Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q658_LEIMA

TriTrypDb:

LmjF.31.2040 , LMJLV39_310029000 , LMJSD75_310029000

Length:

500

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q658

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q658

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.596
CLV_C14_Caspase3-7	311	315	PF00656	0.658
CLV_MEL_PAP_1	7	13	PF00089	0.567
CLV_NRD_NRD_1	106	108	PF00675	0.647
CLV_NRD_NRD_1	301	303	PF00675	0.700
CLV_NRD_NRD_1	41	43	PF00675	0.588
CLV_NRD_NRD_1	472	474	PF00675	0.644
CLV_PCSK_KEX2_1	106	108	PF00082	0.647
CLV_PCSK_KEX2_1	301	303	PF00082	0.700
CLV_PCSK_KEX2_1	41	43	PF00082	0.588
CLV_PCSK_KEX2_1	472	474	PF00082	0.644
CLV_PCSK_PC7_1	468	474	PF00082	0.646
CLV_PCSK_SKI1_1	335	339	PF00082	0.673
CLV_PCSK_SKI1_1	369	373	PF00082	0.642
CLV_PCSK_SKI1_1	375	379	PF00082	0.590
CLV_PCSK_SKI1_1	42	46	PF00082	0.592
DEG_SPOP_SBC_1	203	207	PF00917	0.679
DOC_CKS1_1	137	142	PF01111	0.579
DOC_CKS1_1	354	359	PF01111	0.640
DOC_CKS1_1	416	421	PF01111	0.604
DOC_CYCLIN_RxL_1	42	55	PF00134	0.635
DOC_CYCLIN_yCln2_LP_2	3	9	PF00134	0.620
DOC_MAPK_gen_1	290	300	PF00069	0.610
DOC_MAPK_gen_1	318	328	PF00069	0.666
DOC_MAPK_gen_1	335	345	PF00069	0.566
DOC_PP1_RVXF_1	367	373	PF00149	0.642
DOC_PP2B_LxvP_1	3	6	PF13499	0.621
DOC_PP2B_LxvP_1	343	346	PF13499	0.700
DOC_PP2B_LxvP_1	50	53	PF13499	0.649
DOC_PP2B_LxvP_1	67	70	PF13499	0.511
DOC_USP7_MATH_1	124	128	PF00917	0.581
DOC_USP7_MATH_1	181	185	PF00917	0.639
DOC_USP7_MATH_1	198	202	PF00917	0.696
DOC_USP7_MATH_1	304	308	PF00917	0.658
DOC_USP7_MATH_1	336	340	PF00917	0.649
DOC_USP7_MATH_1	403	407	PF00917	0.723
DOC_USP7_MATH_1	408	412	PF00917	0.667
DOC_USP7_MATH_1	446	450	PF00917	0.671
DOC_USP7_MATH_2	419	425	PF00917	0.596
DOC_WW_Pin1_4	136	141	PF00397	0.577
DOC_WW_Pin1_4	159	164	PF00397	0.674
DOC_WW_Pin1_4	270	275	PF00397	0.574
DOC_WW_Pin1_4	300	305	PF00397	0.671
DOC_WW_Pin1_4	353	358	PF00397	0.646
DOC_WW_Pin1_4	404	409	PF00397	0.622
DOC_WW_Pin1_4	415	420	PF00397	0.575
LIG_14-3-3_CanoR_1	170	180	PF00244	0.662
LIG_14-3-3_CanoR_1	236	244	PF00244	0.556
LIG_14-3-3_CanoR_1	293	298	PF00244	0.680
LIG_14-3-3_CanoR_1	330	337	PF00244	0.585
LIG_14-3-3_CanoR_1	369	377	PF00244	0.657
LIG_Actin_WH2_2	325	340	PF00022	0.691
LIG_AP2alpha_1	372	376	PF02296	0.649
LIG_APCC_ABBA_1	77	82	PF00400	0.556
LIG_BRCT_BRCA1_1	198	202	PF00533	0.644
LIG_BRCT_BRCA1_1	486	490	PF00533	0.600
LIG_BRCT_BRCA1_2	486	492	PF00533	0.604
LIG_deltaCOP1_diTrp_1	421	425	PF00928	0.524
