Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q649_LEIMA

TriTrypDb:

LmjF.31.2120 , LMJLV39_310030100 , LMJSD75_310030100

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q649

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q649

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.732
CLV_C14_Caspase3-7	632	636	PF00656	0.579
CLV_C14_Caspase3-7	66	70	PF00656	0.718
CLV_NRD_NRD_1	127	129	PF00675	0.676
CLV_NRD_NRD_1	347	349	PF00675	0.749
CLV_NRD_NRD_1	40	42	PF00675	0.671
CLV_NRD_NRD_1	405	407	PF00675	0.676
CLV_NRD_NRD_1	610	612	PF00675	0.608
CLV_NRD_NRD_1	758	760	PF00675	0.708
CLV_PCSK_FUR_1	40	44	PF00082	0.741
CLV_PCSK_KEX2_1	277	279	PF00082	0.620
CLV_PCSK_KEX2_1	40	42	PF00082	0.729
CLV_PCSK_KEX2_1	405	407	PF00082	0.635
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.620
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.746
CLV_PCSK_SKI1_1	200	204	PF00082	0.713
CLV_PCSK_SKI1_1	349	353	PF00082	0.699
CLV_PCSK_SKI1_1	685	689	PF00082	0.726
CLV_Separin_Metazoa	157	161	PF03568	0.573
DEG_APCC_DBOX_1	57	65	PF00400	0.726
DEG_COP1_1	527	536	PF00400	0.558
DEG_Nend_UBRbox_2	1	3	PF02207	0.708
DEG_SCF_FBW7_1	148	154	PF00400	0.747
DEG_SPOP_SBC_1	72	76	PF00917	0.621
DOC_CDC14_PxL_1	134	142	PF14671	0.716
DOC_CKS1_1	148	153	PF01111	0.747
DOC_CKS1_1	294	299	PF01111	0.596
DOC_CKS1_1	522	527	PF01111	0.737
DOC_CYCLIN_RxL_1	197	205	PF00134	0.705
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.626
DOC_CYCLIN_yCln2_LP_2	702	708	PF00134	0.660
DOC_MAPK_gen_1	15	22	PF00069	0.592
DOC_MAPK_gen_1	701	709	PF00069	0.672
DOC_MAPK_gen_1	86	95	PF00069	0.741
DOC_MAPK_MEF2A_6	701	709	PF00069	0.659
DOC_PP1_SILK_1	124	129	PF00149	0.735
DOC_PP2B_LxvP_1	119	122	PF13499	0.671
DOC_PP2B_LxvP_1	241	244	PF13499	0.677
DOC_PP2B_LxvP_1	506	509	PF13499	0.669
DOC_PP2B_LxvP_1	531	534	PF13499	0.560
DOC_PP4_FxxP_1	671	674	PF00568	0.608
DOC_USP7_MATH_1	122	126	PF00917	0.668
DOC_USP7_MATH_1	166	170	PF00917	0.730
DOC_USP7_MATH_1	189	193	PF00917	0.737
DOC_USP7_MATH_1	232	236	PF00917	0.707
DOC_USP7_MATH_1	273	277	PF00917	0.613
DOC_USP7_MATH_1	284	288	PF00917	0.618
DOC_USP7_MATH_1	432	436	PF00917	0.601
DOC_USP7_MATH_1	563	567	PF00917	0.733
DOC_USP7_MATH_1	596	600	PF00917	0.721
DOC_USP7_MATH_1	613	617	PF00917	0.577
DOC_USP7_MATH_1	624	628	PF00917	0.671
