Putative 3,2-trans-enoyl-CoA isomerase mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3,2-trans-enoyl-CoA isomerase, mitochondrial precursor, putative

Species:

Leishmania major

UniProt:

Q4Q628_LEIMA

TriTrypDb:

LmjF.31.2330 , LMJLV39_310032700 , LMJSD75_310031800

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	5
GO:0016020	membrane	2	2

Expansion

Sequence features

Q4Q628

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q628

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	3
GO:0006629	lipid metabolic process	3	3
GO:0006631	fatty acid metabolic process	4	3
GO:0006635	fatty acid beta-oxidation	6	3
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	3
GO:0009062	fatty acid catabolic process	5	3
GO:0009987	cellular process	1	3
GO:0016042	lipid catabolic process	4	3
GO:0016054	organic acid catabolic process	4	3
GO:0019395	fatty acid oxidation	5	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0030258	lipid modification	4	3
GO:0032787	monocarboxylic acid metabolic process	6	3
GO:0034440	lipid oxidation	5	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044242	cellular lipid catabolic process	4	3
GO:0044248	cellular catabolic process	3	3
GO:0044255	cellular lipid metabolic process	3	3
GO:0044281	small molecule metabolic process	2	3
GO:0044282	small molecule catabolic process	3	3
GO:0046395	carboxylic acid catabolic process	5	3
GO:0071704	organic substance metabolic process	2	3
GO:0072329	monocarboxylic acid catabolic process	6	3
GO:1901575	organic substance catabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	5	5
GO:0004165	delta(3)-delta(2)-enoyl-CoA isomerase activity	5	12
GO:0004300	enoyl-CoA hydratase activity	5	3
GO:0016491	oxidoreductase activity	2	5
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	5
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	5
GO:0016829	lyase activity	2	3
GO:0016835	carbon-oxygen lyase activity	3	3
GO:0016836	hydro-lyase activity	4	3
GO:0016853	isomerase activity	2	19
GO:0016860	intramolecular oxidoreductase activity	3	12
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.578
CLV_NRD_NRD_1	295	297	PF00675	0.315
CLV_NRD_NRD_1	347	349	PF00675	0.586
CLV_PCSK_KEX2_1	2	4	PF00082	0.578
CLV_PCSK_KEX2_1	295	297	PF00082	0.315
CLV_PCSK_SKI1_1	90	94	PF00082	0.333
DEG_MDM2_SWIB_1	163	170	PF02201	0.250
DEG_Nend_UBRbox_1	1	4	PF02207	0.603
DEG_SPOP_SBC_1	4	8	PF00917	0.709
DOC_CYCLIN_yClb5_NLxxxL_5	334	340	PF00134	0.414
DOC_CYCLIN_yCln2_LP_2	226	229	PF00134	0.278
DOC_PP2B_LxvP_1	226	229	PF13499	0.360
DOC_PP2B_LxvP_1	288	291	PF13499	0.358
DOC_PP4_FxxP_1	173	176	PF00568	0.285
DOC_PP4_FxxP_1	70	73	PF00568	0.469
DOC_USP7_MATH_1	101	105	PF00917	0.277
DOC_WW_Pin1_4	182	187	PF00397	0.260
DOC_WW_Pin1_4	251	256	PF00397	0.289
LIG_14-3-3_CanoR_1	286	291	PF00244	0.389
LIG_14-3-3_CanoR_1	308	318	PF00244	0.220
LIG_APCC_ABBA_1	107	112	PF00400	0.292
LIG_BIR_III_2	65	69	PF00653	0.576
LIG_BRCT_BRCA1_1	19	23	PF00533	0.535
LIG_deltaCOP1_diTrp_1	165	173	PF00928	0.285
LIG_FHA_1	124	130	PF00498	0.317
LIG_FHA_1	13	19	PF00498	0.665
LIG_FHA_2	310	316	PF00498	0.296
LIG_LIR_Apic_2	171	176	PF02991	0.285
LIG_LIR_Apic_2	69	73	PF02991	0.492
LIG_LIR_Gen_1	108	118	PF02991	0.309
LIG_LIR_Gen_1	144	153	PF02991	0.451
LIG_LIR_Gen_1	162	170	PF02991	0.289
LIG_LIR_Gen_1	234	240	PF02991	0.212
LIG_LIR_Gen_1	285	294	PF02991	0.285
LIG_LIR_Gen_1	305	311	PF02991	0.153
LIG_LIR_Nem_3	108	113	PF02991	0.309
LIG_LIR_Nem_3	144	148	PF02991	0.293
LIG_LIR_Nem_3	165	170	PF02991	0.281
LIG_LIR_Nem_3	234	239	PF02991	0.212
LIG_LIR_Nem_3	285	290	PF02991	0.285
LIG_LIR_Nem_3	305	309	PF02991	0.153
LIG_LIR_Nem_3	320	326	PF02991	0.402
LIG_LYPXL_SIV_4	280	288	PF13949	0.430
LIG_MAD2	168	176	PF02301	0.205
LIG_PCNA_PIPBox_1	333	342	PF02747	0.358
LIG_PCNA_yPIPBox_3	329	340	PF02747	0.321
LIG_Pex14_2	159	163	PF04695	0.295
LIG_SH2_CRK	236	240	PF00017	0.269
