Tubercidin resistance protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubercidin resistance protein

Species:

Leishmania major

UniProt:

Q4Q661_LEIMA

TriTrypDb:

LmjF.31.2010 , LMJLV39_310028800 , LMJSD75_310028900

Length:

606

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	6
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q661

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q661

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.680
CLV_C14_Caspase3-7	354	358	PF00656	0.681
CLV_C14_Caspase3-7	396	400	PF00656	0.677
CLV_C14_Caspase3-7	412	416	PF00656	0.709
CLV_NRD_NRD_1	149	151	PF00675	0.477
CLV_NRD_NRD_1	277	279	PF00675	0.520
CLV_NRD_NRD_1	476	478	PF00675	0.535
CLV_PCSK_KEX2_1	148	150	PF00082	0.476
CLV_PCSK_KEX2_1	476	478	PF00082	0.535
CLV_PCSK_SKI1_1	12	16	PF00082	0.519
CLV_PCSK_SKI1_1	279	283	PF00082	0.459
CLV_PCSK_SKI1_1	481	485	PF00082	0.550
DEG_Nend_UBRbox_2	1	3	PF02207	0.703
DEG_SPOP_SBC_1	308	312	PF00917	0.746
DEG_SPOP_SBC_1	81	85	PF00917	0.701
DOC_CKS1_1	144	149	PF01111	0.749
DOC_CKS1_1	540	545	PF01111	0.741
DOC_MAPK_MEF2A_6	432	441	PF00069	0.660
DOC_PP4_FxxP_1	575	578	PF00568	0.689
DOC_USP7_MATH_1	108	112	PF00917	0.676
DOC_USP7_MATH_1	187	191	PF00917	0.680
DOC_USP7_MATH_1	281	285	PF00917	0.721
DOC_USP7_MATH_1	307	311	PF00917	0.743
DOC_USP7_MATH_1	318	322	PF00917	0.649
DOC_USP7_MATH_1	367	371	PF00917	0.744
DOC_USP7_MATH_1	589	593	PF00917	0.369
DOC_USP7_MATH_1	80	84	PF00917	0.728
DOC_WW_Pin1_4	134	139	PF00397	0.802
DOC_WW_Pin1_4	143	148	PF00397	0.770
DOC_WW_Pin1_4	216	221	PF00397	0.760
DOC_WW_Pin1_4	29	34	PF00397	0.720
DOC_WW_Pin1_4	303	308	PF00397	0.731
DOC_WW_Pin1_4	310	315	PF00397	0.709
DOC_WW_Pin1_4	371	376	PF00397	0.744
DOC_WW_Pin1_4	433	438	PF00397	0.703
DOC_WW_Pin1_4	460	465	PF00397	0.737
DOC_WW_Pin1_4	494	499	PF00397	0.703
DOC_WW_Pin1_4	539	544	PF00397	0.745
LIG_14-3-3_CanoR_1	143	147	PF00244	0.728
LIG_14-3-3_CanoR_1	234	244	PF00244	0.703
LIG_14-3-3_CanoR_1	476	480	PF00244	0.675
LIG_deltaCOP1_diTrp_1	232	240	PF00928	0.695
LIG_DLG_GKlike_1	534	542	PF00625	0.702
LIG_FHA_1	314	320	PF00498	0.825
LIG_FHA_1	329	335	PF00498	0.822
LIG_FHA_1	351	357	PF00498	0.715
LIG_FHA_1	406	412	PF00498	0.768
LIG_FHA_1	436	442	PF00498	0.653
LIG_FHA_1	488	494	PF00498	0.657
LIG_FHA_2	318	324	PF00498	0.853
LIG_FHA_2	410	416	PF00498	0.740
LIG_LIR_Gen_1	93	103	PF02991	0.671
