LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q654_LEIMA
TriTrypDb:
LmjF.31.2080 , LMJLV39_310029500 * , LMJSD75_310029500 *
Length:
825

Annotations

LeishMANIAdb annotations

A bacterial-type Mg2+ transporter found in kinetoplastids.. Expanded extensively on multiple lineages, especially T cruzi

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

Q4Q654
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q654

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 240 244 PF00656 0.503
CLV_C14_Caspase3-7 540 544 PF00656 0.588
CLV_C14_Caspase3-7 556 560 PF00656 0.499
CLV_C14_Caspase3-7 609 613 PF00656 0.722
CLV_C14_Caspase3-7 668 672 PF00656 0.679
CLV_NRD_NRD_1 10 12 PF00675 0.752
CLV_NRD_NRD_1 408 410 PF00675 0.704
CLV_NRD_NRD_1 424 426 PF00675 0.680
CLV_NRD_NRD_1 51 53 PF00675 0.733
CLV_NRD_NRD_1 562 564 PF00675 0.402
CLV_NRD_NRD_1 569 571 PF00675 0.365
CLV_NRD_NRD_1 575 577 PF00675 0.348
CLV_NRD_NRD_1 63 65 PF00675 0.711
CLV_NRD_NRD_1 818 820 PF00675 0.416
CLV_NRD_NRD_1 99 101 PF00675 0.830
CLV_PCSK_FUR_1 421 425 PF00082 0.731
CLV_PCSK_FUR_1 61 65 PF00082 0.734
CLV_PCSK_KEX2_1 272 274 PF00082 0.750
CLV_PCSK_KEX2_1 408 410 PF00082 0.705
CLV_PCSK_KEX2_1 421 423 PF00082 0.684
CLV_PCSK_KEX2_1 424 426 PF00082 0.679
CLV_PCSK_KEX2_1 51 53 PF00082 0.733
CLV_PCSK_KEX2_1 562 564 PF00082 0.402
CLV_PCSK_KEX2_1 568 570 PF00082 0.381
CLV_PCSK_KEX2_1 575 577 PF00082 0.348
CLV_PCSK_KEX2_1 63 65 PF00082 0.711
CLV_PCSK_KEX2_1 99 101 PF00082 0.830
CLV_PCSK_PC1ET2_1 272 274 PF00082 0.750
CLV_PCSK_PC7_1 59 65 PF00082 0.736
CLV_PCSK_SKI1_1 137 141 PF00082 0.721
CLV_PCSK_SKI1_1 362 366 PF00082 0.724
CLV_PCSK_SKI1_1 562 566 PF00082 0.411
CLV_PCSK_SKI1_1 575 579 PF00082 0.340
CLV_PCSK_SKI1_1 601 605 PF00082 0.477
CLV_PCSK_SKI1_1 82 86 PF00082 0.734
DEG_APCC_DBOX_1 160 168 PF00400 0.480
DEG_APCC_DBOX_1 238 246 PF00400 0.527
DEG_SCF_FBW7_1 374 381 PF00400 0.479
DEG_SPOP_SBC_1 119 123 PF00917 0.534
DOC_PP1_RVXF_1 573 580 PF00149 0.619
DOC_PP1_RVXF_1 739 745 PF00149 0.602
DOC_PP2B_LxvP_1 498 501 PF13499 0.541
DOC_USP7_MATH_1 119 123 PF00917 0.583
DOC_USP7_MATH_1 237 241 PF00917 0.574
DOC_USP7_MATH_1 307 311 PF00917 0.471
DOC_USP7_MATH_1 314 318 PF00917 0.437
DOC_USP7_MATH_1 410 414 PF00917 0.523
DOC_USP7_MATH_1 436 440 PF00917 0.498
