CRAL-TRIO domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q657_LEIMA

TriTrypDb:

LmjF.31.2050 , LMJLV39_310029100 , LMJSD75_310029100

Length:

517

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 39
NetGPI	no	yes: 0, no: 39

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q657

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q657

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.517
CLV_NRD_NRD_1	144	146	PF00675	0.495
CLV_NRD_NRD_1	322	324	PF00675	0.291
CLV_NRD_NRD_1	342	344	PF00675	0.412
CLV_NRD_NRD_1	376	378	PF00675	0.484
CLV_NRD_NRD_1	487	489	PF00675	0.392
CLV_NRD_NRD_1	75	77	PF00675	0.543
CLV_PCSK_FUR_1	374	378	PF00082	0.471
CLV_PCSK_KEX2_1	264	266	PF00082	0.326
CLV_PCSK_KEX2_1	376	378	PF00082	0.481
CLV_PCSK_KEX2_1	487	489	PF00082	0.442
CLV_PCSK_KEX2_1	494	496	PF00082	0.367
CLV_PCSK_KEX2_1	75	77	PF00082	0.555
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.170
CLV_PCSK_PC1ET2_1	494	496	PF00082	0.461
CLV_PCSK_SKI1_1	174	178	PF00082	0.337
CLV_PCSK_SKI1_1	191	195	PF00082	0.294
CLV_PCSK_SKI1_1	236	240	PF00082	0.436
CLV_PCSK_SKI1_1	264	268	PF00082	0.360
CLV_PCSK_SKI1_1	284	288	PF00082	0.334
CLV_PCSK_SKI1_1	307	311	PF00082	0.384
CLV_PCSK_SKI1_1	314	318	PF00082	0.378
CLV_Separin_Metazoa	188	192	PF03568	0.226
DEG_APCC_DBOX_1	264	272	PF00400	0.360
DOC_CYCLIN_yCln2_LP_2	54	57	PF00134	0.553
DOC_MAPK_gen_1	171	181	PF00069	0.340
DOC_MAPK_gen_1	29	36	PF00069	0.445
DOC_MAPK_HePTP_8	266	278	PF00069	0.467
DOC_MAPK_MEF2A_6	269	278	PF00069	0.415
DOC_PP1_RVXF_1	321	328	PF00149	0.318
DOC_PP2B_LxvP_1	54	57	PF13499	0.348
DOC_PP4_FxxP_1	327	330	PF00568	0.358
DOC_PP4_FxxP_1	435	438	PF00568	0.391
DOC_USP7_MATH_1	237	241	PF00917	0.414
DOC_USP7_MATH_1	466	470	PF00917	0.499
DOC_USP7_MATH_1	74	78	PF00917	0.657
DOC_USP7_UBL2_3	269	273	PF12436	0.480
DOC_WW_Pin1_4	140	145	PF00397	0.332
DOC_WW_Pin1_4	299	304	PF00397	0.270
DOC_WW_Pin1_4	326	331	PF00397	0.368
LIG_14-3-3_CanoR_1	129	136	PF00244	0.403
LIG_14-3-3_CanoR_1	265	269	PF00244	0.375
LIG_14-3-3_CanoR_1	323	328	PF00244	0.278
LIG_14-3-3_CanoR_1	374	380	PF00244	0.623
LIG_14-3-3_CanoR_1	75	82	PF00244	0.508
LIG_APCC_ABBA_1	276	281	PF00400	0.366
LIG_BIR_II_1	1	5	PF00653	0.731
LIG_BRCT_BRCA1_1	282	286	PF00533	0.186
LIG_BRCT_BRCA1_1	468	472	PF00533	0.589
LIG_BRCT_BRCA1_1	9	13	PF00533	0.449
LIG_deltaCOP1_diTrp_1	94	101	PF00928	0.489
LIG_eIF4E_1	85	91	PF01652	0.455
LIG_FHA_1	131	137	PF00498	0.381
LIG_FHA_1	17	23	PF00498	0.589
LIG_FHA_1	216	222	PF00498	0.389
LIG_FHA_1	392	398	PF00498	0.404
LIG_FHA_1	432	438	PF00498	0.375
LIG_FHA_1	85	91	PF00498	0.434
LIG_FHA_2	1	7	PF00498	0.658
LIG_FHA_2	240	246	PF00498	0.386
LIG_FHA_2	337	343	PF00498	0.386
LIG_FHA_2	446	452	PF00498	0.342
LIG_Integrin_isoDGR_2	172	174	PF01839	0.194
