Putative 3,2-trans-enoyl-CoA isomerase,mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3,2-trans-enoyl-CoA isomerase, mitochondrial precursor, putative

Species:

Leishmania major

UniProt:

Q4Q636_LEIMA

TriTrypDb:

LmjF.31.2250 , LMJLV39_310031800 , LMJSD75_310031800

Length:

380

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	5
GO:0016020	membrane	2	2

Expansion

Sequence features

Q4Q636

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q636

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	3
GO:0006629	lipid metabolic process	3	3
GO:0006631	fatty acid metabolic process	4	3
GO:0006635	fatty acid beta-oxidation	6	3
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	3
GO:0009062	fatty acid catabolic process	5	3
GO:0009987	cellular process	1	3
GO:0016042	lipid catabolic process	4	3
GO:0016054	organic acid catabolic process	4	3
GO:0019395	fatty acid oxidation	5	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0030258	lipid modification	4	3
GO:0032787	monocarboxylic acid metabolic process	6	3
GO:0034440	lipid oxidation	5	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044242	cellular lipid catabolic process	4	3
GO:0044248	cellular catabolic process	3	3
GO:0044255	cellular lipid metabolic process	3	3
GO:0044281	small molecule metabolic process	2	3
GO:0044282	small molecule catabolic process	3	3
GO:0046395	carboxylic acid catabolic process	5	3
GO:0071704	organic substance metabolic process	2	3
GO:0072329	monocarboxylic acid catabolic process	6	3
GO:1901575	organic substance catabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0004165	delta(3)-delta(2)-enoyl-CoA isomerase activity	5	12
GO:0004300	enoyl-CoA hydratase activity	5	3
GO:0016829	lyase activity	2	3
GO:0016835	carbon-oxygen lyase activity	3	3
GO:0016836	hydro-lyase activity	4	3
GO:0016853	isomerase activity	2	19
GO:0016860	intramolecular oxidoreductase activity	3	12
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	4	12
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	5	4
GO:0016491	oxidoreductase activity	2	4
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	4
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	32	34	PF00675	0.577
CLV_NRD_NRD_1	334	336	PF00675	0.322
CLV_NRD_NRD_1	378	380	PF00675	0.619
CLV_NRD_NRD_1	40	42	PF00675	0.601
CLV_NRD_NRD_1	7	9	PF00675	0.496
CLV_PCSK_KEX2_1	32	34	PF00082	0.577
CLV_PCSK_KEX2_1	334	336	PF00082	0.315
CLV_PCSK_KEX2_1	40	42	PF00082	0.601
CLV_PCSK_KEX2_1	6	8	PF00082	0.499
CLV_PCSK_PC7_1	330	336	PF00082	0.300
CLV_PCSK_SKI1_1	121	125	PF00082	0.373
DEG_APCC_DBOX_1	334	342	PF00400	0.307
DEG_MDM2_SWIB_1	194	201	PF02201	0.259
DEG_Nend_UBRbox_1	1	4	PF02207	0.484