LIG_SH2_STAP1	236	240	PF00017	0.269
LIG_SH2_STAP1	318	322	PF00017	0.273
LIG_SH2_STAT3	28	31	PF00017	0.693
LIG_SH2_STAT5	238	241	PF00017	0.297
LIG_SH2_STAT5	306	309	PF00017	0.395
LIG_SH2_STAT5	339	342	PF00017	0.334
LIG_SH3_3	145	151	PF00018	0.430
LIG_SH3_3	224	230	PF00018	0.393
LIG_SH3_3	33	39	PF00018	0.600
LIG_SH3_3	70	76	PF00018	0.456
LIG_SxIP_EBH_1	127	141	PF03271	0.298
LIG_TRAF2_1	162	165	PF00917	0.297
LIG_TRAF2_1	271	274	PF00917	0.471
LIG_TRFH_1	326	330	PF08558	0.205
MOD_CK1_1	60	66	PF00069	0.582
MOD_CK1_1	7	13	PF00069	0.717
MOD_CK2_1	159	165	PF00069	0.371
MOD_CK2_1	335	341	PF00069	0.299
MOD_CMANNOS	116	119	PF00535	0.285
MOD_GlcNHglycan	132	135	PF01048	0.335
MOD_GlcNHglycan	139	142	PF01048	0.285
MOD_GlcNHglycan	19	22	PF01048	0.631
MOD_GlcNHglycan	233	236	PF01048	0.198
MOD_GSK3_1	130	137	PF00069	0.277
MOD_GSK3_1	3	10	PF00069	0.682
MOD_GSK3_1	317	324	PF00069	0.420
MOD_N-GLC_1	219	224	PF02516	0.290
MOD_NEK2_1	159	164	PF00069	0.296
MOD_NEK2_1	219	224	PF00069	0.293
MOD_NEK2_1	23	28	PF00069	0.555
MOD_NEK2_1	239	244	PF00069	0.427
MOD_PIKK_1	23	29	PF00454	0.612
MOD_PIKK_1	321	327	PF00454	0.285
MOD_PK_1	286	292	PF00069	0.389
MOD_PKA_1	295	301	PF00069	0.168
MOD_PKA_1	74	80	PF00069	0.583
MOD_PKA_2	295	301	PF00069	0.168
MOD_Plk_4	134	140	PF00069	0.298
MOD_Plk_4	335	341	PF00069	0.306
MOD_ProDKin_1	182	188	PF00069	0.260
MOD_ProDKin_1	251	257	PF00069	0.289
MOD_SUMO_rev_2	124	129	PF00179	0.391
TRG_DiLeu_BaEn_1	305	310	PF01217	0.220
TRG_DiLeu_BaEn_1	78	83	PF01217	0.477
TRG_DiLeu_BaEn_4	246	252	PF01217	0.348
TRG_DiLeu_LyEn_5	305	310	PF01217	0.220
TRG_ENDOCYTIC_2	198	201	PF00928	0.430
TRG_ENDOCYTIC_2	236	239	PF00928	0.285
TRG_ENDOCYTIC_2	306	309	PF00928	0.395
TRG_ER_diArg_1	1	3	PF00400	0.584
TRG_ER_diArg_1	295	297	PF00400	0.312
TRG_Pf-PMV_PEXEL_1	308	313	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4C8	Leptomonas seymouri	69%	99%
A0A0S4IKH3	Bodo saltans	54%	100%
A0A0S4JA19	Bodo saltans	32%	100%
A0A1X0NRI1	Trypanosomatidae	51%	95%
A0A3Q8IE71	Leishmania donovani	36%	100%
A0A3Q8IIZ5	Leishmania donovani	27%	100%
A0A3R7N7B2	Trypanosoma rangeli	24%	100%
A0A3S7X4R5	Leishmania donovani	85%	100%
A0A3S7X4T7	Leishmania donovani	87%	100%
A0A422N418	Trypanosoma rangeli	57%	100%
A4HH09	Leishmania braziliensis	35%	100%
A4HJK3	Leishmania braziliensis	71%	100%
A4HJK8	Leishmania braziliensis	74%	100%
A4HJL5	Leishmania braziliensis	72%	100%
A4I438	Leishmania infantum	35%	100%
A4I4U5	Leishmania infantum	27%	100%
A4I708	Leishmania infantum	85%	100%
A4I738	Leishmania infantum	90%	100%
A9JS71	Xenopus laevis	26%	100%
C9ZKS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZME0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	74%
C9ZWP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	97%
E9ADK3	Leishmania major	33%	100%
E9AE93	Leishmania major	27%	100%
E9AEL3	Leishmania major	26%	100%
E9ALJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AM78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B226	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9B233	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9B5S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
O35459	Mus musculus	24%	100%
P23965	Rattus norvegicus	36%	100%
P30084	Homo sapiens	24%	100%
P42125	Mus musculus	36%	100%
P42126	Homo sapiens	35%	100%
P52046	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	23%	100%
P76082	Escherichia coli (strain K12)	25%	100%
Q0AVM1	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	25%	100%
Q13011	Homo sapiens	25%	100%
Q1ZXF1	Dictyostelium discoideum	24%	100%
Q4Q636	Leishmania major	88%	92%
Q52995	Rhizobium meliloti (strain 1021)	24%	100%
Q58DM8	Bos taurus	25%	100%
Q5R646	Pongo abelii	24%	100%
Q5RFG0	Pongo abelii	25%	100%
Q62651	Rattus norvegicus	22%	100%
Q8BH95	Mus musculus	26%	100%
V5B2L9	Trypanosoma cruzi	55%	89%
V5BK92	Trypanosoma cruzi	31%	100%