Putative 3'-nucleotidase/nuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3'-nucleotidase/nuclease precursor, putative

Species:

Leishmania major

UniProt:

Q4Q630_LEIMA

TriTrypDb:

LmjF.31.2310 , LMJLV39_310032500 , LMJSD75_310032500

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 22, no: 6
NetGPI	no	yes: 0, no: 28

Cellular components
Term	Name	Level	Count
GO:0009986	cell surface	2	2
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q630

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q630

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	29
GO:0006163	purine nucleotide metabolic process	5	2
GO:0006195	purine nucleotide catabolic process	6	2
GO:0006196	AMP catabolic process	7	2
GO:0006259	DNA metabolic process	4	29
GO:0006308	DNA catabolic process	5	29
GO:0006725	cellular aromatic compound metabolic process	3	29
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	29
GO:0008152	metabolic process	1	29
GO:0009056	catabolic process	2	29
GO:0009057	macromolecule catabolic process	4	29
GO:0009117	nucleotide metabolic process	5	2
GO:0009123	nucleoside monophosphate metabolic process	5	2
GO:0009125	nucleoside monophosphate catabolic process	6	2
GO:0009126	purine nucleoside monophosphate metabolic process	6	2
GO:0009128	purine nucleoside monophosphate catabolic process	7	2
GO:0009150	purine ribonucleotide metabolic process	6	2
GO:0009154	purine ribonucleotide catabolic process	6	2
GO:0009158	ribonucleoside monophosphate catabolic process	7	2
GO:0009161	ribonucleoside monophosphate metabolic process	6	2
GO:0009166	nucleotide catabolic process	6	2
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	2
GO:0009169	purine ribonucleoside monophosphate catabolic process	8	2
GO:0009259	ribonucleotide metabolic process	5	2
GO:0009261	ribonucleotide catabolic process	5	2
GO:0009987	cellular process	1	29
GO:0019439	aromatic compound catabolic process	4	29
GO:0019637	organophosphate metabolic process	3	2
GO:0019693	ribose phosphate metabolic process	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	29
GO:0034655	nucleobase-containing compound catabolic process	4	29
GO:0043170	macromolecule metabolic process	3	29
GO:0044237	cellular metabolic process	2	29
GO:0044238	primary metabolic process	2	29
GO:0044248	cellular catabolic process	3	29
GO:0044260	obsolete cellular macromolecule metabolic process	3	29
GO:0044265	obsolete cellular macromolecule catabolic process	4	29
GO:0044270	cellular nitrogen compound catabolic process	4	29
GO:0044281	small molecule metabolic process	2	2
GO:0046033	AMP metabolic process	7	2
GO:0046434	organophosphate catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	29
GO:0046700	heterocycle catabolic process	4	29
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	29
GO:0072521	purine-containing compound metabolic process	4	2
GO:0072523	purine-containing compound catabolic process	5	2
GO:0090304	nucleic acid metabolic process	4	29
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901136	carbohydrate derivative catabolic process	4	2
GO:1901292	nucleoside phosphate catabolic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	29
GO:1901361	organic cyclic compound catabolic process	4	29
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	29

