Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q637_LEIMA

TriTrypDb:

LmjF.31.2240 , LMJLV39_310031700 , LMJSD75_310031700

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q637

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q637

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.492
CLV_NRD_NRD_1	52	54	PF00675	0.424
CLV_PCSK_KEX2_1	116	118	PF00082	0.492
CLV_PCSK_KEX2_1	47	49	PF00082	0.432
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.432
CLV_PCSK_PC7_1	112	118	PF00082	0.476
CLV_PCSK_SKI1_1	47	51	PF00082	0.429
DOC_CKS1_1	68	73	PF01111	0.678
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.389
DOC_PP2B_LxvP_1	14	17	PF13499	0.389
DOC_PP4_FxxP_1	22	25	PF00568	0.373
DOC_USP7_MATH_1	108	112	PF00917	0.785
DOC_WW_Pin1_4	67	72	PF00397	0.678
DOC_WW_Pin1_4	92	97	PF00397	0.743
LIG_14-3-3_CanoR_1	102	108	PF00244	0.685
LIG_FHA_1	13	19	PF00498	0.414
LIG_FHA_2	145	151	PF00498	0.640
LIG_FHA_2	5	11	PF00498	0.458
LIG_LIR_Gen_1	77	86	PF02991	0.617
LIG_LIR_Nem_3	77	83	PF02991	0.674
LIG_Pex14_2	22	26	PF04695	0.360
LIG_SH2_CRK	33	37	PF00017	0.614
LIG_SH2_STAP1	45	49	PF00017	0.630
LIG_SH2_STAT5	12	15	PF00017	0.389
LIG_SH3_3	65	71	PF00018	0.681
LIG_UBA3_1	49	55	PF00899	0.566
MOD_CDC14_SPxK_1	99	102	PF00782	0.760
MOD_CDK_SPK_2	67	72	PF00069	0.678
MOD_CDK_SPxK_1	96	102	PF00069	0.760
MOD_CDK_SPxxK_3	67	74	PF00069	0.676
MOD_CK1_1	106	112	PF00069	0.801
MOD_CK1_1	119	125	PF00069	0.701
MOD_CK1_1	126	132	PF00069	0.595
MOD_CK1_1	4	10	PF00069	0.531
MOD_CK2_1	136	142	PF00069	0.713
MOD_GlcNHglycan	125	128	PF01048	0.605
MOD_GSK3_1	106	113	PF00069	0.796
MOD_GSK3_1	116	123	PF00069	0.716
MOD_GSK3_1	136	143	PF00069	0.712
MOD_GSK3_1	144	151	PF00069	0.670
MOD_GSK3_1	92	99	PF00069	0.782
MOD_N-GLC_1	103	108	PF02516	0.536
MOD_N-GLC_1	123	128	PF02516	0.403
MOD_PIKK_1	116	122	PF00454	0.734
MOD_PKA_1	116	122	PF00069	0.672
MOD_PKA_2	111	117	PF00069	0.790
MOD_PKA_2	120	126	PF00069	0.758
MOD_Plk_1	103	109	PF00069	0.735
MOD_Plk_1	136	142	PF00069	0.713
MOD_Plk_2-3	136	142	PF00069	0.713
MOD_Plk_2-3	145	151	PF00069	0.663
MOD_Plk_2-3	85	91	PF00069	0.722
MOD_Plk_4	129	135	PF00069	0.711
MOD_Plk_4	136	142	PF00069	0.618
MOD_ProDKin_1	67	73	PF00069	0.677
MOD_ProDKin_1	92	98	PF00069	0.746
TRG_DiLeu_BaEn_2	45	51	PF01217	0.566
TRG_ENDOCYTIC_2	33	36	PF00928	0.616
TRG_ER_diArg_1	56	59	PF00400	0.644
TRG_NLS_MonoExtC_3	52	57	PF00514	0.614
TRG_NLS_MonoExtN_4	53	58	PF00514	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGB0	Leishmania donovani	87%	100%
A4I707	Leishmania infantum	87%	100%
E9B225	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%