DEG_SPOP_SBC_1	42	46	PF00917	0.728
DOC_CYCLIN_RxL_1	274	285	PF00134	0.318
DOC_CYCLIN_yClb5_NLxxxL_5	365	371	PF00134	0.436
DOC_PP2B_LxvP_1	257	260	PF13499	0.392
DOC_PP2B_LxvP_1	319	322	PF13499	0.390
DOC_PP4_FxxP_1	101	104	PF00568	0.513
DOC_PP4_FxxP_1	204	207	PF00568	0.321
DOC_USP7_MATH_1	132	136	PF00917	0.313
DOC_USP7_MATH_1	322	326	PF00917	0.279
DOC_WW_Pin1_4	213	218	PF00397	0.294
DOC_WW_Pin1_4	282	287	PF00397	0.321
DOC_WW_Pin1_4	357	362	PF00397	0.275
LIG_14-3-3_CanoR_1	317	322	PF00244	0.408
LIG_14-3-3_CanoR_1	32	42	PF00244	0.494
LIG_14-3-3_CanoR_1	67	72	PF00244	0.643
LIG_APCC_ABBA_1	138	143	PF00400	0.328
LIG_BIR_III_2	96	100	PF00653	0.629
LIG_BRCT_BRCA1_1	57	61	PF00533	0.706
LIG_deltaCOP1_diTrp_1	196	204	PF00928	0.321
LIG_FHA_1	155	161	PF00498	0.336
LIG_FHA_1	33	39	PF00498	0.550
LIG_FHA_1	353	359	PF00498	0.310
LIG_FHA_1	51	57	PF00498	0.659
LIG_LIR_Apic_2	100	104	PF02991	0.539
LIG_LIR_Apic_2	203	207	PF02991	0.320
LIG_LIR_Gen_1	139	149	PF02991	0.324
LIG_LIR_Gen_1	193	201	PF02991	0.294
LIG_LIR_Gen_1	316	322	PF02991	0.321
LIG_LIR_Gen_1	336	342	PF02991	0.380
LIG_LIR_Gen_1	351	361	PF02991	0.316
LIG_LIR_Nem_3	139	144	PF02991	0.324
LIG_LIR_Nem_3	16	22	PF02991	0.545
LIG_LIR_Nem_3	196	201	PF02991	0.311
LIG_LIR_Nem_3	316	321	PF02991	0.321
LIG_LIR_Nem_3	351	357	PF02991	0.406
LIG_LYPXL_SIV_4	311	319	PF13949	0.449
LIG_PCNA_PIPBox_1	364	373	PF02747	0.390
LIG_PCNA_yPIPBox_3	364	375	PF02747	0.344
LIG_Pex14_2	190	194	PF04695	0.321
LIG_Pex14_2	353	357	PF04695	0.416
LIG_RPA_C_Fungi	21	33	PF08784	0.397
LIG_SH2_CRK	267	271	PF00017	0.292
LIG_SH2_STAP1	267	271	PF00017	0.292
LIG_SH2_STAP1	349	353	PF00017	0.309
LIG_SH2_STAT3	66	69	PF00017	0.723
LIG_SH2_STAT5	269	272	PF00017	0.327
LIG_SH2_STAT5	337	340	PF00017	0.389
LIG_SH2_STAT5	370	373	PF00017	0.368
LIG_SH3_3	101	107	PF00018	0.499
LIG_SH3_3	14	20	PF00018	0.580
LIG_SH3_3	176	182	PF00018	0.449
LIG_SH3_3	255	261	PF00018	0.408
LIG_SH3_3	355	361	PF00018	0.363
LIG_SH3_3	71	77	PF00018	0.619
LIG_SxIP_EBH_1	158	172	PF03271	0.334
LIG_TRAF2_1	153	156	PF00917	0.436
LIG_TRAF2_1	193	196	PF00917	0.310
LIG_TRAF2_1	302	305	PF00917	0.478
LIG_TRAF2_1	343	346	PF00917	0.368
LIG_WRC_WIRS_1	19	24	PF05994	0.398
MOD_CK1_1	45	51	PF00069	0.707
MOD_CK1_1	91	97	PF00069	0.639
MOD_CK2_1	150	156	PF00069	0.397
MOD_CK2_1	190	196	PF00069	0.381
MOD_CK2_1	340	346	PF00069	0.368
MOD_CK2_1	366	372	PF00069	0.344
MOD_CMANNOS	147	150	PF00535	0.321
MOD_GlcNHglycan	163	166	PF01048	0.324
MOD_GlcNHglycan	170	173	PF01048	0.291
MOD_GlcNHglycan	35	38	PF01048	0.634
MOD_GlcNHglycan	57	60	PF01048	0.639
MOD_GSK3_1	150	157	PF00069	0.333
MOD_GSK3_1	161	168	PF00069	0.284
MOD_GSK3_1	348	355	PF00069	0.441
