Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q641_LEIMA

TriTrypDb:

LmjF.31.2200 , LMJLV39_310031300 , LMJSD75_310031300

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q641

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q641

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.534
CLV_NRD_NRD_1	201	203	PF00675	0.626
CLV_NRD_NRD_1	221	223	PF00675	0.595
CLV_NRD_NRD_1	24	26	PF00675	0.785
CLV_NRD_NRD_1	299	301	PF00675	0.713
CLV_NRD_NRD_1	338	340	PF00675	0.634
CLV_NRD_NRD_1	374	376	PF00675	0.643
CLV_NRD_NRD_1	44	46	PF00675	0.535
CLV_PCSK_KEX2_1	122	124	PF00082	0.534
CLV_PCSK_KEX2_1	221	223	PF00082	0.595
CLV_PCSK_KEX2_1	24	26	PF00082	0.788
CLV_PCSK_KEX2_1	299	301	PF00082	0.713
CLV_PCSK_KEX2_1	338	340	PF00082	0.682
CLV_PCSK_KEX2_1	374	376	PF00082	0.643
CLV_PCSK_KEX2_1	44	46	PF00082	0.533
CLV_PCSK_KEX2_1	473	475	PF00082	0.487
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.479
CLV_PCSK_PC7_1	40	46	PF00082	0.579
CLV_PCSK_SKI1_1	202	206	PF00082	0.683
CLV_PCSK_SKI1_1	47	51	PF00082	0.574
DEG_APCC_DBOX_1	213	221	PF00400	0.592
DEG_COP1_1	433	443	PF00400	0.620
DEG_SPOP_SBC_1	11	15	PF00917	0.615
DEG_SPOP_SBC_1	116	120	PF00917	0.517
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.510
DOC_MAPK_gen_1	343	350	PF00069	0.651
DOC_MAPK_MEF2A_6	68	77	PF00069	0.533
DOC_PP2B_LxvP_1	75	78	PF13499	0.568
DOC_PP2B_LxvP_1	84	87	PF13499	0.529
DOC_USP7_MATH_1	116	120	PF00917	0.735
DOC_USP7_MATH_1	141	145	PF00917	0.664
DOC_USP7_MATH_1	283	287	PF00917	0.771
DOC_USP7_MATH_1	329	333	PF00917	0.593
DOC_USP7_MATH_1	337	341	PF00917	0.583
DOC_USP7_MATH_1	69	73	PF00917	0.568
DOC_WW_Pin1_4	172	177	PF00397	0.564
DOC_WW_Pin1_4	31	36	PF00397	0.609
DOC_WW_Pin1_4	327	332	PF00397	0.633
DOC_WW_Pin1_4	439	444	PF00397	0.748
LIG_14-3-3_CanoR_1	122	127	PF00244	0.629
LIG_14-3-3_CanoR_1	150	156	PF00244	0.644
LIG_14-3-3_CanoR_1	214	218	PF00244	0.682
LIG_14-3-3_CanoR_1	221	227	PF00244	0.666
LIG_14-3-3_CanoR_1	299	304	PF00244	0.702
LIG_14-3-3_CanoR_1	338	342	PF00244	0.675
LIG_14-3-3_CanoR_1	92	97	PF00244	0.542
LIG_BRCT_BRCA1_1	270	274	PF00533	0.645
LIG_BRCT_BRCA1_1	420	424	PF00533	0.656
LIG_BRCT_BRCA1_1	435	439	PF00533	0.473
LIG_FHA_1	110	116	PF00498	0.598
LIG_FHA_1	149	155	PF00498	0.739
LIG_FHA_1	300	306	PF00498	0.705
LIG_FHA_1	72	78	PF00498	0.593
LIG_FHA_2	150	156	PF00498	0.644
LIG_FHA_2	277	283	PF00498	0.707
LIG_FHA_2	352	358	PF00498	0.549
LIG_LIR_Apic_2	125	130	PF02991	0.636
LIG_LIR_Apic_2	144	149	PF02991	0.616
LIG_LIR_Gen_1	442	452	PF02991	0.596
LIG_LIR_Nem_3	225	229	PF02991	0.671
LIG_LIR_Nem_3	442	448	PF02991	0.747
LIG_PDZ_Class_2	480	485	PF00595	0.539
LIG_SH2_CRK	137	141	PF00017	0.607
LIG_SH2_CRK	146	150	PF00017	0.597
LIG_SH2_NCK_1	137	141	PF00017	0.640
LIG_SH2_STAT5	137	140	PF00017	0.670
LIG_SH2_STAT5	146	149	PF00017	0.614
LIG_SH2_STAT5	261	264	PF00017	0.528
LIG_SH3_3	302	308	PF00018	0.754
LIG_SH3_3	389	395	PF00018	0.630
LIG_SH3_3	437	443	PF00018	0.749
LIG_SH3_3	70	76	PF00018	0.683
LIG_TRAF2_1	195	198	PF00917	0.559