LIG_LIR_Apic_2	326	330	PF02991	0.372
LIG_LIR_Apic_2	433	438	PF02991	0.428
LIG_LIR_Gen_1	205	215	PF02991	0.413
LIG_LIR_Gen_1	394	401	PF02991	0.424
LIG_LIR_Gen_1	429	438	PF02991	0.435
LIG_LIR_Gen_1	49	57	PF02991	0.338
LIG_LIR_Nem_3	283	289	PF02991	0.385
LIG_LIR_Nem_3	39	44	PF02991	0.495
LIG_LIR_Nem_3	394	399	PF02991	0.418
LIG_LIR_Nem_3	429	435	PF02991	0.391
LIG_LIR_Nem_3	49	54	PF02991	0.552
LIG_Pex14_2	122	126	PF04695	0.344
LIG_Pex14_2	432	436	PF04695	0.335
LIG_SH2_CRK	110	114	PF00017	0.428
LIG_SH2_CRK	224	228	PF00017	0.338
LIG_SH2_CRK	308	312	PF00017	0.366
LIG_SH2_CRK	41	45	PF00017	0.503
LIG_SH2_PTP2	396	399	PF00017	0.496
LIG_SH2_SRC	345	348	PF00017	0.398
LIG_SH2_STAP1	308	312	PF00017	0.479
LIG_SH2_STAT5	345	348	PF00017	0.378
LIG_SH2_STAT5	396	399	PF00017	0.433
LIG_SH2_STAT5	51	54	PF00017	0.499
LIG_SH2_STAT5	85	88	PF00017	0.367
LIG_SH3_1	40	46	PF00018	0.296
LIG_SH3_3	297	303	PF00018	0.356
LIG_SH3_3	40	46	PF00018	0.312
LIG_SUMO_SIM_anti_2	202	209	PF11976	0.318
LIG_SUMO_SIM_anti_2	476	483	PF11976	0.409
LIG_SUMO_SIM_par_1	213	220	PF11976	0.244
LIG_TRAF2_1	243	246	PF00917	0.162
LIG_TYR_ITIM	108	113	PF00017	0.241
LIG_TYR_ITIM	176	181	PF00017	0.379
LIG_TYR_ITIM	222	227	PF00017	0.265
LIG_TYR_ITIM	306	311	PF00017	0.443
LIG_UBA3_1	162	171	PF00899	0.329
LIG_UBA3_1	189	194	PF00899	0.400
LIG_UBA3_1	33	38	PF00899	0.473
LIG_WRC_WIRS_1	181	186	PF05994	0.186
LIG_WRC_WIRS_1	432	437	PF05994	0.422
MOD_CDC14_SPxK_1	143	146	PF00782	0.318
MOD_CDK_SPK_2	140	145	PF00069	0.322
MOD_CDK_SPxK_1	140	146	PF00069	0.311
MOD_CK1_1	240	246	PF00069	0.178
MOD_CK1_1	326	332	PF00069	0.372
MOD_CK1_1	440	446	PF00069	0.436
MOD_CK1_1	453	459	PF00069	0.412
MOD_CK2_1	180	186	PF00069	0.432
MOD_CK2_1	213	219	PF00069	0.434
MOD_CK2_1	239	245	PF00069	0.453
MOD_CK2_1	445	451	PF00069	0.543
MOD_CK2_1	511	517	PF00069	0.728
MOD_GlcNHglycan	233	236	PF01048	0.414
MOD_GlcNHglycan	364	367	PF01048	0.507
MOD_GlcNHglycan	439	442	PF01048	0.390
MOD_GlcNHglycan	58	61	PF01048	0.722
MOD_GlcNHglycan	62	65	PF01048	0.760
MOD_GSK3_1	16	23	PF00069	0.640
MOD_GSK3_1	195	202	PF00069	0.352
MOD_GSK3_1	213	220	PF00069	0.258
MOD_GSK3_1	236	243	PF00069	0.363
MOD_GSK3_1	326	333	PF00069	0.324
MOD_GSK3_1	375	382	PF00069	0.631
MOD_GSK3_1	450	457	PF00069	0.486
MOD_GSK3_1	56	63	PF00069	0.593
MOD_GSK3_1	7	14	PF00069	0.755
MOD_GSK3_1	80	87	PF00069	0.433
MOD_N-GLC_1	411	416	PF02516	0.281
MOD_NEK2_1	445	450	PF00069	0.558
MOD_NEK2_1	84	89	PF00069	0.441
MOD_NEK2_2	124	129	PF00069	0.370
MOD_PIKK_1	445	451	PF00454	0.485
MOD_PKA_1	264	270	PF00069	0.386
MOD_PKA_1	323	329	PF00069	0.379
MOD_PKA_2	264	270	PF00069	0.355
MOD_PKA_2	369	375	PF00069	0.648
MOD_PKA_2	74	80	PF00069	0.639
MOD_Plk_1	117	123	PF00069	0.455
MOD_Plk_1	403	409	PF00069	0.387