DOC_USP7_MATH_1 482 486 PF00917 0.604
DOC_USP7_MATH_1 492 496 PF00917 0.573
DOC_USP7_MATH_1 610 614 PF00917 0.769
DOC_USP7_MATH_1 672 676 PF00917 0.687
DOC_WW_Pin1_4 115 120 PF00397 0.530
DOC_WW_Pin1_4 23 28 PF00397 0.493
DOC_WW_Pin1_4 252 257 PF00397 0.520
DOC_WW_Pin1_4 374 379 PF00397 0.506
DOC_WW_Pin1_4 423 428 PF00397 0.533
DOC_WW_Pin1_4 480 485 PF00397 0.529
DOC_WW_Pin1_4 602 607 PF00397 0.663
DOC_WW_Pin1_4 695 700 PF00397 0.699
DOC_WW_Pin1_4 704 709 PF00397 0.625
DOC_WW_Pin1_4 789 794 PF00397 0.398
DOC_WW_Pin1_4 82 87 PF00397 0.531
LIG_14-3-3_CanoR_1 109 119 PF00244 0.570
LIG_14-3-3_CanoR_1 120 125 PF00244 0.519
LIG_14-3-3_CanoR_1 236 246 PF00244 0.526
LIG_14-3-3_CanoR_1 315 319 PF00244 0.529
LIG_14-3-3_CanoR_1 351 357 PF00244 0.523
LIG_14-3-3_CanoR_1 362 369 PF00244 0.460
LIG_14-3-3_CanoR_1 39 45 PF00244 0.541
LIG_14-3-3_CanoR_1 409 415 PF00244 0.504
LIG_14-3-3_CanoR_1 51 56 PF00244 0.490
LIG_14-3-3_CanoR_1 598 604 PF00244 0.636
LIG_14-3-3_CanoR_1 642 649 PF00244 0.672
LIG_14-3-3_CanoR_1 692 700 PF00244 0.682
LIG_14-3-3_CanoR_1 748 756 PF00244 0.603
LIG_Actin_WH2_2 157 175 PF00022 0.514
LIG_Actin_WH2_2 346 364 PF00022 0.452
LIG_BIR_II_1 1 5 PF00653 0.544
LIG_BIR_III_4 671 675 PF00653 0.674
LIG_BRCT_BRCA1_1 130 134 PF00533 0.536
LIG_Clathr_ClatBox_1 548 552 PF01394 0.630
LIG_deltaCOP1_diTrp_1 328 335 PF00928 0.496
LIG_EH_1 13 17 PF12763 0.474
LIG_eIF4E_1 762 768 PF01652 0.367
LIG_FHA_1 161 167 PF00498 0.499
LIG_FHA_1 281 287 PF00498 0.505
LIG_FHA_1 374 380 PF00498 0.500
LIG_FHA_1 388 394 PF00498 0.378
LIG_FHA_1 398 404 PF00498 0.438
LIG_FHA_1 638 644 PF00498 0.665
LIG_FHA_1 816 822 PF00498 0.505
LIG_FHA_2 157 163 PF00498 0.453
LIG_FHA_2 328 334 PF00498 0.496
LIG_FHA_2 402 408 PF00498 0.510
LIG_FHA_2 492 498 PF00498 0.488
LIG_FHA_2 607 613 PF00498 0.722
LIG_GBD_Chelix_1 286 294 PF00786 0.679
LIG_LIR_Gen_1 208 218 PF02991 0.477
LIG_LIR_Gen_1 283 293 PF02991 0.524
LIG_LIR_Gen_1 439 446 PF02991 0.451
LIG_LIR_Gen_1 459 468 PF02991 0.467
LIG_LIR_Gen_1 513 524 PF02991 0.367
LIG_LIR_Gen_1 646 657 PF02991 0.695
LIG_LIR_Gen_1 754 764 PF02991 0.519
LIG_LIR_Gen_1 792 803 PF02991 0.319
LIG_LIR_Nem_3 208 214 PF02991 0.479
LIG_LIR_Nem_3 283 288 PF02991 0.534
LIG_LIR_Nem_3 439 444 PF02991 0.451
LIG_LIR_Nem_3 459 463 PF02991 0.475
