tRNA_lig_CPD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q648_LEIMA

TriTrypDb:

LmjF.31.2130 , LMJLV39_310030200 , LMJSD75_310030200

Length:

929

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q648

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q648

Function

Biological processes
Term	Name	Level	Count
GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	8	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	9	10
GO:0006396	RNA processing	6	10
GO:0006399	tRNA metabolic process	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008033	tRNA processing	8	10
GO:0008152	metabolic process	1	10
GO:0008380	RNA splicing	7	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0016310	phosphorylation	5	2
GO:0033554	cellular response to stress	3	2
GO:0034470	ncRNA processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034660	ncRNA metabolic process	6	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	10
GO:0046939	obsolete nucleotide phosphorylation	6	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003690	double-stranded DNA binding	5	2
GO:0003824	catalytic activity	1	10
GO:0003972	RNA ligase (ATP) activity	5	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0008452	RNA ligase activity	4	10
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0016874	ligase activity	2	10
GO:0016886	ligase activity, forming phosphoric ester bonds	3	10
GO:0017076	purine nucleotide binding	4	10
GO:0019205	nucleobase-containing compound kinase activity	5	2
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0046403	polynucleotide 3'-phosphatase activity	6	2
GO:0046404	polydeoxyribonucleotide 5'-hydroxyl-kinase activity	7	2
GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	5	2
GO:0051733	polydeoxyribonucleotide kinase activity	6	2
GO:0051734	polynucleotide kinase activity	6	2
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140098	catalytic activity, acting on RNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	372	376	PF00656	0.702
CLV_C14_Caspase3-7	384	388	PF00656	0.379
CLV_C14_Caspase3-7	547	551	PF00656	0.513
CLV_NRD_NRD_1	152	154	PF00675	0.344
CLV_NRD_NRD_1	16	18	PF00675	0.739
CLV_NRD_NRD_1	215	217	PF00675	0.430
CLV_NRD_NRD_1	430	432	PF00675	0.453
CLV_NRD_NRD_1	534	536	PF00675	0.423
CLV_NRD_NRD_1	713	715	PF00675	0.477
CLV_NRD_NRD_1	867	869	PF00675	0.497
CLV_NRD_NRD_1	886	888	PF00675	0.304
CLV_NRD_NRD_1	910	912	PF00675	0.549
CLV_PCSK_FUR_1	14	18	PF00082	0.774
CLV_PCSK_KEX2_1	16	18	PF00082	0.718
