Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q652_LEIMA

TriTrypDb:

LmjF.31.2100 , LMJLV39_310029800 , LMJSD75_310029800

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q652

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q652

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	334	338	PF00656	0.678
CLV_C14_Caspase3-7	97	101	PF00656	0.524
CLV_NRD_NRD_1	166	168	PF00675	0.685
CLV_NRD_NRD_1	177	179	PF00675	0.622
CLV_NRD_NRD_1	203	205	PF00675	0.738
CLV_NRD_NRD_1	262	264	PF00675	0.670
CLV_NRD_NRD_1	268	270	PF00675	0.632
CLV_NRD_NRD_1	311	313	PF00675	0.713
CLV_NRD_NRD_1	32	34	PF00675	0.536
CLV_NRD_NRD_1	327	329	PF00675	0.664
CLV_NRD_NRD_1	9	11	PF00675	0.679
CLV_PCSK_FUR_1	201	205	PF00082	0.653
CLV_PCSK_KEX2_1	166	168	PF00082	0.685
CLV_PCSK_KEX2_1	177	179	PF00082	0.622
CLV_PCSK_KEX2_1	200	202	PF00082	0.763
CLV_PCSK_KEX2_1	203	205	PF00082	0.724
CLV_PCSK_KEX2_1	262	264	PF00082	0.670
CLV_PCSK_KEX2_1	311	313	PF00082	0.713
CLV_PCSK_KEX2_1	32	34	PF00082	0.536
CLV_PCSK_KEX2_1	327	329	PF00082	0.664
CLV_PCSK_KEX2_1	9	11	PF00082	0.679
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.641
CLV_PCSK_SKI1_1	195	199	PF00082	0.627
DEG_COP1_1	354	362	PF00400	0.677
DOC_CKS1_1	76	81	PF01111	0.680
DOC_MAPK_gen_1	311	319	PF00069	0.689
DOC_MAPK_MEF2A_6	312	321	PF00069	0.690
DOC_MAPK_RevD_3	186	201	PF00069	0.649
DOC_USP7_MATH_1	103	107	PF00917	0.668
DOC_USP7_MATH_1	115	119	PF00917	0.566
DOC_USP7_MATH_1	135	139	PF00917	0.623
DOC_USP7_MATH_1	208	212	PF00917	0.658
DOC_USP7_MATH_1	358	362	PF00917	0.592
DOC_USP7_MATH_1	71	75	PF00917	0.576
DOC_USP7_UBL2_3	304	308	PF12436	0.696
DOC_WW_Pin1_4	1	6	PF00397	0.718
DOC_WW_Pin1_4	17	22	PF00397	0.662
DOC_WW_Pin1_4	181	186	PF00397	0.797
DOC_WW_Pin1_4	228	233	PF00397	0.802
DOC_WW_Pin1_4	25	30	PF00397	0.649
DOC_WW_Pin1_4	252	257	PF00397	0.655
DOC_WW_Pin1_4	345	350	PF00397	0.687
DOC_WW_Pin1_4	35	40	PF00397	0.679
DOC_WW_Pin1_4	75	80	PF00397	0.686
LIG_14-3-3_CanoR_1	166	171	PF00244	0.706
LIG_14-3-3_CanoR_1	311	320	PF00244	0.690
LIG_14-3-3_CanoR_1	32	38	PF00244	0.571
LIG_14-3-3_CanoR_1	327	333	PF00244	0.545
LIG_14-3-3_CanoR_1	52	60	PF00244	0.524
LIG_14-3-3_CanoR_1	90	95	PF00244	0.686
LIG_BIR_II_1	1	5	PF00653	0.706
LIG_BIR_III_2	182	186	PF00653	0.676
LIG_BRCT_BRCA1_1	105	109	PF00533	0.563
LIG_BRCT_BRCA1_1	137	141	PF00533	0.688
LIG_BRCT_BRCA1_1	254	258	PF00533	0.734
