MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q634_LEIMA

TriTrypDb:

LmjF.31.2270 , LMJLV39_310032000 , LMJSD75_310032000

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q634

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q634

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0000774	adenyl-nucleotide exchange factor activity	3	2
GO:0005488	binding	1	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0036094	small molecule binding	2	2
GO:0060590	ATPase regulator activity	2	2
GO:0097159	organic cyclic compound binding	2	2
GO:0098772	molecular function regulator activity	1	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.402
CLV_PCSK_KEX2_1	151	153	PF00082	0.394
CLV_PCSK_KEX2_1	91	93	PF00082	0.445
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.483
CLV_PCSK_SKI1_1	365	369	PF00082	0.410
CLV_PCSK_SKI1_1	417	421	PF00082	0.485
CLV_PCSK_SKI1_1	80	84	PF00082	0.556
CLV_PCSK_SKI1_1	91	95	PF00082	0.446
CLV_Separin_Metazoa	421	425	PF03568	0.366
DEG_APCC_DBOX_1	79	87	PF00400	0.608
DOC_CYCLIN_RxL_1	91	101	PF00134	0.473
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.509
DOC_MAPK_gen_1	151	161	PF00069	0.471
DOC_MAPK_gen_1	91	98	PF00069	0.529
DOC_PP1_RVXF_1	363	370	PF00149	0.441
DOC_PP1_RVXF_1	449	455	PF00149	0.503
DOC_PP1_RVXF_1	92	99	PF00149	0.515
DOC_USP7_MATH_1	167	171	PF00917	0.666
DOC_USP7_MATH_1	37	41	PF00917	0.749
DOC_USP7_MATH_1	44	48	PF00917	0.744
DOC_USP7_MATH_1	82	86	PF00917	0.566
DOC_WW_Pin1_4	289	294	PF00397	0.447
DOC_WW_Pin1_4	328	333	PF00397	0.674
DOC_WW_Pin1_4	412	417	PF00397	0.524
DOC_WW_Pin1_4	85	90	PF00397	0.585
LIG_14-3-3_CanoR_1	312	318	PF00244	0.531
LIG_14-3-3_CanoR_1	71	79	PF00244	0.549
LIG_14-3-3_CterR_2	460	462	PF00244	0.523
LIG_APCC_ABBA_1	197	202	PF00400	0.462
LIG_BIR_II_1	1	5	PF00653	0.627
LIG_Clathr_ClatBox_1	97	101	PF01394	0.513
LIG_deltaCOP1_diTrp_1	129	137	PF00928	0.468
LIG_FHA_1	299	305	PF00498	0.468
LIG_FHA_1	308	314	PF00498	0.399
LIG_FHA_1	407	413	PF00498	0.434
LIG_FHA_2	314	320	PF00498	0.555
LIG_FHA_2	323	329	PF00498	0.655
LIG_FHA_2	445	451	PF00498	0.574
LIG_Integrin_RGD_1	179	181	PF01839	0.657
LIG_LIR_Gen_1	136	143	PF02991	0.438
LIG_LIR_Gen_1	74	84	PF02991	0.585
LIG_LIR_Nem_3	349	355	PF02991	0.561
LIG_LIR_Nem_3	74	79	PF02991	0.569
LIG_NRBOX	272	278	PF00104	0.452
LIG_Pex14_1	133	137	PF04695	0.449
LIG_PTAP_UEV_1	30	35	PF05743	0.723
LIG_SH2_CRK	352	356	PF00017	0.594
LIG_SH2_STAT5	372	375	PF00017	0.377
LIG_SH3_3	28	34	PF00018	0.733
LIG_SH3_3	66	72	PF00018	0.573
LIG_SH3_3	83	89	PF00018	0.559
LIG_SH3_5	72	76	PF00018	0.539
LIG_SUMO_SIM_anti_2	301	310	PF11976	0.526
LIG_SUMO_SIM_par_1	157	162	PF11976	0.510
LIG_SUMO_SIM_par_1	331	336	PF11976	0.652