LIG_TRAF2_1	354	357	PF00917	0.547
LIG_TRFH_1	137	141	PF08558	0.614
MOD_CK1_1	175	181	PF00069	0.626
MOD_CK1_1	196	202	PF00069	0.717
MOD_CK1_1	213	219	PF00069	0.667
MOD_CK1_1	245	251	PF00069	0.640
MOD_CK1_1	286	292	PF00069	0.685
MOD_CK1_1	293	299	PF00069	0.614
MOD_CK1_1	31	37	PF00069	0.658
MOD_CK1_1	346	352	PF00069	0.630
MOD_CK1_1	416	422	PF00069	0.666
MOD_CK1_1	433	439	PF00069	0.444
MOD_CK2_1	149	155	PF00069	0.643
MOD_CK2_1	24	30	PF00069	0.633
MOD_CK2_1	245	251	PF00069	0.700
MOD_CK2_1	263	269	PF00069	0.582
MOD_CK2_1	276	282	PF00069	0.595
MOD_CK2_1	351	357	PF00069	0.551
MOD_CK2_1	85	91	PF00069	0.672
MOD_GlcNHglycan	14	17	PF01048	0.682
MOD_GlcNHglycan	251	254	PF01048	0.610
MOD_GlcNHglycan	432	435	PF01048	0.700
MOD_GSK3_1	100	107	PF00069	0.647
MOD_GSK3_1	20	27	PF00069	0.692
MOD_GSK3_1	242	249	PF00069	0.647
MOD_GSK3_1	259	266	PF00069	0.649
MOD_GSK3_1	285	292	PF00069	0.693
MOD_GSK3_1	295	302	PF00069	0.637
MOD_GSK3_1	36	43	PF00069	0.585
MOD_GSK3_1	393	400	PF00069	0.641
MOD_GSK3_1	426	433	PF00069	0.578
MOD_N-GLC_1	351	356	PF02516	0.631
MOD_N-GLC_1	36	41	PF02516	0.627
MOD_N-GLC_1	416	421	PF02516	0.667
MOD_N-GLC_1	61	66	PF02516	0.585
MOD_N-GLC_2	98	100	PF02516	0.664
MOD_NEK2_1	1	6	PF00069	0.765
MOD_NEK2_1	20	25	PF00069	0.727
MOD_NEK2_1	418	423	PF00069	0.663
MOD_NEK2_1	430	435	PF00069	0.489
MOD_NEK2_2	141	146	PF00069	0.613
MOD_NMyristoyl	1	7	PF02799	0.680
MOD_PIKK_1	193	199	PF00454	0.584
MOD_PIKK_1	290	296	PF00454	0.710
MOD_PIKK_1	309	315	PF00454	0.677
MOD_PKA_1	122	128	PF00069	0.532
MOD_PKA_1	24	30	PF00069	0.794
MOD_PKA_1	299	305	PF00069	0.704
MOD_PKA_2	122	128	PF00069	0.640
MOD_PKA_2	149	155	PF00069	0.643
MOD_PKA_2	20	26	PF00069	0.765
MOD_PKA_2	213	219	PF00069	0.671
MOD_PKA_2	275	281	PF00069	0.651
MOD_PKA_2	299	305	PF00069	0.704
MOD_PKA_2	337	343	PF00069	0.685
MOD_PKA_2	39	45	PF00069	0.590
MOD_PKA_2	91	97	PF00069	0.662
MOD_PKB_1	45	53	PF00069	0.654
MOD_Plk_1	242	248	PF00069	0.689
MOD_Plk_1	268	274	PF00069	0.638
MOD_Plk_1	426	432	PF00069	0.657
MOD_Plk_4	109	115	PF00069	0.637
MOD_Plk_4	122	128	PF00069	0.559
MOD_Plk_4	135	141	PF00069	0.553
MOD_Plk_4	269	275	PF00069	0.691
MOD_Plk_4	286	292	PF00069	0.551
MOD_ProDKin_1	172	178	PF00069	0.566
MOD_ProDKin_1	31	37	PF00069	0.612
MOD_ProDKin_1	327	333	PF00069	0.634
MOD_ProDKin_1	439	445	PF00069	0.748
MOD_SUMO_rev_2	186	194	PF00179	0.666
MOD_SUMO_rev_2	452	456	PF00179	0.563
TRG_DiLeu_BaEn_4	453	459	PF01217	0.564
TRG_ENDOCYTIC_2	137	140	PF00928	0.644
TRG_ER_diArg_1	122	124	PF00400	0.534
TRG_ER_diArg_1	220	222	PF00400	0.599
TRG_ER_diArg_1	420	423	PF00400	0.608
TRG_ER_diArg_1	44	47	PF00400	0.600
TRG_ER_diArg_1	96	99	PF00400	0.528
TRG_NES_CRM1_1	65	79	PF08389	0.628
TRG_NLS_MonoExtC_3	469	474	PF00514	0.494
TRG_NLS_MonoExtN_4	468	474	PF00514	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4Q7	Leishmania donovani	82%	100%
A4HJK2	Leishmania braziliensis	54%	100%
A4I703	Leishmania infantum	83%	100%
E9B221	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%