Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q638_LEIMA

TriTrypDb:

LmjF.31.2230 , LMJLV39_310031600 , LMJSD75_310031600

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q638

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q638

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.556
CLV_C14_Caspase3-7	403	407	PF00656	0.664
CLV_C14_Caspase3-7	9	13	PF00656	0.659
CLV_NRD_NRD_1	247	249	PF00675	0.629
CLV_PCSK_FUR_1	245	249	PF00082	0.612
CLV_PCSK_KEX2_1	245	247	PF00082	0.626
CLV_PCSK_SKI1_1	281	285	PF00082	0.636
CLV_PCSK_SKI1_1	289	293	PF00082	0.574
CLV_PCSK_SKI1_1	396	400	PF00082	0.557
CLV_PCSK_SKI1_1	441	445	PF00082	0.574
DOC_CKS1_1	118	123	PF01111	0.553
DOC_CKS1_1	61	66	PF01111	0.550
DOC_CKS1_1	95	100	PF01111	0.581
DOC_MAPK_gen_1	107	115	PF00069	0.579
DOC_MAPK_MEF2A_6	51	60	PF00069	0.544
DOC_PP1_RVXF_1	364	371	PF00149	0.556
DOC_USP7_MATH_1	136	140	PF00917	0.601
DOC_USP7_MATH_1	19	23	PF00917	0.622
DOC_USP7_MATH_1	32	36	PF00917	0.672
DOC_USP7_MATH_1	380	384	PF00917	0.540
DOC_USP7_MATH_1	65	69	PF00917	0.692
DOC_WW_Pin1_4	101	106	PF00397	0.750
DOC_WW_Pin1_4	117	122	PF00397	0.535
DOC_WW_Pin1_4	160	165	PF00397	0.573
DOC_WW_Pin1_4	191	196	PF00397	0.675
DOC_WW_Pin1_4	353	358	PF00397	0.719
DOC_WW_Pin1_4	404	409	PF00397	0.607
DOC_WW_Pin1_4	416	421	PF00397	0.707
DOC_WW_Pin1_4	52	57	PF00397	0.626
DOC_WW_Pin1_4	60	65	PF00397	0.613
DOC_WW_Pin1_4	94	99	PF00397	0.701
LIG_14-3-3_CanoR_1	15	24	PF00244	0.707
LIG_14-3-3_CanoR_1	302	310	PF00244	0.608
LIG_14-3-3_CanoR_1	382	392	PF00244	0.698
LIG_14-3-3_CanoR_1	400	408	PF00244	0.512
LIG_Clathr_ClatBox_1	58	62	PF01394	0.595
LIG_eIF4E_1	71	77	PF01652	0.623
LIG_FHA_1	199	205	PF00498	0.645
LIG_FHA_1	286	292	PF00498	0.582
LIG_FHA_1	339	345	PF00498	0.635
LIG_FHA_1	53	59	PF00498	0.666
LIG_FHA_2	250	256	PF00498	0.623
LIG_FHA_2	419	425	PF00498	0.631
LIG_FHA_2	9	15	PF00498	0.761
LIG_Integrin_RGD_1	296	298	PF01839	0.553
LIG_LIR_Gen_1	137	146	PF02991	0.631
LIG_LIR_Gen_1	268	279	PF02991	0.624
LIG_LIR_LC3C_4	57	61	PF02991	0.659
LIG_LIR_Nem_3	137	143	PF02991	0.629
LIG_LIR_Nem_3	176	180	PF02991	0.607
LIG_LIR_Nem_3	202	208	PF02991	0.613
LIG_LIR_Nem_3	268	274	PF02991	0.627
LIG_PAM2_1	15	27	PF00658	0.634
LIG_Pex14_1	155	159	PF04695	0.601
LIG_SH2_NCK_1	49	53	PF00017	0.638
LIG_SH2_SRC	71	74	PF00017	0.623
LIG_SH2_STAP1	49	53	PF00017	0.667
LIG_SH2_STAT5	159	162	PF00017	0.589
LIG_SH2_STAT5	71	74	PF00017	0.623
LIG_SH3_2	64	69	PF14604	0.646
LIG_SH3_3	192	198	PF00018	0.670
LIG_SH3_3	220	226	PF00018	0.669
LIG_SH3_3	310	316	PF00018	0.658
LIG_SH3_3	58	64	PF00018	0.628
LIG_SH3_3	92	98	PF00018	0.583
LIG_SUMO_SIM_anti_2	57	63	PF11976	0.601
LIG_SUMO_SIM_par_1	57	63	PF11976	0.601
LIG_WW_3	436	440	PF00397	0.683
MOD_CDC14_SPxK_1	66	69	PF00782	0.646
MOD_CDK_SPK_2	191	196	PF00069	0.675
MOD_CDK_SPxK_1	101	107	PF00069	0.669
