Phosphatidylethanolamine N-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylethanolaminen-methyltransferase-lik e protein

Species:

Leishmania major

UniProt:

Q4Q632_LEIMA

TriTrypDb:

LmjF.31.2290 , LMJLV39_310032200 , LMJSD75_310032200

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	8
GO:0016020	membrane	2	8
GO:0031090	organelle membrane	3	8
GO:0031966	mitochondrial membrane	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q632

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q632

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	8
GO:0006644	phospholipid metabolic process	4	8
GO:0006650	glycerophospholipid metabolic process	5	8
GO:0006656	phosphatidylcholine biosynthetic process	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0008610	lipid biosynthetic process	4	8
GO:0008654	phospholipid biosynthetic process	5	8
GO:0009058	biosynthetic process	2	8
GO:0009987	cellular process	1	8
GO:0019637	organophosphate metabolic process	3	8
GO:0032259	methylation	2	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0044255	cellular lipid metabolic process	3	8
GO:0045017	glycerolipid biosynthetic process	4	8
GO:0046470	phosphatidylcholine metabolic process	4	8
GO:0046474	glycerophospholipid biosynthetic process	5	8
GO:0046486	glycerolipid metabolic process	4	8
GO:0071704	organic substance metabolic process	2	8
GO:0090407	organophosphate biosynthetic process	4	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901566	organonitrogen compound biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0000773	phosphatidyl-N-methylethanolamine N-methyltransferase activity	6	8
GO:0003824	catalytic activity	1	8
GO:0004608	phosphatidylethanolamine N-methyltransferase activity	6	8
GO:0008168	methyltransferase activity	4	8
GO:0008170	N-methyltransferase activity	5	8
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016741	transferase activity, transferring one-carbon groups	3	8
GO:0080101	phosphatidyl-N-dimethylethanolamine N-methyltransferase activity	6	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	206	208	PF00675	0.377
CLV_NRD_NRD_1	41	43	PF00675	0.368
CLV_PCSK_KEX2_1	208	210	PF00082	0.328
CLV_PCSK_KEX2_1	41	43	PF00082	0.404
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.328
CLV_PCSK_PC7_1	37	43	PF00082	0.385
DEG_SCF_FBW7_1	4	11	PF00400	0.376
DOC_CKS1_1	5	10	PF01111	0.407
DOC_PP4_FxxP_1	155	158	PF00568	0.489
DOC_PP4_FxxP_1	197	200	PF00568	0.528
DOC_USP7_MATH_1	216	220	PF00917	0.630
DOC_USP7_MATH_1	8	12	PF00917	0.444
DOC_WW_Pin1_4	196	201	PF00397	0.493
DOC_WW_Pin1_4	4	9	PF00397	0.411
LIG_14-3-3_CanoR_1	146	152	PF00244	0.489
LIG_BRCT_BRCA1_1	82	86	PF00533	0.388
LIG_FHA_1	116	122	PF00498	0.474
LIG_FHA_1	181	187	PF00498	0.402
LIG_FHA_1	200	206	PF00498	0.481
LIG_FHA_1	89	95	PF00498	0.460
LIG_LIR_Apic_2	153	158	PF02991	0.489
LIG_LIR_Apic_2	194	200	PF02991	0.310
LIG_LIR_Gen_1	123	130	PF02991	0.389
LIG_LIR_Gen_1	30	40	PF02991	0.440
LIG_LIR_LC3C_4	118	122	PF02991	0.435
LIG_LIR_Nem_3	123	128	PF02991	0.340
LIG_LIR_Nem_3	137	142	PF02991	0.406
LIG_LIR_Nem_3	30	35	PF02991	0.377
LIG_LIR_Nem_3	83	89	PF02991	0.469
LIG_Pex14_2	197	201	PF04695	0.512
LIG_PTB_Apo_2	154	161	PF02174	0.528
LIG_PTB_Phospho_1	154	160	PF10480	0.528
LIG_SH2_CRK	15	19	PF00017	0.348
LIG_SH2_STAT5	134	137	PF00017	0.489
LIG_SH2_STAT5	138	141	PF00017	0.489
LIG_SH2_STAT5	160	163	PF00017	0.348
LIG_SH2_STAT5	196	199	PF00017	0.504
LIG_SH2_STAT5	57	60	PF00017	0.351
LIG_SH3_3	2	8	PF00018	0.418
LIG_SUMO_SIM_par_1	118	124	PF11976	0.473
LIG_TYR_ITIM	13	18	PF00017	0.282
LIG_WRC_WIRS_1	122	127	PF05994	0.473
MOD_CK1_1	199	205	PF00069	0.468
MOD_Cter_Amidation	50	53	PF01082	0.378
MOD_GlcNHglycan	218	221	PF01048	0.438
MOD_GlcNHglycan	66	69	PF01048	0.450
MOD_GSK3_1	116	123	PF00069	0.348
MOD_GSK3_1	4	11	PF00069	0.425
MOD_NEK2_1	120	125	PF00069	0.305
MOD_NEK2_1	128	133	PF00069	0.302
MOD_NEK2_1	168	173	PF00069	0.383
MOD_NEK2_1	64	69	PF00069	0.310
MOD_PIKK_1	88	94	PF00454	0.425
MOD_PKA_1	41	47	PF00069	0.558
MOD_PKA_2	145	151	PF00069	0.489
MOD_PKA_2	41	47	PF00069	0.597
MOD_Plk_4	116	122	PF00069	0.348
MOD_Plk_4	130	136	PF00069	0.348
MOD_Plk_4	177	183	PF00069	0.438
MOD_Plk_4	27	33	PF00069	0.402
MOD_Plk_4	81	87	PF00069	0.394
MOD_ProDKin_1	196	202	PF00069	0.493
MOD_ProDKin_1	4	10	PF00069	0.409
TRG_AP2beta_CARGO_1	137	146	PF09066	0.489
TRG_ENDOCYTIC_2	138	141	PF00928	0.499
TRG_ENDOCYTIC_2	15	18	PF00928	0.348
TRG_ER_diArg_1	206	209	PF00400	0.582
TRG_ER_diArg_1	40	42	PF00400	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H5	Leptomonas seymouri	67%	100%
A0A0S4IUX3	Bodo saltans	53%	100%
A0A3Q8IF09	Leishmania donovani	90%	100%
A4HJL2	Leishmania braziliensis	80%	97%
A4I735	Leishmania infantum	89%	100%
C8VRV0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	43%	100%
E9B230	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O74827	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
P05375	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
Q08388	Rattus norvegicus	40%	100%
Q54H80	Dictyostelium discoideum	28%	100%
Q54SD5	Dictyostelium discoideum	39%	100%
Q61907	Mus musculus	39%	100%
Q7S5W9	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	46%	100%
Q7YRH6	Bos taurus	42%	100%
Q9UBM1	Homo sapiens	41%	100%