Putative aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aminopeptidase, putative

Species:

Leishmania major

UniProt:

Q4Q635_LEIMA

TriTrypDb:

LmjF.31.2260 , LMJLV39_310031900 , LMJSD75_310031900

Length:

654

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q635

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q635

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006518	peptide metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043171	peptide catabolic process	4	2
GO:0043603	amide metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004177	aminopeptidase activity	5	9
GO:0005488	binding	1	10
GO:0008233	peptidase activity	3	10
GO:0008235	metalloexopeptidase activity	5	2
GO:0008237	metallopeptidase activity	4	10
GO:0008238	exopeptidase activity	4	9
GO:0008270	zinc ion binding	6	10
GO:0016787	hydrolase activity	2	10
GO:0033218	amide binding	2	2
GO:0042277	peptide binding	3	2
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0070006	metalloaminopeptidase activity	6	2
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.672
CLV_C14_Caspase3-7	82	86	PF00656	0.630
CLV_NRD_NRD_1	112	114	PF00675	0.495
CLV_NRD_NRD_1	185	187	PF00675	0.684
CLV_NRD_NRD_1	192	194	PF00675	0.614
CLV_NRD_NRD_1	320	322	PF00675	0.443
CLV_NRD_NRD_1	404	406	PF00675	0.525
CLV_NRD_NRD_1	76	78	PF00675	0.485
CLV_PCSK_FUR_1	110	114	PF00082	0.539
CLV_PCSK_FUR_1	74	78	PF00082	0.560
CLV_PCSK_KEX2_1	112	114	PF00082	0.533
CLV_PCSK_KEX2_1	185	187	PF00082	0.717
CLV_PCSK_KEX2_1	404	406	PF00082	0.525
CLV_PCSK_KEX2_1	76	78	PF00082	0.485
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.759
CLV_PCSK_PC7_1	400	406	PF00082	0.497
CLV_PCSK_SKI1_1	118	122	PF00082	0.501
CLV_PCSK_SKI1_1	222	226	PF00082	0.387
CLV_PCSK_SKI1_1	283	287	PF00082	0.376
CLV_PCSK_SKI1_1	310	314	PF00082	0.473
CLV_PCSK_SKI1_1	408	412	PF00082	0.583
CLV_PCSK_SKI1_1	574	578	PF00082	0.328
CLV_PCSK_SKI1_1	586	590	PF00082	0.344
DEG_SPOP_SBC_1	175	179	PF00917	0.587
DEG_SPOP_SBC_1	550	554	PF00917	0.468
DEG_SPOP_SBC_1	555	559	PF00917	0.405
DOC_CYCLIN_RxL_1	413	423	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	510	516	PF00134	0.312
DOC_MAPK_MEF2A_6	605	614	PF00069	0.402
DOC_PP1_RVXF_1	220	227	PF00149	0.391
DOC_PP1_RVXF_1	293	299	PF00149	0.434
DOC_PP2B_LxvP_1	510	513	PF13499	0.312
DOC_PP2B_PxIxI_1	614	620	PF00149	0.507
DOC_PP4_FxxP_1	286	289	PF00568	0.344
DOC_PP4_FxxP_1	432	435	PF00568	0.344
DOC_PP4_FxxP_1	52	55	PF00568	0.456
DOC_USP7_MATH_1	175	179	PF00917	0.716
DOC_USP7_MATH_1	542	546	PF00917	0.391
DOC_USP7_MATH_1	550	554	PF00917	0.389
DOC_USP7_MATH_1	555	559	PF00917	0.354
DOC_USP7_MATH_1	90	94	PF00917	0.740
DOC_USP7_MATH_2	98	104	PF00917	0.529
DOC_USP7_UBL2_3	187	191	PF12436	0.635
DOC_USP7_UBL2_3	531	535	PF12436	0.418
DOC_WW_Pin1_4	208	213	PF00397	0.712
