Tryparedoxin-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tryparedoxin 4, putative

Species:

Leishmania major

UniProt:

Q4Q665_LEIMA

TriTrypDb:

LmjF.31.1970 , LMJLV39_310028100 , LMJSD75_310028100

Length:

180

Annotations

LeishMANIAdb annotations

A large family of kinetoplastid-specific oxidoreductases. Only expanded in the Leptomonas genus. Localization: ER (by feature) / Mitochondial outer membrane (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 27

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0016020	membrane	2	7
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	1
GO:0032473	cytoplasmic side of mitochondrial outer membrane	4	1
GO:0098552	side of membrane	2	1
GO:0098562	cytoplasmic side of membrane	3	1
GO:0005829	cytosol	2	1

Expansion

Sequence features

Q4Q665

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q665

PDB structure(s): 3s9f_A

Function

Biological processes
Term	Name	Level	Count
GO:0009892	negative regulation of metabolic process	4	3
GO:0009966	regulation of signal transduction	4	3
GO:0009968	negative regulation of signal transduction	5	3
GO:0010605	negative regulation of macromolecule metabolic process	5	3
GO:0010646	regulation of cell communication	4	3
GO:0010648	negative regulation of cell communication	5	3
GO:0019222	regulation of metabolic process	3	3
GO:0023051	regulation of signaling	3	3
GO:0023057	negative regulation of signaling	4	3
GO:0030111	regulation of Wnt signaling pathway	5	3
GO:0030178	negative regulation of Wnt signaling pathway	6	3
GO:0031396	regulation of protein ubiquitination	8	3
GO:0031397	negative regulation of protein ubiquitination	9	3
GO:0031399	regulation of protein modification process	6	3
GO:0031400	negative regulation of protein modification process	7	3
GO:0048519	negative regulation of biological process	3	3
GO:0048523	negative regulation of cellular process	4	3
GO:0048583	regulation of response to stimulus	3	3
GO:0048585	negative regulation of response to stimulus	4	3
GO:0050789	regulation of biological process	2	3
GO:0050794	regulation of cellular process	3	3
GO:0051171	regulation of nitrogen compound metabolic process	4	3
GO:0051172	negative regulation of nitrogen compound metabolic process	5	3
GO:0051246	regulation of protein metabolic process	5	3
GO:0051248	negative regulation of protein metabolic process	6	3
GO:0060255	regulation of macromolecule metabolic process	4	3
GO:0065007	biological regulation	1	3
GO:0080090	regulation of primary metabolic process	4	3
GO:1903320	regulation of protein modification by small protein conjugation or removal	7	3
GO:1903321	negative regulation of protein modification by small protein conjugation or removal	8	3
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0042743	hydrogen peroxide metabolic process	4	2
GO:0042744	hydrogen peroxide catabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0072593	reactive oxygen species metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0004791	thioredoxin-disulfide reductase activity	2	17
GO:0015035	protein-disulfide reductase activity	3	17
GO:0015036	disulfide oxidoreductase activity	4	17
GO:0016209	antioxidant activity	1	17
GO:0016491	oxidoreductase activity	2	17
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	17
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	4	17
GO:0047134	protein-disulfide reductase (NAD(P)) activity	4	17
GO:0140096	catalytic activity, acting on a protein	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.492
CLV_NRD_NRD_1	13	15	PF00675	0.442
CLV_NRD_NRD_1	157	159	PF00675	0.324
CLV_PCSK_KEX2_1	124	126	PF00082	0.436
CLV_PCSK_KEX2_1	157	159	PF00082	0.269
CLV_PCSK_SKI1_1	125	129	PF00082	0.496
CLV_PCSK_SKI1_1	29	33	PF00082	0.245
CLV_PCSK_SKI1_1	44	48	PF00082	0.283
CLV_Separin_Metazoa	11	15	PF03568	0.382
DOC_CDC14_PxL_1	109	117	PF14671	0.531
DOC_MAPK_gen_1	162	170	PF00069	0.321
DOC_MAPK_gen_1	28	35	PF00069	0.273
DOC_MAPK_MEF2A_6	162	170	PF00069	0.477
DOC_MAPK_MEF2A_6	28	35	PF00069	0.275
DOC_PP4_FxxP_1	110	113	PF00568	0.360
DOC_USP7_MATH_1	156	160	PF00917	0.506
DOC_USP7_MATH_1	42	46	PF00917	0.420
DOC_WW_Pin1_4	44	49	PF00397	0.459
DOC_WW_Pin1_4	70	75	PF00397	0.463
LIG_14-3-3_CanoR_1	124	134	PF00244	0.357
LIG_14-3-3_CanoR_1	157	161	PF00244	0.459
LIG_14-3-3_CanoR_1	78	88	PF00244	0.360
LIG_BIR_II_1	1	5	PF00653	0.449
LIG_BRCT_BRCA1_1	1	5	PF00533	0.364
LIG_Clathr_ClatBox_1	115	119	PF01394	0.500
LIG_FHA_1	45	51	PF00498	0.474
LIG_GBD_Chelix_1	170	178	PF00786	0.333
LIG_LIR_Apic_2	36	42	PF02991	0.458
LIG_LIR_Gen_1	87	96	PF02991	0.423
LIG_LIR_Nem_3	87	92	PF02991	0.476
LIG_NRBOX	169	175	PF00104	0.259
LIG_PALB2_WD40_1	84	92	PF16756	0.351
LIG_Pex14_2	35	39	PF04695	0.454
LIG_Pex14_2	63	67	PF04695	0.474
LIG_SH2_PTP2	30	33	PF00017	0.377
LIG_SH2_STAT5	30	33	PF00017	0.463
LIG_SH2_STAT5	34	37	PF00017	0.454
LIG_SH2_STAT5	80	83	PF00017	0.473
LIG_SUMO_SIM_anti_2	114	119	PF11976	0.369
LIG_SUMO_SIM_par_1	114	119	PF11976	0.421
MOD_CDK_SPK_2	44	49	PF00069	0.420
MOD_CDK_SPxxK_3	44	51	PF00069	0.531
MOD_CK1_1	111	117	PF00069	0.457
MOD_CK1_1	69	75	PF00069	0.518
MOD_CK2_1	70	76	PF00069	0.469
MOD_Cter_Amidation	26	29	PF01082	0.360
MOD_DYRK1A_RPxSP_1	44	48	PF00069	0.455
MOD_GlcNHglycan	35	38	PF01048	0.261
MOD_GSK3_1	66	73	PF00069	0.461
MOD_PKA_2	156	162	PF00069	0.268
MOD_Plk_4	111	117	PF00069	0.473
MOD_ProDKin_1	44	50	PF00069	0.459
MOD_ProDKin_1	70	76	PF00069	0.463
TRG_ENDOCYTIC_2	30	33	PF00928	0.531
TRG_ER_diArg_1	124	126	PF00400	0.397
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.180