LIG_LIR_Nem_3 466 471 PF02991 0.510
LIG_LIR_Nem_3 513 519 PF02991 0.367
LIG_LIR_Nem_3 523 529 PF02991 0.283
LIG_LIR_Nem_3 646 652 PF02991 0.694
LIG_LIR_Nem_3 752 758 PF02991 0.594
LIG_LIR_Nem_3 791 797 PF02991 0.384
LIG_LIR_Nem_3 809 814 PF02991 0.216
LIG_NRBOX 289 295 PF00104 0.476
LIG_PAM2_1 768 780 PF00658 0.306
LIG_PDZ_Class_2 820 825 PF00595 0.637
LIG_Pex14_1 331 335 PF04695 0.494
LIG_PTB_Apo_2 11 18 PF02174 0.492
LIG_REV1ctd_RIR_1 14 23 PF16727 0.540
LIG_RPA_C_Fungi 564 576 PF08784 0.489
LIG_SH2_CRK 441 445 PF00017 0.552
LIG_SH2_CRK 526 530 PF00017 0.504
LIG_SH2_CRK 814 818 PF00017 0.367
LIG_SH2_PTP2 285 288 PF00017 0.607
LIG_SH2_PTP2 762 765 PF00017 0.367
LIG_SH2_SRC 822 825 PF00017 0.548
LIG_SH2_STAP1 132 136 PF00017 0.682
LIG_SH2_STAP1 246 250 PF00017 0.658
LIG_SH2_STAP1 441 445 PF00017 0.552
LIG_SH2_STAT3 473 476 PF00017 0.583
LIG_SH2_STAT5 285 288 PF00017 0.607
LIG_SH2_STAT5 352 355 PF00017 0.552
LIG_SH2_STAT5 384 387 PF00017 0.668
LIG_SH2_STAT5 456 459 PF00017 0.562
LIG_SH2_STAT5 528 531 PF00017 0.497
LIG_SH2_STAT5 762 765 PF00017 0.367
LIG_SH2_STAT5 816 819 PF00017 0.495
LIG_SH2_STAT5 822 825 PF00017 0.498
LIG_SH3_1 24 30 PF00018 0.614
LIG_SH3_1 424 430 PF00018 0.661
LIG_SH3_3 188 194 PF00018 0.794
LIG_SH3_3 24 30 PF00018 0.673
LIG_SH3_3 276 282 PF00018 0.663
LIG_SH3_3 383 389 PF00018 0.557
LIG_SH3_3 424 430 PF00018 0.692
LIG_SH3_3 481 487 PF00018 0.640
LIG_SH3_3 675 681 PF00018 0.595
LIG_SH3_3 763 769 PF00018 0.367
LIG_SUMO_SIM_par_1 547 552 PF11976 0.519
LIG_TYR_ITIM 524 529 PF00017 0.367
LIG_WRC_WIRS_1 356 361 PF05994 0.551
MOD_CDC14_SPxK_1 605 608 PF00782 0.573
MOD_CDK_SPK_2 115 120 PF00069 0.624
MOD_CDK_SPxK_1 602 608 PF00069 0.546
MOD_CDK_SPxxK_3 252 259 PF00069 0.648
MOD_CDK_SPxxK_3 483 490 PF00069 0.684
MOD_CDK_SPxxK_3 82 89 PF00069 0.670
MOD_CK1_1 111 117 PF00069 0.855
MOD_CK1_1 118 124 PF00069 0.748
MOD_CK1_1 354 360 PF00069 0.643
MOD_CK1_1 466 472 PF00069 0.549
MOD_CK1_1 475 481 PF00069 0.539
MOD_CK1_1 483 489 PF00069 0.540
MOD_CK1_1 506 512 PF00069 0.364
MOD_CK1_1 602 608 PF00069 0.607
MOD_CK1_1 637 643 PF00069 0.603
MOD_CK1_1 70 76 PF00069 0.712
MOD_CK1_1 740 746 PF00069 0.454
MOD_CK1_1 747 753 PF00069 0.461
MOD_CK1_1 77 83 PF00069 0.648
MOD_CK2_1 314 320 PF00069 0.613
MOD_CK2_1 327 333 PF00069 0.501
MOD_CK2_1 491 497 PF00069 0.602
