Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q643_LEIMA

TriTrypDb:

LmjF.31.2180 , LMJLV39_310030800 , LMJSD75_310030800

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q643

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q643

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	565	569	PF00656	0.638
CLV_NRD_NRD_1	151	153	PF00675	0.739
CLV_NRD_NRD_1	191	193	PF00675	0.722
CLV_NRD_NRD_1	196	198	PF00675	0.727
CLV_NRD_NRD_1	324	326	PF00675	0.622
CLV_NRD_NRD_1	37	39	PF00675	0.552
CLV_NRD_NRD_1	42	44	PF00675	0.583
CLV_NRD_NRD_1	444	446	PF00675	0.746
CLV_NRD_NRD_1	501	503	PF00675	0.653
CLV_NRD_NRD_1	55	57	PF00675	0.529
CLV_NRD_NRD_1	551	553	PF00675	0.615
CLV_NRD_NRD_1	619	621	PF00675	0.710
CLV_NRD_NRD_1	648	650	PF00675	0.623
CLV_NRD_NRD_1	79	81	PF00675	0.700
CLV_NRD_NRD_1	9	11	PF00675	0.572
CLV_PCSK_FUR_1	194	198	PF00082	0.719
CLV_PCSK_FUR_1	38	42	PF00082	0.559
CLV_PCSK_FUR_1	617	621	PF00082	0.661
CLV_PCSK_KEX2_1	11	13	PF00082	0.728
CLV_PCSK_KEX2_1	151	153	PF00082	0.721
CLV_PCSK_KEX2_1	191	193	PF00082	0.722
CLV_PCSK_KEX2_1	196	198	PF00082	0.727
CLV_PCSK_KEX2_1	244	246	PF00082	0.694
CLV_PCSK_KEX2_1	350	352	PF00082	0.728
CLV_PCSK_KEX2_1	40	42	PF00082	0.595
CLV_PCSK_KEX2_1	444	446	PF00082	0.664
CLV_PCSK_KEX2_1	55	57	PF00082	0.550
CLV_PCSK_KEX2_1	60	62	PF00082	0.509
CLV_PCSK_KEX2_1	619	621	PF00082	0.772
CLV_PCSK_KEX2_1	650	652	PF00082	0.622
CLV_PCSK_KEX2_1	81	83	PF00082	0.706
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.728
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.694
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.661
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.572
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.508
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.772
CLV_PCSK_PC1ET2_1	650	652	PF00082	0.622
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.633
CLV_PCSK_PC7_1	192	198	PF00082	0.620
CLV_PCSK_PC7_1	240	246	PF00082	0.597
CLV_PCSK_PC7_1	36	42	PF00082	0.547
CLV_PCSK_PC7_1	56	62	PF00082	0.508
CLV_PCSK_SKI1_1	21	25	PF00082	0.546
CLV_PCSK_SKI1_1	320	324	PF00082	0.552
CLV_PCSK_SKI1_1	685	689	PF00082	0.635
CLV_PCSK_SKI1_1	82	86	PF00082	0.695
DEG_SCF_FBW7_2	710	716	PF00400	0.727
DEG_SPOP_SBC_1	574	578	PF00917	0.672
DOC_CKS1_1	710	715	PF01111	0.733
DOC_CKS1_1	846	851	PF01111	0.561
DOC_CYCLIN_RxL_1	317	328	PF00134	0.487
DOC_MAPK_gen_1	701	710	PF00069	0.663
DOC_MAPK_gen_1	813	821	PF00069	0.693
DOC_MAPK_MEF2A_6	212	220	PF00069	0.575
DOC_MAPK_MEF2A_6	309	318	PF00069	0.460
DOC_MAPK_RevD_3	310	326	PF00069	0.535
DOC_PP1_RVXF_1	683	689	PF00149	0.626