MOD_CDK_SPxK_1	63	69	PF00069	0.646
MOD_CK1_1	129	135	PF00069	0.645
MOD_CK1_1	163	169	PF00069	0.610
MOD_CK1_1	189	195	PF00069	0.644
MOD_CK1_1	235	241	PF00069	0.658
MOD_CK1_1	358	364	PF00069	0.698
MOD_CK1_1	383	389	PF00069	0.533
MOD_CK1_1	401	407	PF00069	0.623
MOD_CK1_1	8	14	PF00069	0.676
MOD_CK2_1	151	157	PF00069	0.546
MOD_CK2_1	249	255	PF00069	0.641
MOD_CK2_1	406	412	PF00069	0.682
MOD_CK2_1	416	422	PF00069	0.661
MOD_GlcNHglycan	121	124	PF01048	0.759
MOD_GlcNHglycan	17	20	PF01048	0.657
MOD_GlcNHglycan	205	208	PF01048	0.754
MOD_GlcNHglycan	211	214	PF01048	0.667
MOD_GlcNHglycan	232	237	PF01048	0.636
MOD_GlcNHglycan	28	32	PF01048	0.756
MOD_GlcNHglycan	304	307	PF01048	0.616
MOD_GlcNHglycan	371	374	PF01048	0.663
MOD_GlcNHglycan	38	42	PF01048	0.564
MOD_GlcNHglycan	385	388	PF01048	0.565
MOD_GSK3_1	147	154	PF00069	0.585
MOD_GSK3_1	15	22	PF00069	0.614
MOD_GSK3_1	185	192	PF00069	0.636
MOD_GSK3_1	249	256	PF00069	0.616
MOD_GSK3_1	353	360	PF00069	0.766
MOD_GSK3_1	378	385	PF00069	0.680
MOD_GSK3_1	398	405	PF00069	0.649
MOD_GSK3_1	4	11	PF00069	0.682
MOD_GSK3_1	406	413	PF00069	0.717
MOD_GSK3_1	82	89	PF00069	0.705
MOD_GSK3_1	97	104	PF00069	0.652
MOD_N-GLC_1	24	29	PF02516	0.659
MOD_N-GLC_1	338	343	PF02516	0.541
MOD_NEK2_1	151	156	PF00069	0.708
MOD_NEK2_1	249	254	PF00069	0.640
MOD_NEK2_1	26	31	PF00069	0.732
MOD_NEK2_1	309	314	PF00069	0.587
MOD_NEK2_1	423	428	PF00069	0.700
MOD_NEK2_1	430	435	PF00069	0.652
MOD_NEK2_2	297	302	PF00069	0.550
MOD_PIKK_1	406	412	PF00454	0.581
MOD_PIKK_1	71	77	PF00454	0.575
MOD_PIKK_1	82	88	PF00454	0.601
MOD_PK_1	126	132	PF00069	0.532
MOD_PKA_2	401	407	PF00069	0.694
MOD_PKA_2	430	436	PF00069	0.579
MOD_PKA_2	47	53	PF00069	0.724
MOD_PKB_1	400	408	PF00069	0.664
MOD_Plk_1	126	132	PF00069	0.643
MOD_Plk_1	297	303	PF00069	0.642
MOD_Plk_4	126	132	PF00069	0.632
MOD_Plk_4	155	161	PF00069	0.572
MOD_Plk_4	19	25	PF00069	0.717
MOD_ProDKin_1	101	107	PF00069	0.750
MOD_ProDKin_1	117	123	PF00069	0.531
MOD_ProDKin_1	160	166	PF00069	0.570
MOD_ProDKin_1	191	197	PF00069	0.671
MOD_ProDKin_1	353	359	PF00069	0.715
MOD_ProDKin_1	404	410	PF00069	0.607
MOD_ProDKin_1	416	422	PF00069	0.708
MOD_ProDKin_1	52	58	PF00069	0.629
MOD_ProDKin_1	60	66	PF00069	0.611
MOD_ProDKin_1	94	100	PF00069	0.703
MOD_SUMO_rev_2	347	353	PF00179	0.721
TRG_AP2beta_CARGO_1	138	147	PF09066	0.625
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.616
TRG_ER_diArg_1	245	248	PF00400	0.612
TRG_ER_diArg_1	399	402	PF00400	0.672
TRG_ER_diArg_1	438	441	PF00400	0.575
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ50	Leptomonas seymouri	33%	98%
A0A3S7X4S8	Leishmania donovani	83%	100%
A4HJK4	Leishmania braziliensis	51%	100%
A4HJK7	Leishmania braziliensis	51%	100%
A4I706	Leishmania infantum	82%	100%
E9B224	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%