MOD_GSK3_1	41	48	PF00069	0.679
MOD_N-GLC_1	250	255	PF02516	0.326
MOD_NEK2_1	1	6	PF00069	0.489
MOD_NEK2_1	190	195	PF00069	0.333
MOD_NEK2_1	250	255	PF00069	0.329
MOD_NEK2_1	270	275	PF00069	0.139
MOD_NEK2_1	61	66	PF00069	0.582
MOD_PIKK_1	352	358	PF00454	0.320
MOD_PIKK_1	61	67	PF00454	0.650
MOD_PK_1	317	323	PF00069	0.416
MOD_PKA_1	105	111	PF00069	0.605
MOD_PKA_1	32	38	PF00069	0.533
MOD_PKA_2	31	37	PF00069	0.493
MOD_PKB_1	8	16	PF00069	0.491
MOD_Plk_4	165	171	PF00069	0.340
MOD_Plk_4	18	24	PF00069	0.549
MOD_Plk_4	366	372	PF00069	0.344
MOD_ProDKin_1	213	219	PF00069	0.294
MOD_ProDKin_1	282	288	PF00069	0.321
MOD_ProDKin_1	357	363	PF00069	0.275
MOD_SUMO_rev_2	153	160	PF00179	0.415
TRG_DiLeu_BaEn_1	109	114	PF01217	0.513
TRG_ENDOCYTIC_2	19	22	PF00928	0.411
TRG_ENDOCYTIC_2	229	232	PF00928	0.449
TRG_ENDOCYTIC_2	267	270	PF00928	0.309
TRG_ENDOCYTIC_2	337	340	PF00928	0.412
TRG_ER_diArg_1	333	335	PF00400	0.320
TRG_ER_diArg_1	39	41	PF00400	0.601
TRG_ER_diArg_1	5	8	PF00400	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4C8	Leptomonas seymouri	76%	100%
A0A0S4IKH3	Bodo saltans	59%	100%
A0A0S4JA19	Bodo saltans	35%	100%
A0A1X0NRI1	Trypanosomatidae	54%	100%
A0A3Q8IE71	Leishmania donovani	38%	100%
A0A3Q8IIZ5	Leishmania donovani	24%	100%
A0A3S7X4R5	Leishmania donovani	95%	100%
A0A3S7X4T7	Leishmania donovani	93%	100%
A0A422N418	Trypanosoma rangeli	61%	100%
A4HH09	Leishmania braziliensis	36%	100%
A4HJK3	Leishmania braziliensis	76%	100%
A4HJK8	Leishmania braziliensis	82%	100%
A4HJL5	Leishmania braziliensis	77%	100%
A4HM74	Leishmania braziliensis	26%	100%
A4I438	Leishmania infantum	37%	100%
A4I4U5	Leishmania infantum	24%	100%
A4I708	Leishmania infantum	95%	100%
A4I738	Leishmania infantum	87%	100%
C9ZKS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZME0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	81%
C9ZWP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9ADK3	Leishmania major	35%	100%
E9AE93	Leishmania major	25%	100%
E9ALJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AM78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B226	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B233	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
O35459	Mus musculus	22%	100%
P14604	Rattus norvegicus	23%	100%
P23965	Rattus norvegicus	39%	100%
P34559	Caenorhabditis elegans	21%	100%
P42125	Mus musculus	39%	100%
P42126	Homo sapiens	37%	100%
P94549	Bacillus subtilis (strain 168)	26%	100%
Q13011	Homo sapiens	25%	100%
Q4Q628	Leishmania major	88%	100%
Q58DM8	Bos taurus	24%	100%
Q5RFG0	Pongo abelii	26%	100%
Q62651	Rattus norvegicus	22%	100%
Q8BH95	Mus musculus	24%	100%
V5B2L9	Trypanosoma cruzi	59%	97%