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	29
GO:0003824	catalytic activity	1	29
GO:0004518	nuclease activity	4	29
GO:0004519	endonuclease activity	5	29
GO:0005488	binding	1	29
GO:0008252	nucleotidase activity	6	2
GO:0008254	3'-nucleotidase activity	7	2
GO:0016787	hydrolase activity	2	29
GO:0016788	hydrolase activity, acting on ester bonds	3	29
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0043167	ion binding	2	29
GO:0043169	cation binding	3	29
GO:0046872	metal ion binding	4	29
GO:0097159	organic cyclic compound binding	2	29
GO:1901363	heterocyclic compound binding	2	29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	366	368	PF00082	0.438
CLV_PCSK_KEX2_1	40	42	PF00082	0.470
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.402
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.478
CLV_PCSK_SKI1_1	280	284	PF00082	0.448
CLV_PCSK_SKI1_1	288	292	PF00082	0.464
DOC_CKS1_1	94	99	PF01111	0.282
DOC_CYCLIN_RxL_1	2	13	PF00134	0.419
DOC_CYCLIN_RxL_1	50	61	PF00134	0.233
DOC_MAPK_gen_1	3	12	PF00069	0.444
DOC_MAPK_MEF2A_6	3	11	PF00069	0.496
DOC_MAPK_MEF2A_6	30	37	PF00069	0.383
DOC_PP1_RVXF_1	54	61	PF00149	0.214
DOC_PP4_FxxP_1	60	63	PF00568	0.310
DOC_USP7_MATH_1	131	135	PF00917	0.218
DOC_USP7_UBL2_3	271	275	PF12436	0.307
DOC_WW_Pin1_4	106	111	PF00397	0.367
DOC_WW_Pin1_4	64	69	PF00397	0.335
DOC_WW_Pin1_4	93	98	PF00397	0.282
LIG_14-3-3_CanoR_1	206	213	PF00244	0.287
LIG_Actin_WH2_2	285	300	PF00022	0.257
LIG_APCC_ABBA_1	158	163	PF00400	0.207
LIG_BIR_II_1	1	5	PF00653	0.535
LIG_BIR_III_3	1	5	PF00653	0.450
LIG_EH1_1	344	352	PF00400	0.276
LIG_FHA_1	103	109	PF00498	0.390
LIG_FHA_1	11	17	PF00498	0.442
LIG_FHA_1	111	117	PF00498	0.335
LIG_FHA_1	182	188	PF00498	0.314
LIG_FHA_1	246	252	PF00498	0.343
LIG_FHA_1	300	306	PF00498	0.260
LIG_FHA_1	336	342	PF00498	0.374
LIG_FHA_1	80	86	PF00498	0.353
LIG_FHA_2	123	129	PF00498	0.275
LIG_FHA_2	228	234	PF00498	0.382
LIG_FHA_2	263	269	PF00498	0.374
LIG_GBD_Chelix_1	137	145	PF00786	0.420
LIG_GBD_Chelix_1	289	297	PF00786	0.506
LIG_GBD_Chelix_1	356	364	PF00786	0.350
LIG_LIR_Apic_2	59	63	PF02991	0.349
LIG_LIR_Gen_1	210	220	PF02991	0.318
LIG_LIR_Gen_1	89	99	PF02991	0.336
LIG_LIR_LC3C_4	354	357	PF02991	0.236
LIG_LIR_Nem_3	210	216	PF02991	0.318
LIG_LIR_Nem_3	368	373	PF02991	0.570
LIG_LIR_Nem_3	89	94	PF02991	0.342
LIG_NRBOX	140	146	PF00104	0.220
LIG_NRBOX	6	12	PF00104	0.583
LIG_PDZ_Class_2	373	378	PF00595	0.601
LIG_SH2_CRK	255	259	PF00017	0.275
LIG_SH2_SRC	222	225	PF00017	0.385
LIG_SH2_SRC	255	258	PF00017	0.255
LIG_SH2_SRC	373	376	PF00017	0.576
LIG_SH2_STAP1	227	231	PF00017	0.340
LIG_SH2_STAP1	373	377	PF00017	0.568
LIG_SH2_STAT5	222	225	PF00017	0.291
LIG_SH2_STAT5	363	366	PF00017	0.563
LIG_SH2_STAT5	93	96	PF00017	0.259
LIG_SH3_3	201	207	PF00018	0.304
LIG_SH3_3	62	68	PF00018	0.272
LIG_SUMO_SIM_anti_2	13	18	PF11976	0.467
LIG_SUMO_SIM_anti_2	140	145	PF11976	0.232
LIG_SUMO_SIM_anti_2	34	39	PF11976	0.244
LIG_SUMO_SIM_anti_2	354	359	PF11976	0.249
LIG_SUMO_SIM_par_1	104	109	PF11976	0.379
LIG_SUMO_SIM_par_1	8	13	PF11976	0.552
LIG_TRAF2_1	232	235	PF00917	0.196
LIG_WRC_WIRS_1	57	62	PF05994	0.214
MOD_CK1_1	181	187	PF00069	0.427
