Putative p-nitrophenylphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p-nitrophenylphosphatase, putative

Species:

Leishmania major

UniProt:

Q4Q627_LEIMA

TriTrypDb:

LmjF.31.2340 , LMJLV39_310032800 , LMJSD75_310032800

Length:

446

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q627

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q627

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016791	phosphatase activity	5	3
GO:0042578	phosphoric ester hydrolase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	43	45	PF00675	0.466
CLV_PCSK_KEX2_1	252	254	PF00082	0.542
CLV_PCSK_KEX2_1	356	358	PF00082	0.531
CLV_PCSK_KEX2_1	43	45	PF00082	0.466
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.462
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.467
CLV_PCSK_SKI1_1	101	105	PF00082	0.419
CLV_PCSK_SKI1_1	178	182	PF00082	0.340
CLV_PCSK_SKI1_1	428	432	PF00082	0.441
DEG_ODPH_VHL_1	213	224	PF01847	0.421
DEG_SCF_FBW7_2	29	35	PF00400	0.468
DOC_CKS1_1	29	34	PF01111	0.470
DOC_CYCLIN_yCln2_LP_2	58	64	PF00134	0.516
DOC_MAPK_gen_1	154	163	PF00069	0.523
DOC_MAPK_gen_1	20	29	PF00069	0.473
DOC_MAPK_gen_1	364	374	PF00069	0.382
DOC_PP1_RVXF_1	131	138	PF00149	0.493
DOC_PP2B_LxvP_1	247	250	PF13499	0.397
DOC_PP2B_LxvP_1	58	61	PF13499	0.570
DOC_PP4_FxxP_1	53	56	PF00568	0.505
DOC_PP4_MxPP_1	1	4	PF00568	0.417
DOC_USP7_MATH_1	13	17	PF00917	0.655
DOC_USP7_MATH_1	237	241	PF00917	0.511
DOC_USP7_MATH_1	299	303	PF00917	0.443
DOC_USP7_MATH_1	36	40	PF00917	0.465
DOC_USP7_MATH_1	7	11	PF00917	0.617
DOC_USP7_MATH_2	76	82	PF00917	0.469
DOC_WW_Pin1_4	28	33	PF00397	0.472
DOC_WW_Pin1_4	315	320	PF00397	0.567
DOC_WW_Pin1_4	52	57	PF00397	0.440
DOC_WW_Pin1_4	64	69	PF00397	0.630
DOC_WW_Pin1_4	95	100	PF00397	0.525
LIG_14-3-3_CanoR_1	20	29	PF00244	0.473
LIG_14-3-3_CanoR_1	392	399	PF00244	0.346
LIG_Actin_WH2_2	88	103	PF00022	0.447
LIG_BIR_II_1	1	5	PF00653	0.421
LIG_BIR_III_4	236	240	PF00653	0.474
LIG_Clathr_ClatBox_1	104	108	PF01394	0.501
LIG_CtBP_PxDLS_1	77	81	PF00389	0.475
LIG_FHA_1	170	176	PF00498	0.519
LIG_FHA_1	217	223	PF00498	0.440
LIG_FHA_1	233	239	PF00498	0.507
LIG_FHA_1	316	322	PF00498	0.573
LIG_FHA_1	392	398	PF00498	0.375
LIG_FHA_1	427	433	PF00498	0.441
LIG_FHA_1	86	92	PF00498	0.537
LIG_FHA_2	160	166	PF00498	0.538
LIG_FHA_2	323	329	PF00498	0.436
LIG_GBD_Chelix_1	436	444	PF00786	0.412
LIG_LIR_Apic_2	240	245	PF02991	0.584
LIG_LIR_Apic_2	314	320	PF02991	0.496
LIG_LIR_Gen_1	290	300	PF02991	0.391
LIG_LIR_Nem_3	290	296	PF02991	0.399
LIG_MYND_1	245	249	PF01753	0.501
LIG_NRBOX	47	53	PF00104	0.448
LIG_PDZ_Class_2	441	446	PF00595	0.318
LIG_PTB_Apo_2	368	375	PF02174	0.350
LIG_RPA_C_Fungi	39	51	PF08784	0.557
LIG_SH2_CRK	300	304	PF00017	0.442
LIG_SH2_CRK	317	321	PF00017	0.470
LIG_SH2_NCK_1	167	171	PF00017	0.457
LIG_SH2_PTP2	102	105	PF00017	0.347
LIG_SH2_STAP1	171	175	PF00017	0.392
LIG_SH2_STAP1	233	237	PF00017	0.510
LIG_SH2_STAT5	102	105	PF00017	0.328
LIG_SH2_STAT5	127	130	PF00017	0.352
LIG_SH2_STAT5	171	174	PF00017	0.429
LIG_SH2_STAT5	317	320	PF00017	0.491
LIG_SH2_STAT5	435	438	PF00017	0.450