DOC_WW_Pin1_4	332	337	PF00397	0.416
DOC_WW_Pin1_4	5	10	PF00397	0.498
DOC_WW_Pin1_4	551	556	PF00397	0.440
DOC_WW_Pin1_4	634	639	PF00397	0.657
DOC_WW_Pin1_4	94	99	PF00397	0.708
LIG_14-3-3_CanoR_1	247	252	PF00244	0.402
LIG_14-3-3_CanoR_1	36	44	PF00244	0.312
LIG_14-3-3_CanoR_1	408	417	PF00244	0.503
LIG_14-3-3_CanoR_1	568	576	PF00244	0.402
LIG_14-3-3_CanoR_1	629	639	PF00244	0.557
LIG_Actin_WH2_2	146	163	PF00022	0.384
LIG_Clathr_ClatBox_1	223	227	PF01394	0.493
LIG_deltaCOP1_diTrp_1	218	226	PF00928	0.493
LIG_FHA_1	212	218	PF00498	0.660
LIG_FHA_1	266	272	PF00498	0.484
LIG_FHA_1	387	393	PF00498	0.592
LIG_FHA_1	409	415	PF00498	0.562
LIG_FHA_1	45	51	PF00498	0.412
LIG_FHA_1	486	492	PF00498	0.440
LIG_FHA_1	557	563	PF00498	0.409
LIG_FHA_1	68	74	PF00498	0.461
LIG_FHA_2	205	211	PF00498	0.777
LIG_FHA_2	273	279	PF00498	0.344
LIG_FHA_2	312	318	PF00498	0.443
LIG_FHA_2	546	552	PF00498	0.361
LIG_LIR_Gen_1	103	109	PF02991	0.573
LIG_LIR_Gen_1	346	354	PF02991	0.474
LIG_LIR_Gen_1	393	402	PF02991	0.481
LIG_LIR_Nem_3	103	108	PF02991	0.543
LIG_LIR_Nem_3	307	312	PF02991	0.384
LIG_LIR_Nem_3	346	350	PF02991	0.410
LIG_LIR_Nem_3	38	44	PF02991	0.367
LIG_LIR_Nem_3	393	397	PF02991	0.504
LIG_NRBOX	443	449	PF00104	0.484
LIG_PDZ_Class_1	649	654	PF00595	0.589
LIG_Pex14_2	277	281	PF04695	0.484
LIG_SH2_CRK	394	398	PF00017	0.520
LIG_SH2_NCK_1	394	398	PF00017	0.444
LIG_SH2_SRC	471	474	PF00017	0.402
LIG_SH2_SRC	581	584	PF00017	0.443
LIG_SH2_STAP1	105	109	PF00017	0.559
LIG_SH2_STAT5	343	346	PF00017	0.378
LIG_SH2_STAT5	394	397	PF00017	0.520
LIG_SH2_STAT5	454	457	PF00017	0.369
LIG_SH2_STAT5	640	643	PF00017	0.412
LIG_SH3_3	286	292	PF00018	0.395
LIG_SH3_3	333	339	PF00018	0.369
LIG_SH3_3	370	376	PF00018	0.471
LIG_SH3_3	447	453	PF00018	0.379
LIG_SH3_3	609	615	PF00018	0.521
LIG_SH3_3	632	638	PF00018	0.604
LIG_SUMO_SIM_anti_2	363	370	PF11976	0.573
LIG_SUMO_SIM_anti_2	442	448	PF11976	0.357
LIG_SUMO_SIM_par_1	137	143	PF11976	0.418
LIG_SUMO_SIM_par_1	161	166	PF11976	0.534
LIG_TRAF2_1	618	621	PF00917	0.555
LIG_TRFH_1	394	398	PF08558	0.444
LIG_TYR_ITIM	392	397	PF00017	0.449
LIG_WRC_WIRS_1	248	253	PF05994	0.443
LIG_WRC_WIRS_1	344	349	PF05994	0.452
MOD_CK1_1	152	158	PF00069	0.583
MOD_CK1_1	174	180	PF00069	0.760
MOD_CK1_1	208	214	PF00069	0.685
MOD_CK1_1	308	314	PF00069	0.356
MOD_CK1_1	384	390	PF00069	0.604
MOD_CK1_1	53	59	PF00069	0.561
MOD_CK1_1	544	550	PF00069	0.477
MOD_CK1_1	553	559	PF00069	0.394
MOD_CK1_1	93	99	PF00069	0.699
MOD_CK2_1	272	278	PF00069	0.344
MOD_CK2_1	311	317	PF00069	0.443
MOD_CK2_1	453	459	PF00069	0.324
MOD_CK2_1	545	551	PF00069	0.361
MOD_CK2_1	94	100	PF00069	0.634
MOD_Cter_Amidation	319	322	PF01082	0.443
MOD_Cter_Amidation	473	476	PF01082	0.428
MOD_GlcNHglycan	149	152	PF01048	0.545
MOD_GlcNHglycan	173	176	PF01048	0.635
MOD_GlcNHglycan	207	210	PF01048	0.719