LIG_FHA_1	203	209	PF00498	0.650
LIG_FHA_1	246	252	PF00498	0.672
LIG_FHA_1	271	277	PF00498	0.696
LIG_FHA_1	327	333	PF00498	0.645
LIG_FHA_1	411	417	PF00498	0.636
LIG_FHA_1	62	68	PF00498	0.798
LIG_FHA_2	205	211	PF00498	0.736
LIG_FHA_2	218	224	PF00498	0.681
LIG_FHA_2	263	269	PF00498	0.681
LIG_FHA_2	416	422	PF00498	0.677
LIG_FHA_2	450	456	PF00498	0.637
LIG_KLC1_Yacidic_2	218	223	PF13176	0.597
LIG_LIR_Gen_1	114	122	PF02991	0.630
LIG_LIR_Gen_1	291	300	PF02991	0.635
LIG_LIR_Gen_1	420	431	PF02991	0.597
LIG_LIR_Nem_3	114	118	PF02991	0.636
LIG_LIR_Nem_3	291	297	PF02991	0.672
LIG_LIR_Nem_3	390	395	PF02991	0.632
LIG_LIR_Nem_3	420	426	PF02991	0.607
LIG_LIR_Nem_3	487	493	PF02991	0.587
LIG_LIR_Nem_3	83	89	PF02991	0.619
LIG_PDZ_Class_1	495	500	PF00595	0.614
LIG_Pex14_2	372	376	PF04695	0.770
LIG_SH2_CRK	4	8	PF00017	0.572
LIG_SH2_SRC	221	224	PF00017	0.818
LIG_SH2_STAP1	115	119	PF00017	0.658
LIG_SH2_STAT5	221	224	PF00017	0.818
LIG_SH2_STAT5	417	420	PF00017	0.628
LIG_SH2_STAT5	437	440	PF00017	0.473
LIG_SH2_STAT5	485	488	PF00017	0.654
LIG_SH3_3	118	124	PF00018	0.602
LIG_SH3_3	131	137	PF00018	0.706
LIG_SH3_3	219	225	PF00018	0.689
LIG_SH3_3	248	254	PF00018	0.685
LIG_SH3_3	50	56	PF00018	0.637
LIG_SH3_3	82	88	PF00018	0.676
LIG_SUMO_SIM_par_1	223	231	PF11976	0.623
LIG_SUMO_SIM_par_1	411	418	PF11976	0.611
LIG_Vh1_VBS_1	445	463	PF01044	0.621
LIG_WRC_WIRS_1	297	302	PF05994	0.625
MOD_CDK_SPK_2	159	164	PF00069	0.650
MOD_CK1_1	151	157	PF00069	0.630
MOD_CK1_1	158	164	PF00069	0.587
MOD_CK1_1	206	212	PF00069	0.777
MOD_CK1_1	279	285	PF00069	0.646
MOD_CK1_1	288	294	PF00069	0.583
MOD_CK1_1	296	302	PF00069	0.563
MOD_CK1_1	305	311	PF00069	0.565
MOD_CK1_1	341	347	PF00069	0.646
MOD_CK1_1	348	354	PF00069	0.616
MOD_CK1_1	398	404	PF00069	0.721
MOD_CK1_1	449	455	PF00069	0.645
MOD_CK2_1	125	131	PF00069	0.761
MOD_CK2_1	151	157	PF00069	0.610
MOD_CK2_1	204	210	PF00069	0.650
MOD_CK2_1	235	241	PF00069	0.553
MOD_CK2_1	262	268	PF00069	0.586
MOD_CK2_1	336	342	PF00069	0.652
MOD_CK2_1	415	421	PF00069	0.678
MOD_CK2_1	449	455	PF00069	0.743
MOD_GlcNHglycan	157	160	PF01048	0.664
MOD_GlcNHglycan	198	201	PF01048	0.679
MOD_GlcNHglycan	214	217	PF01048	0.715
MOD_GlcNHglycan	238	241	PF01048	0.723
MOD_GlcNHglycan	278	281	PF01048	0.711
MOD_GlcNHglycan	304	307	PF01048	0.653
MOD_GlcNHglycan	314	317	PF01048	0.595
MOD_GlcNHglycan	347	350	PF01048	0.697
MOD_GlcNHglycan	351	354	PF01048	0.668
MOD_GlcNHglycan	389	392	PF01048	0.679
MOD_GlcNHglycan	397	400	PF01048	0.559