CLV_PCSK_KEX2_1	193	195	PF00082	0.623
CLV_PCSK_KEX2_1	215	217	PF00082	0.430
CLV_PCSK_KEX2_1	343	345	PF00082	0.470
CLV_PCSK_KEX2_1	430	432	PF00082	0.451
CLV_PCSK_KEX2_1	617	619	PF00082	0.522
CLV_PCSK_KEX2_1	867	869	PF00082	0.391
CLV_PCSK_KEX2_1	910	912	PF00082	0.505
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.623
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.470
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.606
CLV_PCSK_PC1ET2_1	910	912	PF00082	0.564
CLV_PCSK_PC7_1	426	432	PF00082	0.424
CLV_PCSK_SKI1_1	259	263	PF00082	0.457
CLV_PCSK_SKI1_1	292	296	PF00082	0.531
CLV_PCSK_SKI1_1	343	347	PF00082	0.510
CLV_PCSK_SKI1_1	626	630	PF00082	0.447
CLV_PCSK_SKI1_1	759	763	PF00082	0.367
CLV_PCSK_SKI1_1	802	806	PF00082	0.475
CLV_PCSK_SKI1_1	911	915	PF00082	0.586
DEG_APCC_DBOX_1	527	535	PF00400	0.560
DEG_Nend_UBRbox_1	1	4	PF02207	0.763
DEG_SPOP_SBC_1	32	36	PF00917	0.661
DOC_ANK_TNKS_1	215	222	PF00023	0.452
DOC_CKS1_1	720	725	PF01111	0.359
DOC_CYCLIN_RxL_1	799	810	PF00134	0.487
DOC_CYCLIN_yClb1_LxF_4	331	337	PF00134	0.480
DOC_CYCLIN_yCln2_LP_2	806	809	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	85	91	PF00134	0.566
DOC_MAPK_gen_1	77	85	PF00069	0.473
DOC_MAPK_gen_1	910	916	PF00069	0.493
DOC_MAPK_MEF2A_6	724	733	PF00069	0.479
DOC_PP2B_LxvP_1	389	392	PF13499	0.421
DOC_PP2B_LxvP_1	806	809	PF13499	0.488
DOC_PP2B_LxvP_1	83	86	PF13499	0.492
DOC_PP2B_LxvP_1	914	917	PF13499	0.451
DOC_PP2B_PxIxI_1	879	885	PF00149	0.321
DOC_PP4_FxxP_1	187	190	PF00568	0.504
DOC_PP4_FxxP_1	581	584	PF00568	0.450
DOC_PP4_FxxP_1	720	723	PF00568	0.345
DOC_SPAK_OSR1_1	216	220	PF12202	0.357
DOC_USP7_MATH_1	32	36	PF00917	0.765
DOC_USP7_MATH_1	43	47	PF00917	0.710
DOC_USP7_MATH_1	442	446	PF00917	0.426
DOC_USP7_MATH_1	584	588	PF00917	0.447
DOC_USP7_MATH_1	71	75	PF00917	0.465
DOC_USP7_UBL2_3	154	158	PF12436	0.481
DOC_WW_Pin1_4	137	142	PF00397	0.589
DOC_WW_Pin1_4	275	280	PF00397	0.537
DOC_WW_Pin1_4	292	297	PF00397	0.468
DOC_WW_Pin1_4	39	44	PF00397	0.752
DOC_WW_Pin1_4	415	420	PF00397	0.542
DOC_WW_Pin1_4	520	525	PF00397	0.547
DOC_WW_Pin1_4	719	724	PF00397	0.523
DOC_WW_Pin1_4	734	739	PF00397	0.532
DOC_WW_Pin1_4	897	902	PF00397	0.393
LIG_14-3-3_CanoR_1	247	254	PF00244	0.452
LIG_14-3-3_CanoR_1	30	39	PF00244	0.812
LIG_14-3-3_CanoR_1	409	413	PF00244	0.428
LIG_14-3-3_CanoR_1	626	635	PF00244	0.543
LIG_14-3-3_CanoR_1	708	713	PF00244	0.426
LIG_14-3-3_CanoR_1	759	766	PF00244	0.349
LIG_Actin_WH2_2	541	558	PF00022	0.420
LIG_Actin_WH2_2	743	761	PF00022	0.326
LIG_APCC_ABBA_1	316	321	PF00400	0.402