LIG_LIR_Nem_3	569	575	PF02991	0.695
LIG_LIR_Nem_3	93	98	PF02991	0.697
LIG_NRBOX	226	232	PF00104	0.694
LIG_PTAP_UEV_1	485	490	PF05743	0.633
LIG_REV1ctd_RIR_1	357	366	PF16727	0.733
LIG_SH2_CRK	95	99	PF00017	0.701
LIG_SH2_STAP1	465	469	PF00017	0.679
LIG_SH3_3	18	24	PF00018	0.694
LIG_SH3_3	27	33	PF00018	0.650
LIG_SH3_3	369	375	PF00018	0.746
LIG_SH3_3	483	489	PF00018	0.648
LIG_SH3_3	540	546	PF00018	0.738
LIG_SUMO_SIM_anti_2	592	598	PF11976	0.289
LIG_SUMO_SIM_par_1	330	335	PF11976	0.697
LIG_SUMO_SIM_par_1	436	442	PF11976	0.653
LIG_TRAF2_1	567	570	PF00917	0.666
MOD_CDK_SPK_2	143	148	PF00069	0.720
MOD_CDK_SPK_2	539	544	PF00069	0.745
MOD_CDK_SPxK_1	143	149	PF00069	0.678
MOD_CDK_SPxxK_3	143	150	PF00069	0.720
MOD_CK1_1	10	16	PF00069	0.721
MOD_CK1_1	111	117	PF00069	0.645
MOD_CK1_1	155	161	PF00069	0.718
MOD_CK1_1	206	212	PF00069	0.711
MOD_CK1_1	243	249	PF00069	0.678
MOD_CK1_1	284	290	PF00069	0.707
MOD_CK1_1	310	316	PF00069	0.756
MOD_CK1_1	321	327	PF00069	0.753
MOD_CK1_1	365	371	PF00069	0.726
MOD_CK1_1	463	469	PF00069	0.731
MOD_CK1_1	487	493	PF00069	0.681
MOD_CK1_1	518	524	PF00069	0.727
MOD_CK1_1	539	545	PF00069	0.714
MOD_CK1_1	55	61	PF00069	0.737
MOD_CK1_1	85	91	PF00069	0.710
MOD_CK2_1	288	294	PF00069	0.686
MOD_CK2_1	317	323	PF00069	0.854
MOD_CK2_1	348	354	PF00069	0.776
MOD_CK2_1	44	50	PF00069	0.709
MOD_CK2_1	98	104	PF00069	0.684
MOD_GlcNHglycan	12	15	PF01048	0.484
MOD_GlcNHglycan	123	126	PF01048	0.566
MOD_GlcNHglycan	138	141	PF01048	0.516
MOD_GlcNHglycan	154	157	PF01048	0.460
MOD_GlcNHglycan	18	21	PF01048	0.454
MOD_GlcNHglycan	180	183	PF01048	0.542
MOD_GlcNHglycan	206	209	PF01048	0.502
MOD_GlcNHglycan	237	240	PF01048	0.496
MOD_GlcNHglycan	320	323	PF01048	0.559
MOD_GlcNHglycan	346	349	PF01048	0.529
MOD_GlcNHglycan	365	368	PF01048	0.429
MOD_GlcNHglycan	387	390	PF01048	0.457
MOD_GlcNHglycan	427	430	PF01048	0.544
MOD_GlcNHglycan	467	470	PF01048	0.471
MOD_GlcNHglycan	481	484	PF01048	0.482
MOD_GlcNHglycan	486	489	PF01048	0.452
MOD_GlcNHglycan	515	518	PF01048	0.495
MOD_GlcNHglycan	524	527	PF01048	0.460
MOD_GlcNHglycan	57	60	PF01048	0.521
MOD_GlcNHglycan	591	594	PF01048	0.369
MOD_GlcNHglycan	7	10	PF01048	0.488
MOD_GSK3_1	12	19	PF00069	0.698
MOD_GSK3_1	284	291	PF00069	0.700
MOD_GSK3_1	303	310	PF00069	0.820
MOD_GSK3_1	313	320	PF00069	0.712
MOD_GSK3_1	328	335	PF00069	0.731
MOD_GSK3_1	340	347	PF00069	0.803
MOD_GSK3_1	358	365	PF00069	0.622