MOD_CK1_1	229	235	PF00069	0.345
MOD_CK1_1	245	251	PF00069	0.238
MOD_CK2_1	122	128	PF00069	0.253
MOD_CK2_1	191	197	PF00069	0.375
MOD_CK2_1	229	235	PF00069	0.337
MOD_CK2_1	262	268	PF00069	0.296
MOD_CK2_1	43	49	PF00069	0.343
MOD_GlcNHglycan	199	202	PF01048	0.591
MOD_GlcNHglycan	24	27	PF01048	0.621
MOD_GlcNHglycan	333	336	PF01048	0.595
MOD_GlcNHglycan	60	63	PF01048	0.460
MOD_GSK3_1	102	109	PF00069	0.303
MOD_GSK3_1	22	29	PF00069	0.497
MOD_GSK3_1	223	230	PF00069	0.280
MOD_GSK3_1	311	318	PF00069	0.429
MOD_GSK3_1	331	338	PF00069	0.476
MOD_N-GLC_1	239	244	PF02516	0.467
MOD_N-GLC_1	293	298	PF02516	0.581
MOD_NEK2_1	10	15	PF00069	0.509
MOD_NEK2_1	122	127	PF00069	0.354
MOD_NEK2_1	223	228	PF00069	0.306
MOD_NEK2_1	293	298	PF00069	0.337
MOD_NEK2_1	43	48	PF00069	0.358
MOD_NEK2_1	58	63	PF00069	0.268
MOD_NEK2_1	70	75	PF00069	0.285
MOD_PKA_1	275	281	PF00069	0.309
MOD_Plk_1	223	229	PF00069	0.285
MOD_Plk_1	293	299	PF00069	0.341
MOD_Plk_2-3	102	108	PF00069	0.324
MOD_Plk_4	115	121	PF00069	0.281
MOD_Plk_4	12	18	PF00069	0.498
MOD_Plk_4	351	357	PF00069	0.266
MOD_Plk_4	43	49	PF00069	0.233
MOD_ProDKin_1	106	112	PF00069	0.367
MOD_ProDKin_1	64	70	PF00069	0.335
MOD_ProDKin_1	93	99	PF00069	0.282
MOD_SUMO_rev_2	193	200	PF00179	0.315
MOD_SUMO_rev_2	229	238	PF00179	0.417
MOD_SUMO_rev_2	267	272	PF00179	0.239
MOD_SUMO_rev_2	314	322	PF00179	0.389
MOD_SUMO_rev_2	323	333	PF00179	0.354
MOD_SUMO_rev_2	78	83	PF00179	0.305
TRG_DiLeu_BaEn_1	234	239	PF01217	0.196
TRG_DiLeu_BaEn_1	279	284	PF01217	0.257
TRG_ENDOCYTIC_2	213	216	PF00928	0.293
TRG_ENDOCYTIC_2	373	376	PF00928	0.589
TRG_ER_diArg_1	3	6	PF00400	0.437
TRG_NES_CRM1_1	150	163	PF08389	0.324
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8Q7	Leptomonas seymouri	37%	100%
A0A0S4JAL3	Bodo saltans	41%	100%
A0A1X0P2K7	Trypanosomatidae	45%	100%
A0A3Q8IBF6	Leishmania donovani	45%	99%
A0A3Q8IEW3	Leishmania donovani	37%	100%
A0A3Q8IFH4	Leishmania donovani	93%	100%
A0A3Q8IK90	Leishmania donovani	62%	100%
A0A3S7X3A6	Leishmania donovani	37%	100%
A0A422N7B0	Trypanosoma rangeli	41%	100%
A4H6V5	Leishmania braziliensis	45%	100%
A4HI96	Leishmania braziliensis	34%	100%
A4HJL3	Leishmania braziliensis	73%	100%
A4I5I0	Leishmania infantum	37%	100%
A4I736	Leishmania infantum	92%	100%
C9ZQH5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZQH6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZQW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AGC7	Leishmania infantum	45%	99%
E9ANW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	99%
E9B0S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B0S5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B231	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
F4JJL0	Arabidopsis thaliana	29%	100%
F4JJL3	Arabidopsis thaliana	26%	100%
P24021	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	24%	100%
Q4Q7F3	Leishmania major	36%	100%
Q4Q7F4	Leishmania major	36%	100%
Q4QGQ3	Leishmania major	44%	99%
Q66VY6	Leishmania major	61%	99%
Q8LDW6	Arabidopsis thaliana	27%	100%
Q9C9G4	Arabidopsis thaliana	28%	100%
Q9SXA6	Arabidopsis thaliana	28%	100%
V5B8Z9	Trypanosoma cruzi	38%	97%