MOD_Plk_4	217	223	PF00069	0.403
MOD_Plk_4	255	261	PF00069	0.342
MOD_Plk_4	282	288	PF00069	0.388
MOD_Plk_4	301	307	PF00069	0.302
MOD_Plk_4	336	342	PF00069	0.332
MOD_Plk_4	391	397	PF00069	0.450
MOD_Plk_4	431	437	PF00069	0.422
MOD_Plk_4	454	460	PF00069	0.470
MOD_Plk_4	47	53	PF00069	0.536
MOD_Plk_4	80	86	PF00069	0.388
MOD_ProDKin_1	140	146	PF00069	0.337
MOD_ProDKin_1	299	305	PF00069	0.270
MOD_ProDKin_1	326	332	PF00069	0.368
MOD_SUMO_rev_2	338	346	PF00179	0.272
MOD_SUMO_rev_2	63	72	PF00179	0.654
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.331
TRG_ENDOCYTIC_2	110	113	PF00928	0.426
TRG_ENDOCYTIC_2	178	181	PF00928	0.334
TRG_ENDOCYTIC_2	224	227	PF00928	0.360
TRG_ENDOCYTIC_2	308	311	PF00928	0.381
TRG_ENDOCYTIC_2	396	399	PF00928	0.421
TRG_ENDOCYTIC_2	41	44	PF00928	0.513
TRG_ENDOCYTIC_2	51	54	PF00928	0.485
TRG_ER_diArg_1	374	377	PF00400	0.486
TRG_ER_diArg_1	74	76	PF00400	0.591
TRG_NES_CRM1_1	205	219	PF08389	0.210
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D4	Leptomonas seymouri	43%	98%
A0A0N0P991	Leptomonas seymouri	26%	100%
A0A0N0P992	Leptomonas seymouri	23%	68%
A0A0N0P9K9	Leptomonas seymouri	28%	100%
A0A0N1I2J8	Leptomonas seymouri	35%	100%
A0A0N1PCS4	Leptomonas seymouri	37%	100%
A0A0S4J7N0	Bodo saltans	25%	100%
A0A0S4KJL3	Bodo saltans	29%	100%
A0A1X0NUH5	Trypanosomatidae	23%	89%
A0A1X0NUJ5	Trypanosomatidae	27%	100%
A0A3Q8ICN0	Leishmania donovani	38%	100%
A0A3Q8IGQ2	Leishmania donovani	28%	100%
A0A3R7MUL5	Trypanosoma rangeli	24%	94%
A0A3S5H7R8	Leishmania donovani	25%	67%
A0A3S7X4P4	Leishmania donovani	88%	99%
A0A3S7X4R1	Leishmania donovani	41%	100%
A0A422P1E3	Trypanosoma rangeli	28%	100%
A4HJI7	Leishmania braziliensis	66%	100%
A4HJI8	Leishmania braziliensis	40%	100%
A4HJI9	Leishmania braziliensis	39%	100%
A4HKB3	Leishmania braziliensis	28%	100%
A4HKB4	Leishmania braziliensis	26%	100%
A4HKB5	Leishmania braziliensis	22%	68%
A4I6Y2	Leishmania infantum	88%	99%
A4I6Y3	Leishmania infantum	41%	100%
A4I6Y4	Leishmania infantum	39%	100%
A4I7U3	Leishmania infantum	28%	100%
A4I7U4	Leishmania infantum	25%	67%
A8Y5H7	Mus musculus	22%	72%
E9B204	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9B205	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B206	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B2Q1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B2Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	67%
O43304	Homo sapiens	22%	74%
Q0V9N0	Xenopus tropicalis	22%	73%
Q4Q5F5	Leishmania major	23%	67%
Q4Q5F6	Leishmania major	27%	100%
Q4Q655	Leishmania major	39%	100%
Q4Q656	Leishmania major	41%	99%
Q92503	Homo sapiens	23%	72%
Q99J08	Mus musculus	22%	100%
Q9VMD6	Drosophila melanogaster	22%	78%
V5BL84	Trypanosoma cruzi	27%	100%
V5BQT0	Trypanosoma cruzi	24%	93%