MOD_GSK3_1	367	374	PF00069	0.708
MOD_GSK3_1	381	388	PF00069	0.744
MOD_GSK3_1	405	412	PF00069	0.768
MOD_GSK3_1	433	440	PF00069	0.726
MOD_GSK3_1	44	51	PF00069	0.662
MOD_GSK3_1	455	462	PF00069	0.677
MOD_GSK3_1	475	482	PF00069	0.647
MOD_GSK3_1	515	522	PF00069	0.711
MOD_GSK3_1	530	537	PF00069	0.670
MOD_GSK3_1	81	88	PF00069	0.723
MOD_GSK3_1	90	97	PF00069	0.640
MOD_LATS_1	532	538	PF00433	0.700
MOD_N-GLC_1	255	260	PF02516	0.476
MOD_N-GLC_1	456	461	PF02516	0.483
MOD_N-GLC_1	518	523	PF02516	0.503
MOD_N-GLC_1	65	70	PF02516	0.513
MOD_NEK2_1	142	147	PF00069	0.680
MOD_NEK2_1	439	444	PF00069	0.705
MOD_NEK2_1	44	49	PF00069	0.707
MOD_NEK2_1	493	498	PF00069	0.789
MOD_NEK2_1	94	99	PF00069	0.700
MOD_PIKK_1	119	125	PF00454	0.648
MOD_PIKK_1	155	161	PF00454	0.676
MOD_PIKK_1	172	178	PF00454	0.630
MOD_PIKK_1	206	212	PF00454	0.730
MOD_PIKK_1	243	249	PF00454	0.644
MOD_PIKK_1	284	290	PF00454	0.735
MOD_PIKK_1	348	354	PF00454	0.751
MOD_PIKK_1	382	388	PF00454	0.714
MOD_PIKK_1	400	406	PF00454	0.716
MOD_PIKK_1	52	58	PF00454	0.706
MOD_PIKK_1	536	542	PF00454	0.723
MOD_PKA_2	142	148	PF00069	0.729
MOD_PKA_2	475	481	PF00069	0.695
MOD_PKB_1	420	428	PF00069	0.664
MOD_Plk_1	255	261	PF00069	0.719
MOD_Plk_1	518	524	PF00069	0.715
MOD_Plk_1	534	540	PF00069	0.672
MOD_Plk_1	90	96	PF00069	0.695
MOD_Plk_4	187	193	PF00069	0.641
MOD_Plk_4	409	415	PF00069	0.712
MOD_Plk_4	82	88	PF00069	0.722
MOD_Plk_4	90	96	PF00069	0.645
MOD_ProDKin_1	134	140	PF00069	0.802
MOD_ProDKin_1	143	149	PF00069	0.770
MOD_ProDKin_1	216	222	PF00069	0.756
MOD_ProDKin_1	29	35	PF00069	0.720
MOD_ProDKin_1	303	309	PF00069	0.733
MOD_ProDKin_1	310	316	PF00069	0.710
MOD_ProDKin_1	371	377	PF00069	0.745
MOD_ProDKin_1	433	439	PF00069	0.702
MOD_ProDKin_1	460	466	PF00069	0.738
MOD_ProDKin_1	494	500	PF00069	0.701
MOD_ProDKin_1	539	545	PF00069	0.743
MOD_SUMO_rev_2	565	573	PF00179	0.612
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.714
TRG_ENDOCYTIC_2	572	575	PF00928	0.694
TRG_ENDOCYTIC_2	95	98	PF00928	0.700
TRG_ER_diArg_1	147	150	PF00400	0.688
TRG_ER_diArg_1	549	552	PF00400	0.652
TRG_Pf-PMV_PEXEL_1	118	123	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	561	565	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4Q2	Leishmania donovani	89%	100%
A4HJI3	Leishmania braziliensis	54%	99%
A4I732	Leishmania infantum	89%	85%
E9B200	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%