LIG_BRCT_BRCA1_1	42	46	PF00533	0.530
LIG_CtBP_PxDLS_1	185	189	PF00389	0.668
LIG_DLG_GKlike_1	166	173	PF00625	0.539
LIG_DLG_GKlike_1	90	98	PF00625	0.685
LIG_FHA_1	25	31	PF00498	0.663
LIG_FHA_1	276	282	PF00498	0.595
LIG_FHA_1	312	318	PF00498	0.688
LIG_FHA_1	40	46	PF00498	0.670
LIG_FHA_1	89	95	PF00498	0.719
LIG_FHA_2	311	317	PF00498	0.687
LIG_Integrin_RGD_1	335	337	PF01839	0.708
LIG_IRF3_LxIS_1	317	322	PF10401	0.694
LIG_LIR_Gen_1	168	175	PF02991	0.540
LIG_LIR_Gen_1	285	292	PF02991	0.671
LIG_LIR_Gen_1	43	51	PF02991	0.534
LIG_LIR_Nem_3	138	144	PF02991	0.751
LIG_LIR_Nem_3	168	173	PF02991	0.542
LIG_LIR_Nem_3	243	248	PF02991	0.519
LIG_LIR_Nem_3	285	291	PF02991	0.786
LIG_LIR_Nem_3	370	375	PF02991	0.629
LIG_LIR_Nem_3	43	49	PF02991	0.534
LIG_PCNA_PIPBox_1	241	250	PF02747	0.523
LIG_PCNA_yPIPBox_3	238	248	PF02747	0.526
LIG_SH2_CRK	170	174	PF00017	0.541
LIG_SH2_STAP1	170	174	PF00017	0.541
LIG_SH2_STAP1	88	92	PF00017	0.658
LIG_SH2_STAT5	290	293	PF00017	0.678
LIG_SH3_3	131	137	PF00018	0.672
LIG_SH3_3	139	145	PF00018	0.614
LIG_SH3_3	157	163	PF00018	0.625
LIG_SH3_3	314	320	PF00018	0.778
LIG_SH3_3	343	349	PF00018	0.634
LIG_SUMO_SIM_anti_2	373	381	PF11976	0.636
LIG_SUMO_SIM_par_1	319	325	PF11976	0.588
LIG_SUMO_SIM_par_1	373	381	PF11976	0.636
LIG_TRAF2_1	313	316	PF00917	0.651
LIG_TRAF2_1	54	57	PF00917	0.518
MOD_CDK_SPK_2	1	6	PF00069	0.668
MOD_CDK_SPxxK_3	25	32	PF00069	0.529
MOD_CK1_1	158	164	PF00069	0.696
MOD_CK1_1	165	171	PF00069	0.670
MOD_CK1_1	184	190	PF00069	0.541
MOD_CK1_1	215	221	PF00069	0.687
MOD_CK1_1	240	246	PF00069	0.646
MOD_CK1_1	322	328	PF00069	0.804
MOD_CK1_1	35	41	PF00069	0.618
MOD_CK1_1	361	367	PF00069	0.630
MOD_CK1_1	75	81	PF00069	0.538
MOD_CK1_1	86	92	PF00069	0.690
MOD_CK1_1	93	99	PF00069	0.642
MOD_CK2_1	17	23	PF00069	0.785
MOD_CK2_1	228	234	PF00069	0.700
MOD_CK2_1	310	316	PF00069	0.686
MOD_CK2_1	51	57	PF00069	0.593
MOD_Cter_Amidation	267	270	PF01082	0.571
MOD_GlcNHglycan	105	108	PF01048	0.659
MOD_GlcNHglycan	210	213	PF01048	0.786
MOD_GlcNHglycan	250	253	PF01048	0.660
MOD_GlcNHglycan	258	261	PF01048	0.603
MOD_GlcNHglycan	304	307	PF01048	0.694
MOD_GlcNHglycan	330	333	PF01048	0.699
MOD_GlcNHglycan	356	359	PF01048	0.636
MOD_GlcNHglycan	372	375	PF01048	0.551
MOD_GlcNHglycan	42	45	PF01048	0.739
MOD_GSK3_1	151	158	PF00069	0.673
MOD_GSK3_1	161	168	PF00069	0.721
MOD_GSK3_1	208	215	PF00069	0.706
MOD_GSK3_1	221	228	PF00069	0.728