MOD_GlcNHglycan 143 146 PF01048 0.659
MOD_GlcNHglycan 149 152 PF01048 0.593
MOD_GlcNHglycan 207 210 PF01048 0.543
MOD_GlcNHglycan 309 312 PF01048 0.558
MOD_GlcNHglycan 40 43 PF01048 0.651
MOD_GlcNHglycan 404 407 PF01048 0.618
MOD_GlcNHglycan 412 415 PF01048 0.604
MOD_GlcNHglycan 494 497 PF01048 0.697
MOD_GlcNHglycan 498 501 PF01048 0.645
MOD_GlcNHglycan 503 506 PF01048 0.577
MOD_GlcNHglycan 623 626 PF01048 0.666
MOD_GlcNHglycan 630 633 PF01048 0.577
MOD_GlcNHglycan 662 665 PF01048 0.633
MOD_GSK3_1 103 110 PF00069 0.813
MOD_GSK3_1 111 118 PF00069 0.785
MOD_GSK3_1 119 126 PF00069 0.646
MOD_GSK3_1 147 154 PF00069 0.643
MOD_GSK3_1 156 163 PF00069 0.483
MOD_GSK3_1 216 223 PF00069 0.575
MOD_GSK3_1 267 274 PF00069 0.801
MOD_GSK3_1 289 296 PF00069 0.592
MOD_GSK3_1 297 304 PF00069 0.568
MOD_GSK3_1 351 358 PF00069 0.660
MOD_GSK3_1 374 381 PF00069 0.621
MOD_GSK3_1 387 394 PF00069 0.454
MOD_GSK3_1 397 404 PF00069 0.527
MOD_GSK3_1 478 485 PF00069 0.645
MOD_GSK3_1 492 499 PF00069 0.572
MOD_GSK3_1 506 513 PF00069 0.250
MOD_GSK3_1 515 522 PF00069 0.299
MOD_GSK3_1 602 609 PF00069 0.749
MOD_GSK3_1 610 617 PF00069 0.678
MOD_GSK3_1 67 74 PF00069 0.707
MOD_GSK3_1 691 698 PF00069 0.615
MOD_GSK3_1 740 747 PF00069 0.450
MOD_GSK3_1 789 796 PF00069 0.466
MOD_GSK3_1 802 809 PF00069 0.250
MOD_LATS_1 107 113 PF00433 0.775
MOD_LATS_1 69 75 PF00433 0.710
MOD_N-GLC_1 732 737 PF02516 0.457
MOD_N-GLC_1 75 80 PF02516 0.706
MOD_N-GLC_1 82 87 PF02516 0.636
MOD_NEK2_1 216 221 PF00069 0.538
MOD_NEK2_1 293 298 PF00069 0.617
MOD_NEK2_1 379 384 PF00069 0.574
MOD_NEK2_1 401 406 PF00069 0.628
MOD_NEK2_1 463 468 PF00069 0.536
MOD_NEK2_1 503 508 PF00069 0.630
MOD_NEK2_1 511 516 PF00069 0.312
MOD_NEK2_1 519 524 PF00069 0.245
MOD_NEK2_1 599 604 PF00069 0.664
MOD_NEK2_1 744 749 PF00069 0.459
MOD_NEK2_2 156 161 PF00069 0.618
MOD_PIKK_1 151 157 PF00454 0.604
MOD_PIKK_1 362 368 PF00454 0.657
MOD_PIKK_1 472 478 PF00454 0.710
MOD_PIKK_1 691 697 PF00454 0.599
MOD_PKA_1 272 278 PF00069 0.739
MOD_PKA_1 51 57 PF00069 0.645
MOD_PKA_2 108 114 PF00069 0.782
MOD_PKA_2 119 125 PF00069 0.683
MOD_PKA_2 160 166 PF00069 0.615
MOD_PKA_2 238 244 PF00069 0.659
MOD_PKA_2 272 278 PF00069 0.709
MOD_PKA_2 314 320 PF00069 0.617
MOD_PKA_2 38 44 PF00069 0.654
MOD_PKA_2 51 57 PF00069 0.597