LIG_TRAF2_1	113	116	PF00917	0.556
LIG_TRAF2_1	120	123	PF00917	0.444
LIG_TRAF2_1	344	347	PF00917	0.685
LIG_UBA3_1	355	361	PF00899	0.327
MOD_CDC14_SPxK_1	88	91	PF00782	0.555
MOD_CDK_SPK_2	412	417	PF00069	0.505
MOD_CDK_SPxK_1	85	91	PF00069	0.582
MOD_CDK_SPxxK_3	85	92	PF00069	0.574
MOD_CK1_1	2	8	PF00069	0.615
MOD_CK1_1	292	298	PF00069	0.502
MOD_CK1_1	393	399	PF00069	0.597
MOD_CK1_1	47	53	PF00069	0.646
MOD_CK1_1	85	91	PF00069	0.636
MOD_CK2_1	313	319	PF00069	0.516
MOD_CK2_1	341	347	PF00069	0.640
MOD_CK2_1	444	450	PF00069	0.483
MOD_CK2_1	71	77	PF00069	0.538
MOD_GlcNHglycan	163	166	PF01048	0.679
MOD_GlcNHglycan	167	170	PF01048	0.663
MOD_GlcNHglycan	194	197	PF01048	0.532
MOD_GlcNHglycan	209	212	PF01048	0.490
MOD_GlcNHglycan	24	27	PF01048	0.470
MOD_GlcNHglycan	301	304	PF01048	0.505
MOD_GlcNHglycan	31	34	PF01048	0.708
MOD_GlcNHglycan	392	395	PF01048	0.551
MOD_GlcNHglycan	4	7	PF01048	0.601
MOD_GlcNHglycan	49	52	PF01048	0.521
MOD_GlcNHglycan	80	83	PF01048	0.559
MOD_GSK3_1	161	168	PF00069	0.666
MOD_GSK3_1	258	265	PF00069	0.504
MOD_GSK3_1	288	295	PF00069	0.492
MOD_GSK3_1	307	314	PF00069	0.404
MOD_GSK3_1	333	340	PF00069	0.694
MOD_GSK3_1	372	379	PF00069	0.425
MOD_GSK3_1	78	85	PF00069	0.560
MOD_N-GLC_1	101	106	PF02516	0.645
MOD_N-GLC_2	13	15	PF02516	0.539
MOD_NEK2_1	159	164	PF00069	0.702
MOD_NEK2_1	298	303	PF00069	0.539
MOD_NEK2_1	307	312	PF00069	0.448
MOD_NEK2_1	313	318	PF00069	0.392
MOD_NEK2_1	355	360	PF00069	0.432
MOD_NEK2_1	373	378	PF00069	0.424
MOD_PIKK_1	37	43	PF00454	0.566
MOD_PIKK_1	433	439	PF00454	0.539
MOD_PIKK_1	444	450	PF00454	0.461
MOD_PKA_2	288	294	PF00069	0.441
MOD_PKA_2	311	317	PF00069	0.561
MOD_PKA_2	444	450	PF00069	0.483
MOD_PKA_2	47	53	PF00069	0.599
MOD_Plk_4	269	275	PF00069	0.513
MOD_Plk_4	292	298	PF00069	0.524
MOD_ProDKin_1	289	295	PF00069	0.441
MOD_ProDKin_1	328	334	PF00069	0.669
MOD_ProDKin_1	412	418	PF00069	0.522
MOD_ProDKin_1	85	91	PF00069	0.582
MOD_SUMO_rev_2	101	109	PF00179	0.577
TRG_DiLeu_BaEn_2	449	455	PF01217	0.477
TRG_DiLeu_BaEn_3	122	128	PF01217	0.483
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.553
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.431
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.525
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.597
TRG_ENDOCYTIC_2	352	355	PF00928	0.528
TRG_ENDOCYTIC_2	76	79	PF00928	0.569
TRG_ER_diArg_1	150	152	PF00400	0.366
TRG_NES_CRM1_1	236	250	PF08389	0.507
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXH6	Leptomonas seymouri	47%	100%
A0A3S7X4Q0	Leishmania donovani	87%	100%
A4HJL0	Leishmania braziliensis	66%	100%
A4I710	Leishmania infantum	87%	100%
E9B228	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5BA98	Trypanosoma cruzi	27%	100%