DOC_USP7_MATH_1	636	640	PF00917	0.611
DOC_USP7_MATH_1	681	685	PF00917	0.736
DOC_USP7_MATH_1	708	712	PF00917	0.730
DOC_USP7_MATH_1	736	740	PF00917	0.692
DOC_USP7_MATH_1	742	746	PF00917	0.678
DOC_USP7_UBL2_3	730	734	PF12436	0.620
DOC_WW_Pin1_4	1	6	PF00397	0.493
DOC_WW_Pin1_4	144	149	PF00397	0.737
DOC_WW_Pin1_4	151	156	PF00397	0.664
DOC_WW_Pin1_4	202	207	PF00397	0.713
DOC_WW_Pin1_4	208	213	PF00397	0.648
DOC_WW_Pin1_4	263	268	PF00397	0.797
DOC_WW_Pin1_4	293	298	PF00397	0.628
DOC_WW_Pin1_4	316	321	PF00397	0.653
DOC_WW_Pin1_4	338	343	PF00397	0.740
DOC_WW_Pin1_4	399	404	PF00397	0.709
DOC_WW_Pin1_4	458	463	PF00397	0.776
DOC_WW_Pin1_4	485	490	PF00397	0.837
DOC_WW_Pin1_4	498	503	PF00397	0.665
DOC_WW_Pin1_4	52	57	PF00397	0.653
DOC_WW_Pin1_4	521	526	PF00397	0.729
DOC_WW_Pin1_4	532	537	PF00397	0.592
DOC_WW_Pin1_4	588	593	PF00397	0.639
DOC_WW_Pin1_4	615	620	PF00397	0.663
DOC_WW_Pin1_4	670	675	PF00397	0.835
DOC_WW_Pin1_4	676	681	PF00397	0.688
LIG_14-3-3_CanoR_1	190	198	PF00244	0.697
LIG_14-3-3_CanoR_1	200	206	PF00244	0.644
LIG_14-3-3_CanoR_1	250	254	PF00244	0.603
LIG_14-3-3_CanoR_1	285	291	PF00244	0.686
LIG_14-3-3_CanoR_1	544	548	PF00244	0.682
LIG_14-3-3_CanoR_1	581	588	PF00244	0.683
LIG_14-3-3_CanoR_1	694	702	PF00244	0.697
LIG_14-3-3_CanoR_1	71	81	PF00244	0.698
LIG_14-3-3_CanoR_1	741	749	PF00244	0.702
LIG_14-3-3_CanoR_1	757	763	PF00244	0.654
LIG_14-3-3_CanoR_1	86	95	PF00244	0.517
LIG_Actin_WH2_2	114	130	PF00022	0.731
LIG_APCC_ABBA_1	222	227	PF00400	0.659
LIG_APCC_ABBAyCdc20_2	221	227	PF00400	0.660
LIG_APCC_ABBAyCdc20_2	425	431	PF00400	0.723
LIG_BRCT_BRCA1_1	601	605	PF00533	0.740
LIG_BRCT_BRCA1_1	667	671	PF00533	0.604
LIG_BRCT_BRCA1_1	91	95	PF00533	0.750
LIG_Clathr_ClatBox_1	140	144	PF01394	0.719
LIG_EH1_1	572	580	PF00400	0.628
LIG_eIF4E_1	573	579	PF01652	0.627
LIG_FHA_1	229	235	PF00498	0.588
LIG_FHA_1	294	300	PF00498	0.597
LIG_FHA_1	360	366	PF00498	0.694
LIG_FHA_1	525	531	PF00498	0.751
LIG_FHA_1	589	595	PF00498	0.688
LIG_FHA_1	620	626	PF00498	0.781
LIG_FHA_2	402	408	PF00498	0.745
LIG_FHA_2	61	67	PF00498	0.599
LIG_FXI_DFP_1	140	144	PF00024	0.655
LIG_Integrin_isoDGR_2	335	337	PF01839	0.718
LIG_LIR_Apic_2	142	148	PF02991	0.731
LIG_LIR_Apic_2	516	522	PF02991	0.743
LIG_LIR_Apic_2	668	674	PF02991	0.604