MOD_PKA_2 589 595 PF00069 0.555
MOD_PKA_2 610 616 PF00069 0.638
MOD_PKA_2 62 68 PF00069 0.615
MOD_PKA_2 672 678 PF00069 0.615
MOD_PKA_2 691 697 PF00069 0.528
MOD_PKA_2 70 76 PF00069 0.552
MOD_PKA_2 747 753 PF00069 0.488
MOD_PKA_2 98 104 PF00069 0.789
MOD_PKB_1 470 478 PF00069 0.547
MOD_Plk_1 128 134 PF00069 0.674
MOD_Plk_1 31 37 PF00069 0.597
MOD_Plk_1 327 333 PF00069 0.614
MOD_Plk_1 436 442 PF00069 0.558
MOD_Plk_1 732 738 PF00069 0.453
MOD_Plk_2-3 538 544 PF00069 0.456
MOD_Plk_4 289 295 PF00069 0.587
MOD_Plk_4 31 37 PF00069 0.597
MOD_Plk_4 379 385 PF00069 0.569
MOD_Plk_4 463 469 PF00069 0.540
MOD_Plk_4 506 512 PF00069 0.359
MOD_Plk_4 515 521 PF00069 0.299
MOD_Plk_4 529 535 PF00069 0.361
MOD_Plk_4 541 547 PF00069 0.362
MOD_Plk_4 713 719 PF00069 0.494
MOD_Plk_4 732 738 PF00069 0.293
MOD_Plk_4 754 760 PF00069 0.367
MOD_Plk_4 806 812 PF00069 0.367
MOD_ProDKin_1 115 121 PF00069 0.661
MOD_ProDKin_1 23 29 PF00069 0.608
MOD_ProDKin_1 252 258 PF00069 0.649
MOD_ProDKin_1 374 380 PF00069 0.624
MOD_ProDKin_1 423 429 PF00069 0.666
MOD_ProDKin_1 480 486 PF00069 0.663
MOD_ProDKin_1 602 608 PF00069 0.576
MOD_ProDKin_1 695 701 PF00069 0.621
MOD_ProDKin_1 704 710 PF00069 0.498
MOD_ProDKin_1 789 795 PF00069 0.476
MOD_ProDKin_1 82 88 PF00069 0.665
TRG_DiLeu_BaEn_1 289 294 PF01217 0.583
TRG_DiLeu_BaEn_4 248 254 PF01217 0.654
TRG_DiLeu_BaLyEn_6 375 380 PF01217 0.621
TRG_DiLeu_BaLyEn_6 544 549 PF01217 0.480
TRG_DiLeu_BaLyEn_6 573 578 PF01217 0.499
TRG_ENDOCYTIC_2 285 288 PF00928 0.607
TRG_ENDOCYTIC_2 441 444 PF00928 0.552
TRG_ENDOCYTIC_2 526 529 PF00928 0.514
TRG_ENDOCYTIC_2 755 758 PF00928 0.467
TRG_ENDOCYTIC_2 762 765 PF00928 0.308
TRG_ENDOCYTIC_2 814 817 PF00928 0.367
TRG_ER_diArg_1 421 424 PF00400 0.691
TRG_ER_diArg_1 438 441 PF00400 0.508
TRG_ER_diArg_1 470 473 PF00400 0.597
TRG_ER_diArg_1 50 52 PF00400 0.668
TRG_ER_diArg_1 561 563 PF00400 0.495
TRG_ER_diArg_1 567 570 PF00400 0.435
TRG_ER_diArg_1 575 577 PF00400 0.399
TRG_ER_diArg_1 61 64 PF00400 0.641
TRG_ER_diArg_1 99 102 PF00400 0.737
TRG_Pf-PMV_PEXEL_1 259 264 PF00026 0.624
TRG_Pf-PMV_PEXEL_1 575 580 PF00026 0.510

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X4P2 Leishmania donovani 89% 100%
A4I6Y6 Leishmania infantum 90% 100%
E9B207 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS