Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q642_LEIMA

TriTrypDb:

LmjF.31.2190 , LMJLV39_310030900 , LMJSD75_310030900

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q642

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q642

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	630	634	PF00656	0.617
CLV_NRD_NRD_1	274	276	PF00675	0.743
CLV_NRD_NRD_1	299	301	PF00675	0.733
CLV_NRD_NRD_1	339	341	PF00675	0.731
CLV_NRD_NRD_1	34	36	PF00675	0.663
CLV_NRD_NRD_1	431	433	PF00675	0.704
CLV_PCSK_KEX2_1	274	276	PF00082	0.799
CLV_PCSK_KEX2_1	299	301	PF00082	0.733
CLV_PCSK_KEX2_1	339	341	PF00082	0.737
CLV_PCSK_KEX2_1	34	36	PF00082	0.663
CLV_PCSK_KEX2_1	583	585	PF00082	0.753
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.753
CLV_PCSK_PC7_1	579	585	PF00082	0.691
CLV_PCSK_SKI1_1	206	210	PF00082	0.601
CLV_PCSK_SKI1_1	303	307	PF00082	0.731
CLV_PCSK_SKI1_1	340	344	PF00082	0.727
CLV_PCSK_SKI1_1	391	395	PF00082	0.697
CLV_PCSK_SKI1_1	426	430	PF00082	0.721
DEG_SPOP_SBC_1	537	541	PF00917	0.675
DEG_SPOP_SBC_1	561	565	PF00917	0.760
DOC_CDC14_PxL_1	94	102	PF14671	0.563
DOC_CKS1_1	165	170	PF01111	0.611
DOC_CKS1_1	304	309	PF01111	0.692
DOC_CYCLIN_RxL_1	203	212	PF00134	0.597
DOC_MAPK_gen_1	583	589	PF00069	0.755
DOC_PP1_SILK_1	700	705	PF00149	0.738
DOC_PP2B_LxvP_1	125	128	PF13499	0.694
DOC_PP2B_LxvP_1	351	354	PF13499	0.777
DOC_PP2B_LxvP_1	450	453	PF13499	0.755
DOC_PP4_FxxP_1	173	176	PF00568	0.564
DOC_PP4_MxPP_1	352	355	PF00568	0.610
DOC_USP7_MATH_1	118	122	PF00917	0.716
DOC_USP7_MATH_1	148	152	PF00917	0.653
DOC_USP7_MATH_1	156	160	PF00917	0.580
DOC_USP7_MATH_1	168	172	PF00917	0.503
DOC_USP7_MATH_1	195	199	PF00917	0.611
DOC_USP7_MATH_1	292	296	PF00917	0.709
DOC_USP7_MATH_1	478	482	PF00917	0.673
DOC_USP7_MATH_1	536	540	PF00917	0.748
DOC_USP7_MATH_1	561	565	PF00917	0.736
DOC_USP7_MATH_1	631	635	PF00917	0.688
DOC_USP7_MATH_1	723	727	PF00917	0.734
DOC_USP7_MATH_1	739	743	PF00917	0.471
DOC_USP7_MATH_2	156	162	PF00917	0.583
DOC_USP7_UBL2_3	755	759	PF12436	0.737
DOC_WW_Pin1_4	103	108	PF00397	0.667
DOC_WW_Pin1_4	164	169	PF00397	0.649
DOC_WW_Pin1_4	187	192	PF00397	0.734
DOC_WW_Pin1_4	193	198	PF00397	0.673
DOC_WW_Pin1_4	199	204	PF00397	0.647
DOC_WW_Pin1_4	209	214	PF00397	0.613
DOC_WW_Pin1_4	232	237	PF00397	0.700
DOC_WW_Pin1_4	240	245	PF00397	0.657
DOC_WW_Pin1_4	262	267	PF00397	0.767
DOC_WW_Pin1_4	285	290	PF00397	0.669
DOC_WW_Pin1_4	303	308	PF00397	0.564
DOC_WW_Pin1_4	421	426	PF00397	0.787
DOC_WW_Pin1_4	51	56	PF00397	0.708
DOC_WW_Pin1_4	516	521	PF00397	0.627
DOC_WW_Pin1_4	610	615	PF00397	0.590
DOC_WW_Pin1_4	62	67	PF00397	0.657
DOC_WW_Pin1_4	662	667	PF00397	0.788
DOC_WW_Pin1_4	712	717	PF00397	0.688
LIG_14-3-3_CanoR_1	102	109	PF00244	0.613
LIG_14-3-3_CanoR_1	21	29	PF00244	0.637
LIG_14-3-3_CanoR_1	34	40	PF00244	0.621
LIG_14-3-3_CanoR_1	461	469	PF00244	0.588
LIG_14-3-3_CanoR_1	584	590	PF00244	0.798
LIG_14-3-3_CanoR_1	672	680	PF00244	0.698
LIG_14-3-3_CanoR_1	682	687	PF00244	0.667
LIG_Actin_WH2_2	178	196	PF00022	0.586
LIG_Actin_WH2_2	632	649	PF00022	0.566
LIG_BIR_III_2	141	145	PF00653	0.667
LIG_BIR_III_2	524	528	PF00653	0.594
LIG_BIR_III_4	406	410	PF00653	0.617
LIG_BRCT_BRCA1_1	162	166	PF00533	0.718
LIG_BRCT_BRCA1_1	725	729	PF00533	0.762
LIG_CtBP_PxDLS_1	176	180	PF00389	0.694
LIG_CtBP_PxDLS_1	690	694	PF00389	0.660
LIG_EH1_1	696	704	PF00400	0.674
LIG_EVH1_1	450	454	PF00568	0.716
LIG_FHA_1	104	110	PF00498	0.677
LIG_FHA_1	235	241	PF00498	0.737
LIG_FHA_1	315	321	PF00498	0.709
LIG_FHA_1	346	352	PF00498	0.651
LIG_FHA_1	438	444	PF00498	0.628
LIG_FHA_1	561	567	PF00498	0.758
LIG_FHA_1	599	605	PF00498	0.697
LIG_FHA_2	517	523	PF00498	0.666
LIG_FHA_2	586	592	PF00498	0.793
LIG_FHA_2	628	634	PF00498	0.575
LIG_FHA_2	713	719	PF00498	0.557
LIG_LIR_Apic_2	163	168	PF02991	0.615
LIG_LIR_Apic_2	171	176	PF02991	0.543
LIG_LIR_Apic_2	260	266	PF02991	0.598
LIG_LIR_Gen_1	134	142	PF02991	0.627
LIG_LIR_Gen_1	466	475	PF02991	0.680
LIG_LIR_Nem_3	134	138	PF02991	0.658
LIG_LIR_Nem_3	243	248	PF02991	0.713
LIG_LIR_Nem_3	466	472	PF02991	0.672
LIG_LIR_Nem_3	706	712	PF02991	0.679
LIG_MLH1_MIPbox_1	162	166	PF16413	0.718
LIG_MYND_1	123	127	PF01753	0.699
LIG_MYND_1	386	390	PF01753	0.668
LIG_RPA_C_Fungi	738	750	PF08784	0.732
LIG_SH2_CRK	709	713	PF00017	0.685
LIG_SH2_STAP1	131	135	PF00017	0.701
LIG_SH2_STAT5	165	168	PF00017	0.727
LIG_SH2_STAT5	372	375	PF00017	0.693
LIG_SH3_3	117	123	PF00018	0.709
LIG_SH3_3	150	156	PF00018	0.595
LIG_SH3_3	185	191	PF00018	0.707
LIG_SH3_3	201	207	PF00018	0.587
LIG_SH3_3	211	217	PF00018	0.653
LIG_SH3_3	233	239	PF00018	0.763
LIG_SH3_3	241	247	PF00018	0.657
LIG_SH3_3	253	259	PF00018	0.519
LIG_SH3_3	286	292	PF00018	0.794
LIG_SH3_3	384	390	PF00018	0.700
LIG_SH3_3	448	454	PF00018	0.766
LIG_SH3_4	755	762	PF00018	0.738
LIG_SUMO_SIM_anti_2	91	99	PF11976	0.633
LIG_SUMO_SIM_par_1	207	212	PF11976	0.609
LIG_TRAF2_1	492	495	PF00917	0.587
LIG_TRAF2_2	756	761	PF00917	0.705
MOD_CDK_SPK_2	421	426	PF00069	0.787
MOD_CDK_SPxK_1	51	57	PF00069	0.669
MOD_CDK_SPxK_1	610	616	PF00069	0.592
MOD_CDK_SPxxK_3	187	194	PF00069	0.721
MOD_CDK_SPxxK_3	199	206	PF00069	0.597
MOD_CDK_SPxxK_3	712	719	PF00069	0.685
MOD_CK1_1	160	166	PF00069	0.702
MOD_CK1_1	243	249	PF00069	0.698
MOD_CK1_1	265	271	PF00069	0.772
MOD_CK1_1	421	427	PF00069	0.723
MOD_CK1_1	445	451	PF00069	0.657
MOD_CK1_1	479	485	PF00069	0.621
MOD_CK1_1	540	546	PF00069	0.612
MOD_CK1_1	562	568	PF00069	0.743
MOD_CK1_1	634	640	PF00069	0.790
MOD_CK1_1	708	714	PF00069	0.809
MOD_CK1_1	77	83	PF00069	0.668
MOD_CK1_1	88	94	PF00069	0.597
MOD_CK2_1	168	174	PF00069	0.752
MOD_CK2_1	209	215	PF00069	0.711
MOD_CK2_1	516	522	PF00069	0.636
MOD_CK2_1	585	591	PF00069	0.800
MOD_CK2_1	662	668	PF00069	0.791
MOD_CK2_1	712	718	PF00069	0.749
MOD_CK2_1	80	86	PF00069	0.690
MOD_DYRK1A_RPxSP_1	187	191	PF00069	0.710
MOD_GlcNHglycan	103	106	PF01048	0.653
MOD_GlcNHglycan	170	173	PF01048	0.747
MOD_GlcNHglycan	269	272	PF01048	0.736
MOD_GlcNHglycan	322	325	PF01048	0.791
MOD_GlcNHglycan	348	351	PF01048	0.760
MOD_GlcNHglycan	435	440	PF01048	0.695
MOD_GlcNHglycan	444	447	PF01048	0.669
MOD_GlcNHglycan	478	481	PF01048	0.721
MOD_GlcNHglycan	498	501	PF01048	0.602
MOD_GlcNHglycan	575	578	PF01048	0.704
MOD_GlcNHglycan	606	609	PF01048	0.789
MOD_GlcNHglycan	636	639	PF01048	0.827
MOD_GlcNHglycan	82	85	PF01048	0.533
MOD_GSK3_1	112	119	PF00069	0.743
MOD_GSK3_1	12	19	PF00069	0.722
MOD_GSK3_1	154	161	PF00069	0.713
MOD_GSK3_1	164	171	PF00069	0.621
MOD_GSK3_1	193	200	PF00069	0.769
MOD_GSK3_1	314	321	PF00069	0.714
MOD_GSK3_1	370	377	PF00069	0.760
MOD_GSK3_1	435	442	PF00069	0.736
MOD_GSK3_1	476	483	PF00069	0.791
MOD_GSK3_1	536	543	PF00069	0.711
MOD_GSK3_1	548	555	PF00069	0.723
MOD_GSK3_1	562	569	PF00069	0.617
MOD_GSK3_1	583	590	PF00069	0.766
MOD_GSK3_1	627	634	PF00069	0.643
MOD_GSK3_1	704	711	PF00069	0.795
MOD_GSK3_1	85	92	PF00069	0.644
MOD_N-GLC_1	168	173	PF02516	0.561
MOD_N-GLC_1	250	255	PF02516	0.726
MOD_N-GLC_1	374	379	PF02516	0.645
MOD_N-GLC_1	490	495	PF02516	0.690
MOD_N-GLC_1	662	667	PF02516	0.654
MOD_N-GLC_1	712	717	PF02516	0.799
MOD_N-GLC_2	262	264	PF02516	0.735
MOD_NEK2_1	112	117	PF00069	0.737
MOD_NEK2_1	381	386	PF00069	0.677
MOD_NEK2_1	529	534	PF00069	0.775
MOD_NEK2_1	578	583	PF00069	0.724
MOD_NEK2_1	642	647	PF00069	0.630
MOD_NEK2_1	693	698	PF00069	0.735
MOD_NEK2_1	703	708	PF00069	0.622
MOD_NEK2_1	717	722	PF00069	0.583
MOD_PIKK_1	21	27	PF00454	0.601
MOD_PIKK_1	290	296	PF00454	0.748
MOD_PIKK_1	381	387	PF00454	0.791
MOD_PIKK_1	490	496	PF00454	0.713
MOD_PIKK_1	680	686	PF00454	0.670
MOD_PK_1	682	688	PF00069	0.688
MOD_PK_1	698	704	PF00069	0.597
MOD_PKA_1	257	263	PF00069	0.732
MOD_PKA_1	34	40	PF00069	0.566
MOD_PKA_1	583	589	PF00069	0.692
MOD_PKA_1	704	710	PF00069	0.746
MOD_PKA_2	101	107	PF00069	0.608
MOD_PKA_2	20	26	PF00069	0.601
MOD_PKA_2	34	40	PF00069	0.519
MOD_PKA_2	578	584	PF00069	0.725
MOD_PKA_2	627	633	PF00069	0.690
MOD_PKA_2	671	677	PF00069	0.821
MOD_PKB_1	395	403	PF00069	0.566
MOD_Plk_1	374	380	PF00069	0.646
MOD_Plk_1	397	403	PF00069	0.656
MOD_Plk_1	717	723	PF00069	0.778
MOD_Plk_1	734	740	PF00069	0.644
MOD_Plk_1	85	91	PF00069	0.579
MOD_Plk_2-3	671	677	PF00069	0.620
MOD_Plk_4	161	167	PF00069	0.714
MOD_Plk_4	631	637	PF00069	0.724
MOD_Plk_4	698	704	PF00069	0.737
MOD_Plk_4	725	731	PF00069	0.732
MOD_ProDKin_1	103	109	PF00069	0.667
MOD_ProDKin_1	164	170	PF00069	0.647
MOD_ProDKin_1	187	193	PF00069	0.736
MOD_ProDKin_1	197	203	PF00069	0.667
MOD_ProDKin_1	209	215	PF00069	0.628
MOD_ProDKin_1	232	238	PF00069	0.699
MOD_ProDKin_1	240	246	PF00069	0.658
MOD_ProDKin_1	262	268	PF00069	0.767
MOD_ProDKin_1	285	291	PF00069	0.671
MOD_ProDKin_1	303	309	PF00069	0.563
MOD_ProDKin_1	421	427	PF00069	0.787
MOD_ProDKin_1	51	57	PF00069	0.713
MOD_ProDKin_1	516	522	PF00069	0.627
MOD_ProDKin_1	610	616	PF00069	0.592
MOD_ProDKin_1	62	68	PF00069	0.655
MOD_ProDKin_1	662	668	PF00069	0.791
MOD_ProDKin_1	712	718	PF00069	0.688
MOD_SUMO_rev_2	45	50	PF00179	0.698
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.729
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.700
TRG_ENDOCYTIC_2	245	248	PF00928	0.715
TRG_ENDOCYTIC_2	709	712	PF00928	0.687
TRG_ER_diArg_1	273	275	PF00400	0.712
TRG_ER_diArg_1	299	301	PF00400	0.733
TRG_ER_diArg_1	33	35	PF00400	0.659
TRG_ER_diArg_1	338	340	PF00400	0.740
TRG_ER_diArg_1	625	628	PF00400	0.582
TRG_ER_FFAT_2	159	171	PF00635	0.610
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.727
TRG_Pf-PMV_PEXEL_1	644	648	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFQ0	Leishmania donovani	85%	100%
A4HJK1	Leishmania braziliensis	44%	100%
A4I6Z8	Leishmania infantum	85%	100%
E9B219	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%