LIG_LIR_Gen_1	105	116	PF02991	0.550
LIG_LIR_Gen_1	516	525	PF02991	0.680
LIG_LIR_Nem_3	105	111	PF02991	0.557
LIG_LIR_Nem_3	314	318	PF02991	0.749
LIG_LIR_Nem_3	389	393	PF02991	0.692
LIG_LIR_Nem_3	511	517	PF02991	0.736
LIG_MAD2	236	244	PF02301	0.586
LIG_MYND_1	32	36	PF01753	0.589
LIG_PAM2_1	109	121	PF00658	0.672
LIG_PTAP_UEV_1	341	346	PF05743	0.704
LIG_Rb_pABgroove_1	135	143	PF01858	0.715
LIG_SH2_CRK	145	149	PF00017	0.673
LIG_SH2_CRK	18	22	PF00017	0.561
LIG_SH2_CRK	315	319	PF00017	0.762
LIG_SH2_CRK	393	397	PF00017	0.690
LIG_SH2_CRK	573	577	PF00017	0.656
LIG_SH2_GRB2like	519	522	PF00017	0.711
LIG_SH2_PTP2	519	522	PF00017	0.743
LIG_SH2_SRC	161	164	PF00017	0.562
LIG_SH2_SRC	18	21	PF00017	0.561
LIG_SH2_SRC	517	520	PF00017	0.754
LIG_SH2_STAP1	466	470	PF00017	0.587
LIG_SH2_STAT3	446	449	PF00017	0.740
LIG_SH2_STAT5	161	164	PF00017	0.562
LIG_SH2_STAT5	393	396	PF00017	0.713
LIG_SH2_STAT5	444	447	PF00017	0.740
LIG_SH2_STAT5	519	522	PF00017	0.743
LIG_SH3_1	145	151	PF00018	0.738
LIG_SH3_1	262	268	PF00018	0.721
LIG_SH3_1	519	525	PF00018	0.737
LIG_SH3_2	680	685	PF14604	0.595
LIG_SH3_3	145	151	PF00018	0.748
LIG_SH3_3	26	32	PF00018	0.565
LIG_SH3_3	262	268	PF00018	0.721
LIG_SH3_3	278	284	PF00018	0.816
LIG_SH3_3	339	345	PF00018	0.706
LIG_SH3_3	348	354	PF00018	0.641
LIG_SH3_3	475	481	PF00018	0.724
LIG_SH3_3	519	525	PF00018	0.772
LIG_SH3_3	53	59	PF00018	0.678
LIG_SH3_3	530	536	PF00018	0.599
LIG_SH3_3	675	681	PF00018	0.756
LIG_SH3_3	702	708	PF00018	0.775
LIG_SH3_3	713	719	PF00018	0.581
LIG_SUMO_SIM_anti_2	527	532	PF11976	0.625
LIG_SUMO_SIM_par_1	523	529	PF11976	0.677
LIG_TRAF2_1	179	182	PF00917	0.689
LIG_WW_3	353	357	PF00397	0.743
LIG_WW_3	558	562	PF00397	0.628
MOD_CDC14_SPxK_1	266	269	PF00782	0.581
MOD_CDC14_SPxK_1	55	58	PF00782	0.593
MOD_CDC14_SPxK_1	673	676	PF00782	0.766
MOD_CDK_SPK_2	147	152	PF00069	0.743
MOD_CDK_SPxK_1	263	269	PF00069	0.592
MOD_CDK_SPxK_1	399	405	PF00069	0.614
MOD_CDK_SPxK_1	52	58	PF00069	0.590
MOD_CDK_SPxK_1	670	676	PF00069	0.780
MOD_CDK_SPxxK_3	399	406	PF00069	0.712
MOD_CK1_1	147	153	PF00069	0.746
MOD_CK1_1	165	171	PF00069	0.736
MOD_CK1_1	213	219	PF00069	0.735
MOD_CK1_1	257	263	PF00069	0.719
MOD_CK1_1	276	282	PF00069	0.756
MOD_CK1_1	289	295	PF00069	0.591
MOD_CK1_1	298	304	PF00069	0.654
MOD_CK1_1	383	389	PF00069	0.759