DOC_PP2B_LxvP_1	232	235	PF13499	0.629
DOC_PP2B_LxvP_1	95	98	PF13499	0.729
DOC_PP4_FxxP_1	16	19	PF00568	0.683
DOC_PP4_FxxP_1	472	475	PF00568	0.612
DOC_USP7_MATH_1	169	173	PF00917	0.691
DOC_USP7_MATH_1	202	206	PF00917	0.671
DOC_USP7_MATH_1	235	239	PF00917	0.618
DOC_USP7_MATH_1	423	427	PF00917	0.573
DOC_USP7_MATH_1	436	440	PF00917	0.589
DOC_USP7_MATH_1	453	457	PF00917	0.700
DOC_USP7_MATH_1	462	466	PF00917	0.639
DOC_USP7_MATH_1	49	53	PF00917	0.558
DOC_USP7_MATH_1	574	578	PF00917	0.666
DOC_USP7_MATH_1	610	614	PF00917	0.676
DOC_USP7_MATH_1	671	675	PF00917	0.535
DOC_USP7_MATH_1	717	721	PF00917	0.709
DOC_USP7_MATH_1	749	753	PF00917	0.714
DOC_USP7_MATH_1	90	94	PF00917	0.687
DOC_USP7_MATH_1	96	100	PF00917	0.633
DOC_USP7_UBL2_3	339	343	PF12436	0.675
DOC_USP7_UBL2_3	40	44	PF12436	0.587
DOC_USP7_UBL2_3	646	650	PF12436	0.619
DOC_USP7_UBL2_3	71	75	PF12436	0.650
DOC_WW_Pin1_4	186	191	PF00397	0.833
DOC_WW_Pin1_4	206	211	PF00397	0.694
DOC_WW_Pin1_4	395	400	PF00397	0.723
DOC_WW_Pin1_4	414	419	PF00397	0.519
DOC_WW_Pin1_4	575	580	PF00397	0.652
DOC_WW_Pin1_4	606	611	PF00397	0.666
DOC_WW_Pin1_4	629	634	PF00397	0.679
DOC_WW_Pin1_4	651	656	PF00397	0.647
DOC_WW_Pin1_4	676	681	PF00397	0.676
DOC_WW_Pin1_4	695	700	PF00397	0.544
DOC_WW_Pin1_4	709	714	PF00397	0.617
DOC_WW_Pin1_4	792	797	PF00397	0.707
DOC_WW_Pin1_4	82	87	PF00397	0.708
DOC_WW_Pin1_4	825	830	PF00397	0.680
DOC_WW_Pin1_4	845	850	PF00397	0.496
DOC_WW_Pin1_4	97	102	PF00397	0.559
LIG_14-3-3_CanoR_1	284	293	PF00244	0.522
LIG_14-3-3_CanoR_1	378	383	PF00244	0.660
LIG_14-3-3_CanoR_1	593	599	PF00244	0.656
LIG_14-3-3_CanoR_1	611	615	PF00244	0.588
LIG_14-3-3_CanoR_1	704	711	PF00244	0.728
LIG_14-3-3_CanoR_1	757	762	PF00244	0.702
LIG_14-3-3_CanoR_1	80	85	PF00244	0.671
LIG_14-3-3_CanoR_1	815	820	PF00244	0.697
LIG_14-3-3_CanoR_1	837	841	PF00244	0.584
LIG_14-3-3_CanoR_1	92	96	PF00244	0.604
LIG_BRCT_BRCA1_1	295	299	PF00533	0.637
LIG_BRCT_BRCA1_1	554	558	PF00533	0.560
LIG_BRCT_BRCA1_1	721	725	PF00533	0.690
LIG_Clathr_ClatBox_1	315	319	PF01394	0.455
LIG_EH_1	473	477	PF12763	0.538
LIG_FHA_1	117	123	PF00498	0.634
LIG_FHA_1	211	217	PF00498	0.645
LIG_FHA_1	309	315	PF00498	0.566
LIG_FHA_1	578	584	PF00498	0.607
LIG_FHA_1	626	632	PF00498	0.588
LIG_FHA_1	71	77	PF00498	0.632
LIG_FHA_1	737	743	PF00498	0.726
LIG_FHA_2	13	19	PF00498	0.698
LIG_FHA_2	22	28	PF00498	0.492
LIG_FHA_2	330	336	PF00498	0.635
LIG_FHA_2	514	520	PF00498	0.610
LIG_FHA_2	563	569	PF00498	0.640
LIG_FHA_2	61	67	PF00498	0.613
LIG_FHA_2	857	863	PF00498	0.658
LIG_Integrin_RGD_1	351	353	PF01839	0.588
LIG_LIR_Apic_2	15	19	PF02991	0.687
LIG_LIR_Gen_1	29	37	PF02991	0.573
LIG_LIR_Nem_3	29	34	PF02991	0.467
LIG_LYPXL_yS_3	661	664	PF13949	0.643
LIG_Pex14_2	472	476	PF04695	0.666
LIG_SH2_CRK	31	35	PF00017	0.491
LIG_SH2_GRB2like	31	34	PF00017	0.487
LIG_SH2_SRC	159	162	PF00017	0.549
LIG_SH2_SRC	744	747	PF00017	0.649
LIG_SH2_STAP1	31	35	PF00017	0.566
LIG_SH2_STAT3	525	528	PF00017	0.555
LIG_SH2_STAT5	293	296	PF00017	0.704
LIG_SH2_STAT5	31	34	PF00017	0.412
LIG_SH2_STAT5	506	509	PF00017	0.664
LIG_SH2_STAT5	525	528	PF00017	0.505
LIG_SH2_STAT5	871	874	PF00017	0.673
LIG_SH3_1	196	202	PF00018	0.619
LIG_SH3_2	98	103	PF14604	0.718
LIG_SH3_3	110	116	PF00018	0.547
LIG_SH3_3	120	126	PF00018	0.652
LIG_SH3_3	196	202	PF00018	0.619
LIG_SH3_3	211	217	PF00018	0.665
LIG_SH3_3	705	711	PF00018	0.711
LIG_SH3_3	823	829	PF00018	0.587
LIG_SH3_3	843	849	PF00018	0.503
LIG_SH3_3	95	101	PF00018	0.698
LIG_SUMO_SIM_anti_2	311	316	PF11976	0.562
LIG_SUMO_SIM_par_1	313	319	PF11976	0.458
LIG_SUMO_SIM_par_1	760	767	PF11976	0.649
LIG_TRAF2_1	603	606	PF00917	0.661
LIG_TRAF2_1	748	751	PF00917	0.668
LIG_UBA3_1	222	230	PF00899	0.585
LIG_UBA3_1	321	326	PF00899	0.490
LIG_UBA3_1	76	81	PF00899	0.630
LIG_WRC_WIRS_1	13	18	PF05994	0.706
LIG_WRC_WIRS_1	735	740	PF05994	0.644
LIG_WW_3	100	104	PF00397	0.710
MOD_CDC14_SPxK_1	100	103	PF00782	0.660
MOD_CDC14_SPxK_1	209	212	PF00782	0.604
MOD_CDC14_SPxK_1	578	581	PF00782	0.641
MOD_CDC14_SPxK_1	698	701	PF00782	0.643
MOD_CDK_SPK_2	186	191	PF00069	0.686
MOD_CDK_SPK_2	606	611	PF00069	0.641
MOD_CDK_SPxK_1	186	192	PF00069	0.725
MOD_CDK_SPxK_1	206	212	PF00069	0.614
MOD_CDK_SPxK_1	395	401	PF00069	0.690
MOD_CDK_SPxK_1	575	581	PF00069	0.652
MOD_CDK_SPxK_1	695	701	PF00069	0.645
MOD_CDK_SPxK_1	709	715	PF00069	0.561
MOD_CDK_SPxK_1	97	103	PF00069	0.670
MOD_CDK_SPxxK_3	575	582	PF00069	0.652
MOD_CK1_1	181	187	PF00069	0.723
MOD_CK1_1	248	254	PF00069	0.704
MOD_CK1_1	295	301	PF00069	0.773
MOD_CK1_1	328	334	PF00069	0.709
MOD_CK1_1	381	387	PF00069	0.659
MOD_CK1_1	426	432	PF00069	0.605
MOD_CK1_1	456	462	PF00069	0.681
MOD_CK1_1	464	470	PF00069	0.592
MOD_CK1_1	513	519	PF00069	0.619
MOD_CK1_1	577	583	PF00069	0.624
MOD_CK1_1	587	593	PF00069	0.691
MOD_CK1_1	600	606	PF00069	0.624
MOD_CK1_1	609	615	PF00069	0.601
MOD_CK1_1	645	651	PF00069	0.637
MOD_CK1_1	65	71	PF00069	0.665
MOD_CK1_1	676	682	PF00069	0.627
MOD_CK1_1	752	758	PF00069	0.783
MOD_CK1_1	766	772	PF00069	0.556
MOD_CK1_1	827	833	PF00069	0.599
MOD_CK1_1	836	842	PF00069	0.624
MOD_CK1_1	91	97	PF00069	0.587
MOD_CK2_1	12	18	PF00069	0.640
MOD_CK2_1	181	187	PF00069	0.683
MOD_CK2_1	21	27	PF00069	0.565