LIG_BIR_III_4	443	447	PF00653	0.507
LIG_BIR_III_4	557	561	PF00653	0.459
LIG_BIR_III_4	858	862	PF00653	0.333
LIG_BRCT_BRCA1_1	213	217	PF00533	0.497
LIG_Clathr_ClatBox_1	730	734	PF01394	0.309
LIG_CtBP_PxDLS_1	657	661	PF00389	0.468
LIG_CtBP_PxDLS_1	808	812	PF00389	0.324
LIG_deltaCOP1_diTrp_1	500	508	PF00928	0.392
LIG_deltaCOP1_diTrp_1	537	545	PF00928	0.505
LIG_EH1_1	739	747	PF00400	0.365
LIG_EVH1_1	783	787	PF00568	0.351
LIG_EVH1_1	914	918	PF00568	0.347
LIG_FHA_1	140	146	PF00498	0.587
LIG_FHA_1	329	335	PF00498	0.547
LIG_FHA_1	517	523	PF00498	0.464
LIG_FHA_1	571	577	PF00498	0.504
LIG_FHA_1	634	640	PF00498	0.403
LIG_FHA_1	734	740	PF00498	0.428
LIG_FHA_1	753	759	PF00498	0.335
LIG_FHA_1	847	853	PF00498	0.470
LIG_FHA_2	51	57	PF00498	0.670
LIG_FHA_2	545	551	PF00498	0.500
LIG_FHA_2	627	633	PF00498	0.552
LIG_FHA_2	696	702	PF00498	0.501
LIG_FHA_2	720	726	PF00498	0.517
LIG_FHA_2	760	766	PF00498	0.499
LIG_LIR_Apic_2	159	165	PF02991	0.442
LIG_LIR_Apic_2	185	190	PF02991	0.488
LIG_LIR_Apic_2	408	413	PF02991	0.529
LIG_LIR_Apic_2	661	667	PF02991	0.381
LIG_LIR_Apic_2	719	723	PF02991	0.443
LIG_LIR_Gen_1	118	128	PF02991	0.448
LIG_LIR_Gen_1	140	149	PF02991	0.454
LIG_LIR_Gen_1	312	319	PF02991	0.350
LIG_LIR_Gen_1	652	660	PF02991	0.421
LIG_LIR_Gen_1	788	795	PF02991	0.478
LIG_LIR_Nem_3	118	123	PF02991	0.457
LIG_LIR_Nem_3	140	146	PF02991	0.480
LIG_LIR_Nem_3	214	220	PF02991	0.402
LIG_LIR_Nem_3	312	318	PF02991	0.340
LIG_LIR_Nem_3	333	339	PF02991	0.366
LIG_LIR_Nem_3	537	541	PF02991	0.509
LIG_LIR_Nem_3	652	656	PF02991	0.418
LIG_LIR_Nem_3	788	792	PF02991	0.477
LIG_NRBOX	595	601	PF00104	0.365
LIG_NRBOX	839	845	PF00104	0.479
LIG_PCNA_yPIPBox_3	797	805	PF02747	0.424
LIG_PCNA_yPIPBox_3	912	926	PF02747	0.317
LIG_Pex14_1	311	315	PF04695	0.425
LIG_Pex14_1	508	512	PF04695	0.446
LIG_Pex14_2	315	319	PF04695	0.441
LIG_SH2_CRK	143	147	PF00017	0.589
LIG_SH2_CRK	241	245	PF00017	0.481
LIG_SH2_CRK	410	414	PF00017	0.453
LIG_SH2_CRK	653	657	PF00017	0.531
LIG_SH2_CRK	789	793	PF00017	0.359
LIG_SH2_GRB2like	653	656	PF00017	0.536
LIG_SH2_GRB2like	894	897	PF00017	0.296
LIG_SH2_NCK_1	143	147	PF00017	0.589
LIG_SH2_NCK_1	789	793	PF00017	0.384
LIG_SH2_PTP2	597	600	PF00017	0.372
LIG_SH2_SRC	131	134	PF00017	0.348
LIG_SH2_STAP1	248	252	PF00017	0.423
LIG_SH2_STAP1	337	341	PF00017	0.535
LIG_SH2_STAP1	674	678	PF00017	0.455
LIG_SH2_STAP1	776	780	PF00017	0.385
LIG_SH2_STAP1	894	898	PF00017	0.296
LIG_SH2_STAT3	383	386	PF00017	0.422
LIG_SH2_STAT5	131	134	PF00017	0.553
LIG_SH2_STAT5	324	327	PF00017	0.364
LIG_SH2_STAT5	421	424	PF00017	0.479
LIG_SH2_STAT5	597	600	PF00017	0.426
LIG_SH2_STAT5	779	782	PF00017	0.434
LIG_SH2_STAT5	827	830	PF00017	0.477
LIG_SH3_1	912	918	PF00018	0.350
LIG_SH3_2	905	910	PF14604	0.545
LIG_SH3_3	185	191	PF00018	0.504
LIG_SH3_3	720	726	PF00018	0.537
LIG_SH3_3	781	787	PF00018	0.539
LIG_SH3_3	902	908	PF00018	0.513
LIG_SH3_3	912	918	PF00018	0.407
LIG_SUMO_SIM_anti_2	575	580	PF11976	0.441
LIG_SUMO_SIM_par_1	656	661	PF11976	0.480
LIG_SUMO_SIM_par_1	728	734	PF11976	0.469
LIG_SUMO_SIM_par_1	847	854	PF11976	0.425
LIG_TRAF2_1	173	176	PF00917	0.501
LIG_TRAF2_1	208	211	PF00917	0.560
LIG_TRAF2_1	698	701	PF00917	0.610
LIG_UBA3_1	531	536	PF00899	0.442
LIG_UBA3_1	639	648	PF00899	0.427
LIG_WW_1	786	789	PF00397	0.332
LIG_WW_1	891	894	PF00397	0.411
MOD_CDK_SPK_2	719	724	PF00069	0.437
MOD_CK1_1	134	140	PF00069	0.425
MOD_CK1_1	198	204	PF00069	0.622
MOD_CK1_1	277	283	PF00069	0.558
MOD_CK1_1	33	39	PF00069	0.742
MOD_CK1_1	408	414	PF00069	0.468
MOD_CK1_1	5	11	PF00069	0.572
MOD_CK1_1	50	56	PF00069	0.544
MOD_CK1_1	587	593	PF00069	0.327
MOD_CK1_1	633	639	PF00069	0.491
MOD_CK2_1	626	632	PF00069	0.527
MOD_CK2_1	695	701	PF00069	0.519
MOD_Cter_Amidation	615	618	PF01082	0.546
MOD_GlcNHglycan	105	108	PF01048	0.522
MOD_GlcNHglycan	184	187	PF01048	0.450
MOD_GlcNHglycan	268	271	PF01048	0.583
MOD_GlcNHglycan	280	283	PF01048	0.561
MOD_GlcNHglycan	327	331	PF01048	0.557
MOD_GlcNHglycan	410	413	PF01048	0.425
MOD_GlcNHglycan	443	447	PF01048	0.429
MOD_GlcNHglycan	570	573	PF01048	0.584
MOD_GlcNHglycan	586	589	PF01048	0.332
MOD_GlcNHglycan	613	617	PF01048	0.421
MOD_GlcNHglycan	8	11	PF01048	0.689
MOD_GSK3_1	1	8	PF00069	0.720
MOD_GSK3_1	12	19	PF00069	0.600
MOD_GSK3_1	133	140	PF00069	0.532
MOD_GSK3_1	197	204	PF00069	0.545
MOD_GSK3_1	274	281	PF00069	0.655
MOD_GSK3_1	33	40	PF00069	0.767
MOD_GSK3_1	351	358	PF00069	0.637
MOD_GSK3_1	43	50	PF00069	0.739
MOD_GSK3_1	516	523	PF00069	0.429
MOD_GSK3_1	544	551	PF00069	0.485
MOD_GSK3_1	584	591	PF00069	0.310
MOD_GSK3_1	626	633	PF00069	0.536
MOD_GSK3_1	656	663	PF00069	0.484
MOD_GSK3_1	764	771	PF00069	0.440
MOD_GSK3_1	844	851	PF00069	0.324
MOD_N-GLC_1	137	142	PF02516	0.569
MOD_N-GLC_1	43	48	PF02516	0.670
MOD_N-GLC_1	695	700	PF02516	0.512
MOD_N-GLC_1	752	757	PF02516	0.523
MOD_N-GLC_1	918	923	PF02516	0.481
MOD_NEK2_1	1	6	PF00069	0.759
MOD_NEK2_1	302	307	PF00069	0.392
MOD_NEK2_1	310	315	PF00069	0.360
MOD_NEK2_1	319	324	PF00069	0.274
MOD_NEK2_1	326	331	PF00069	0.460
MOD_NEK2_1	405	410	PF00069	0.448
MOD_NEK2_1	516	521	PF00069	0.421
MOD_NEK2_1	599	604	PF00069	0.496
MOD_NEK2_1	621	626	PF00069	0.491
MOD_NEK2_1	658	663	PF00069	0.460
MOD_NEK2_1	66	71	PF00069	0.539
MOD_NEK2_1	733	738	PF00069	0.483
MOD_NEK2_1	821	826	PF00069	0.357
MOD_NEK2_1	844	849	PF00069	0.496
MOD_NEK2_2	687	692	PF00069	0.505
MOD_NEK2_2	754	759	PF00069	0.357
MOD_PIKK_1	198	204	PF00454	0.635
MOD_PIKK_1	246	252	PF00454	0.430
MOD_PIKK_1	319	325	PF00454	0.442
MOD_PIKK_1	381	387	PF00454	0.378
MOD_PIKK_1	43	49	PF00454	0.731
MOD_PIKK_1	516	522	PF00454	0.335
MOD_PIKK_1	626	632	PF00454	0.494
MOD_PIKK_1	822	828	PF00454	0.298
MOD_PKA_1	16	22	PF00069	0.671
MOD_PKA_2	1	7	PF00069	0.815
MOD_PKA_2	16	22	PF00069	0.604
MOD_PKA_2	246	252	PF00069	0.405
MOD_PKA_2	408	414	PF00069	0.551
MOD_PKA_2	462	468	PF00069	0.446
MOD_PKB_1	14	22	PF00069	0.571
MOD_Plk_1	101	107	PF00069	0.387
MOD_Plk_1	158	164	PF00069	0.506
MOD_Plk_1	631	637	PF00069	0.545
MOD_Plk_1	695	701	PF00069	0.423
MOD_Plk_1	918	924	PF00069	0.490
MOD_Plk_4	141	147	PF00069	0.486
MOD_Plk_4	167	173	PF00069	0.433
MOD_Plk_4	302	308	PF00069	0.366
MOD_Plk_4	544	550	PF00069	0.326
MOD_Plk_4	660	666	PF00069	0.419
MOD_Plk_4	851	857	PF00069	0.363
MOD_Plk_4	918	924	PF00069	0.417
MOD_ProDKin_1	137	143	PF00069	0.578
MOD_ProDKin_1	275	281	PF00069	0.533
MOD_ProDKin_1	292	298	PF00069	0.462
MOD_ProDKin_1	39	45	PF00069	0.753
MOD_ProDKin_1	415	421	PF00069	0.536
MOD_ProDKin_1	520	526	PF00069	0.544
MOD_ProDKin_1	719	725	PF00069	0.518
MOD_ProDKin_1	734	740	PF00069	0.529
MOD_ProDKin_1	897	903	PF00069	0.393
MOD_SUMO_rev_2	550	555	PF00179	0.556
MOD_SUMO_rev_2	641	649	PF00179	0.439
TRG_DiLeu_BaEn_1	78	83	PF01217	0.333
TRG_DiLeu_LyEn_5	78	83	PF01217	0.333
TRG_ENDOCYTIC_2	143	146	PF00928	0.453
TRG_ENDOCYTIC_2	241	244	PF00928	0.474
TRG_ENDOCYTIC_2	307	310	PF00928	0.390
TRG_ENDOCYTIC_2	597	600	PF00928	0.392
TRG_ENDOCYTIC_2	653	656	PF00928	0.474
TRG_ENDOCYTIC_2	789	792	PF00928	0.439
TRG_ER_diArg_1	14	17	PF00400	0.630
TRG_ER_diArg_1	215	217	PF00400	0.430
TRG_ER_diArg_1	430	432	PF00400	0.504
TRG_ER_diArg_1	866	868	PF00400	0.337
TRG_NES_CRM1_1	734	748	PF08389	0.406
TRG_NLS_MonoExtN_4	908	914	PF00514	0.533
TRG_Pf-PMV_PEXEL_1	697	701	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S2	Leptomonas seymouri	59%	100%
A0A0S4J4W5	Bodo saltans	35%	100%
A0A1X0NHZ8	Trypanosomatidae	33%	100%
A0A3R7M5Z2	Trypanosoma rangeli	36%	100%
A0A3S7X4Q3	Leishmania donovani	89%	100%
A4HJJ5	Leishmania braziliensis	70%	100%
A4I6Z2	Leishmania infantum	89%	100%
E9B213	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%