MOD_GlcNHglycan	227	231	PF01048	0.258
MOD_GlcNHglycan	359	362	PF01048	0.688
MOD_GlcNHglycan	383	386	PF01048	0.602
MOD_GlcNHglycan	455	458	PF01048	0.324
MOD_GlcNHglycan	543	547	PF01048	0.371
MOD_GlcNHglycan	56	59	PF01048	0.509
MOD_GlcNHglycan	564	567	PF01048	0.454
MOD_GlcNHglycan	64	67	PF01048	0.406
MOD_GlcNHglycan	651	654	PF01048	0.575
MOD_GlcNHglycan	85	88	PF01048	0.737
MOD_GlcNHglycan	92	95	PF01048	0.749
MOD_GSK3_1	171	178	PF00069	0.693
MOD_GSK3_1	204	211	PF00069	0.699
MOD_GSK3_1	261	268	PF00069	0.446
MOD_GSK3_1	304	311	PF00069	0.366
MOD_GSK3_1	386	393	PF00069	0.561
MOD_GSK3_1	481	488	PF00069	0.411
MOD_GSK3_1	50	57	PF00069	0.539
MOD_GSK3_1	541	548	PF00069	0.334
MOD_GSK3_1	549	556	PF00069	0.344
MOD_GSK3_1	558	565	PF00069	0.188
MOD_GSK3_1	630	637	PF00069	0.680
MOD_GSK3_1	89	96	PF00069	0.718
MOD_N-GLC_1	390	395	PF02516	0.525
MOD_NEK2_1	226	231	PF00069	0.574
MOD_NEK2_1	34	39	PF00069	0.622
MOD_NEK2_1	356	361	PF00069	0.651
MOD_NEK2_1	386	391	PF00069	0.653
MOD_NEK2_1	392	397	PF00069	0.536
MOD_NEK2_1	50	55	PF00069	0.448
MOD_NEK2_1	576	581	PF00069	0.402
MOD_PIKK_1	239	245	PF00454	0.402
MOD_PK_1	161	167	PF00069	0.530
MOD_PKA_1	186	192	PF00069	0.704
MOD_PKA_2	35	41	PF00069	0.484
MOD_PKA_2	418	424	PF00069	0.484
MOD_PKA_2	53	59	PF00069	0.512
MOD_PKA_2	567	573	PF00069	0.440
MOD_PKA_2	80	86	PF00069	0.621
MOD_Plk_1	390	396	PF00069	0.481
MOD_Plk_2-3	100	106	PF00069	0.617
MOD_Plk_4	392	398	PF00069	0.448
MOD_Plk_4	460	466	PF00069	0.406
MOD_Plk_4	68	74	PF00069	0.518
MOD_ProDKin_1	208	214	PF00069	0.709
MOD_ProDKin_1	332	338	PF00069	0.416
MOD_ProDKin_1	5	11	PF00069	0.498
MOD_ProDKin_1	551	557	PF00069	0.440
MOD_ProDKin_1	634	640	PF00069	0.636
MOD_ProDKin_1	94	100	PF00069	0.710
MOD_SUMO_for_1	354	357	PF00179	0.561
TRG_DiLeu_BaEn_1	492	497	PF01217	0.378
TRG_DiLeu_BaEn_2	103	109	PF01217	0.571
TRG_DiLeu_BaEn_4	620	626	PF01217	0.407
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.443
TRG_DiLeu_LyEn_5	269	274	PF01217	0.484
TRG_ENDOCYTIC_2	105	108	PF00928	0.567
TRG_ENDOCYTIC_2	133	136	PF00928	0.356
TRG_ENDOCYTIC_2	394	397	PF00928	0.520
TRG_ER_diArg_1	109	112	PF00400	0.538
TRG_ER_diArg_1	75	77	PF00400	0.471
TRG_NLS_MonoExtN_4	191	197	PF00514	0.615
TRG_NLS_MonoExtN_4	319	325	PF00514	0.258
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	137	142	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	586	590	PF00026	0.258

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC92	Leptomonas seymouri	56%	100%
A0A3S7X4Q1	Leishmania donovani	92%	100%
A0A422N3Z8	Trypanosoma rangeli	36%	100%
A4HJK9	Leishmania braziliensis	74%	100%
A4I709	Leishmania infantum	92%	100%
C9ZWP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B227	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5AMB1	Trypanosoma cruzi	35%	100%