MOD_CK1_1	491	497	PF00069	0.748
MOD_CK1_1	535	541	PF00069	0.710
MOD_CK1_1	54	60	PF00069	0.737
MOD_CK1_1	543	549	PF00069	0.687
MOD_CK1_1	599	605	PF00069	0.788
MOD_CK1_1	618	624	PF00069	0.528
MOD_CK1_1	62	68	PF00069	0.707
MOD_CK1_1	627	633	PF00069	0.695
MOD_CK1_1	643	649	PF00069	0.604
MOD_CK1_1	665	671	PF00069	0.783
MOD_CK1_1	73	79	PF00069	0.575
MOD_CK1_1	743	749	PF00069	0.730
MOD_CK1_1	84	90	PF00069	0.551
MOD_CK2_1	151	157	PF00069	0.760
MOD_CK2_1	401	407	PF00069	0.709
MOD_CK2_1	432	438	PF00069	0.695
MOD_CK2_1	563	569	PF00069	0.696
MOD_CK2_1	60	66	PF00069	0.745
MOD_CK2_1	617	623	PF00069	0.700
MOD_CK2_1	634	640	PF00069	0.588
MOD_CK2_1	647	653	PF00069	0.760
MOD_CK2_1	669	675	PF00069	0.742
MOD_CK2_1	694	700	PF00069	0.701
MOD_CK2_1	708	714	PF00069	0.555
MOD_CK2_1	71	77	PF00069	0.622
MOD_DYRK1A_RPxSP_1	458	462	PF00069	0.711
MOD_GlcNHglycan	130	133	PF01048	0.674
MOD_GlcNHglycan	164	167	PF01048	0.592
MOD_GlcNHglycan	177	180	PF01048	0.747
MOD_GlcNHglycan	192	195	PF01048	0.694
MOD_GlcNHglycan	291	294	PF01048	0.769
MOD_GlcNHglycan	451	454	PF01048	0.704
MOD_GlcNHglycan	471	475	PF01048	0.771
MOD_GlcNHglycan	601	604	PF01048	0.734
MOD_GlcNHglycan	738	741	PF01048	0.805
MOD_GlcNHglycan	744	748	PF01048	0.757
MOD_GSK3_1	147	154	PF00069	0.746
MOD_GSK3_1	162	169	PF00069	0.478
MOD_GSK3_1	228	235	PF00069	0.587
MOD_GSK3_1	249	256	PF00069	0.663
MOD_GSK3_1	284	291	PF00069	0.667
MOD_GSK3_1	307	314	PF00069	0.689
MOD_GSK3_1	376	383	PF00069	0.783
MOD_GSK3_1	407	414	PF00069	0.787
MOD_GSK3_1	47	54	PF00069	0.767
MOD_GSK3_1	488	495	PF00069	0.809
MOD_GSK3_1	520	527	PF00069	0.772
MOD_GSK3_1	60	67	PF00069	0.680
MOD_GSK3_1	613	620	PF00069	0.768
MOD_GSK3_1	623	630	PF00069	0.671
MOD_GSK3_1	636	643	PF00069	0.662
MOD_GSK3_1	665	672	PF00069	0.783
MOD_GSK3_1	71	78	PF00069	0.650
MOD_GSK3_1	736	743	PF00069	0.738
MOD_GSK3_1	82	89	PF00069	0.606
MOD_N-GLC_1	213	218	PF02516	0.708
MOD_N-GLC_1	640	645	PF02516	0.708
MOD_N-GLC_2	409	411	PF02516	0.687
MOD_NEK2_1	418	423	PF00069	0.585
MOD_NEK2_1	470	475	PF00069	0.768
MOD_NEK2_1	542	547	PF00069	0.670
MOD_NEK2_1	582	587	PF00069	0.679
MOD_NEK2_1	644	649	PF00069	0.797
MOD_NEK2_1	81	86	PF00069	0.696
MOD_NEK2_2	563	568	PF00069	0.700
MOD_NEK2_2	758	763	PF00069	0.704
MOD_PIKK_1	166	172	PF00454	0.750
MOD_PIKK_1	284	290	PF00454	0.575