MOD_GlcNHglycan	487	490	PF01048	0.594
MOD_GlcNHglycan	61	64	PF01048	0.541
MOD_GSK3_1	125	132	PF00069	0.609
MOD_GSK3_1	151	158	PF00069	0.688
MOD_GSK3_1	166	173	PF00069	0.585
MOD_GSK3_1	198	205	PF00069	0.756
MOD_GSK3_1	227	234	PF00069	0.705
MOD_GSK3_1	281	288	PF00069	0.701
MOD_GSK3_1	289	296	PF00069	0.623
MOD_GSK3_1	300	307	PF00069	0.525
MOD_GSK3_1	308	315	PF00069	0.534
MOD_GSK3_1	324	331	PF00069	0.567
MOD_GSK3_1	337	344	PF00069	0.562
MOD_GSK3_1	345	352	PF00069	0.610
MOD_GSK3_1	380	387	PF00069	0.626
MOD_GSK3_1	395	402	PF00069	0.584
MOD_GSK3_1	404	411	PF00069	0.639
MOD_GSK3_1	417	424	PF00069	0.493
MOD_GSK3_1	480	487	PF00069	0.593
MOD_GSK3_1	491	498	PF00069	0.522
MOD_N-GLC_1	124	129	PF02516	0.584
MOD_N-GLC_1	203	208	PF02516	0.701
MOD_N-GLC_1	80	85	PF02516	0.669
MOD_NEK2_1	129	134	PF00069	0.634
MOD_NEK2_1	202	207	PF00069	0.707
MOD_NEK2_1	217	222	PF00069	0.538
MOD_NEK2_1	235	240	PF00069	0.505
MOD_NEK2_1	244	249	PF00069	0.531
MOD_NEK2_1	285	290	PF00069	0.555
MOD_NEK2_1	326	331	PF00069	0.696
MOD_NEK2_1	479	484	PF00069	0.635
MOD_NEK2_1	59	64	PF00069	0.537
MOD_PIKK_1	151	157	PF00454	0.673
MOD_PIKK_1	330	336	PF00454	0.621
MOD_PIKK_1	408	414	PF00454	0.633
MOD_PKA_2	235	241	PF00069	0.591
MOD_PKA_2	259	265	PF00069	0.704
MOD_PKA_2	289	295	PF00069	0.632
MOD_PKA_2	467	473	PF00069	0.671
MOD_PKA_2	9	15	PF00069	0.580
MOD_PKB_1	168	176	PF00069	0.553
MOD_Plk_1	113	119	PF00069	0.658
MOD_Plk_1	181	187	PF00069	0.642
MOD_Plk_1	203	209	PF00069	0.665
MOD_Plk_1	217	223	PF00069	0.585
MOD_Plk_1	341	347	PF00069	0.628
MOD_Plk_4	113	119	PF00069	0.656
MOD_Plk_4	125	131	PF00069	0.737
MOD_Plk_4	198	204	PF00069	0.719
MOD_Plk_4	217	223	PF00069	0.712
MOD_Plk_4	293	299	PF00069	0.613
MOD_Plk_4	384	390	PF00069	0.617
MOD_ProDKin_1	136	142	PF00069	0.579
MOD_ProDKin_1	159	165	PF00069	0.675
MOD_ProDKin_1	270	276	PF00069	0.574
MOD_ProDKin_1	300	306	PF00069	0.672
MOD_ProDKin_1	353	359	PF00069	0.640
MOD_ProDKin_1	404	410	PF00069	0.622
MOD_ProDKin_1	415	421	PF00069	0.575
TRG_DiLeu_BaEn_2	420	426	PF01217	0.528
TRG_ENDOCYTIC_2	115	118	PF00928	0.728
TRG_ENDOCYTIC_2	4	7	PF00928	0.622
TRG_ER_diArg_1	167	170	PF00400	0.557
TRG_ER_diArg_1	18	21	PF00400	0.541
TRG_ER_diArg_1	23	26	PF00400	0.524
TRG_ER_diArg_1	300	302	PF00400	0.663
TRG_ER_diArg_1	471	473	PF00400	0.657
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4R8	Leishmania donovani	90%	100%
A4HJI6	Leishmania braziliensis	63%	100%
A4I6Y1	Leishmania infantum	90%	100%
E9B203	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%