MOD_CK2_1	235	241	PF00069	0.605
MOD_CK2_1	404	410	PF00069	0.722
MOD_CK2_1	60	66	PF00069	0.613
MOD_CK2_1	600	606	PF00069	0.592
MOD_CK2_1	744	750	PF00069	0.764
MOD_CK2_1	775	781	PF00069	0.715
MOD_DYRK1A_RPxSP_1	651	655	PF00069	0.580
MOD_DYRK1A_RPxSP_1	82	86	PF00069	0.667
MOD_GlcNHglycan	110	113	PF01048	0.625
MOD_GlcNHglycan	180	183	PF01048	0.724
MOD_GlcNHglycan	204	207	PF01048	0.740
MOD_GlcNHglycan	232	235	PF01048	0.713
MOD_GlcNHglycan	237	240	PF01048	0.713
MOD_GlcNHglycan	254	257	PF01048	0.625
MOD_GlcNHglycan	286	289	PF01048	0.557
MOD_GlcNHglycan	295	298	PF01048	0.694
MOD_GlcNHglycan	358	361	PF01048	0.714
MOD_GlcNHglycan	438	441	PF01048	0.642
MOD_GlcNHglycan	451	454	PF01048	0.679
MOD_GlcNHglycan	455	458	PF01048	0.705
MOD_GlcNHglycan	512	515	PF01048	0.694
MOD_GlcNHglycan	554	557	PF01048	0.658
MOD_GlcNHglycan	558	561	PF01048	0.622
MOD_GlcNHglycan	562	565	PF01048	0.578
MOD_GlcNHglycan	570	573	PF01048	0.526
MOD_GlcNHglycan	586	589	PF01048	0.524
MOD_GlcNHglycan	595	598	PF01048	0.607
MOD_GlcNHglycan	599	602	PF01048	0.609
MOD_GlcNHglycan	651	654	PF01048	0.737
MOD_GlcNHglycan	680	683	PF01048	0.657
MOD_GlcNHglycan	747	750	PF01048	0.700
MOD_GlcNHglycan	829	832	PF01048	0.686
MOD_GlcNHglycan	841	844	PF01048	0.616
MOD_GlcNHglycan	852	856	PF01048	0.630
MOD_GSK3_1	134	141	PF00069	0.804
MOD_GSK3_1	174	181	PF00069	0.703
MOD_GSK3_1	202	209	PF00069	0.761
MOD_GSK3_1	230	237	PF00069	0.700
MOD_GSK3_1	245	252	PF00069	0.690
MOD_GSK3_1	325	332	PF00069	0.730
MOD_GSK3_1	335	342	PF00069	0.642
MOD_GSK3_1	381	388	PF00069	0.643
MOD_GSK3_1	395	402	PF00069	0.588
MOD_GSK3_1	436	443	PF00069	0.668
MOD_GSK3_1	445	452	PF00069	0.646
MOD_GSK3_1	506	513	PF00069	0.755
MOD_GSK3_1	552	559	PF00069	0.689
MOD_GSK3_1	560	567	PF00069	0.622
MOD_GSK3_1	573	580	PF00069	0.608
MOD_GSK3_1	593	600	PF00069	0.618
MOD_GSK3_1	606	613	PF00069	0.592
MOD_GSK3_1	625	632	PF00069	0.659
MOD_GSK3_1	641	648	PF00069	0.669
MOD_GSK3_1	649	656	PF00069	0.659
MOD_GSK3_1	672	679	PF00069	0.695
MOD_GSK3_1	695	702	PF00069	0.572
MOD_GSK3_1	736	743	PF00069	0.714
MOD_GSK3_1	745	752	PF00069	0.736
MOD_GSK3_1	753	760	PF00069	0.646
MOD_GSK3_1	762	769	PF00069	0.549
MOD_GSK3_1	771	778	PF00069	0.533
MOD_GSK3_1	788	795	PF00069	0.547
MOD_GSK3_1	820	827	PF00069	0.690
MOD_GSK3_1	847	854	PF00069	0.716
MOD_LATS_1	591	597	PF00433	0.648
MOD_N-GLC_1	462	467	PF02516	0.599
MOD_N-GLC_1	479	484	PF02516	0.506
MOD_N-GLC_1	642	647	PF02516	0.661
MOD_N-GLC_1	699	704	PF02516	0.578
MOD_NEK2_1	385	390	PF00069	0.659
MOD_NEK2_1	476	481	PF00069	0.567
MOD_NEK2_1	562	567	PF00069	0.649
MOD_NEK2_1	642	647	PF00069	0.582
MOD_NEK2_1	851	856	PF00069	0.674
MOD_PIKK_1	21	27	PF00454	0.593
MOD_PIKK_1	345	351	PF00454	0.706
MOD_PIKK_1	372	378	PF00454	0.684
MOD_PIKK_1	504	510	PF00454	0.774
MOD_PIKK_1	749	755	PF00454	0.596
MOD_PK_1	757	763	PF00069	0.659
MOD_PK_1	815	821	PF00069	0.698
MOD_PKA_1	325	331	PF00069	0.615
MOD_PKA_1	39	45	PF00069	0.586
MOD_PKA_1	552	558	PF00069	0.561
MOD_PKA_1	60	66	PF00069	0.573
MOD_PKA_1	649	655	PF00069	0.611
MOD_PKA_1	80	86	PF00069	0.592
MOD_PKA_2	592	598	PF00069	0.628
MOD_PKA_2	60	66	PF00069	0.573
MOD_PKA_2	610	616	PF00069	0.605
MOD_PKA_2	703	709	PF00069	0.697
MOD_PKA_2	833	839	PF00069	0.687
MOD_PKA_2	91	97	PF00069	0.608
MOD_PKB_1	10	18	PF00069	0.562
MOD_PKB_1	132	140	PF00069	0.672
MOD_PKB_1	544	552	PF00069	0.615
MOD_PKB_1	813	821	PF00069	0.693
MOD_Plk_1	21	27	PF00069	0.443
MOD_Plk_1	263	269	PF00069	0.751
MOD_Plk_1	749	755	PF00069	0.767
MOD_Plk_1	780	786	PF00069	0.747
MOD_Plk_2-3	269	275	PF00069	0.549
MOD_Plk_2-3	775	781	PF00069	0.640
MOD_Plk_4	169	175	PF00069	0.693
MOD_Plk_4	249	255	PF00069	0.663
MOD_Plk_4	381	387	PF00069	0.674
MOD_Plk_4	836	842	PF00069	0.585
MOD_ProDKin_1	186	192	PF00069	0.835
MOD_ProDKin_1	206	212	PF00069	0.694
MOD_ProDKin_1	395	401	PF00069	0.725
MOD_ProDKin_1	414	420	PF00069	0.522
MOD_ProDKin_1	575	581	PF00069	0.652
MOD_ProDKin_1	606	612	PF00069	0.667
MOD_ProDKin_1	629	635	PF00069	0.680
MOD_ProDKin_1	651	657	PF00069	0.642
MOD_ProDKin_1	676	682	PF00069	0.677
MOD_ProDKin_1	695	701	PF00069	0.547
MOD_ProDKin_1	709	715	PF00069	0.619
MOD_ProDKin_1	792	798	PF00069	0.707
MOD_ProDKin_1	82	88	PF00069	0.712
MOD_ProDKin_1	825	831	PF00069	0.681
MOD_ProDKin_1	845	851	PF00069	0.497
MOD_ProDKin_1	97	103	PF00069	0.560
MOD_SUMO_rev_2	269	276	PF00179	0.611
MOD_SUMO_rev_2	306	311	PF00179	0.482
MOD_SUMO_rev_2	532	539	PF00179	0.494
TRG_DiLeu_BaEn_3	781	787	PF01217	0.571
TRG_ENDOCYTIC_2	31	34	PF00928	0.562
TRG_ENDOCYTIC_2	661	664	PF00928	0.643
TRG_ER_diArg_1	150	152	PF00400	0.712
TRG_ER_diArg_1	190	192	PF00400	0.718
TRG_ER_diArg_1	194	197	PF00400	0.730
TRG_ER_diArg_1	721	724	PF00400	0.687
TRG_ER_diArg_1	79	82	PF00400	0.669
TRG_ER_diArg_1	9	12	PF00400	0.572
TRG_NES_CRM1_1	313	327	PF08389	0.551
TRG_NLS_MonoCore_2	37	42	PF00514	0.552
TRG_NLS_MonoExtC_3	38	43	PF00514	0.491
TRG_NLS_MonoExtN_4	36	43	PF00514	0.553
TRG_NLS_MonoExtN_4	646	653	PF00514	0.617
TRG_NLS_MonoExtN_4	7	14	PF00514	0.573
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIP7	Leishmania donovani	81%	97%
A4HJK0	Leishmania braziliensis	46%	100%
A4I6Z7	Leishmania infantum	81%	97%
E9B218	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%