MOD_PIKK_1	329	335	PF00454	0.807
MOD_PIKK_1	383	389	PF00454	0.631
MOD_PIKK_1	488	494	PF00454	0.731
MOD_PIKK_1	665	671	PF00454	0.783
MOD_PK_1	694	700	PF00069	0.701
MOD_PKA_1	128	134	PF00069	0.676
MOD_PKA_2	189	195	PF00069	0.693
MOD_PKA_2	249	255	PF00069	0.600
MOD_PKA_2	284	290	PF00069	0.575
MOD_PKA_2	543	549	PF00069	0.748
MOD_PKA_2	57	63	PF00069	0.633
MOD_PKA_2	693	699	PF00069	0.706
MOD_PKA_2	70	76	PF00069	0.659
MOD_PKA_2	740	746	PF00069	0.748
MOD_PKA_2	82	88	PF00069	0.612
MOD_Plk_1	244	250	PF00069	0.693
MOD_Plk_1	257	263	PF00069	0.586
MOD_Plk_1	411	417	PF00069	0.783
MOD_Plk_1	470	476	PF00069	0.796
MOD_Plk_1	596	602	PF00069	0.785
MOD_Plk_1	640	646	PF00069	0.708
MOD_Plk_1	76	82	PF00069	0.697
MOD_Plk_1	89	95	PF00069	0.568
MOD_Plk_4	122	128	PF00069	0.734
MOD_Plk_4	411	417	PF00069	0.751
MOD_Plk_4	492	498	PF00069	0.701
MOD_Plk_4	501	507	PF00069	0.603
MOD_Plk_4	526	532	PF00069	0.751
MOD_Plk_4	543	549	PF00069	0.540
MOD_Plk_4	574	580	PF00069	0.663
MOD_Plk_4	76	82	PF00069	0.595
MOD_ProDKin_1	1	7	PF00069	0.486
MOD_ProDKin_1	144	150	PF00069	0.736
MOD_ProDKin_1	151	157	PF00069	0.666
MOD_ProDKin_1	202	208	PF00069	0.714
MOD_ProDKin_1	263	269	PF00069	0.799
MOD_ProDKin_1	293	299	PF00069	0.627
MOD_ProDKin_1	316	322	PF00069	0.654
MOD_ProDKin_1	338	344	PF00069	0.739
MOD_ProDKin_1	399	405	PF00069	0.709
MOD_ProDKin_1	458	464	PF00069	0.773
MOD_ProDKin_1	485	491	PF00069	0.836
MOD_ProDKin_1	498	504	PF00069	0.664
MOD_ProDKin_1	52	58	PF00069	0.654
MOD_ProDKin_1	521	527	PF00069	0.732
MOD_ProDKin_1	532	538	PF00069	0.591
MOD_ProDKin_1	588	594	PF00069	0.640
MOD_ProDKin_1	615	621	PF00069	0.660
MOD_ProDKin_1	670	676	PF00069	0.837
MOD_SUMO_for_1	179	182	PF00179	0.673
MOD_SUMO_for_1	357	360	PF00179	0.701
MOD_SUMO_rev_2	142	148	PF00179	0.667
MOD_SUMO_rev_2	374	379	PF00179	0.771
TRG_DiLeu_BaEn_2	435	441	PF01217	0.555
TRG_DiLeu_BaLyEn_6	702	707	PF01217	0.670
TRG_ENDOCYTIC_2	315	318	PF00928	0.817
TRG_ENDOCYTIC_2	517	520	PF00928	0.754
TRG_ENDOCYTIC_2	573	576	PF00928	0.657
TRG_ER_diArg_1	40	43	PF00400	0.675
TRG_NLS_MonoExtN_4	38	45	PF00514	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEZ8	Leishmania donovani	86%	100%
A4HJJ4	Leishmania braziliensis	49%	99%
A4I6Z1	Leishmania infantum	85%	100%
E9B212	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%