:1903320 regulation of protein modification by small protein conjugation or removal 7 3
GO:1903321 negative regulation of protein modification by small protein conjugation or removal 8 3
GO:0008152 metabolic process 1 2
GO:0009056 catabolic process 2 2
GO:0009987 cellular process 1 2
GO:0042743 hydrogen peroxide metabolic process 4 2
GO:0042744 hydrogen peroxide catabolic process 4 2
GO:0044237 cellular metabolic process 2 2
GO:0044248 cellular catabolic process 3 2
GO:0072593 reactive oxygen species metabolic process 3 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 15
GO:0004791 thioredoxin-disulfide reductase activity 2 15
GO:0015035 protein-disulfide reductase activity 3 15
GO:0015036 disulfide oxidoreductase activity 4 15
GO:0016209 antioxidant activity 1 15
GO:0016491 oxidoreductase activity 2 15
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3 15
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 4 15
GO:0047134 protein-disulfide reductase (NAD(P)) activity 4 15
GO:0140096 catalytic activity, acting on a protein 2 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 125 127 PF00675 0.442
CLV_NRD_NRD_1 165 167 PF00675 0.487
CLV_PCSK_SKI1_1 46 50 PF00082 0.263
DEG_Nend_UBRbox_2 1 3 PF02207 0.546
DOC_CDC14_PxL_1 111 119 PF14671 0.480
DOC_MAPK_DCC_7 110 119 PF00069 0.462
DOC_MAPK_gen_1 110 119 PF00069 0.380
DOC_MAPK_gen_1 166 174 PF00069 0.472
DOC_MAPK_gen_1 62 69 PF00069 0.490
DOC_MAPK_MEF2A_6 110 119 PF00069 0.498
DOC_MAPK_MEF2A_6 166 174 PF00069 0.435
DOC_MAPK_NFAT4_5 167 175 PF00069 0.432
DOC_PP4_FxxP_1 146 149 PF00568 0.419
DOC_USP7_MATH_1 156 160 PF00917 0.458
DOC_WW_Pin1_4 46 51 PF00397 0.472
LIG_BRCT_BRCA1_1 158 162 PF00533 0.329
LIG_Clathr_ClatBox_1 117 121 PF01394 0.487
LIG_FHA_1 114 120 PF00498 0.445
LIG_FHA_1 47 53 PF00498 0.462
LIG_GBD_Chelix_1 170 178 PF00786 0.350
LIG_IRF3_LxIS_1 170 175 PF10401 0.259
LIG_LIR_Apic_2 38 44 PF02991 0.461
LIG_LIR_Apic_2 89 94 PF02991 0.501
LIG_LIR_Gen_1 29 39 PF02991 0.347
LIG_LIR_Nem_3 108 114 PF02991 0.480
LIG_LIR_Nem_3 89 93 PF02991 0.480
LIG_Pex14_1 105 109 PF04695 0.501
LIG_Pex14_2 37 41 PF04695 0.468
LIG_Pex14_2 65 69 PF04695 0.466
LIG_SH2_CRK 179 183 PF00017 0.355
LIG_SH2_CRK 91 95 PF00017 0.490
LIG_SH2_NCK_1 179 183 PF00017 0.265
LIG_SH2_SRC 95 98 PF00017 0.415
LIG_SH2_STAP1 164 168 PF00017 0.354
LIG_SH2_STAT5 164 167 PF00017 0.427
LIG_SH2_STAT5 32 35 PF00017 0.463
LIG_SH2_STAT5 36 39 PF00017 0.459
LIG_SH2_STAT5 82 85 PF00017 0.455
LIG_SH2_STAT5 91 94 PF00017 0.501
LIG_SUMO_SIM_anti_2 9 15 PF11976 0.363
LIG_SUMO_SIM_par_1 115 121 PF11976 0.473
LIG_TRAF2_1 75 78 PF00917 0.398
LIG_TYR_ITIM 177 182 PF00017 0.355
LIG_UBA3_1 11 16 PF00899 0.281
LIG_WRC_WIRS_1 52 57 PF05994 0.444
MOD_CDK_SPxxK_3 46 53 PF00069 0.520
MOD_CK1_1 180 186 PF00069 0.327
MOD_CK1_1 72 78 PF00069 0.541
MOD_CK2_1 51 57 PF00069 0.436
MOD_CK2_1 72 78 PF00069 0.506
MOD_GlcNHglycan 17 21 PF01048 0.430
MOD_GlcNHglycan 37 40 PF01048 0.232
MOD_GlcNHglycan 8 11 PF01048 0.454
MOD_GSK3_1 51 58 PF00069 0.446
MOD_GSK3_1 68 75 PF00069 0.424
MOD_N-GLC_1 6 11 PF02516 0.471
MOD_NEK2_1 162 167 PF00069 0.506
MOD_NEK2_1 172 177 PF00069 0.368
MOD_NEK2_1 35 40 PF00069 0.461
MOD_NEK2_1 51 56 PF00069 0.437
MOD_NEK2_1 6 11 PF00069 0.482
MOD_NEK2_1 83 88 PF00069 0.415
MOD_PKA_2 83 89 PF00069 0.406
MOD_Plk_4 113 119 PF00069 0.478
MOD_Plk_4 156 162 PF00069 0.529
MOD_Plk_4 177 183 PF00069 0.414
MOD_Plk_4 51 57 PF00069 0.447
MOD_Plk_4 78 84 PF00069 0.485
MOD_ProDKin_1 46 52 PF00069 0.472
TRG_ENDOCYTIC_2 179 182 PF00928 0.405
TRG_ENDOCYTIC_2 32 35 PF00928 0.480
TRG_ENDOCYTIC_2 90 93 PF00928 0.488

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HT51 Leptomonas seymouri 60% 100%
A0A0N1HZM3 Leptomonas seymouri 39% 100%
A0A1X0P005 Trypanosomatidae 39% 100%
A0A1X0P190 Trypanosomatidae 38% 94%
A0A3Q8IED6 Leishmania donovani 39% 100%
A0A3Q8IG90 Leishmania donovani 90% 100%
A0A3S7X2H1 Leishmania donovani 37% 100%
A0A422MZX1 Trypanosoma rangeli 39% 96%
A0A6L0XIW2 Leishmania infantum 38% 100%
A0A6L0XKX4 Leishmania infantum 39% 100%
A4HHC6 Leishmania braziliensis 38% 100%
A4HHC7 Leishmania braziliensis 33% 100%
A4HHC8 Leishmania braziliensis 32% 100%
A4HJH8 Leishmania braziliensis 82% 100%
A4I6X1 Leishmania infantum 90% 100%
C9ZKL4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 94%
C9ZL57 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9ADX3 Leishmania major 36% 100%
E9ADX4 Leishmania major 38% 100%
E9ALV7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9ALV8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9B1Z5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 97%
E9B1Z6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
O77404 Trypanosoma brucei brucei 43% 100%
Q4Q665 Leishmania major 44% 100%
Q5VZ03 Homo sapiens 34% 100%
Q9D531 Mus musculus 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS