Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q645_LEIMA

TriTrypDb:

LmjF.31.2160 , LMJLV39_310030500 , LMJSD75_310030500

Length:

825

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q645

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q645

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.618
CLV_C14_Caspase3-7	420	424	PF00656	0.620
CLV_C14_Caspase3-7	596	600	PF00656	0.745
CLV_C14_Caspase3-7	615	619	PF00656	0.578
CLV_NRD_NRD_1	106	108	PF00675	0.706
CLV_NRD_NRD_1	180	182	PF00675	0.677
CLV_NRD_NRD_1	269	271	PF00675	0.810
CLV_NRD_NRD_1	34	36	PF00675	0.692
CLV_NRD_NRD_1	443	445	PF00675	0.708
CLV_NRD_NRD_1	574	576	PF00675	0.808
CLV_NRD_NRD_1	85	87	PF00675	0.764
CLV_NRD_NRD_1	95	97	PF00675	0.652
CLV_PCSK_KEX2_1	106	108	PF00082	0.706
CLV_PCSK_KEX2_1	180	182	PF00082	0.737
CLV_PCSK_KEX2_1	328	330	PF00082	0.762
CLV_PCSK_KEX2_1	33	35	PF00082	0.876
CLV_PCSK_KEX2_1	443	445	PF00082	0.708
CLV_PCSK_KEX2_1	46	48	PF00082	0.648
CLV_PCSK_KEX2_1	534	536	PF00082	0.749
CLV_PCSK_KEX2_1	574	576	PF00082	0.769
CLV_PCSK_KEX2_1	585	587	PF00082	0.821
CLV_PCSK_KEX2_1	696	698	PF00082	0.815
CLV_PCSK_KEX2_1	95	97	PF00082	0.669
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.762
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.876
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.648
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.749
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.778
CLV_PCSK_PC1ET2_1	696	698	PF00082	0.782
CLV_PCSK_SKI1_1	100	104	PF00082	0.623
CLV_PCSK_SKI1_1	181	185	PF00082	0.573
CLV_PCSK_SKI1_1	217	221	PF00082	0.667
DEG_Nend_UBRbox_1	1	4	PF02207	0.675
DEG_SCF_FBW7_1	396	403	PF00400	0.605
DEG_SPOP_SBC_1	121	125	PF00917	0.718
DEG_SPOP_SBC_1	186	190	PF00917	0.768
DEG_SPOP_SBC_1	251	255	PF00917	0.687
DEG_SPOP_SBC_1	500	504	PF00917	0.747
DEG_SPOP_SBC_1	90	94	PF00917	0.617
DOC_CYCLIN_RxL_1	178	188	PF00134	0.586
DOC_MAPK_gen_1	328	335	PF00069	0.596
DOC_PP1_RVXF_1	215	222	PF00149	0.709
DOC_PP4_FxxP_1	260	263	PF00568	0.779
DOC_PP4_FxxP_1	285	288	PF00568	0.802
DOC_PP4_FxxP_1	388	391	PF00568	0.761
DOC_PP4_FxxP_1	760	763	PF00568	0.665
DOC_PP4_MxPP_1	291	294	PF00568	0.783
DOC_PP4_MxPP_1	711	714	PF00568	0.724
DOC_SPAK_OSR1_1	314	318	PF12202	0.695
DOC_USP7_MATH_1	114	118	PF00917	0.610
DOC_USP7_MATH_1	134	138	PF00917	0.727
DOC_USP7_MATH_1	140	144	PF00917	0.678
DOC_USP7_MATH_1	186	190	PF00917	0.814
DOC_USP7_MATH_1	23	27	PF00917	0.684
DOC_USP7_MATH_1	232	236	PF00917	0.615
DOC_USP7_MATH_1	237	241	PF00917	0.596
DOC_USP7_MATH_1	323	327	PF00917	0.613
DOC_USP7_MATH_1	356	360	PF00917	0.715
DOC_USP7_MATH_1	430	434	PF00917	0.765
DOC_USP7_MATH_1	453	457	PF00917	0.621
DOC_USP7_MATH_1	498	502	PF00917	0.782
DOC_USP7_MATH_1	5	9	PF00917	0.626
DOC_USP7_MATH_1	593	597	PF00917	0.662
DOC_USP7_MATH_1	672	676	PF00917	0.783
DOC_USP7_MATH_1	783	787	PF00917	0.682
DOC_USP7_MATH_1	90	94	PF00917	0.691
DOC_USP7_UBL2_3	2	6	PF12436	0.657
DOC_USP7_UBL2_3	226	230	PF12436	0.754
DOC_USP7_UBL2_3	60	64	PF12436	0.758
DOC_WW_Pin1_4	11	16	PF00397	0.800
DOC_WW_Pin1_4	132	137	PF00397	0.734
DOC_WW_Pin1_4	209	214	PF00397	0.694
DOC_WW_Pin1_4	221	226	PF00397	0.782
DOC_WW_Pin1_4	235	240	PF00397	0.601
DOC_WW_Pin1_4	349	354	PF00397	0.815
DOC_WW_Pin1_4	36	41	PF00397	0.693
DOC_WW_Pin1_4	379	384	PF00397	0.674
DOC_WW_Pin1_4	392	397	PF00397	0.736
DOC_WW_Pin1_4	426	431	PF00397	0.723
DOC_WW_Pin1_4	449	454	PF00397	0.594
DOC_WW_Pin1_4	576	581	PF00397	0.777
DOC_WW_Pin1_4	626	631	PF00397	0.638
DOC_WW_Pin1_4	661	666	PF00397	0.648
DOC_WW_Pin1_4	703	708	PF00397	0.695
DOC_WW_Pin1_4	709	714	PF00397	0.679
DOC_WW_Pin1_4	741	746	PF00397	0.746
DOC_WW_Pin1_4	759	764	PF00397	0.776
DOC_WW_Pin1_4	771	776	PF00397	0.715
DOC_WW_Pin1_4	814	819	PF00397	0.768
LIG_14-3-3_CanoR_1	174	183	PF00244	0.701
LIG_14-3-3_CanoR_1	243	250	PF00244	0.817
LIG_14-3-3_CanoR_1	34	40	PF00244	0.642
LIG_14-3-3_CanoR_1	389	395	PF00244	0.608
LIG_14-3-3_CanoR_1	47	55	PF00244	0.752
LIG_14-3-3_CanoR_1	518	525	PF00244	0.714
LIG_14-3-3_CanoR_1	528	532	PF00244	0.701
LIG_14-3-3_CanoR_1	535	540	PF00244	0.594
LIG_14-3-3_CanoR_1	632	636	PF00244	0.655
LIG_14-3-3_CanoR_1	697	702	PF00244	0.786
LIG_14-3-3_CanoR_1	792	800	PF00244	0.586
LIG_BIR_III_2	191	195	PF00653	0.617
LIG_BIR_III_4	618	622	PF00653	0.652
LIG_BRCT_BRCA1_1	13	17	PF00533	0.722
LIG_BRCT_BRCA1_1	256	260	PF00533	0.659
LIG_BRCT_BRCA1_1	371	375	PF00533	0.742
LIG_Clathr_ClatBox_1	803	807	PF01394	0.736
LIG_CtBP_PxDLS_1	391	395	PF00389	0.763
LIG_deltaCOP1_diTrp_1	750	760	PF00928	0.598
LIG_FHA_1	123	129	PF00498	0.722
LIG_FHA_1	444	450	PF00498	0.660
LIG_FHA_1	456	462	PF00498	0.699
LIG_FHA_1	60	66	PF00498	0.673
LIG_FHA_1	662	668	PF00498	0.781
LIG_FHA_1	777	783	PF00498	0.749
LIG_FHA_1	795	801	PF00498	0.531
LIG_FHA_2	198	204	PF00498	0.771
LIG_FHA_2	418	424	PF00498	0.696
LIG_FHA_2	609	615	PF00498	0.649
LIG_HCF-1_HBM_1	514	517	PF13415	0.762
LIG_Integrin_RGD_1	329	331	PF01839	0.756
LIG_LIR_Apic_2	147	153	PF02991	0.793
LIG_LIR_Apic_2	257	263	PF02991	0.660
LIG_LIR_Apic_2	283	288	PF02991	0.799
LIG_LIR_Apic_2	386	391	PF02991	0.756
LIG_LIR_Apic_2	759	763	PF02991	0.668
LIG_LIR_Gen_1	331	340	PF02991	0.755
LIG_LIR_Nem_3	283	289	PF02991	0.758
LIG_LIR_Nem_3	331	335	PF02991	0.751
LIG_LIR_Nem_3	411	417	PF02991	0.583
LIG_LIR_Nem_3	817	823	PF02991	0.767
LIG_LYPXL_S_1	285	289	PF13949	0.761
LIG_LYPXL_yS_3	286	289	PF13949	0.720
LIG_MAD2	638	646	PF02301	0.769
LIG_MLH1_MIPbox_1	13	17	PF16413	0.722
LIG_MLH1_MIPbox_1	372	376	PF16413	0.742
LIG_Pex14_1	414	418	PF04695	0.813
LIG_Pex14_1	720	724	PF04695	0.537
LIG_Pex14_2	151	155	PF04695	0.824
LIG_SH2_CRK	450	454	PF00017	0.594
LIG_SH2_CRK	704	708	PF00017	0.638
LIG_SH2_CRK	738	742	PF00017	0.651
LIG_SH2_CRK	772	776	PF00017	0.722
LIG_SH2_NCK_1	129	133	PF00017	0.589
LIG_SH2_NCK_1	772	776	PF00017	0.735
LIG_SH2_SRC	731	734	PF00017	0.544
LIG_SH2_STAT3	264	267	PF00017	0.828
LIG_SH2_STAT3	724	727	PF00017	0.513
LIG_SH2_STAT5	150	153	PF00017	0.818
LIG_SH2_STAT5	16	19	PF00017	0.770
LIG_SH2_STAT5	731	734	PF00017	0.738
LIG_SH3_1	226	232	PF00018	0.645
LIG_SH3_1	666	672	PF00018	0.784
LIG_SH3_2	627	632	PF14604	0.597
LIG_SH3_2	669	674	PF14604	0.785
LIG_SH3_3	226	232	PF00018	0.685
LIG_SH3_3	37	43	PF00018	0.701
LIG_SH3_3	624	630	PF00018	0.616
LIG_SH3_3	643	649	PF00018	0.631
LIG_SH3_3	666	672	PF00018	0.862
LIG_SH3_3	812	818	PF00018	0.755
LIG_SH3_CIN85_PxpxPR_1	396	401	PF14604	0.603
LIG_TRAF2_1	657	660	PF00917	0.777
LIG_TRAF2_1	8	11	PF00917	0.851
LIG_UBA3_1	219	226	PF00899	0.602
LIG_UBA3_1	639	645	PF00899	0.773
MOD_CDC14_SPxK_1	629	632	PF00782	0.600
MOD_CDK_SPK_2	221	226	PF00069	0.763
MOD_CDK_SPK_2	36	41	PF00069	0.727
MOD_CDK_SPK_2	396	401	PF00069	0.603
MOD_CDK_SPK_2	661	666	PF00069	0.627
MOD_CDK_SPK_2	703	708	PF00069	0.789
MOD_CDK_SPxK_1	626	632	PF00069	0.603
MOD_CDK_SPxxK_3	39	46	PF00069	0.700
MOD_CDK_SPxxK_3	814	821	PF00069	0.691
MOD_CK1_1	143	149	PF00069	0.661
MOD_CK1_1	156	162	PF00069	0.794
MOD_CK1_1	209	215	PF00069	0.677
MOD_CK1_1	235	241	PF00069	0.754
MOD_CK1_1	252	258	PF00069	0.677
MOD_CK1_1	367	373	PF00069	0.740
MOD_CK1_1	377	383	PF00069	0.614
MOD_CK1_1	49	55	PF00069	0.778
MOD_CK1_1	501	507	PF00069	0.649
MOD_CK1_1	520	526	PF00069	0.772
MOD_CK1_1	579	585	PF00069	0.845
MOD_CK1_1	600	606	PF00069	0.615
MOD_CK1_1	613	619	PF00069	0.577
MOD_CK1_1	631	637	PF00069	0.734
MOD_CK1_1	670	676	PF00069	0.677
MOD_CK1_1	762	768	PF00069	0.779
MOD_CK1_1	89	95	PF00069	0.742
MOD_CK2_1	143	149	PF00069	0.636
MOD_CK2_1	197	203	PF00069	0.773
MOD_CK2_1	23	29	PF00069	0.555
MOD_CK2_1	5	11	PF00069	0.846
MOD_CK2_1	581	587	PF00069	0.618
MOD_CK2_1	91	97	PF00069	0.728
MOD_Cter_Amidation	326	329	PF01082	0.692
MOD_Cter_Amidation	441	444	PF01082	0.673
MOD_DYRK1A_RPxSP_1	743	747	PF00069	0.590
MOD_GlcNHglycan	10	14	PF01048	0.690
MOD_GlcNHglycan	136	139	PF01048	0.700
MOD_GlcNHglycan	234	238	PF01048	0.806
MOD_GlcNHglycan	325	328	PF01048	0.708
MOD_GlcNHglycan	372	375	PF01048	0.816
MOD_GlcNHglycan	432	435	PF01048	0.737
MOD_GlcNHglycan	455	458	PF01048	0.766
MOD_GlcNHglycan	51	54	PF01048	0.706
MOD_GlcNHglycan	581	584	PF01048	0.660
MOD_GlcNHglycan	614	618	PF01048	0.600
MOD_GlcNHglycan	640	643	PF01048	0.778
MOD_GlcNHglycan	674	677	PF01048	0.723
MOD_GlcNHglycan	79	82	PF01048	0.730
MOD_GlcNHglycan	88	91	PF01048	0.805
MOD_GlcNHglycan	97	100	PF01048	0.588
MOD_GSK3_1	128	135	PF00069	0.706
MOD_GSK3_1	193	200	PF00069	0.775
MOD_GSK3_1	205	212	PF00069	0.636
MOD_GSK3_1	233	240	PF00069	0.674
MOD_GSK3_1	249	256	PF00069	0.554
MOD_GSK3_1	29	36	PF00069	0.680
MOD_GSK3_1	301	308	PF00069	0.705
MOD_GSK3_1	370	377	PF00069	0.741
MOD_GSK3_1	379	386	PF00069	0.746
MOD_GSK3_1	392	399	PF00069	0.631
MOD_GSK3_1	426	433	PF00069	0.691
MOD_GSK3_1	449	456	PF00069	0.782
MOD_GSK3_1	45	52	PF00069	0.730
MOD_GSK3_1	498	505	PF00069	0.788
MOD_GSK3_1	5	12	PF00069	0.821
MOD_GSK3_1	555	562	PF00069	0.756
MOD_GSK3_1	589	596	PF00069	0.794
MOD_GSK3_1	739	746	PF00069	0.759
MOD_GSK3_1	86	93	PF00069	0.780
MOD_LATS_1	231	237	PF00433	0.730
MOD_LATS_1	7	13	PF00433	0.770
MOD_N-GLC_1	186	191	PF02516	0.770
MOD_N-GLC_1	305	310	PF02516	0.642
MOD_N-GLC_1	343	348	PF02516	0.644
MOD_N-GLC_1	36	41	PF02516	0.630
MOD_N-GLC_1	484	489	PF02516	0.629
MOD_N-GLC_1	608	613	PF02516	0.656
MOD_N-GLC_1	709	714	PF02516	0.572
MOD_NEK2_1	105	110	PF00069	0.658
MOD_NEK2_1	128	133	PF00069	0.786
MOD_NEK2_1	17	22	PF00069	0.769
MOD_NEK2_1	205	210	PF00069	0.726
MOD_NEK2_1	250	255	PF00069	0.785
MOD_NEK2_1	343	348	PF00069	0.714
MOD_NEK2_1	375	380	PF00069	0.745
MOD_NEK2_1	45	50	PF00069	0.824
MOD_NEK2_1	499	504	PF00069	0.596
MOD_NEK2_1	543	548	PF00069	0.746
MOD_NEK2_1	791	796	PF00069	0.746
MOD_PIKK_1	140	146	PF00454	0.746
MOD_PIKK_1	212	218	PF00454	0.673
MOD_PIKK_1	243	249	PF00454	0.819
MOD_PK_1	535	541	PF00069	0.593
MOD_PK_1	697	703	PF00069	0.734
MOD_PKA_1	33	39	PF00069	0.731
MOD_PKA_1	443	449	PF00069	0.635
MOD_PKA_1	46	52	PF00069	0.676
MOD_PKA_1	86	92	PF00069	0.763
MOD_PKA_1	95	101	PF00069	0.672
MOD_PKA_2	105	111	PF00069	0.590
MOD_PKA_2	173	179	PF00069	0.711
MOD_PKA_2	33	39	PF00069	0.649
MOD_PKA_2	357	363	PF00069	0.750
MOD_PKA_2	400	406	PF00069	0.722
MOD_PKA_2	408	414	PF00069	0.604
MOD_PKA_2	443	449	PF00069	0.674
MOD_PKA_2	46	52	PF00069	0.774
MOD_PKA_2	517	523	PF00069	0.715
MOD_PKA_2	527	533	PF00069	0.700
MOD_PKA_2	631	637	PF00069	0.672
MOD_PKA_2	678	684	PF00069	0.698
MOD_PKA_2	791	797	PF00069	0.601
MOD_PKA_2	95	101	PF00069	0.683
MOD_Plk_1	153	159	PF00069	0.692
MOD_Plk_1	197	203	PF00069	0.734
MOD_Plk_1	484	490	PF00069	0.707
MOD_Plk_2-3	566	572	PF00069	0.711
MOD_Plk_2-3	610	616	PF00069	0.764
MOD_Plk_4	254	260	PF00069	0.727
MOD_Plk_4	383	389	PF00069	0.741
MOD_Plk_4	408	414	PF00069	0.777
MOD_Plk_4	485	491	PF00069	0.821
MOD_Plk_4	535	541	PF00069	0.680
MOD_Plk_4	631	637	PF00069	0.603
MOD_ProDKin_1	11	17	PF00069	0.801
MOD_ProDKin_1	132	138	PF00069	0.742
MOD_ProDKin_1	209	215	PF00069	0.692
MOD_ProDKin_1	221	227	PF00069	0.781
MOD_ProDKin_1	235	241	PF00069	0.600
MOD_ProDKin_1	349	355	PF00069	0.818
MOD_ProDKin_1	36	42	PF00069	0.691
MOD_ProDKin_1	379	385	PF00069	0.676
MOD_ProDKin_1	392	398	PF00069	0.736
MOD_ProDKin_1	426	432	PF00069	0.724
MOD_ProDKin_1	449	455	PF00069	0.594
MOD_ProDKin_1	576	582	PF00069	0.777
MOD_ProDKin_1	626	632	PF00069	0.640
MOD_ProDKin_1	661	667	PF00069	0.649
MOD_ProDKin_1	703	709	PF00069	0.693
MOD_ProDKin_1	741	747	PF00069	0.746
MOD_ProDKin_1	759	765	PF00069	0.775
MOD_ProDKin_1	771	777	PF00069	0.711
MOD_ProDKin_1	814	820	PF00069	0.769
MOD_SUMO_rev_2	52	62	PF00179	0.766
MOD_SUMO_rev_2	647	652	PF00179	0.807
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.705
TRG_ENDOCYTIC_2	129	132	PF00928	0.591
TRG_ENDOCYTIC_2	286	289	PF00928	0.759
TRG_ENDOCYTIC_2	490	493	PF00928	0.738
TRG_ENDOCYTIC_2	738	741	PF00928	0.810
TRG_ER_diArg_1	105	107	PF00400	0.761
TRG_ER_diArg_1	179	181	PF00400	0.674
TRG_ER_diArg_1	311	314	PF00400	0.826
TRG_ER_diArg_1	574	577	PF00400	0.655
TRG_ER_diArg_1	73	76	PF00400	0.732
TRG_NLS_MonoExtN_4	31	37	PF00514	0.864
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.730
TRG_Pf-PMV_PEXEL_1	735	739	PF00026	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4Q4	Leishmania donovani	83%	100%
A4HJJ8	Leishmania braziliensis	42%	90%
A4I6Z5	Leishmania infantum	83%	100%
E9B216	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%