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT51	Leptomonas seymouri	47%	98%
A0A0N1HZM3	Leptomonas seymouri	39%	100%
A0A0N1I697	Leptomonas seymouri	38%	100%
A0A1X0P005	Trypanosomatidae	41%	100%
A0A1X0P190	Trypanosomatidae	35%	91%
A0A3Q8IED6	Leishmania donovani	38%	100%
A0A3Q8IG90	Leishmania donovani	42%	97%
A0A3S7X2H1	Leishmania donovani	37%	100%
A0A422MZX1	Trypanosoma rangeli	36%	93%
A0A6L0XIW2	Leishmania infantum	37%	100%
A0A6L0XKX4	Leishmania infantum	38%	100%
A4HHC6	Leishmania braziliensis	37%	100%
A4HHC7	Leishmania braziliensis	35%	100%
A4HHC8	Leishmania braziliensis	33%	100%
A4HJH8	Leishmania braziliensis	45%	97%
A4I6X1	Leishmania infantum	42%	97%
B6DTG3	Bodo saltans	41%	100%
B6DTG4	Bodo saltans	37%	100%
C9ZKL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	91%
C9ZL57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ADX3	Leishmania major	36%	100%
E9ADX4	Leishmania major	40%	100%
E9ALV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9ALV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B1Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	94%
E9B1Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O77404	Trypanosoma brucei brucei	40%	100%
Q4Q666	Leishmania major	44%	97%
Q5VZ03	Homo sapiens	34%	100%
Q8VC33	Mus musculus	27%	83%
Q96CM4	Homo sapiens	28%	85%
Q9D531	Mus musculus	36%	100%