MOD_GSK3_1	248	255	PF00069	0.656
MOD_GSK3_1	272	279	PF00069	0.586
MOD_GSK3_1	296	303	PF00069	0.682
MOD_GSK3_1	322	329	PF00069	0.756
MOD_GSK3_1	336	343	PF00069	0.585
MOD_GSK3_1	35	42	PF00069	0.716
MOD_GSK3_1	354	361	PF00069	0.544
MOD_GSK3_1	71	78	PF00069	0.761
MOD_GSK3_1	86	93	PF00069	0.690
MOD_GSK3_1	94	101	PF00069	0.656
MOD_LATS_1	326	332	PF00433	0.556
MOD_N-GLC_1	151	156	PF02516	0.628
MOD_N-GLC_1	352	357	PF02516	0.609
MOD_NEK2_1	155	160	PF00069	0.664
MOD_NEK2_1	24	29	PF00069	0.631
MOD_NEK2_1	247	252	PF00069	0.656
MOD_NEK2_1	352	357	PF00069	0.606
MOD_NEK2_1	363	368	PF00069	0.505
MOD_NEK2_1	40	45	PF00069	0.603
MOD_NEK2_1	94	99	PF00069	0.621
MOD_PIKK_1	126	132	PF00454	0.588
MOD_PIKK_1	225	231	PF00454	0.608
MOD_PIKK_1	237	243	PF00454	0.604
MOD_PIKK_1	311	317	PF00454	0.652
MOD_PIKK_1	51	57	PF00454	0.555
MOD_PK_1	216	222	PF00069	0.690
MOD_PK_1	33	39	PF00069	0.633
MOD_PKA_1	166	172	PF00069	0.678
MOD_PKA_1	203	209	PF00069	0.653
MOD_PKA_1	262	268	PF00069	0.666
MOD_PKA_1	311	317	PF00069	0.687
MOD_PKA_1	32	38	PF00069	0.529
MOD_PKA_2	115	121	PF00069	0.742
MOD_PKA_2	126	132	PF00069	0.544
MOD_PKA_2	165	171	PF00069	0.713
MOD_PKA_2	203	209	PF00069	0.751
MOD_PKA_2	215	221	PF00069	0.635
MOD_PKA_2	237	243	PF00069	0.670
MOD_PKA_2	262	268	PF00069	0.666
MOD_PKA_2	310	316	PF00069	0.710
MOD_PKA_2	32	38	PF00069	0.529
MOD_PKA_2	326	332	PF00069	0.665
MOD_PKA_2	51	57	PF00069	0.523
MOD_PKB_1	201	209	PF00069	0.652
MOD_Plk_1	151	157	PF00069	0.541
MOD_Plk_1	284	290	PF00069	0.671
MOD_Plk_1	296	302	PF00069	0.566
MOD_Plk_1	364	370	PF00069	0.530
MOD_Plk_4	151	157	PF00069	0.668
MOD_Plk_4	189	195	PF00069	0.645
MOD_Plk_4	240	246	PF00069	0.608
MOD_Plk_4	358	364	PF00069	0.718
MOD_ProDKin_1	1	7	PF00069	0.715
MOD_ProDKin_1	17	23	PF00069	0.663
MOD_ProDKin_1	181	187	PF00069	0.797
MOD_ProDKin_1	228	234	PF00069	0.801
MOD_ProDKin_1	25	31	PF00069	0.652
MOD_ProDKin_1	252	258	PF00069	0.658
MOD_ProDKin_1	345	351	PF00069	0.685
MOD_ProDKin_1	35	41	PF00069	0.679
MOD_ProDKin_1	75	81	PF00069	0.685
TRG_ENDOCYTIC_2	170	173	PF00928	0.542
TRG_ENDOCYTIC_2	245	248	PF00928	0.663
TRG_ER_diArg_1	203	205	PF00400	0.754
TRG_ER_diArg_1	31	33	PF00400	0.574
TRG_ER_diArg_1	310	312	PF00400	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4R2	Leishmania donovani	83%	99%
A4I6Y8	Leishmania infantum	83%	99%
E9B209	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%