LIG_SH3_3	209	215	PF00018	0.412
LIG_SH3_3	242	248	PF00018	0.566
LIG_SH3_3	326	332	PF00018	0.482
LIG_SH3_3	376	382	PF00018	0.255
LIG_SH3_3	93	99	PF00018	0.519
LIG_SUMO_SIM_par_1	103	108	PF11976	0.348
LIG_SUMO_SIM_par_1	407	412	PF11976	0.355
LIG_TRAF2_1	162	165	PF00917	0.444
LIG_TRAF2_1	187	190	PF00917	0.446
LIG_TRAF2_1	382	385	PF00917	0.480
LIG_TYR_ITIM	100	105	PF00017	0.364
LIG_TYR_ITIM	298	303	PF00017	0.443
LIG_UBA3_1	149	156	PF00899	0.446
MOD_CDC14_SPxK_1	98	101	PF00782	0.499
MOD_CDK_SPxK_1	95	101	PF00069	0.500
MOD_CK1_1	169	175	PF00069	0.469
MOD_CK1_1	21	27	PF00069	0.681
MOD_CK1_1	345	351	PF00069	0.484
MOD_CK2_1	159	165	PF00069	0.410
MOD_CK2_1	409	415	PF00069	0.365
MOD_Cter_Amidation	354	357	PF01082	0.540
MOD_GlcNHglycan	15	18	PF01048	0.623
MOD_GlcNHglycan	168	171	PF01048	0.349
MOD_GlcNHglycan	239	242	PF01048	0.458
MOD_GlcNHglycan	270	273	PF01048	0.618
MOD_GlcNHglycan	347	350	PF01048	0.405
MOD_GlcNHglycan	38	41	PF01048	0.467
MOD_GlcNHglycan	411	414	PF01048	0.386
MOD_GlcNHglycan	48	51	PF01048	0.429
MOD_GlcNHglycan	5	8	PF01048	0.575
MOD_GlcNHglycan	80	83	PF01048	0.546
MOD_GlcNHglycan	9	12	PF01048	0.601
MOD_GSK3_1	136	143	PF00069	0.351
MOD_GSK3_1	3	10	PF00069	0.535
MOD_GSK3_1	345	352	PF00069	0.419
MOD_GSK3_1	52	59	PF00069	0.699
MOD_GSK3_1	60	67	PF00069	0.592
MOD_N-GLC_1	140	145	PF02516	0.352
MOD_N-GLC_1	78	83	PF02516	0.585
MOD_NEK2_1	149	154	PF00069	0.453
MOD_NEK2_1	409	414	PF00069	0.344
MOD_PIKK_1	21	27	PF00454	0.473
MOD_PKA_2	13	19	PF00069	0.453
MOD_PKA_2	21	27	PF00069	0.461
MOD_PKA_2	391	397	PF00069	0.352
MOD_PKA_2	85	91	PF00069	0.508
MOD_Plk_1	140	146	PF00069	0.352
MOD_Plk_1	313	319	PF00069	0.443
MOD_Plk_1	78	84	PF00069	0.427
MOD_Plk_2-3	159	165	PF00069	0.446
MOD_Plk_2-3	273	279	PF00069	0.569
MOD_Plk_4	299	305	PF00069	0.475
MOD_Plk_4	335	341	PF00069	0.667
MOD_Plk_4	342	348	PF00069	0.434
MOD_Plk_4	404	410	PF00069	0.408
MOD_ProDKin_1	28	34	PF00069	0.471
MOD_ProDKin_1	315	321	PF00069	0.559
MOD_ProDKin_1	52	58	PF00069	0.442
MOD_ProDKin_1	64	70	PF00069	0.628
MOD_ProDKin_1	95	101	PF00069	0.526
TRG_ENDOCYTIC_2	102	105	PF00928	0.346
TRG_ENDOCYTIC_2	300	303	PF00928	0.430
TRG_ER_diArg_1	175	178	PF00400	0.381
TRG_ER_diArg_1	19	22	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P266	Leptomonas seymouri	41%	100%
A0A0S4IZ46	Bodo saltans	46%	100%
A0A3Q8IFQ8	Leishmania donovani	93%	100%
A0A422N412	Trypanosoma rangeli	56%	100%
A4HJL7	Leishmania braziliensis	86%	100%
A4I739	Leishmania infantum	93%	100%
A4I740	Leishmania infantum	41%	100%
A6NDG6	Homo sapiens	29%	100%
C9ZWP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
D3ZDK7	Rattus norvegicus	30%	100%
E9B234	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P0DKC3	Arabidopsis thaliana	29%	100%
P0DKC4	Arabidopsis thaliana	29%	100%
P19881	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P34492	Caenorhabditis elegans	28%	85%
Q00472	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q2T9S4	Bos taurus	29%	100%
Q5F4B1	Gallus gallus	29%	100%
Q8CHP8	Mus musculus	31%	100%
Q8GWU0	Arabidopsis thaliana	31%	100%
V5D2X9	Trypanosoma cruzi	53%	100%